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EP0543902A4 - Use of metalloporphyrins to potentiate aids therapy - Google Patents

Use of metalloporphyrins to potentiate aids therapy

Info

Publication number
EP0543902A4
EP0543902A4 EP19910915068 EP91915068A EP0543902A4 EP 0543902 A4 EP0543902 A4 EP 0543902A4 EP 19910915068 EP19910915068 EP 19910915068 EP 91915068 A EP91915068 A EP 91915068A EP 0543902 A4 EP0543902 A4 EP 0543902A4
Authority
EP
European Patent Office
Prior art keywords
metalloporphyrins
potentiate
aids therapy
aids
therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910915068
Other versions
EP0543902A1 (en
Inventor
Attallah Kappas
Richard D. Levere
Nader G. Abraham
Doris J. Bucher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Publication of EP0543902A1 publication Critical patent/EP0543902A1/en
Publication of EP0543902A4 publication Critical patent/EP0543902A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19910915068 1990-07-31 1991-07-25 Use of metalloporphyrins to potentiate aids therapy Withdrawn EP0543902A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56019190A 1990-07-31 1990-07-31
US73509091A 1991-07-24 1991-07-24
US735090 1991-07-24
US560191 2000-04-28

Publications (2)

Publication Number Publication Date
EP0543902A1 EP0543902A1 (en) 1993-06-02
EP0543902A4 true EP0543902A4 (en) 1993-10-27

Family

ID=27072276

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910915068 Withdrawn EP0543902A4 (en) 1990-07-31 1991-07-25 Use of metalloporphyrins to potentiate aids therapy

Country Status (5)

Country Link
EP (1) EP0543902A4 (en)
JP (1) JPH05504774A (en)
AU (1) AU645131B2 (en)
CA (1) CA2088593A1 (en)
WO (1) WO1992002242A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005285A1 (en) * 1992-09-03 1994-03-17 The Regents Of The University Of California Metallo porphyrin compositions
WO1995017893A1 (en) * 1993-12-28 1995-07-06 New York Blood Center Methods for preventing or treating hiv-1 or hiv-2 infection
TW247876B (en) 1993-12-28 1995-05-21 New York Blood Ct Inc Pharmaceutical compositions for prevention or treating HIV-1 or HIV-2 infection
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
ATE257712T1 (en) * 1996-08-27 2004-01-15 Hemosol Inc INCREASED STIMULATION OF ERYTHROPOIESIS
AU765856B2 (en) * 1996-08-27 2003-10-02 Hemosol Inc. Enhanced stimulation of erythropoiesis
US20020072512A1 (en) * 2000-12-08 2002-06-13 Metaphore Pharmaceuticals, Inc Method of preventing and treating HIV-mediated central nervous system damage
CA2480141A1 (en) * 2002-03-28 2003-10-09 Exponential Biotherapies, Inc. Oxygenating agents for enhancing host responses to microbial infections
GB0519169D0 (en) * 2005-09-21 2005-10-26 Leuven K U Res & Dev Novel anti-viral strategy
RU2475498C1 (en) * 2011-11-17 2013-02-20 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Novel hemin derivatives having antibacterial and antiviral activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0337598A2 (en) * 1988-02-26 1989-10-18 Georgia State University Foundation, Inc. Use of porphyrins and metalloporphyrins in the treatment of diseases caused by Human Immunodeficiency Viruses
WO1989011277A2 (en) * 1988-05-23 1989-11-30 Georgia State University Foundation, Inc. Porphyrin and phthalocyanine antiviral compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049493A (en) * 1987-10-23 1991-09-17 California Institute Of Technology Enhancement of cell growth by expression of a cloned hemoglobin gene

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0337598A2 (en) * 1988-02-26 1989-10-18 Georgia State University Foundation, Inc. Use of porphyrins and metalloporphyrins in the treatment of diseases caused by Human Immunodeficiency Viruses
WO1989011277A2 (en) * 1988-05-23 1989-11-30 Georgia State University Foundation, Inc. Porphyrin and phthalocyanine antiviral compositions

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
17TH ANNUAL MEETING OF THE INT. SOCIETY FOR EXPERIMENTAL HEMATOLOGY, HOUSTON, TEXAS, USA, AUGUST 21-25, 1988. EXP.HEMATOL. (NY) 16(6). 1988. 477 'Microenvironmental toxicity of AZT: partial sparing with hemin' *
AIDS vol. 3, no. 6, 1989, pages 403 - 4 'Anti-HIV activity of protoporphyrin' *
AM.J.HEMATOL. vol. 35, no. 1, 1990, pages 1 - 5 'Role of heme metabolism in AZT-induced bone marrow toxicity' *
INT.CONF. AIDS, JUNE 20-23 1990, 6(1) P177 *
N.ENGL.J.MED. vol. 322, no. 21, 24 May 1990, 'Recombinant human erythropoietin for patients with AIDS treated with zidovudine.' *
PROC.AM.ASSOC.CANCER RES. ANNU.MEET. 29(0). 1988. 476 'Protective effect of tin-protoporphyrin against doxorubicin-induced perturbations of heme metabolism' *
PROC.NATL.ACAD.SCI.USA vol. 88, no. 5, 1 March 1991, pages 1756 - 9 'Heme inhibits human immunodeficiency virus 1 replication in cell cultures and enhances the antiviral effect of zidovudine' *
See also references of WO9202242A1 *

Also Published As

Publication number Publication date
AU645131B2 (en) 1994-01-06
EP0543902A1 (en) 1993-06-02
AU8410491A (en) 1992-03-02
CA2088593A1 (en) 1992-02-01
JPH05504774A (en) 1993-07-22
WO1992002242A1 (en) 1992-02-20

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19930225

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: KAPPAS, ATTALLAH

Inventor name: BUCHER, DORIS, J.

Inventor name: LEVERE, RICHARD, D.

Inventor name: ABRAHAM, NADER, G.

A4 Supplementary search report drawn up and despatched

Effective date: 19930909

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

17Q First examination report despatched

Effective date: 19940422

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19940906