Nothing Special   »   [go: up one dir, main page]

EP1090843B1 - Machine d'emballage, spécialement pour remplir et fermer des récipients contenant des produits médicamenteux liquides - Google Patents

Machine d'emballage, spécialement pour remplir et fermer des récipients contenant des produits médicamenteux liquides Download PDF

Info

Publication number
EP1090843B1
EP1090843B1 EP00119535A EP00119535A EP1090843B1 EP 1090843 B1 EP1090843 B1 EP 1090843B1 EP 00119535 A EP00119535 A EP 00119535A EP 00119535 A EP00119535 A EP 00119535A EP 1090843 B1 EP1090843 B1 EP 1090843B1
Authority
EP
European Patent Office
Prior art keywords
insulator housing
packaging machine
covering panel
machine
boundary surface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP00119535A
Other languages
German (de)
English (en)
Other versions
EP1090843A3 (fr
EP1090843A2 (fr
Inventor
Thomas Hertfelder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert Bosch GmbH
Original Assignee
Robert Bosch GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Bosch GmbH filed Critical Robert Bosch GmbH
Publication of EP1090843A2 publication Critical patent/EP1090843A2/fr
Publication of EP1090843A3 publication Critical patent/EP1090843A3/fr
Application granted granted Critical
Publication of EP1090843B1 publication Critical patent/EP1090843B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages

Definitions

  • the invention relates to a packaging machine, especially for filling and closing liquid Containers containing pharmaceuticals according to the generic term of claim 1.
  • a packaging machine a hood-like insulator housing, the one Seals machine plate of a machine frame and thereby form a sterile room in which the containers filled with a filling material and then sealed become.
  • the insulator housing has its Machine frame facing underside a circumferential, edge drawn inwards with the interposition of a Sealing element, for example silicone, over the entire surface of the Top of the machine plate at its edge areas rests.
  • the packaging machine according to the invention in particular for Filling and sealing of liquid pharmaceuticals Containing containers with the characteristic features of claim 1 has the advantage that the manufacturing cost both the machine plate and the insulator housing is reduced because the tolerances of the individual components can be larger. Furthermore, both for bottling plants, who use an insulator housing, as well as for such Filling systems without isolator one and the same relatively narrow Machine plate can be used.
  • the invention Arrangement of the insulator housing also enables easier control and exchange of the Sealing element, since this is no longer the case Insulator housing must be removed.
  • the packaging machine 10 shown in the figures serves in the pharmaceutical industry for filling and Sealing containers such as ampoules, vials or like.
  • the packaging machine 10 is in a so-called Insulator technology built, that is, in the interior 11th the packaging machine has 10 sterile conditions.
  • the packaging machine 10 has a 12 designated machine frame in which the essential Drive components are arranged.
  • the top of the Machine frame 12 is at least one Machine plate 13 completed in the illustrated Example of performance of two machine plates 13a, 13b are arranged at different levels ( Figure 2). in the Areas above the one machine plate 13a are located Filling and closing devices for the containers, while in the area above the machine plate 13b a transport device for the containers is located.
  • the interior 11 is delimited by the machine plate 13 on the one hand and a seal surrounding it Insulator housing 15.
  • the hood-like insulator housing 15 has side walls 16, in which viewing panels 17 are inserted are. Furthermore, 17 inserts 18 for Example of rubber gloves arranged to be by hand To be able to make manipulations in the interior 11. To the End faces 19, 20 of the insulator housing 15 are also not Locks shown trained to the containers in the interior 11 in or out.
  • a targeted air flow with laminar air flow To train within the interior 11 serves a Blower or air circulation system, which is in a box-shaped Area 23 arranged in the upper part of the insulator housing 15 is.
  • this area 23 there is, for example Circulating air blower and sterile air filter, which from the Clean interior air 11 and in relation to your Flow direction and flow speed again lead specifically into the interior 11.
  • the suction of the air in the interior 11 preferably takes place in the area of the Edge areas of the insulator housing 15, including the viewing windows 17 are designed as double disks with inner disks 24.
  • the inner panes 24 extend to just above the Machine plate 13 so that the air over the edge Column 25 is suctioned off.
  • the machine plate 13c from a solid Base plate 26 and a covering this, made of sheet metal trained cover plate 27.
  • the cover plate 27 has an angled edge 28 which the base plate 26th covers laterally on their circumference.
  • Machine frame 12 laterally projecting area 29 of the Base plate 26 is formed a through hole 31.
  • a Threaded bolt 34 arranged, the threaded bolt 34 the Cover plate 27 penetrates in the region of a hole 36 and cooperates with a mother 35.
  • the threaded bolt 34 is attached to a profile frame 38 made of sheet metal or welded on.
  • the profile frame 38 is closed Frame or box 39 formed, the viewing panels 17th with the interposition of inflatable molded seals 40 receives.
  • a curved wall 41 of the box 39 runs on the the machine plate 13 facing side in a straight line Edge zone 42 from which the cover plate 27 to approximately in height of the machine frame 12 covered, and on the underside the threaded bolt 34 is attached.
  • a sealing member for Example arranged in the form of a sealing tape 43 to which as a conclusion on the side facing the interior 11 a silicone bead 44 connects.
  • the machine frame 12 is laterally a plurality of holders 45 arranged.
  • This holder 45 serve as a support surface and Attachment possibility for the insulator housing 15 at the Profile frame 46.
  • the profile frame 46 has an im Cross section rectangular base profile 47, which with its Narrow side 48 rests on the top 49 of the carrier 45 and in a suitable manner, for example by means of Screw connections 51, interchangeable with the brackets 45 is attached.
  • the basic profile 47 is laterally of two Shaped sheets 53, 54 at least partially limited, which on the the side facing away from the carriers 45 together with the Form seal 40 a tight and form-fitting reception of the Allow side wall 16. That of the machine plate 13 facing molding plate 54 has a level with the top of the Cover plate 27 outgoing curvature 55 and at least one essentially parallel to the edge 28 of the cover plate 27 arranged, bent portion 56. The distance between the section 56 and the edge 28 of the cover plate 27 about three to ten millimeters, the trained one Gap 57 has a length such that in gap 57 a sealing element 58 can be arranged. In the in the Figure 4 illustrated first embodiment of the Invention, this sealing element 58 is in one piece, for example as a molded seal or inflatable sealing element 58 educated.
  • the second embodiment shown in Figure 5 differs from the first embodiment according to Figure 4 through its sealing element 58a, which is now made consists of two parts, a sealing tape 59 and one Silicone bead 60.
  • the sealing tape 59 is in the gap 57, while the silicone bead 60 towards the interior 11 flat transition between the cover plate 27 and the Form sheet 55 allows.
  • the third exemplary embodiment shown in FIG. 6 differs from the first two Embodiments according to the invention by the waiver on an inner pane 24, between which and the Side wall 16 otherwise the air extraction takes place.
  • the profile frame 61 as in cross section closed box formed on the the interior 11 facing side with an oblique boundary wall 62 Has suction bores 63.
  • the profile frame 61 or its suction channel 64 formed by him is not with one vacuum source shown connected to the suction of air from the interior 11 through the suction holes 63 allows.
  • the holder 45 also at Machine frames 12 can be attached that are not are coupled to an insulator housing 15. In this case can the holder 45 as a mounting option for a Serve cladding or the like.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Vacuum Packaging (AREA)
  • Basic Packing Technique (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (5)

  1. Machine d'emballage (10), en particulier pour remplir et fermer des récipients contenant des produits médicamenteux liquides, comportant un bâti de machine (12) qui est limité par au moins une plaque de recouvrement (13, 13a, 13b) en forme de plateau et comportant un carter isolant (15) en forme de capot relié avec au moins une plaque de recouvrement (13, 13a, 13b), avec un élément d'étanchéité (58, 58a, 59, 60) en position intermédiaire, si bien qu'une chambre intérieure stérile (11) est formée par le carter isolant (15) et la, au moins une, plaque de recouvrement (13, 13a, 13b),
    caractérisée en ce que
    le carter isolant (15) entoure latéralement au moins une plaque de recouvrement (13, 13a, 13b), l'élément d'étanchéité (58, 58a, 59, 60) étant disposé pour l'essentiel dans un intervalle (57) entre une surface de délimitation (28) latérale d'au moins une plaque de recouvrement (13, 13a, 13b) et le carter isolant (15).
  2. Machine d'emballage selon la revendication 1,
    caractérisée en ce que
    le carter isolant (15) possède, sur la face tournée vers la surface de délimitation (28) latérale d'au moins une plaque de recouvrement (13, 13a, 13b), un segment de paroi (56) qui s'étend pour l'essentiel parallèlement à la surface de délimitation (28), si bien que l'intervalle (57) pour l'élément d'étanchéité (58, 58a, 59, 60) est formé entre la surface de délimitation (28) et le segment de paroi (56).
  3. Machine d'emballage selon la revendication 1 ou 2,
    caractérisée en ce que
    sur le bâti de machine (12) on a des éléments supports (45) qui dépassent latéralement de la surface de délimitation (28) et sur lesquels le carter isolant (15) est fixé.
  4. Machine d'emballage selon la revendication 3,
    caractérisée en ce que
    le carter isolant (15) repose sur la face supérieure (49) des éléments supports (45).
  5. Machine d'emballage selon l'une quelconque des revendications 1 à 4,
    caractérisée en ce que
    le carter isolant (15) possède un cadre profilé (61) avec une paroi de délimitation (62) présentant des orifices d'aspiration (63) à travers lesquels l'air peut être aspiré juste au-dessus de la plaque de recouvrement (13) à partir de la chambre intérieure (11).
EP00119535A 1999-10-05 2000-09-07 Machine d'emballage, spécialement pour remplir et fermer des récipients contenant des produits médicamenteux liquides Expired - Lifetime EP1090843B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19947786A DE19947786A1 (de) 1999-10-05 1999-10-05 Verpackungsmaschine, insbesondere zum Abfüllen und Verschliessen von flüssigen Pharmazeutika enthaltenden Behältnissen
DE19947786 1999-10-05

Publications (3)

Publication Number Publication Date
EP1090843A2 EP1090843A2 (fr) 2001-04-11
EP1090843A3 EP1090843A3 (fr) 2002-06-19
EP1090843B1 true EP1090843B1 (fr) 2004-03-24

Family

ID=7924462

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00119535A Expired - Lifetime EP1090843B1 (fr) 1999-10-05 2000-09-07 Machine d'emballage, spécialement pour remplir et fermer des récipients contenant des produits médicamenteux liquides

Country Status (4)

Country Link
US (1) US6651404B1 (fr)
EP (1) EP1090843B1 (fr)
JP (1) JP4727803B2 (fr)
DE (2) DE19947786A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007030789A1 (de) 2007-07-03 2009-01-08 Robert Bosch Gmbh Vorrichtung zum Abdichten eines geschlossenen Raumes

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6799612B2 (en) 2001-08-14 2004-10-05 The Boc Group, Inc. Filling apparatus
US20040020558A1 (en) * 2001-08-14 2004-02-05 Paul Stewart Filling apparatus
BRPI1010524A8 (pt) 2009-03-06 2016-09-13 Disposable Lab Isolador descartavel compreendendo meios de preenchimento de conteineres
WO2010119130A2 (fr) * 2009-04-17 2010-10-21 Gerhard Liepold Appareil de traitement de substance dans une zone fermée
DE102009027452A1 (de) * 2009-07-03 2011-01-05 Robert Bosch Gmbh Vorrichtung zum Füllen und Verschließen von pharmazeutischen Bahältnissen
US9079319B2 (en) 2009-12-21 2015-07-14 Pall Life Sciences Belgium Disposable production line
JP6448298B2 (ja) * 2013-10-18 2019-01-09 ポール ライフ サイエンシズ ベルジウム ビーヴイビーエーＰａｌｌ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｂｅｌｇｉｕｍ Ｂｖｂａ 製品の充填及び仕上げのための使い捨て製造ライン
CN106679297B (zh) * 2017-01-05 2019-07-19 滁州美业机械制造有限公司 一种冰箱门与冲压件连接结构
WO2020102032A1 (fr) 2018-11-16 2020-05-22 Particle Measuring Systems, Inc. Systèmes et procédés d'échantillonnage de particules destinés à des systèmes de barrière de fabrication commandés par robotique
DE102019207280A1 (de) 2019-05-18 2020-11-19 Syntegon Technology Gmbh Anlage zum Handhaben von empfindlichen Produkten, insbesondere Verpackungsanlage
TWI801797B (zh) 2020-01-21 2023-05-11 美商粒子監測系統有限公司 撞擊器及用於對來自一流體流之生物顆粒取樣之方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3337218A1 (de) * 1983-10-13 1985-04-25 Robert Bosch Gmbh, 7000 Stuttgart Maschinengehaeuse
US4730435A (en) * 1986-04-07 1988-03-15 Aqua-Chem, Inc. Sterile docking system for filling IV bags
US4803827A (en) * 1987-11-17 1989-02-14 Baxter International Inc. Means for segregating sterile and nonsterile environments in a packaging machine
FR2651752B1 (fr) * 1989-08-16 1993-12-03 Air Liquide Boite d'isolation de l'atmosphere ambiante pour traitement de produits.
US5007232A (en) * 1989-11-20 1991-04-16 Abbott Laboratories Apparatus and method of use of sterilizing containers using hydrogen peroxide vapor
US5117587A (en) * 1991-05-02 1992-06-02 Rjf International Corporation Sealing structure
US5749203A (en) * 1994-09-23 1998-05-12 Kimberly-Clark Corporation Method of packaging a medical article
IT1279846B1 (it) * 1995-08-11 1997-12-18 Rossi & Catelli Spa Impianto di imbottigliamento asettico in continuo
US5878553A (en) * 1995-10-11 1999-03-09 Chronos Richardson Gmbh Method and device for the spreading and fitting of empty sacks and for grasping and stacking filled sacks and for conveying them into a closure device
US5881535A (en) * 1996-04-09 1999-03-16 Baxter International, Inc. Apparatus and method for filling and sealing intravenous solution bags
FR2749661B1 (fr) * 1996-06-05 1998-08-14 Tech De La Conservation Des Pr Dispositif de controle en continu du contenant d'enceintes fermees hermetiquement
WO1998043878A1 (fr) * 1997-03-28 1998-10-08 Tetra Laval Holdings & Finance, S.A. Machine de remplissage comportant un systeme d'apport d'air sterile
JP4042002B2 (ja) * 1997-09-19 2008-02-06 四国化工機株式会社 包装機械
US6018932A (en) * 1998-01-07 2000-02-01 Premark Feg L.L.C. Gas exchange apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007030789A1 (de) 2007-07-03 2009-01-08 Robert Bosch Gmbh Vorrichtung zum Abdichten eines geschlossenen Raumes

Also Published As

Publication number Publication date
JP2001158404A (ja) 2001-06-12
DE50005775D1 (de) 2004-04-29
US6651404B1 (en) 2003-11-25
JP4727803B2 (ja) 2011-07-20
EP1090843A3 (fr) 2002-06-19
EP1090843A2 (fr) 2001-04-11
DE19947786A1 (de) 2001-04-19

Similar Documents

Publication Publication Date Title
EP1090843B1 (fr) Machine d'emballage, spécialement pour remplir et fermer des récipients contenant des produits médicamenteux liquides
DE69310691T2 (de) Dichtungsanordnung
EP1710053A2 (fr) Appareil pour manipuler et/ou traiter des objets
DE3540002A1 (de) Foerderer mit einem mehrteiligen traeger
DE8900273U1 (de) Verschluß für Dosendeckel
EP0504675B1 (fr) Bande d'étanchéité pour l'enceinte d'une presse à comprimés pharmaceutiques
WO2009003924A1 (fr) Dispositif pour étancher un espace fermé
EP1302352A1 (fr) Panneau pour un toit de véhicule et méthode pour sa production
EP0609755B1 (fr) Dispositif d'étanchéité pour des bas de portes
EP0169354A2 (fr) Plafond à filtre pour filtrer de l'air entrant dans une pièce
DE2239123A1 (de) Zuschnitt fuer blechbehaelter, insbesondere fuer den waschbehaelter in geschirrspuelmaschinen
DE2325970B2 (de) Fensterrahmen
DE10322475B4 (de) Vorrichtung zum Puffern und Vereinzeln von pharmazeutischen Behältnissen
DE7214853U (de) Abstandshalterprofil für Isolierglasscheiben
EP0723063B1 (fr) Dispositif pour fixer un seuil à un dormant de porte qui s'ouvre vers l'extérieur
EP0291783A2 (fr) Module de filtre pour plafonds, murs de chambres antiseptiques, etc.
EP0144540A1 (fr) Machine pour la fabrication de carton ondulé simple face avec un dispositif d'aspiration
EP2956177B1 (fr) Fenêtre d'inspection ménagée dans une enceinte, joint à lèvre conçu pour cette fenêtre d'inspection, et enceinte
AT405932B (de) Vorrichtung zum herstellen von mit füllgas gefüllten isolierglasscheiben
EP0663490A1 (fr) Elément superposé pour ouvertures de toit
DE10218018A1 (de) Vorrichtung, insbesondere zum Behandeln pharmazeutischer Behältnisse wie Vials, Ampullen oder Ähnlichem
DE20001082U1 (de) Anordnung zur Führung einer flexiblen Materialbahn
EP3798580A1 (fr) Procédé de fabrication d'un boitier de tête de mesure, couvercle et boitier de tête de mesure
EP0562544A1 (fr) Boîtier pour contenir des moyens de transmission d'un convoyeur
EP4166745A1 (fr) Caisson de volet roulant/store à lamelles

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

17P Request for examination filed

Effective date: 20021219

AKX Designation fees paid

Designated state(s): CH DE FR GB IT LI

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): CH DE FR GB IT LI

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED.

Effective date: 20040324

Ref country code: GB

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20040324

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: SCINTILLA AG, DIREKTION

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: GERMAN

REF Corresponds to:

Ref document number: 50005775

Country of ref document: DE

Date of ref document: 20040429

Kind code of ref document: P

GBV Gb: ep patent (uk) treated as always having been void in accordance with gb section 77(7)/1977 [no translation filed]

Effective date: 20040324

REG Reference to a national code

Ref country code: IE

Ref legal event code: FD4D

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20041228

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20150923

Year of fee payment: 16

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20170531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160930

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20190924

Year of fee payment: 20

Ref country code: DE

Payment date: 20190924

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 50005775

Country of ref document: DE

Representative=s name: DREISS PATENTANWAELTE PARTG MBB, DE

Ref country code: DE

Ref legal event code: R081

Ref document number: 50005775

Country of ref document: DE

Owner name: SYNTEGON TECHNOLOGY GMBH, DE

Free format text: FORMER OWNER: ROBERT BOSCH PACKAGING TECHNOLOGY GMBH, 71332 WAIBLINGEN, DE

Ref country code: DE

Ref legal event code: R081

Ref document number: 50005775

Country of ref document: DE

Owner name: SYNTEGON TECHNOLOGY GMBH, DE

Free format text: FORMER OWNER: ROBERT BOSCH GMBH, 70469 STUTTGART, DE

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 50005775

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL