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EP0472648A4 - Crosslinking oligonucleotides - Google Patents

Crosslinking oligonucleotides

Info

Publication number
EP0472648A4
EP0472648A4 EP19900908844 EP90908844A EP0472648A4 EP 0472648 A4 EP0472648 A4 EP 0472648A4 EP 19900908844 EP19900908844 EP 19900908844 EP 90908844 A EP90908844 A EP 90908844A EP 0472648 A4 EP0472648 A4 EP 0472648A4
Authority
EP
European Patent Office
Prior art keywords
crosslinking oligonucleotides
oligonucleotides
crosslinking
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900908844
Other versions
EP0472648A1 (en
Inventor
Rich B. Meyer
John C. Tabone
Gerald D. Hurst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanogen Inc
Original Assignee
MicroProbe Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MicroProbe Corp filed Critical MicroProbe Corp
Publication of EP0472648A1 publication Critical patent/EP0472648A1/en
Publication of EP0472648A4 publication Critical patent/EP0472648A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP19900908844 1989-05-18 1990-05-15 Crosslinking oligonucleotides Withdrawn EP0472648A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35385789A 1989-05-18 1989-05-18
US353857 1989-05-18

Publications (2)

Publication Number Publication Date
EP0472648A1 EP0472648A1 (en) 1992-03-04
EP0472648A4 true EP0472648A4 (en) 1992-09-16

Family

ID=23390880

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900908844 Withdrawn EP0472648A4 (en) 1989-05-18 1990-05-15 Crosslinking oligonucleotides

Country Status (3)

Country Link
EP (1) EP0472648A4 (en)
JP (1) JPH04507402A (en)
WO (1) WO1990014353A1 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0615758B1 (en) * 1988-05-24 1999-09-22 Yeda Research And Development Co. Ltd. Anti-tumor vaccines
US5824796A (en) * 1988-09-28 1998-10-20 Epoch Pharmaceuticals, Inc. Cross-linking oligonucleotides
US5849482A (en) * 1988-09-28 1998-12-15 Epoch Pharmaceuticals, Inc. Crosslinking oligonucleotides
USRE38416E1 (en) 1988-09-28 2004-02-03 Epoch Biosciences, Inc. Cross-linking oligonucleotides
US5177196A (en) * 1990-08-16 1993-01-05 Microprobe Corporation Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof
JPH06509945A (en) * 1991-08-19 1994-11-10 マイクロプローブ・コーポレイション Crosslinkable oligonucleotides for enzyme-mediated triplex formation
US6136601A (en) * 1991-08-21 2000-10-24 Epoch Pharmaceuticals, Inc. Targeted mutagenesis in living cells using modified oligonucleotides
AU6296294A (en) * 1993-01-26 1994-08-15 Microprobe Corporation Bifunctional crosslinking oligonucleotides adapted for linking to a desired gene sequence of invading organism or cell
US6312894B1 (en) 1995-04-03 2001-11-06 Epoch Pharmaceuticals, Inc. Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
US5801155A (en) 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
CA2303299C (en) * 1997-09-12 2016-02-23 Exiqon A/S Oligonucleotide analogues
US6054568A (en) * 1998-01-16 2000-04-25 The Perkin-Elmer Corporation Nucleobase oligomers
US6127121A (en) * 1998-04-03 2000-10-03 Epoch Pharmaceuticals, Inc. Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
EP1006199A1 (en) * 1998-12-03 2000-06-07 Kreatech Biotechnology B.V. Applications with and methods for producing selected interstrand crosslinks in nucleic acid
US6660845B1 (en) 1999-11-23 2003-12-09 Epoch Biosciences, Inc. Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
US20040081959A9 (en) 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US7205105B2 (en) 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
US7348146B2 (en) 2003-10-02 2008-03-25 Epoch Biosciences, Inc. Single nucleotide polymorphism analysis of highly polymorphic target sequences
AU2004286352A1 (en) 2003-10-28 2005-05-12 Epoch Biosciences, Inc. Fluorescent probes for DNA detection by hybridization with improved sensitivity and low background
US7439341B2 (en) 2003-11-14 2008-10-21 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
US7476735B2 (en) 2005-05-20 2009-01-13 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
LT2056845T (en) 2006-08-08 2017-11-27 Rheinische Friedrich-Wilhelms-Universität Bonn Structure and use of 5` phosphate oligonucleotides
JP5669721B2 (en) 2008-04-01 2015-02-12 バイオサーチ テクノロジーズ，インコーポレイテッド Stabilized nucleic acid dark quencher-fluorophore probe
JP5689413B2 (en) 2008-05-21 2015-03-25 ライニッシュ フリードリッヒ−ウィルヘルムズ−ユニバーシタット ボン 5 'triphosphate oligonucleotide having blunt ends and uses thereof
US9534255B2 (en) 2008-12-17 2017-01-03 Life Technologies Corporation Methods, compositions, and kits for detecting allelic variants
CN103911428B (en) 2009-03-27 2016-02-24 生命技术公司 For detecting the method for allele variant, composition and test kit
AU2011230496B2 (en) 2010-03-26 2015-09-17 Integrated Dna Technologies, Inc. Methods for enhancing nucleic acid hybridization
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
EP2614149B1 (en) 2010-09-07 2015-04-08 Integrated Dna Technologies, Inc. Modifications for antisense compounds
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
CZ2012282A3 (en) 2012-04-25 2013-11-06 Contipro Biotech S.R.O. Crosslinked hyaluronate derivative, process of its preparation, hydrogel and microfibers based thereon
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
WO2014164874A2 (en) 2013-03-13 2014-10-09 Becton, Dickinson And Company Methods and compositions for modulation of amplification efficiency
JP2018512167A (en) 2015-04-15 2018-05-17 バイオサーチ テクノロジーズ インコーポレイテッド Double quencher probe
JP2021533769A (en) 2018-08-16 2021-12-09 ライフ テクノロジーズ コーポレーション Reagents, mixtures, kits, and methods for nucleic acid amplification
US20240060117A1 (en) 2020-07-23 2024-02-22 Life Technologies Corporation Energy transfer dye conjugates for use in biological assays
US20230304932A1 (en) 2020-07-23 2023-09-28 Life Technologies Corporation Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same
WO2023004400A1 (en) 2021-07-21 2023-01-26 Life Technologies Corporation Dibenzoxanthene quenchers, uses, and methods of preparation
WO2023004356A2 (en) 2021-07-21 2023-01-26 Life Technologies Corporation Azaindole cyanine dyes, uses, and methods of preparation

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002929A1 (en) * 1984-11-08 1986-05-22 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
WO1986004816A1 (en) * 1985-02-18 1986-08-28 Teijin Limited Preparation of 5-fluoro-2'-deoxyuridine esters for intraarterial administration
EP0198207A1 (en) * 1985-03-21 1986-10-22 Molecular Diagnostics, Inc. Specific iodination of nucleic acid
EP0242264A1 (en) * 1986-04-04 1987-10-21 Institut Pasteur Non-radioactive, single-stranded labelled probe, method for its production and method of detecting a target nucleotide sequence using this probe
WO1988010264A1 (en) * 1987-06-24 1988-12-29 Howard Florey Institute Of Experimental Physiology Nucleoside derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
US4950768A (en) * 1984-01-16 1990-08-21 Cronyn Marshall W Cyclic disulfonic ester cross-linking compounds
EP0267996A1 (en) * 1986-11-20 1988-05-25 Tamir Biotechnology Ltd. New nucleotide derivatives
US4837311A (en) * 1987-06-22 1989-06-06 Hoffman-La Roche Inc. Anti-retroviral compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002929A1 (en) * 1984-11-08 1986-05-22 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
WO1986004816A1 (en) * 1985-02-18 1986-08-28 Teijin Limited Preparation of 5-fluoro-2'-deoxyuridine esters for intraarterial administration
EP0198207A1 (en) * 1985-03-21 1986-10-22 Molecular Diagnostics, Inc. Specific iodination of nucleic acid
EP0242264A1 (en) * 1986-04-04 1987-10-21 Institut Pasteur Non-radioactive, single-stranded labelled probe, method for its production and method of detecting a target nucleotide sequence using this probe
WO1988010264A1 (en) * 1987-06-24 1988-12-29 Howard Florey Institute Of Experimental Physiology Nucleoside derivatives

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 92, no. 21, 26th May 1980, page 20, abstract no. 174218s, Columbus, Ohio, US; E. DE CLERCQ et al.: "Antiviral activity of 5-[(methylthio)methyl]-2'deoxyuridine and other 5-substituted 2'-deoxyuridines", & BIOCHEM. PHARMACOL. 1979, 28(22), 3249-54 *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 111, no. 18, 30th August 1989, pages 7226-7232, American Chemical Society; J. TELSER et al.: "DNA duplexes covalently labeled at two sites: synthesis and characterization by steady-state and time-resolved optical spectroscopies" *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 111, no. 22, 25th October 1989, pages 8517-8519, American Chemical Society; R.B. MEYER et al.: "Efficient, specific cross-linking and cleavage of DNA by stable, synthetic complementary oligodeoxynucleotides" *
NUCLEIC ACIDS RESEARCH, vol. 15, no. 16, 25th August 1987, pages 6455-6467, IRL Press Ltd, Oxford, GB; K.J. GIBSON et al.: "synthesis and application of derivatizable oligonucleotides" *
See also references of WO9014353A1 *

Also Published As

Publication number Publication date
WO1990014353A1 (en) 1990-11-29
EP0472648A1 (en) 1992-03-04
JPH04507402A (en) 1992-12-24

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Legal Events

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