Nothing Special   »   [go: up one dir, main page]

EP1631311A4 - Humanized anti-ccr2 antibodies and methods of use - Google Patents

Humanized anti-ccr2 antibodies and methods of use

Info

Publication number
EP1631311A4
EP1631311A4 EP03819151A EP03819151A EP1631311A4 EP 1631311 A4 EP1631311 A4 EP 1631311A4 EP 03819151 A EP03819151 A EP 03819151A EP 03819151 A EP03819151 A EP 03819151A EP 1631311 A4 EP1631311 A4 EP 1631311A4
Authority
EP
European Patent Office
Prior art keywords
methods
humanized anti
ccr2 antibodies
ccr2
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP03819151A
Other languages
German (de)
French (fr)
Other versions
EP1631311A2 (en
Inventor
Theresa O'keefe
Paul Ponath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to EP09169287A priority Critical patent/EP2135619A1/en
Publication of EP1631311A2 publication Critical patent/EP1631311A2/en
Publication of EP1631311A4 publication Critical patent/EP1631311A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP03819151A 2003-12-10 2003-12-10 Humanized anti-ccr2 antibodies and methods of use Ceased EP1631311A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09169287A EP2135619A1 (en) 2003-12-10 2003-12-10 Humanized anti-CCR2 antibodies and methods of use therefor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/039599 WO2005060368A2 (en) 2003-12-10 2003-12-10 Humanized anti-ccr2 antibodies and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP09169287A Division EP2135619A1 (en) 2003-12-10 2003-12-10 Humanized anti-CCR2 antibodies and methods of use therefor

Publications (2)

Publication Number Publication Date
EP1631311A2 EP1631311A2 (en) 2006-03-08
EP1631311A4 true EP1631311A4 (en) 2007-04-11

Family

ID=34709648

Family Applications (2)

Application Number Title Priority Date Filing Date
EP09169287A Withdrawn EP2135619A1 (en) 2003-12-10 2003-12-10 Humanized anti-CCR2 antibodies and methods of use therefor
EP03819151A Ceased EP1631311A4 (en) 2003-12-10 2003-12-10 Humanized anti-ccr2 antibodies and methods of use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP09169287A Withdrawn EP2135619A1 (en) 2003-12-10 2003-12-10 Humanized anti-CCR2 antibodies and methods of use therefor

Country Status (7)

Country Link
EP (2) EP2135619A1 (en)
JP (1) JP2007521248A (en)
AU (1) AU2003300896A1 (en)
CA (1) CA2529694A1 (en)
IL (1) IL172533A (en)
MX (1) MXPA06000176A (en)
WO (1) WO2005060368A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006015341A1 (en) 2006-04-03 2007-10-04 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Use of an antibody, which specifically binds to the chemokine receptor 2, for the production of a medicament for the treatment of therapy-refractory multiple sclerosis and/or therapy-refractory rheumatoid arthritis in the subject
NZ591471A (en) 2008-08-18 2012-08-31 Pfizer Antibodies to ccr2
US9127052B2 (en) 2010-06-29 2015-09-08 Centre National De La Recherche Scientifique LLT-1 antibodies with new functional properties
EP2864358B1 (en) * 2012-06-22 2019-08-07 Sorrento Therapeutics, Inc. Antigen binding proteins that bind ccr2
ES2709996T3 (en) * 2014-02-28 2019-04-22 Astellas Pharma Inc New bispecific antibody that binds to human TLR2 and human TLR4
WO2016081801A1 (en) * 2014-11-21 2016-05-26 Millennium Pharmaceuticals, Inc. Use of an anti-ccr2 antagonist in the treatment of an infectious disease
JP2021534101A (en) 2018-08-09 2021-12-09 ヴェルソー セラピューティクス， インコーポレイテッド Oligonucleotide compositions for targeting CCR2 and CSF1R and their use

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058679A1 (en) * 1998-05-09 1999-11-18 Glaxo Group Limited Antibodies to cd23, derivatives thereof, and their therapeutic uses
WO2001057226A1 (en) * 2000-02-03 2001-08-09 Millennium Pharmaceuticals, Inc. Humanized anti-ccr2 antibodies and methods of use therefor
WO2001070266A2 (en) * 2000-03-17 2001-09-27 Millennium Pharmaceuticals, Inc. Method of inhibiting stenosis and restenosis with a mixture of antibodies anti cd18 and anti ccr2
WO2002062383A2 (en) * 2001-02-08 2002-08-15 Smithkline Beecham P.L.C. Antagonists of myelin-associated glycoprotein and their use in the treatment and/or prevention of neurological diseases
US20020150576A1 (en) * 1998-07-23 2002-10-17 Larosa Gregory J. Humanized anti-CCR2 antibodies and methods of use therefor
WO2002102853A2 (en) * 2001-06-14 2002-12-27 Isis Innovation Limited Cd4-specific antibody trx1 and uses therefor

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (en) 1970-11-10 1977-09-15 Organon Nv PROCEDURE FOR DETERMINING AND DETERMINING LOW MOLECULAR COMPOUNDS AND PROTEINS THAT CAN SPECIFICALLY BIND THESE COMPOUNDS AND TEST PACKAGING.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3817827A (en) 1972-03-30 1974-06-18 Scott Paper Co Soft absorbent fibrous webs containing elastomeric bonding material and formed by creping and embossing
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4172124A (en) 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
US4444878A (en) 1981-12-21 1984-04-24 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
US5292668A (en) 1981-12-21 1994-03-08 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US4699880A (en) 1984-09-25 1987-10-13 Immunomedics, Inc. Method of producing monoclonal anti-idiotype antibody
NZ215865A (en) 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
WO1988007089A1 (en) 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
EP0318554B2 (en) 1987-05-21 2005-01-12 Micromet AG Targeted multifunctional proteins
JP3095168B2 (en) 1988-02-05 2000-10-03 エル． モリソン，シェリー Antibodies with domain-denaturing constants
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
CA2006408A1 (en) 1988-12-27 1990-06-27 Susumu Iwasa Bispecific monoclonal antibody, its production and use
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5266491A (en) 1989-03-14 1993-11-30 Mochida Pharmaceutical Co., Ltd. DNA fragment and expression plasmid containing the DNA fragment
JP3051411B2 (en) 1989-03-14 2000-06-12 持田製薬株式会社 Novel DNA and expression plasmid containing it
US5284746A (en) 1990-02-08 1994-02-08 Zymogenetics, Inc. Methods of producing hybrid G protein-coupled receptors
TW212184B (en) 1990-04-02 1993-09-01 Takeda Pharm Industry Co Ltd
US5182366A (en) 1990-05-15 1993-01-26 Huebner Verena D Controlled synthesis of peptide mixtures using mixed resins
AU8507191A (en) 1990-08-29 1992-03-30 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5948647A (en) 1990-10-29 1999-09-07 Chiron Corporation Nucleic acids encoding antigen-binding sites specific for cancer antigens
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
GB9115364D0 (en) 1991-07-16 1991-08-28 Wellcome Found Antibody
DK0605522T3 (en) 1991-09-23 2000-01-17 Medical Res Council Process for producing humanized antibodies
US5508384A (en) 1992-09-10 1996-04-16 New York University Polypeptide derived from a popamine receptor, and compositions and methods thereof
ATE162957T1 (en) 1992-12-01 1998-02-15 Merck Patent Gmbh COORDINATION CATALYST SYSTEMS
CA2115811A1 (en) 1993-02-17 1994-08-18 Claus Krebber A method for in vivo selection of ligand-binding proteins
US5514555A (en) 1993-03-12 1996-05-07 Center For Blood Research, Inc. Assays and therapeutic methods based on lymphocyte chemoattractants
WO1994026087A2 (en) 1993-05-14 1994-11-24 Connor Kim C O Recombinant protein production and insect cell culture and process
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
AU1679395A (en) 1994-01-13 1995-08-01 Regents Of The University Of California, The Mammalian monocyte chemoattractant protein receptors
US5698762A (en) 1994-12-09 1997-12-16 Dauerman; Leonard Microwave-assisted pyrolysis of waste polyaromatic hydrocarbons
WO1996040662A2 (en) 1995-06-07 1996-12-19 Cellpro, Incorporated Aminooxy-containing linker compounds and their application in conjugates
US5856571A (en) 1995-06-07 1999-01-05 Cellpro, Incorporated Semicarbazide-containing linker compounds for formation of stably-linked conjugates and methods related thereto
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
US20020042370A1 (en) * 2000-04-14 2002-04-11 Millennium Pharmaceuticals, Inc. Method of treating graft rejection using inhibitors of CCR2 function

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058679A1 (en) * 1998-05-09 1999-11-18 Glaxo Group Limited Antibodies to cd23, derivatives thereof, and their therapeutic uses
US20020150576A1 (en) * 1998-07-23 2002-10-17 Larosa Gregory J. Humanized anti-CCR2 antibodies and methods of use therefor
WO2001057226A1 (en) * 2000-02-03 2001-08-09 Millennium Pharmaceuticals, Inc. Humanized anti-ccr2 antibodies and methods of use therefor
WO2001070266A2 (en) * 2000-03-17 2001-09-27 Millennium Pharmaceuticals, Inc. Method of inhibiting stenosis and restenosis with a mixture of antibodies anti cd18 and anti ccr2
WO2002062383A2 (en) * 2001-02-08 2002-08-15 Smithkline Beecham P.L.C. Antagonists of myelin-associated glycoprotein and their use in the treatment and/or prevention of neurological diseases
WO2002102853A2 (en) * 2001-06-14 2002-12-27 Isis Innovation Limited Cd4-specific antibody trx1 and uses therefor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ALBINI ADRIANA: "HIV-1 Tat protein mimicry of chemokines", PROC. NATL. ACAD. SCI., vol. 95, October 1998 (1998-10-01), USA, pages 13153 - 13158, XP002146039, DOI: 10.1073/pnas.95.22.13153 *
COMBADIERE: "Monocyte Chemoattractant Protein-3 is a functional ligand for CC Chemokine Receptors 1 and 2B", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 50, 1998, USA, pages 29671 - 29675 *
GODISKA: "Monocte chemotactic protein-4: tissue-specific expression and signaling trhough CC chemokine receptor-2", J. LEUKOC. BIOL., vol. 61, March 1997 (1997-03-01), pages 353 - 360 *
GONG: "Monocyte chemotactic protein-2 (MCP-2) uses CCR+ and CCR2B as its functional receptors", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 18, 2 May 1997 (1997-05-02), usa, pages 11682 - 11695 *
SARAFI M.: "Murine Monocyte chemoattractant proetein (MCP)-5 a novel CC chemokine that is a structural and functional homologue of human MCP-1", J. EXP. MED., vol. 185, no. 1, 6 January 1997 (1997-01-06), USA, pages 99 - 109, XP055035882, DOI: 10.1084/jem.185.1.99 *

Also Published As

Publication number Publication date
WO2005060368A3 (en) 2005-12-22
EP2135619A1 (en) 2009-12-23
MXPA06000176A (en) 2006-06-27
CA2529694A1 (en) 2005-07-07
IL172533A0 (en) 2006-04-10
IL172533A (en) 2012-02-29
AU2003300896A1 (en) 2005-07-14
WO2005060368A2 (en) 2005-07-07
EP1631311A2 (en) 2006-03-08
JP2007521248A (en) 2007-08-02

Similar Documents

Publication Publication Date Title
IL179102A (en) Humanized fcγriib specific antibodies and methods of use thereof
HK1219487A1 (en) Cd20-specific antibodies and methods of employing same cd20
IL178593A (en) Fcγriib-specific antibodies and methods of use thereof
HK1099935A1 (en) Anti-cd3 antibodies and methods of use thereof -cd3
IL157142A0 (en) Modified antibodies and methods of use
IL172689A0 (en) Pro104 ANTIBODY COMPOSITIONS AND METHODS OF USE
AU2003265522A1 (en) FCGammaRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
TWI350291B (en) Crystal of anti-egfr antibodies
EP1833849A4 (en) Fc gamma riib-specific antibodies and methods of use thereof
EP1841452B8 (en) Single domain antibodies against tnfr1 and methods of use therefor
IL186659A0 (en) Il-31 monoclonal antibodies and methods of use
ZA200507067B (en) Antibodies against human IL-21 receptor and uses therefor
EP1482984A4 (en) Surrogate antibodies and methods of preparation and use thereof
SI1587542T1 (en) Use of anti-cd100 antibodies
HK1084949A1 (en) Arylvinylazacycloalkane compounds and methods of preparation and use thereof
EP1689346A4 (en) Epha2 agonistic monoclonal antibodies and methods of use thereof
AU2002340167A8 (en) Anti-hla-dr antibodies and the methods of using thereof
AU2003277259A8 (en) Immunoassay and method of use
EP1591062A4 (en) Magnetoencephalography device and method of using the same
EP1699485A4 (en) Anti-hydroxylase antibodies and uses thereof
EP1497654A4 (en) Immunoglobulin e vaccines and methods of use thereof
EP1633749A4 (en) Deazaflavin compounds and methods of use thereof
EP1589033A4 (en) Antibody and use thereof
IL172533A0 (en) Humanized anti-ccr2 antibodies and methods of use
IL172510A0 (en) Antibodies and uses thereof

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20051214

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1082205

Country of ref document: HK

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20070312

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 16/28 20060101ALI20070306BHEP

Ipc: A61K 39/395 20060101AFI20051228BHEP

17Q First examination report despatched

Effective date: 20070803

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20091102

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1082205

Country of ref document: HK