EP0921396A3 - Methods of rapid screening of cytochrome cyp2d6 status - Google Patents
Methods of rapid screening of cytochrome cyp2d6 status Download PDFInfo
- Publication number
- EP0921396A3 EP0921396A3 EP98309497A EP98309497A EP0921396A3 EP 0921396 A3 EP0921396 A3 EP 0921396A3 EP 98309497 A EP98309497 A EP 98309497A EP 98309497 A EP98309497 A EP 98309497A EP 0921396 A3 EP0921396 A3 EP 0921396A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- rapid screening
- cytochrome
- status
- cyp2d6 status
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Mammalian subjects may be phenotyped by measuring the ratio of
dextromethorphan to its metabolite dextrorphan in urine, saliva or plasma samples.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6795497P | 1997-12-08 | 1997-12-08 | |
| US67954P | 1997-12-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP0921396A2 EP0921396A2 (en) | 1999-06-09 |
| EP0921396A3 true EP0921396A3 (en) | 2000-05-24 |
Family
ID=22079516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP98309497A Withdrawn EP0921396A3 (en) | 1997-12-08 | 1998-11-19 | Methods of rapid screening of cytochrome cyp2d6 status |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0921396A3 (en) |
| JP (1) | JPH11225791A (en) |
| BR (1) | BR9805299A (en) |
| CA (1) | CA2255154A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040252299A9 (en) | 2000-01-07 | 2004-12-16 | Lemmo Anthony V. | Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions |
| US7108970B2 (en) | 2000-01-07 | 2006-09-19 | Transform Pharmaceuticals, Inc. | Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state |
| GB0008563D0 (en) | 2000-04-07 | 2000-05-24 | Cambridge Discovery Chemistry | Investigating different physical and/or chemical forms of materials |
| AU2002231529A1 (en) * | 2001-02-09 | 2002-08-28 | Mcgill University | Multiple determinants for metabolic phenotypes |
| WO2002073197A2 (en) * | 2001-03-14 | 2002-09-19 | Mcgill University | Individualization of therapy with antidepressants |
| AU2002244576A1 (en) * | 2001-03-14 | 2002-09-24 | Mcgill University | Metabolic phenotyping in therapy with anxiolytics |
| AU2002244568A1 (en) * | 2001-03-14 | 2002-09-24 | Mcgill University | Individualization of therapy with antipsychotics |
| WO2003052123A1 (en) * | 2001-12-19 | 2003-06-26 | Xanthus Life Sciences, Inc. | Individualization of therapy with antihistamines |
| JP2005523451A (en) * | 2002-04-19 | 2005-08-04 | ファイザー・プロダクツ・インク | Measurement test of therapeutic drug concentration |
| JP2008289437A (en) | 2007-05-28 | 2008-12-04 | Sony Corp | Method for measuring enzyme activity, and device for the same using laser |
| EP3384040A4 (en) * | 2015-11-30 | 2019-07-31 | Concordia University, Inc. | Compositions for cyp450 phenotyping using saliva samples |
-
1998
- 1998-11-19 EP EP98309497A patent/EP0921396A3/en not_active Withdrawn
- 1998-12-03 JP JP34370198A patent/JPH11225791A/en active Pending
- 1998-12-04 CA CA 2255154 patent/CA2255154A1/en not_active Abandoned
- 1998-12-07 BR BR9805299A patent/BR9805299A/en not_active IP Right Cessation
Non-Patent Citations (7)
| Title |
|---|
| DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; WOODWORTH J R ET AL: "The polymorphic metabolism of dextromethorphan.", XP002133801, retrieved from STN Database accession no. 88059740 * |
| H K KROEMER, M EICHELBAUM: ""It's the genes, stupid". Molecular bases and clinical consequences of the genetic cytochrome P450 2D6 polymorphism", LIFE SCIENCES, vol. 56, no. 26, 1995, pages 2285 - 2298, XP000892268 * |
| HOU Z Y ET AL: "Salivary analysis for determination of dextromethorphan metabolic phenotype.", CLINICAL PHARMACOLOGY AND THERAPEUTICS, (1991 APR) 49 (4) 410-9., XP000892271 * |
| HOU, ZONE-YUAN ET AL: "Determination of dextromethorphan metabolic phenotype by salivary analysis with a reference to genotype in Chinese patients receiving renal hemodialysis", CLIN. PHARMACOL. THER. (ST. LOUIS) (1996), 59(4), 411-417, XP000892273 * |
| JOURNAL OF CLINICAL PHARMACOLOGY, (1987 FEB) 27 (2) 139-43. * |
| MARINAC JACQUELINE S; FOXWORTH JOHN W; WILLSIE SANDRA K: "Dextromethorphan Polymorphic Hepatic Oxidation (CYP2D6) in Healthy Black American Adult Subjects", THERAPEUTIC DRUG MONITORING, vol. 17, 1995, pages 120 - 124, XP000892269 * |
| SPINA E; CAMPO G M; AVENOSO A; CAPUTI A P; ZUCCARO P; PACIFICI R; GATTI G; STRADA G; BARTOLI A; PERUCCA E: "CYP2D6-related oxidation polymorphism in Italy", PHARMACOLOGICAL RESEARCH, vol. 29, 1994, pages 281 - 289, XP000892266 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11225791A (en) | 1999-08-24 |
| EP0921396A2 (en) | 1999-06-09 |
| CA2255154A1 (en) | 1999-06-08 |
| BR9805299A (en) | 2000-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 19981211 |
|
| AK | Designated contracting states |
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| AX | Request for extension of the european patent |
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|
| PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7G 01N 33/48 A, 7C 12Q 1/44 B, 7C 12Q 1/26 B |
|
| AK | Designated contracting states |
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| AKX | Designation fees paid |
Free format text: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20020601 |