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EP0689450A4 - Composes bloquant les vannes a potassium et leur utilisation - Google Patents

Composes bloquant les vannes a potassium et leur utilisation

Info

Publication number
EP0689450A4
EP0689450A4 EP94911588A EP94911588A EP0689450A4 EP 0689450 A4 EP0689450 A4 EP 0689450A4 EP 94911588 A EP94911588 A EP 94911588A EP 94911588 A EP94911588 A EP 94911588A EP 0689450 A4 EP0689450 A4 EP 0689450A4
Authority
EP
European Patent Office
Prior art keywords
potassium channel
channel blocking
blocking compounds
compounds
potassium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94911588A
Other languages
German (de)
English (en)
Other versions
EP0689450A1 (fr
Inventor
Michael C Sanguinetti
Alan L Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire NPS Pharmaceuticals Inc
Original Assignee
NPS Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NPS Pharmaceuticals Inc filed Critical NPS Pharmaceuticals Inc
Publication of EP0689450A1 publication Critical patent/EP0689450A1/fr
Publication of EP0689450A4 publication Critical patent/EP0689450A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50Isolated enzymes; Isolated proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Insects & Arthropods (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Agronomy & Crop Science (AREA)
EP94911588A 1993-03-18 1994-03-14 Composes bloquant les vannes a potassium et leur utilisation Withdrawn EP0689450A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3338893A 1993-03-18 1993-03-18
US33388 1993-03-18
PCT/US1994/002750 WO1994021278A1 (fr) 1993-03-18 1994-03-14 Composes bloquant les vannes a potassium et leur utilisation

Publications (2)

Publication Number Publication Date
EP0689450A1 EP0689450A1 (fr) 1996-01-03
EP0689450A4 true EP0689450A4 (fr) 1997-05-21

Family

ID=21870134

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94911588A Withdrawn EP0689450A4 (fr) 1993-03-18 1994-03-14 Composes bloquant les vannes a potassium et leur utilisation

Country Status (6)

Country Link
EP (1) EP0689450A4 (fr)
JP (1) JPH08508250A (fr)
CN (1) CN1125402A (fr)
AU (1) AU6407594A (fr)
CA (1) CA2158051A1 (fr)
WO (1) WO1994021278A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60112424T2 (de) * 2000-05-10 2006-05-24 Centre National De La Recherche Scientifique (Cnrs) Protonen-abhängiges na+-kanal hemmendes polypeptid
EP2383280A1 (fr) 2002-09-23 2011-11-02 E. I. du Pont de Nemours and Company Système d'expression pour les canaux d'ion toxiques, par example de récepteurs de la ryanodine
BRPI0605484A8 (pt) 2006-11-21 2017-03-07 Fund Amparo Pesquisa Estado Minas Gerais Fapemig Toxina ph(alfa)1b, cdna do gene da toxina ph(alfa)1b, composições farmacêuticas contendo a toxina ph(alfa)1b, processo para sua obtenção, processo para obtenção do cdna, e produto
CN106146639B (zh) * 2015-04-21 2019-05-03 湖南师范大学 一种来源于雷氏大疣蛛毒液的钾离子通道抑制剂
EP3694432B1 (fr) 2017-10-13 2024-05-01 Mayo Foundation for Medical Education and Research Dispositifs d'électroporation pour le traitement d'une fibrillation ventriculaire

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
WO1994010195A1 (fr) * 1992-10-30 1994-05-11 Pfizer Inc. Polypeptides provenant du venin de l'heteropoda venatoria et bloquant les canaux calciques

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
WO1994010195A1 (fr) * 1992-10-30 1994-05-11 Pfizer Inc. Polypeptides provenant du venin de l'heteropoda venatoria et bloquant les canaux calciques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LAVRETSKY E.ET AL.: "A group of Potassium-Channel Blockers-Acetylcholine Releasers: New Potentials for Alzheimer Disease? A Reviewse", JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, vol. 12, no. 2, April 1992 (1992-04-01), pages 110 - 118, XP000647340 *
See also references of WO9421278A1 *

Also Published As

Publication number Publication date
EP0689450A1 (fr) 1996-01-03
WO1994021278A1 (fr) 1994-09-29
CN1125402A (zh) 1996-06-26
JPH08508250A (ja) 1996-09-03
CA2158051A1 (fr) 1994-09-29
AU6407594A (en) 1994-10-11

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Legal Events

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Effective date: 19951018

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