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EP1474682A4 - Production of human antibodies in immunodeficient, non-human, mammalian hosts - Google Patents

Production of human antibodies in immunodeficient, non-human, mammalian hosts

Info

Publication number
EP1474682A4
EP1474682A4 EP03710962A EP03710962A EP1474682A4 EP 1474682 A4 EP1474682 A4 EP 1474682A4 EP 03710962 A EP03710962 A EP 03710962A EP 03710962 A EP03710962 A EP 03710962A EP 1474682 A4 EP1474682 A4 EP 1474682A4
Authority
EP
European Patent Office
Prior art keywords
human
immunodeficient
production
mammalian hosts
human antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03710962A
Other languages
German (de)
French (fr)
Other versions
EP1474682A2 (en
Inventor
Anke Kretz-Rommel
Hong Xin
Katherine Bowdish
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alexion Pharmaceuticals Inc
Original Assignee
Alexion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexion Pharmaceuticals Inc filed Critical Alexion Pharmaceuticals Inc
Publication of EP1474682A2 publication Critical patent/EP1474682A2/en
Publication of EP1474682A4 publication Critical patent/EP1474682A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP03710962A 2002-02-11 2003-02-10 Production of human antibodies in immunodeficient, non-human, mammalian hosts Withdrawn EP1474682A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35608202P 2002-02-11 2002-02-11
US356082P 2002-02-11
PCT/US2003/003999 WO2003068915A2 (en) 2002-02-11 2003-02-10 Production of human antibodies in immunodeficient, non-human, mammalian hosts

Publications (2)

Publication Number Publication Date
EP1474682A2 EP1474682A2 (en) 2004-11-10
EP1474682A4 true EP1474682A4 (en) 2005-10-12

Family

ID=27734603

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03710962A Withdrawn EP1474682A4 (en) 2002-02-11 2003-02-10 Production of human antibodies in immunodeficient, non-human, mammalian hosts

Country Status (5)

Country Link
EP (1) EP1474682A4 (en)
JP (1) JP2005517401A (en)
AU (1) AU2003215145A1 (en)
CA (1) CA2476232A1 (en)
WO (1) WO2003068915A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070266448A1 (en) 2006-05-11 2007-11-15 Alexander Lifke Method for the production of antibodies
US20150174224A1 (en) * 2011-05-19 2015-06-25 The Regents Of The University Of Michigan Materials and Methods for Eliciting Targeted Antibody Responses In Vivo

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997047654A1 (en) * 1996-06-11 1997-12-18 Yeda Research And Development Co. Ltd. Human monoclonal antibodies to the hepatitis b surface antigen
US5866125A (en) * 1995-06-07 1999-02-02 Idec Pharmaceuticals Corporation Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2103693A1 (en) * 1993-08-06 1995-02-07 Steven Gallinger Animal model of the human immune system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866125A (en) * 1995-06-07 1999-02-02 Idec Pharmaceuticals Corporation Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof
WO1997047654A1 (en) * 1996-06-11 1997-12-18 Yeda Research And Development Co. Ltd. Human monoclonal antibodies to the hepatitis b surface antigen

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHARGUI J ET AL: "The humanized severe combined immunodeficient mouse as a model for primary human humoral response against HIV1 peptides", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 181, no. 1, 12 April 1995 (1995-04-12), pages 91 - 100, XP004021060, ISSN: 0022-1759 *
MCCUNE J M ET AL: "THE SCID-HU MOUSE: MURINE MODEL FOR THE ANALYSIS OF HUMAN HEMATOLUMPHOID DIFFERENTIATION AND FUNCTION", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 241, 23 September 1988 (1988-09-23), pages 1632 - 1639, XP000600471, ISSN: 0036-8075 *
NGUYEN H ET AL: "Efficient generation of respiratory syncytial virus (RSV)-neutralizing human MoAbs via human peripheral blood lymphocyte (hu-PBL)-SCID mice and scFv phage display libraries", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 122, no. 1, October 2000 (2000-10-01), pages 85 - 93, XP002340945, ISSN: 0009-9104 *
NICACIO CRISTINA DE CARVALHO ET AL: "Neutralizing human Fab fragments against measles virus recovered by phage display", JOURNAL OF VIROLOGY, vol. 76, no. 1, January 2002 (2002-01-01), pages 251 - 258, XP002340943, ISSN: 0022-538X *
SALONEN EEVA-MARJATTA ET AL: "Human recombinant Puumala virus antibodies: Cross-reaction with other hantaviruses and use in diagnostics", JOURNAL OF GENERAL VIROLOGY, vol. 79, no. 4, April 1998 (1998-04-01), pages 659 - 665, XP002340944, ISSN: 0022-1317 *

Also Published As

Publication number Publication date
EP1474682A2 (en) 2004-11-10
WO2003068915A2 (en) 2003-08-21
WO2003068915A3 (en) 2004-07-29
JP2005517401A (en) 2005-06-16
CA2476232A1 (en) 2003-08-21
AU2003215145A1 (en) 2003-09-04

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20040809

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO

RIN1 Information on inventor provided before grant (corrected)

Inventor name: BOWDISH, KATHERINE

Inventor name: XIN, HONG

Inventor name: KRETZ-ROMMEL, ANKE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: BOWDISH, KATHERINE

Inventor name: XIN, HONG

Inventor name: KRETZ-ROMMEL, ANKE

A4 Supplementary search report drawn up and despatched

Effective date: 20050830

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060404