Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/04—Antibacterial agents
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
  • C07D463/02—Preparation
  • C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Definitions

• This invention relates to a chemical process for the preparation of P-lactam compounds and intermediates therefor, which process is particularly useful when a formamido substituent is to be introduced into a ⁇ -lactam at the carbon atom adjacent to the carbonyl group in the ⁇ -lactam ring.
• Certain of the substituted ⁇ -lactam compounds produced by the process are antibacterial agents; others are useful as intermediates for producing such agents. Each of these groups is described below.
• the present invention provides a process for the preparation of an imine having the partial structure (I): wherein R 1 is a carboxylic acyl group, which process comprises treating a compound having the partial structure (II) wherein R 2 is a halogen atom, with a non-nucleophilic base.
• 'carboxylic acyl group' herein is meant an aryloxycarbonyl, arylalkyloxycarbonyl, or alkoxycarbonyl group of the formula: wherein R is aryl, aryl(C 1 _ 6 ) alkyl or optionally substituted (C l-6 ) alkyl It will therefore be appreciated that the compounds of formula (II) are N-halocarbamates (N-halourethanes).
• the group R 1 is a removable amino protecting group of the urethane type which may if desired be removed from a compound of formula (I) or, more suitably, from a product for which the compound of formula (I) serves as an intermediate.
• suitable protecting groups of this nature, and conditions for their removal without disruption of the remainder of the molecule are well known in the art.
• Suitable removable amino-protecting carboxylic acyl groups for R 1 include benzyloxycarbonyl optionally substituted in the phenyl ring by one or two substituents selected from C l - 4 alkyl, C l - 4 alkoxy, trifluoromethyl, halogen or nitro; C l - 4 alkyloxycarbonyl, for example tert-butoxycarbonyl; or C l - 4 alkyloxycarbonyl optionally substituted in the alkyl group by up to three substituents chosen from C l - 4 alkoxy, halo or nitro, for example 2,2,2,- trichloroethoxycarbonyl or 1-chloroethoxycarbonyl.
• removable amino-protecting acyl groups within R l include those listed above which are removable under acid conditions optionally in the presence of a group IIb metal.
• Particular carboxylic acyl groups for R 1 include 2,2,2- trichloroethoxycarbonyl, ethoxycarbonyl and benzyloxycarbonyl, and 4-nitrobenzyloxycarbonyl.
• 'halogen' refers to fluorine, chlorine, bromine and iodine.
• a preferred halogen atom for R 2 is chlorine.
• Suitable non-nucleophilic bases for use in the process include 1,8-diazabicyclo [5.4.0]undec-7-ene, 1,5-diazabicyclo [4.3.0] non-5-ene, 1,4-diazabicyclo [2.2.2]octane, dimethylaminopyridine or a tri(lower alkyl) amine.
• a preferred base is 1,8-diazabicyclo [5.4.0]undec-7-ene (DBU).
• Suitable solvents in which the reaction may be performed include for example, tetrahydrofuran, dimethylformamide, dichloromethane and methylisobutylketone.
• the reactions are generally carried out under an inert atmosphere and at moderate to low temperature ie in the range -100°C to +30 o C.
• Suitable values for Q in the compounds of the formula (III) include the acetoxy, heterocyclylthio group, and nitrogen containing heterocyclic group bonded via nitrogen.
• Q represents the acetoxy or heterocyclylthio group.
• the heterocyclylthio group may suitably be represented by the formula: wherein 'Het' is a five or six membered heterocyclic ring containing from 1 to 4 atoms selected from N, O, and S unsubstituted or substituted with one or two groups selected from C l - 6 alkyl, C l - 6 alkoxy, hydroxyalkyl, C l - 6 alkenyl, alkoxyalkyl, carboxyalkyl, sulphonylalkyl, carbamoylalkyl, trifluoromethyl, hydroxy, halogen, oxo, optionally substituted aminoalkyl, and carboxyalkyl or two substituents may be linked to form the residue of a heterocyclic or carbocyclic ring.
• Het' examples include unsubstituted and substituted imidazolyl, triazolyl, tetrazolyl, thiazolyl, thiadiazolyl, thiatriazolyl, oxazolyl, triazinyl and oxadiazolyl.
• Suitable groups 'Het' include unsubstituted and substituted 1, 2, 3-triazolyl; 1, 2, 4-triazolyl; tetrazolyl; oxazolyl; thiazolyl; 1, 3, 4-oxadiazolyl; 1, 3, 4-thiadiazolyl; or 1, 2, 4-thiadiazolyl.
• the heterocyclylthio group is l-methyl-lH-tetrazol-5-ylthio, 2-methyl-1,3,4-thiadiazol-5-ylthio, l-carboxymethyl-1H-tetrazol-5-ylthio or 6-hydroxy-2-methyl-5-oxo-2H-l,2,4-triazin-3-ylthio.
• the nitrogen containing heterocyclic group bonded via nitrogen is suitably a pyridinium group unsubstituted or substituted with one or two groups selected from C l - 6 alkyl, C 1-6 alkoxy, hydroxyalkyl, C 1-6 alkenyl, alkoxyalkyl, carboxyalkyl, sulphonylalkyl, carbamoylmethyl, carbamoyl, trifluoromethyl, hydroxy, halogen, oxo, aminoalkyl, or two substituents on adjacent carbon atoms may form the residue of a carbocyclic ring.
• 'carboxylic ester' suitably includes C l - 6 alkyl esters.
• acyloxy' suitably includes C 1 _ 6 alkylcarbonyloxy groups.
• the term 'aryl' suitably includes phenyl and naphthyl, preferably phenyl, optionally substituted with up to five halogen, C 1 _ 6 alkyl, C l - 6 alkoxy, halo (C 1-6 ) alkyl, hydroxy, amino, carboxy, C l-6 alkoxycarbonyl, or C l-6 alkoxycarbonyl-(C 1-6 )alkyl, C l-6 alkylcarbonyloxy or C l - 6 alkoxycarbonyloxy groups.
• heterocyclyl' suitably includes single or fused aromatic or non-aromatic heterocyclic rings comprising up to four hetero atoms in the ring selected from oxygen, nitrogen, and sulphur and optionally substituted with up to three halogen, C l - 6 alkyl, C l - 6 alkoxy, halo-(C 1-6 )-alkyl, hydroxy, amino, carboxy, C 1-6 alkoxycarbonyl, Cl-6 alkoxycarbonyl(C 1 _ 6 ) alkyl, aryl, oxo, carboxy(C 1 _ 6 )alkyl, carbamoyl-C( 1 - 6 )alkyl, amino(C 1-6 )alkyl, substituted amino(Ci- 6 ) alkyl or sulphonyl(C 1 _ 6 )alkyl groups.
• heterocyclic ring comprises from 4 to 7 ring atoms, preferably 5 or 6 atoms.
• Y is: wherein Y 2 is oxygen, sulphur or -CH 2 - and Z is as hereinbefore defined.
• a particularly preferred value for Y is -S-C(CH 3 ) 2 -.
• the imine of formula (III) is prepared by treatment with base of a compound of formula (IV): wherein R l , R 2 , R x and Y are as hereinbefore defined and wherein any reactive groups may be protected.
• Suitable compounds within formula (IV) are those of formula (V): wherein R 1 and R X are as hereinbefore defined and wherein any reactive groups may be protected; and Y 3 is:
• imine (I) may be generated in a similar manner to that described above from a compound of partial structure (IIA): wherein R 1 and R 2 are as hereinbefore defined.
• the imines of formulae (I) and (III) are often unstable intermediates and are conveniently reacted in situ without isolation, to form other ⁇ -lactam compounds.
• an imine of partial structure (I) as hereinbefore defined can be converted to a ⁇ -lactam having the partial structure (VI): wherein R 1 is as hereinbefore defined, by reaction with a nucleophilic derivative of formamide, as described in our copending European Patent Application No.84300338.5
• Suitable nucleophilic derivatives of formamide include N-silyl, N-stannyl and N-phosphorylated derivatives.
• 'N-silyl derivative' of formamide is meant the product of reaction of the amino group of formamide with a silylating agent such as a halosilane or a silazane of the formula:
• 'N-stannyl derivative' of formamide includes the product of reaction of the amino group of formamide with a stannylating agent such as a halostannane of formula: wherein L and U are as defined hereinbefore.
• 'N-phosphorylated' derivative of formamide is intended to include compounds wherein the amino group of formamide is substituted with a group of formula: wherein Rj is an alkyl, haloalkyl, aryl, aralkyl, alkoxy, haloalkoxy, aryloxy, aralkyloxy or dialkylamino group, R k is the same as R j or is halogen or Rj and R k together form a ring.
• nucleophilic derivatives of formamide include wherein R' and R " may be the same or different and each represent a C l-6 alkyl group or R' and R " together represent a C 2 - 4 alkylene di-radical.
• the nucleophilic derivative of formamide is a N,N-bis (tri-loweralkylsilyl) formamide, in particular N,N-bis(trimethylsilyl)formamide.
• Suitable solvents in which the reaction may be performed include for example, tetrahydrofuran, dimethylformamide, dichloromethane and methylisobutylketone.
• the reactions are generally carried out under an inert atmosphere and at moderate to low temperatures i.e. in the range -100 0 C to +30 0 C.
• the course of the reaction may be followed by conventional methods such as thin layer chromatography and terminated when an optimum quantity of product is present in the reaction mixture.
• suitable methods include those known in the art such as, for example, acid or base hydrolysis or treatment with a metal ion such as mercury, silver, thallium, lead or copper.
• R 1 is as hereinbefore defined by treating a compound of partial structure (II), wherein R 1 and R 2 are as hereinbefore defined with (i) a non-nucleophilic base and subsequently in situ with (ii) a nucleophilic derivative of formamide.
• Suitable pharmaceutically acceptable in vivo hydrolysable ester groups include those which break down readily in the human body to leave the parent acid or its salt.
• Suitable ester groups of this type include those of part formula (i), (ii) and (iii): wherein R a is hydrogen, methyl, or phenyl, R b is C l - 6 alkyl, C 1-6 alkoxy or phenyl; or R a and R b together form a 1,2-phenylene group optionally subsituted by one or two methoxy groups; R C represents C 1-6 alkylene optionally substituted with a methyl or ethyl group - R d and R e independently represent C 1-6 alkyl; R f represents C l-6 alkyl.
• suitable in vivo hydrolysable ester groups include for example acyloxyalkyl groups such as acetoxymethyl, pivaloyloxymethyl, a-acetoxyethyl and a-pivaloyloxyethyl groups; alkoxycarbonyloxyalkyl groups such as ethoxycarbonyloxymethyl and a-ethoxycarbonyloxyethyl; dialkylaminoalkyl especially di-loweralkylamino alkyl groups ; such as dimethylaminomethyl, dimethylaminoethyl, diethylaminomethyl or diethylaminoethyl; lactone groups such as phthalidyl and dimethoxyphthalidyl; and esters linked to a second ( ⁇ -lactam antibiotic or to a ⁇ -lactamase inhibitor.
• acyloxyalkyl groups such as acetoxymethyl, pivaloyloxymethyl, a-acetoxyethyl and
• Suitable readily removable carboxyl protecting groups for the group -C0 2 R 3 in formula (VII) and -C0 2 R x in formula (III) include salt and ester derivatives of the carboxylic acid.
• the derivative is preferably one which may readily be cleaved.
• Suitable ester-forming carboxyl-protecting groups are those which may be removed under conventional conditions.
• the carboxyl group may be regenerated from any of the above esters by usual methods appropriate to the particular R 3 or R X group, for example, acid - and base - catalysed hydrolysis, or by enzymically-catalysed hydrolysis, or by hydrogenolysis.
• Suitable pharmaceutically acceptable salts of the carboxy group of the compounds of formulae (VII) and (III) include metal salts eg aluminium, alkali metal salts such as sodium or potassium, alkaline earth metal salts such as calcium or magnesium and ammonium or substituted ammonium salts, for example those with lower alkylamines such as triethylamine, hydroxy-lower alkylamines such as 2-hydroxyethylamine, bis-(2-hydroxyethyl)-amine or tris-(2-hydroxyethyl)-amine, cycloalkylamines such as dicyclohexylamine, or with procaine, dibenzylamine, N,N-dibenzylethylene-diamine, 1-ephenamine, N-ethylpiperidine, N-benzyl- ⁇ -phenethylamine, dehydroabietylamine, N,N'-bisdehydro-abietylamine, ethylenediamine, or bases of the pyridine type
• antibacterial compounds produced by the process of the present invention may be formulated into pharmaceutical compositions according to techniques per se known in the art and administered by conventional routes and dosage rates; for example, as disclosed in US Patent Application No. 401266 and European Patent Application No. 8230382.1 (publication No. 0071395) which are incorporated herein by reference.
• a preferred group of compounds that may be produced from ⁇ -lactams of structure (X) by such methods can be represented by the formula (XI) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: wherein Y is as defined with respect to formula (III); and R 4 is a group such that R 4- CO is an acyl group, in particular an acyl group found in antibacterially active penicillins or cephalosporins.
• a suitable source of halogen is tert-butyl hypochlorite.
• Suitable bases include 1,8-diazabicyclo[5.4.0]-undec-7-ene, 1,5-diazabicyclo[4.3.0]non-5-ene, 1,4-diazabicyclo[2.2.2.]octane, dimethylaminopyridine or a tri(lower alkyl) amine.
• Suitable solvents in which the reaction may be carried out include for example, tetrahydrofuran, dimethylformamide, dichloromethane and methylisobutylketone.
• the reactions are generally carried out under an inert atmosphere and at moderate to low temperatures i.e. in the range -100°C to +37°C.
• Benzyl 6p-aminopenicillanate toluene-4-sulphonate 120g; 0.25 mol was partitioned between ethyl acetate (750cm 3 ) and saturated aqueous sodium bicarbonate (1000cm 3 ). The phases were separated and the aqueous phase re-extracted with ethyl acetate (2 x 250cm 3 ). The combined extracts were washed with water (500cm 3 ) followed by aqueous sodium chloride (500cm 3 ). The organic solution was dried over anhydrous magnesium sulphate, filtered and the filtrates cooled to -25°C.
• the product ran as one component on t.l.c. (SiO 2 ; 60F 254 ; 50% ethyl acetate/hexane) at an Rf of 0.61 (U.V., 254nm).
• Benzyl 60-(2,2,2,-trichloroethoxycarbonylamino) penicillanate (1050mg; 2.2mmol) was dissolved in dry tetrahydrofuran at -76° under an atmosphere of nitrogen. 1,8-Diazabicyclo[5.4.0]undec-7-ene (D.B.U.) (304mg; 2mmol) was added and the mixture was stirred for 5 minutes at -76 0 .
• Benzyl 6B-ethoxycarbonylaminopenicillanate (1.13g; 0.003 mole) was dissolved in dry tetrahydrofuran (10cm 3 ) and cooled to -65° under an atmosphere of nitrogen. Added D.B.U. (0.45g; 0.003 mole) and the mixture was stirred for 5 minutes at -65°. Added t-butylhypochlorite (0.34g; 0.0032 mole) and stirred for a further 5 minutes at -65°. Added bis(trimethylsilyl)formamide (4.77g; 0.025 mole) and the reaction mixture warmed to ambient temperature during 2 hours.
• the material ran as one component on t.l.c. (silica, 60F 254 ; ethyl acetate-n-hexane, 1:1) at an Rf of 0.10 (u.v. 254 n.m.). ⁇ max(KBr), 3300, 2990, 1780, 1740, 1690, 1510, 1500, 1260cm -1 .
• the title compound was prepared by a similar procedure to that described in Preparation 1, using benzyl chloroformate (4.5g; 0.025 mole). The product was obtained as a viscous oil (8.7g; 100%). ⁇ (CDCl 3 ), 1.35 and 1.50(6H,2s,2 x PhCH 2 ), 5.35(2H,bs,5-H,6-H), 5.6-5.9(lH,bs,CONH), 7.15(10H,bs,2 x PhCH 2 ).
• Benzyl 60-benzyloxycarbonylaminopenicillanate (1.32g; 0.003 mole) was dissolved in dry tetrahydrofuran (10cm 3 ) at -65° under an atmosphere of nitrogen. Added D.B.U. (0.45g; 0.003 mole) and the mixture was stirred for 5 minutes at -65°. Added t - butylhypochlorits (0.34g; 0.003 mole) and stirred for a further 5 minutes at -65°. Added bis(trimethylsilyl) formamide (4.77g; 0.025 mole and the reaction mixture warmed to ambient temperature during 2 hours.
• the product was purified by column chromatography on silica G60 (30g), using ethyl acetate-n-hexane (1:1) as eluent. Removal of the solvent in vacuo gave the title compound as a pale yellow foam (0.94g, 65%).
• the material ran as one component on t.l.c. (Silica 60F 254 ; ethyl acetate-n-hexane, 1:1) at an Rf of 0.10 (u.v. 254nm).
• the title compound was prepared from 4-nitrobenzyl 6-aminopenicillanate, 4-toluene sulphonate (5.23g; O.Olmole) and 4-nitrobenzyl chloroformate (2.16g; O.Olmole), by a procedure similar to that described in Preparation 1.
• the product was obtained as an off-white foam (5.2g; 98%).
• the product ran as one main component on t.l.c. at an Rf of 0.31 with small impurities at 0.44 and 0.56. (Si0 2 ; 60F 254 ; 50% ethyl acetate/n-hexane; u.v. 254nm).
• the material was used without further purification.
• the mixture was partitioned between ethyl acetate (50cm 3 ) and water (50cm 3 ).
• the organic phase was washed sequentially with 1M hydrochloric acid (50cm 3 ), 0.5M sodium bicarbonate (50cm 3 ) and saturated aqueous sodium chloride (50cm 3 ).
• the solution was dried (anhydrous magnesium sulphate) and concentrated in vacuo to a yellow foam.
• 6-Aminopenicillanic acid (21.6g; 0.1 mole) was slurried in water (150cm 3 ) and the pH adjusted to 8.5 by addition of 2M sodium hydroxide. Solution cooled to 5° in an ice salt bath. Added benzyl chloroformate (18.7g; 0.11 mole) dropwise, maintaining the pH at 8.5 by concurrent addition of 1M sodium bicarbonate. When the pH was stable the solution was warmed to ambient temperature and stirred for 1 hour. The solution was washed with diethyl ether (2 x 200cm 3 ), covered with ethyl acetate (250cm 3 ) and acidified to pH 2.0 with 2M hydrochloric acid. Phases separated.
• aqueous phase was further extracted with ethyl acetate (200cm 3 ) and the combined organic phases washed with saturated aqueous sodium chloride (2 x 150cm 3 ), dried (anhdyrous magnesium sulphate) and the solvent removed in vacuo to give 6 ⁇ -benzyloxycarbonylaminopenicillanic acid (35.9g; >100%) as a crisp, white foam.
• the major impurity appeared to be ethyl acetate.
• the material was used for the next reaction without further purification.
• the organic extract was washed with water (2 x 50cm 3 ), 0.5M-sodium bicarbonate (50cm 3 ), water (50cm 3 ), saturated aqueous sodium chloride (25cm 3 ) and dried (anhydrous magnesium sulphate). After filtration, the filtrate was reduced in vacuo to give methyl 65-benzyloxycarbonylaminopenicillanate (2.0g; 55%) as a crisp, yellow-brown foam.
• Methyl 6 ⁇ -benzyloxycarbonylaminopenicillanate (1.09g, 0.003 mole) was dissolved in dry tetrahydrofuran (10cm 3 ) and cooled to -65° under an atmosphere of nitrogen. Added D.B.U. (0.45g; 0.003 mole) and the mixture was stirred for 5 minutes at -65°. Added t-butylhypochlorite (0.34g; 0.0032 moles) and stirred for a further 5 minutes at -65°. Added bis(trimethylsilyl) formamide (4.77g; 0.025 moles) and the reaction mixture warmed to ambient temperature during 2 hours.
• the material ran as one component on t.l.c. (silica, 60F 254 ; ethyl acetate-n-hexane 1:1) at an Rf of 0.10 (u.v. 254nm).
• the title compound was prepared by a similar procedure to that described in Preparation 1 from t-butyl 7 ⁇ -aminocephalosporanate (5g, 0.015 moles). The product was obtained, after evaporation of the solvent, as a yellow-brown foam (8g, 100%).
• the product ran as one component on t.l.c. (silica 60F 254 ; ethyl acetate-n-hexane 1:1) at an Rf of 0.70 (u.v. 254n.m.).
• t-Butyl 7 ⁇ - (2,2,2-trichloroethoxycarbonylamino)cephalosporanate (10g; 0.02 moles) was dissolved in dry tetrahydrofuran (100cm 3 ) and cooled to -60° under an atmosphere of nitrogen. Added D.B.U. (3.05g; 0.02 moles) and the mixture was stirred for 5 minutes at -60°. Added t-butyl hypochlorite (2.04g; 0.019 moles) and stirred for a further 5 minutes at -60°. added bis(trimethylsilyl) formamide (3.8g; 0.02 moles) and the reaction mixture warmed to ambient temperature during 4 hours.
• ethyl acetate (100cm 3 ) and water (100cm 3 ) were added to the reaction mixture.
• the phases were separated and the organic phase washed sequentially with 0.5M hydrochloric acid (25cm 3 ), water (25cm 3 ), 0.25M sodium bicarbonate (25cm 3 ), water (25cm 3 ). and saturated aqueous sodium chloride (25cm 3 ).
• the organic solution was dried (anhydrous magnesium sulphate), filtered, and the filtrates reduced in vacuo to an oil.
• the product was purified by column chromatogrphy on silica C60 (150g) using ethyl acetate-n-hexane 1:1 as eluent.
• the material ran as one component on t . l . c . ( silica; 60 F 254 ; ethyl acetate-n-hexane 1:1) at an Rf of 0.15 (u.v. 254nm). ⁇ max(CH 2 Cl 2 ) 3380, 1790, 1735 and 1700cm -1 .
• Benzyl 6B-benzyloxycarbonylaminopenicillanate (0.82g, 0.00186M) (from Preparation 3) was dissolved in dry tetrahydrofuran (8cm 3 ) at -65° under an atmosphere of nitrogen. Added 1,5-diazabicyclo[4.3.0]-non-5-ene (0.27g; 0.00218 M) and the mixture was stirred for 5 minutes at -65°. Added t-butylhypochlorite (0.24g, 0.00212M) and stirred for a further 5 minutes at -65°. Added bis(trimethylsilyl) formamide (2.5g, 0.013M) and the reaction mixture warmed to ambient temperature during 2 hours.

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• 1984
  • 1984-06-29 GB GB848416648A patent/GB8416648D0/en active Pending
• 1985
  • 1985-06-20 EP EP85107633A patent/EP0166377A1/fr not_active Withdrawn
  • 1985-06-25 AU AU44130/85A patent/AU4413085A/en not_active Abandoned
  • 1985-06-27 ZA ZA854859A patent/ZA854859B/xx unknown
  • 1985-06-27 ES ES544645A patent/ES8609237A1/es not_active Expired
  • 1985-06-27 GR GR851585A patent/GR851585B/el unknown
  • 1985-06-27 PT PT80729A patent/PT80729B/pt unknown
  • 1985-06-27 DK DK291785A patent/DK291785A/da not_active Application Discontinuation
  • 1985-06-28 JP JP60140695A patent/JPS6118787A/ja active Pending

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