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EP0596026A1 - Compositions alimentaires et antibiotiques, et procede d'amelioration de l'efficacite alimentaire et d'acceleration de la croissance d'animaux monogastriques - Google Patents

Compositions alimentaires et antibiotiques, et procede d'amelioration de l'efficacite alimentaire et d'acceleration de la croissance d'animaux monogastriques

Info

Publication number
EP0596026A1
EP0596026A1 EP92917167A EP92917167A EP0596026A1 EP 0596026 A1 EP0596026 A1 EP 0596026A1 EP 92917167 A EP92917167 A EP 92917167A EP 92917167 A EP92917167 A EP 92917167A EP 0596026 A1 EP0596026 A1 EP 0596026A1
Authority
EP
European Patent Office
Prior art keywords
feed
ppm
virginiamycin
ardacin
animals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92917167A
Other languages
German (de)
English (en)
Other versions
EP0596026A4 (en
Inventor
Thomas O. Lindsey
Richard D. Hedde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0596026A1 publication Critical patent/EP0596026A1/fr
Publication of EP0596026A4 publication Critical patent/EP0596026A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Definitions

  • Animal Feed Compositions which are useful to enhance feed efficiency and promote growth.
  • this invention relates to a combination of antibiotics in animal feed which provides an improvement in growth and feed utilization efficiency which is greater than can be achieved when either antibiotic is fed alone.
  • the added response of the combination is novel and unexpected since each of the antibiotics have similar antimicrobial spectra.
  • the animal feed compositions of this invention will contain the combination of ardacin and virginiamycin in an amount of from about 2.5 ppm to about 30 ppm of animal feed. Preferably, the ratio of virginiamycin to the glycopeptide antibiotic derivative will be 1:1.
  • These feed compositions are administered orally to growing meat producing animals such as ruminants, swine and advantageously chickens-.
  • the active ingredients may be used as premix formulations in which the active ingredients are distributed uniformly throughout a standard animal feed carrier. The premix or concentrate is then mixed with either a normal or a special fattening diet of the animal as desired.
  • Such carriers are soybean meal, ' corn oil ground corn, barley, wheat, mineral mixtures such as vermiculites, diotomaceous earth, corn gluten meal, corn distillers solubles or soy flour.
  • the premix may be in a liquid or solid form.
  • the concentration of the combination of active ingredients in the premix may be from about 5% to about 75% by weight or a concentration of 100-2000 times greater than that in the complete feed composition.
  • the premix is then uniformly mixed with the whole ration which is fed to the target animal.
  • Such premix compositions are included in the term feed compositions as employed herein.
  • the supplemental animal feeds themselves may also contain cellulosic roughage such as cellulose, hay,, straw, corn stalks, cotton seed hulls, oats, barley and cereal beans; natural oils such as animal fats, fish oils, and whole oil; vegetable oils such as soybean oil, olive, oil, sunflower oil, peanut oil, and cottonseed oil; antioxidants, minerals, vitamins, antibiotics, anthelmintics and other appropriate medicaments.
  • cellulosic roughage such as cellulose, hay,, straw, corn stalks, cotton seed hulls, oats, barley and cereal beans
  • natural oils such as animal fats, fish oils, and whole oil
  • vegetable oils such as soybean oil, olive, oil, sunflower oil, peanut oil, and cottonseed oil
  • antioxidants, minerals, vitamins, antibiotics, anthelmintics and other appropriate medicaments such as soybean oil, olive, oil, sunflower oil, peanut oil, and cottonseed oil.
  • the diets employed in this invention were prepared from a standard formula characteristic of poultry diets used by the broiler industry.
  • the formulas meet the criteria set forth by the National Research
  • Soybean oil meal ( ehulled, 48%)
  • Virginiamycin and ardacin were fed until the final weigh day with Maduramicin added as a coccidiostat until Day 45.
  • the birds were weighed by pen and sex at change from starter to grower (Day 21) and at end of study (Day 47) .
  • Feed consumption was measured during starter, grower and finisher periods.
  • Mortality was recorded daily along with, weights of dead birds. Any bird that died or was culled during the first seven days of the trial was replaced with a bird of the same sex from a holding pen of the same shipment. The weights of the dead birds were used to calculate feed efficiency. Following are the results obtained. Table ⁇
  • the method of this invention comprises allowing monogastric animals such as poultry or swine, to feed ad- libitum on the supplemented rations or to be fed under pen conditions on a regular schedule.
  • the supplemental feed rations are presented to the animals by methods known to the art.
  • Ad libitum feeding in the pen is most convenient to increase the growth of the animal and feed efficiency of the operation.
  • the animals are fed an effective but nontoxic quantity of the active ingredients sufficient to produce growth and increase feed efficiency.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procédés et compositions comprenant de la virginiamycine et un dérivé glycopeptide antibiotique lesquels améliorent l'efficacité alimentaire et accélère la croissance d'animaux monogastriques, en particulier ceux destinés à la rotisserie. Les composés préférés utilisés en tant qu'ingrédients actifs sont la virginiamycine et l'ardacine.
EP19920917167 1991-07-24 1992-07-24 Antibiotic feed compositions and method of enhancing feed efficiency and promoting growth in monogastic animals Withdrawn EP0596026A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US73513091A 1991-07-24 1991-07-24
US735130 1991-07-24
US86063792A 1992-03-30 1992-03-30
US860637 1992-03-30
PCT/US1992/006313 WO1993001829A1 (fr) 1991-07-24 1992-07-24 Compositions alimentaires et antibiotiques, et procede d'amelioration de l'efficacite alimentaire et d'acceleration de la croissance d'animaux monogastriques

Publications (2)

Publication Number Publication Date
EP0596026A1 true EP0596026A1 (fr) 1994-05-11
EP0596026A4 EP0596026A4 (en) 1994-06-01

Family

ID=27112842

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19920917167 Withdrawn EP0596026A4 (en) 1991-07-24 1992-07-24 Antibiotic feed compositions and method of enhancing feed efficiency and promoting growth in monogastic animals

Country Status (8)

Country Link
EP (1) EP0596026A4 (fr)
JP (1) JPH06509567A (fr)
AU (1) AU2421892A (fr)
CA (1) CA2114140A1 (fr)
IE (1) IE922397A1 (fr)
MX (1) MX9204281A (fr)
NZ (1) NZ243660A (fr)
WO (1) WO1993001829A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011598A1 (fr) * 1993-10-26 1995-05-04 Lachlan Macsmith Aliment en boulettes a haute valeur nutritive pour ruminants
US10676501B2 (en) 2011-07-20 2020-06-09 Brigham Young University Hydrogel materials incorporating eluting ceragenin compound
WO2013165574A2 (fr) 2012-05-02 2013-11-07 Brigham Young University Matériaux particulaires de céragénine et procédés pour fabriquer ceux-ci
US9387215B2 (en) * 2013-04-22 2016-07-12 Brigham Young University Animal feed including cationic cholesterol additive and related methods
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146738A2 (fr) * 1983-12-23 1985-07-03 American Cyanamid Company Compositions d'additifs alimentaires antimicrobiennes pour animaux
EP0255299A2 (fr) * 1986-07-30 1988-02-03 Smithkline Beecham Corporation Antibiotiques du type glycopeptidique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3627885A (en) * 1968-07-18 1971-12-14 Rit Rech Ind Therapeut Stabilized antibiotic compositions for animal feeding
US4548974A (en) * 1983-07-13 1985-10-22 Smithkline Beckman Corporation Antibiotics produced by Kibdelosporangium aridum shearer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146738A2 (fr) * 1983-12-23 1985-07-03 American Cyanamid Company Compositions d'additifs alimentaires antimicrobiennes pour animaux
EP0255299A2 (fr) * 1986-07-30 1988-02-03 Smithkline Beecham Corporation Antibiotiques du type glycopeptidique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9301829A1 *

Also Published As

Publication number Publication date
CA2114140A1 (fr) 1993-02-04
MX9204281A (es) 1993-04-01
JPH06509567A (ja) 1994-10-27
NZ243660A (en) 1994-06-27
WO1993001829A1 (fr) 1993-02-04
AU2421892A (en) 1993-02-23
EP0596026A4 (en) 1994-06-01
IE922397A1 (en) 1993-01-27

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Legal Events

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Inventor name: LINDSEY, THOMAS O.

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Effective date: 19980217

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Effective date: 19980630