EP0840739A4 - High affinity nucleic acid ligands to lectins - Google Patents

High affinity nucleic acid ligands to lectins

Info

Publication number: EP0840739A4
Authority: EP; European Patent Office
Prior art keywords: lectins; nucleic acid; high affinity; acid ligands; affinity nucleic
Prior art date: 1995-06-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP96923232A

Other languages

German (de)

French (fr)

Other versions

EP0840739A1 (en

Inventor

David H Parma

Brian Hicke

Philippe Bridonneau

Larry Gold

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Gilead Sciences Inc

Original Assignee

Gilead Sciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-05

Publication date

2006-02-01

1995-06-07 Priority claimed from US08/472,256 external-priority patent/US6001988A/en

1995-06-07 Priority claimed from US08/479,724 external-priority patent/US5780228A/en

1995-06-07 Priority claimed from US08/472,255 external-priority patent/US5766853A/en

1996-06-05 Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc

1998-05-13 Publication of EP0840739A1 publication Critical patent/EP0840739A1/en

2006-02-01 Publication of EP0840739A4 publication Critical patent/EP0840739A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4724—Lectins
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/7056—Selectin superfamily, e.g. LAM-1, GlyCAM, ELAM-1, PADGEM
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Oncology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
General Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Biophysics (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)

EP96923232A 1995-06-07 1996-06-05 High affinity nucleic acid ligands to lectins Withdrawn EP0840739A4 (en)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
US47782995A	1995-06-07	1995-06-07
US08/472,256 US6001988A (en)	1990-06-11	1995-06-07	High affinity nucleic acid ligands to lectins
US472255		1995-06-07
US477829		1995-06-07
US08/479,724 US5780228A (en)	1990-06-11	1995-06-07	High affinity nucleic acid ligands to lectins
US479724		1995-06-07
US08/472,255 US5766853A (en)	1990-06-11	1995-06-07	Method for identification of high affinity nucleic acid ligands to selectins
PCT/US1996/009455 WO1996040703A1 (en)	1995-06-07	1996-06-05	High affinity nucleic acid ligands to lectins
US472256		1999-12-27

Publications (2)

Publication Number	Publication Date
EP0840739A1 EP0840739A1 (en)	1998-05-13
EP0840739A4 true EP0840739A4 (en)	2006-02-01

Family

ID=27504168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP96923232A Withdrawn EP0840739A4 (en)	1995-06-07	1996-06-05	High affinity nucleic acid ligands to lectins

Country Status (5)

Country	Link
EP (1)	EP0840739A4 (en)
JP (2)	JPH11507526A (en)
AU (1)	AU725590B2 (en)
CA (1)	CA2223275A1 (en)
WO (1)	WO1996040703A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2017248189B2 (en) *	2016-04-08	2021-04-29	Translate Bio, Inc.	Multimeric coding nucleic acid and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5270163A (en) *	1990-06-11	1993-12-14	University Research Corporation	Methods for identifying nucleic acid ligands
WO1994009158A1 (en) *	1992-10-14	1994-04-28	University Research Corporation	Method for selecting nucleic acids on the basis of structure
WO1996034876A1 (en) *	1995-05-04	1996-11-07	Nexstar Pharmaceuticals, Inc.	Nucleic acid ligand complexes
US6280932B1 (en) *	1990-06-11	2001-08-28	Gilead Sciences, Inc.	High affinity nucleic acid ligands to lectins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5489677A (en) *	1990-07-27	1996-02-06	Isis Pharmaceuticals, Inc.	Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
AU1435492A (en) *	1991-02-21	1992-09-15	Gilead Sciences, Inc.	Aptamer specific for biomolecules and method of making
ES2201049T3 (en) *	1991-05-06	2004-03-16	Genentech, Inc.	A BINDING OF SELECTINE.

1996
- 1996-06-05 JP JP9501770A patent/JPH11507526A/en active Pending
- 1996-06-05 WO PCT/US1996/009455 patent/WO1996040703A1/en active Application Filing
- 1996-06-05 CA CA002223275A patent/CA2223275A1/en not_active Abandoned
- 1996-06-05 EP EP96923232A patent/EP0840739A4/en not_active Withdrawn
- 1996-06-05 AU AU64507/96A patent/AU725590B2/en not_active Ceased
2008
- 2008-09-04 JP JP2008227400A patent/JP2009039126A/en active Pending

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5270163A (en) *	1990-06-11	1993-12-14	University Research Corporation	Methods for identifying nucleic acid ligands
US6280932B1 (en) *	1990-06-11	2001-08-28	Gilead Sciences, Inc.	High affinity nucleic acid ligands to lectins
US20030059769A1 (en) *	1990-06-11	2003-03-27	Parma David H.	High affinity nucleic acid ligands to lectins
WO1994009158A1 (en) *	1992-10-14	1994-04-28	University Research Corporation	Method for selecting nucleic acids on the basis of structure
WO1996034876A1 (en) *	1995-05-04	1996-11-07	Nexstar Pharmaceuticals, Inc.	Nucleic acid ligand complexes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HICKE B J ET AL: "DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice.", THE JOURNAL OF CLINICAL INVESTIGATION. 15 DEC 1996, vol. 98, no. 12, 15 December 1996 (1996-12-15), pages 2688 - 2692, XP002294403, ISSN: 0021-9738 *
O'CONNELL D ET AL: "Calcium-dependent oligonucleotide antagonists specific for L-selectin.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 11 JUN 1996, vol. 93, no. 12, 11 June 1996 (1996-06-11), pages 5883 - 5887, XP002294404, ISSN: 0027-8424 *
See also references of WO9640703A1 *

Also Published As

Publication number	Publication date
AU725590B2 (en)	2000-10-12
EP0840739A1 (en)	1998-05-13
JP2009039126A (en)	2009-02-26
WO1996040703A1 (en)	1996-12-19
CA2223275A1 (en)	1996-12-19
AU6450796A (en)	1996-12-30
JPH11507526A (en)	1999-07-06

Publication	Publication Date	Title
AU1310495A (en)	1995-07-10	Polyclonal antibody to pna/nucleic acid complexes
AU1039397A (en)	1997-06-27	Ligands to enhance cellular uptake of biomolecules
HUP9801949A3 (en)	2000-09-28	Ternary radiopharmaceutical complexes
AU6268598A (en)	1998-09-08	High affinity nucleic acid ligands of cd4
GB9518215D0 (en)	1995-11-08	Improvements relating to telecines
GB9408344D0 (en)	1994-06-15	Nucleic acid assays
EP0840739A4 (en)	2006-02-01	High affinity nucleic acid ligands to lectins
GB9518997D0 (en)	1995-11-15	Improvements relating to trolleys
GB2297528B (en)	1998-05-13	Improvements relating to bicycles
GB9507723D0 (en)	1995-05-31	Improvements to brake blocks
ZA983900B (en)	1998-11-13	Process to 5-methyleneoxazolenes
GB8907553D0 (en)	1989-05-17	Improvements relating to vehicles
GB8916254D0 (en)	1989-08-31	Improvements relating to vehicles
GB9426105D0 (en)	1995-02-22	Improvements relating to electrolevels
PL323598A1 (en)	1998-04-14	Sorbic acid containing hydogels
GB2303342B (en)	1999-06-09	Improvements relating to suspension systems
GB9523032D0 (en)	1996-01-10	Improvements to vehicles
GB2294544B (en)	1997-11-26	Sample collector
GB9520213D0 (en)	1995-12-06	Improvements relating to spreading vehicles
GB8510090D0 (en)	1985-05-30	Vehicle parking vouchers
GB9504107D0 (en)	1995-04-19	Modifications to vehicle suspension
GB9415041D0 (en)	1994-09-14	Improvements relating to suspension systems
GB9415947D0 (en)	1994-09-28	Improvements relating to suspension systems
GB9401711D0 (en)	1994-03-23	Improvements relating to mocro-analytical techniques
GB9400734D0 (en)	1994-03-16	Improvements relating to connectors

Legal Events

Date	Code	Title	Description
1998-03-27	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1998-05-13	17P	Request for examination filed	Effective date: 19971121
1998-05-13	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2004-07-28	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: GILEAD SCIENCES, INC.
2006-02-01	A4	Supplementary search report drawn up and despatched	Effective date: 20051220
2009-09-09	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2010-07-02	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2010-08-04	18D	Application deemed to be withdrawn	Effective date: 20100129