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EP0158339A3 - 1,5-benzothiazephine derivatives, processes for preparing the same and pharmaceutical compositions - Google Patents

1,5-benzothiazephine derivatives, processes for preparing the same and pharmaceutical compositions Download PDF

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Publication number
EP0158339A3
EP0158339A3 EP85104341A EP85104341A EP0158339A3 EP 0158339 A3 EP0158339 A3 EP 0158339A3 EP 85104341 A EP85104341 A EP 85104341A EP 85104341 A EP85104341 A EP 85104341A EP 0158339 A3 EP0158339 A3 EP 0158339A3
Authority
EP
European Patent Office
Prior art keywords
sup
pharmaceutical compositions
hydrogen
derivatives
benzothiazephine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP85104341A
Other versions
EP0158339A2 (en
EP0158339B1 (en
Inventor
Mikio Takeda
Tokuro Oh-Ishi
Hiromichi Nakajima
Taku Nagao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to AT85104341T priority Critical patent/ATE40126T1/en
Publication of EP0158339A2 publication Critical patent/EP0158339A2/en
Publication of EP0158339A3 publication Critical patent/EP0158339A3/en
Application granted granted Critical
Publication of EP0158339B1 publication Critical patent/EP0158339B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Novel 1,5-benzothiazepine derivatives of the formula:wherein R<sup>1</sup> is hydrogen or lower alkyl, R<sup>2</sup> is hydrogen, lower alkanoyl or benzyl, R<sup>3</sup> is hydrogen or lower alkyl and either one of R<sup>4</sup> and R<sup>5</sup> is hydrogen and the other is chlorine, or a pharmaceutically acceptable acid addition salt thereof are disclosed. In form of pharmaceutical compositions the said derivative (I) and its salt have a potent platelet aggregation-inhibiting activity.
EP85104341A 1984-04-10 1985-04-10 1,5-benzothiazephine derivatives, processes for preparing the same and pharmaceutical compositions Expired EP0158339B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT85104341T ATE40126T1 (en) 1984-04-10 1985-04-10 1,5-BENZOTHIAZEPINE DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE AND MEDICATIONS.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8409258 1984-04-10
GB8409258 1984-04-10

Publications (3)

Publication Number Publication Date
EP0158339A2 EP0158339A2 (en) 1985-10-16
EP0158339A3 true EP0158339A3 (en) 1986-06-11
EP0158339B1 EP0158339B1 (en) 1989-01-18

Family

ID=10559475

Family Applications (1)

Application Number Title Priority Date Filing Date
EP85104341A Expired EP0158339B1 (en) 1984-04-10 1985-04-10 1,5-benzothiazephine derivatives, processes for preparing the same and pharmaceutical compositions

Country Status (12)

Country Link
US (1) US4585768A (en)
EP (1) EP0158339B1 (en)
JP (1) JPS60226866A (en)
KR (1) KR910005414B1 (en)
AT (1) ATE40126T1 (en)
AU (1) AU572978B2 (en)
CA (1) CA1218991A (en)
DE (1) DE3567650D1 (en)
DK (1) DK172257B1 (en)
ES (2) ES8705408A1 (en)
HU (1) HU191785B (en)
SU (2) SU1632372A3 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2167063A (en) * 1984-11-17 1986-05-21 Tanabe Seiyaku Co 6 or 9-chloro-1, 5-benzothiazepine derivatives
JPS62161776A (en) * 1986-01-07 1987-07-17 Tanabe Seiyaku Co Ltd Production of 1,5-benzothiazepine derivative
US4786634A (en) * 1986-05-23 1988-11-22 Tanabe Seikyaku Co., Ltd. Method for treating arteriosclerosis
US4729994A (en) * 1986-08-20 1988-03-08 Mcneilab, Inc. Benzothiazepine vasodilators having aralkyl substitution
FR2624117B1 (en) * 1987-12-08 1991-02-22 Synthelabo HYDROXY-3 (METHOXY-4 PHENYL) -2 (METHYLAMINO-2 ETHYL) -5 DIHYDRO-2,3 5H-BENZOTHIAZEPINE-1,5 ONE-4 DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2630107B1 (en) * 1988-04-19 1990-06-08 Synthelabo PROCESS FOR THE PREPARATION OF (+) - (2S, 3S) (2-AMINO-PHENYL) THIO) -3 HYDROXY-2 (4-METHOXY-PHENYL) -3 METHYL PROPIONATE
NL8801311A (en) * 1988-05-20 1989-12-18 Stamicarbon PHENYL GLYCIDATE STEREOISOMERS, CONTAINING PRODUCTS THEREOF WITH 2-NITROTHIOPHENOL AND THE PREPARATION OF DILTIAZEM.
FI95931C (en) * 1988-09-02 1996-04-10 Tanabe Seiyaku Co Process for the preparation of the lower alkyl ester of (2R, 3S) -3- (4-methoxyphenyl) glycidic acid
FR2637285B1 (en) * 1988-10-03 1991-04-12 Synthelabo PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES AND PRODUCTS OBTAINED
US6521445B1 (en) * 1988-10-26 2003-02-18 Sepracor, Inc. Process for preparing optically active glycidate esters
US5274300A (en) 1988-10-26 1993-12-28 Sepracor, Inc. Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion
FR2642425A1 (en) * 1989-01-30 1990-08-03 Sanofi Sa PROCESS FOR THE PREPARATION OF BENZOTHIAZEPINE-1.5 ONE-4 DERIVATIVES
JP2674232B2 (en) * 1989-08-31 1997-11-12 田辺製薬株式会社 1,5-benzothiazepine derivative
US5244803A (en) * 1989-09-13 1993-09-14 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 3-phenylglycidic acid esters
US5674863A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
JP2643798B2 (en) * 1992-10-23 1997-08-20 田辺製薬株式会社 Peripheral arterial blood flow enhancer
FR2704848B1 (en) * 1993-05-03 1995-07-21 Prod Chim Auxil Synthese Liquid precursor for the production of fluorine-doped tin oxide coatings and corresponding coating process.
US5580867A (en) * 1994-09-09 1996-12-03 Universite De Montreal Myocardial protection during ischemia and reperfusion

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1805714A1 (en) * 1967-10-28 1969-06-19 Tanabe Seiyaku Co Benzothiazepine derivatives, their salts and processes for their preparation
EP0127882A1 (en) * 1983-06-03 1984-12-12 Tanabe Seiyaku Co., Ltd. Novel 8-chloro-1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3075967A (en) * 1961-06-12 1963-01-29 Olin Mathieson Benzothiazines
US3341519A (en) * 1965-04-28 1967-09-12 Squibb & Sons Inc Novel benzoxazines, benzothiazines, benzoxazepins and benzothiazepins
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
JPS56156217A (en) * 1980-05-02 1981-12-02 Tanabe Seiyaku Co Ltd Inhibitor against blood platelet agglutination
JPS56156218A (en) * 1980-05-02 1981-12-02 Tanabe Seiyaku Co Ltd Inhibitor against blood platelet agglutination
GB8316032D0 (en) * 1983-06-11 1983-07-13 Tanabe Seiyaku Co Benzothiazepine derivatives
CH665909A5 (en) * 1985-05-15 1988-06-15 Matix Ind Sa METHOD AND DEVICE FOR ULTRASONIC DETECTION OF INTERNAL DEFECTS OF A RAILWAY RAIL LOCATED IN THE EDGE OF THE MUSHROOM OF THAT RAIL, USE OF THE DEVICE.
US5708066A (en) * 1995-03-01 1998-01-13 E. I. Du Pont De Nemours And Company Reaction curable composition and solid surface material

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1805714A1 (en) * 1967-10-28 1969-06-19 Tanabe Seiyaku Co Benzothiazepine derivatives, their salts and processes for their preparation
EP0127882A1 (en) * 1983-06-03 1984-12-12 Tanabe Seiyaku Co., Ltd. Novel 8-chloro-1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 101, 1984, page 8, no. 16696w, Columbus, Ohio, US; J. SUGAWARA et al.: "Studies on the metabolism of diltiazem in man", & J. PHARMACOBIO-DYN. 1984, 7(1), 24-32 *
CHEMICAL ABSTRACTS, vol. 96, no. 18, 3rd May 1982, page 422, no. 149164w, Columbus, Ohio, US; & JP-A-56 156 218 (TANABE SEIYAKU CO., LTD.) 02-12-1981 *

Also Published As

Publication number Publication date
DE3567650D1 (en) 1989-02-23
JPS60226866A (en) 1985-11-12
ATE40126T1 (en) 1989-02-15
DK172257B1 (en) 1998-02-09
ES8801230A1 (en) 1988-01-01
EP0158339A2 (en) 1985-10-16
AU4039285A (en) 1985-10-17
JPH0374659B2 (en) 1991-11-27
ES8705408A1 (en) 1987-05-01
AU572978B2 (en) 1988-05-19
DK157785D0 (en) 1985-04-09
KR910005414B1 (en) 1991-07-29
HU191785B (en) 1987-04-28
HUT37411A (en) 1985-12-28
CA1218991A (en) 1987-03-10
US4585768A (en) 1986-04-29
DK157785A (en) 1985-10-11
SU1632372A3 (en) 1991-02-28
SU1358784A3 (en) 1987-12-07
KR850007248A (en) 1985-12-02
EP0158339B1 (en) 1989-01-18
ES557061A0 (en) 1988-01-01
ES542125A0 (en) 1987-05-01

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