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EP0151239A3 - Monoclonal antibodies specific to in vivo fragments derived from fibrinogen - Google Patents

Monoclonal antibodies specific to in vivo fragments derived from fibrinogen Download PDF

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Publication number
EP0151239A3
EP0151239A3 EP84113593A EP84113593A EP0151239A3 EP 0151239 A3 EP0151239 A3 EP 0151239A3 EP 84113593 A EP84113593 A EP 84113593A EP 84113593 A EP84113593 A EP 84113593A EP 0151239 A3 EP0151239 A3 EP 0151239A3
Authority
EP
European Patent Office
Prior art keywords
fibrinogen
vivo
monoclonal antibodies
antibodies specific
fragments derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP84113593A
Other versions
EP0151239B1 (en
EP0151239A2 (en
Inventor
Bohdan J. Kudryk
Michael E. Wiebe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York Blood Center Inc
Original Assignee
New York Blood Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Blood Center Inc filed Critical New York Blood Center Inc
Priority to AT84113593T priority Critical patent/ATE84318T1/en
Publication of EP0151239A2 publication Critical patent/EP0151239A2/en
Publication of EP0151239A3 publication Critical patent/EP0151239A3/en
Application granted granted Critical
Publication of EP0151239B1 publication Critical patent/EP0151239B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A61M1/3689—Chemical treatment by biological cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP84113593A 1983-11-14 1984-11-10 Monoclonal antibodies specific to in vivo fragments derived from fibrinogen Expired - Lifetime EP0151239B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT84113593T ATE84318T1 (en) 1983-11-14 1984-11-10 MONOCLONAL ANTIBODIES SPECIFIC FROM IN VIVO DERIVATIVE PIECES OF FIBRINOGEN.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55083683A 1983-11-14 1983-11-14
US550836 1983-11-14
US06/567,462 US4722903A (en) 1983-11-14 1984-01-03 Monoclonal antibodies specific to in vivo fragments derived from human fibrinogen, human fiberin I or human fibrin II
US567462 1984-01-03

Publications (3)

Publication Number Publication Date
EP0151239A2 EP0151239A2 (en) 1985-08-14
EP0151239A3 true EP0151239A3 (en) 1986-12-30
EP0151239B1 EP0151239B1 (en) 1993-01-07

Family

ID=27069567

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84113593A Expired - Lifetime EP0151239B1 (en) 1983-11-14 1984-11-10 Monoclonal antibodies specific to in vivo fragments derived from fibrinogen

Country Status (6)

Country Link
US (1) US4722903A (en)
EP (1) EP0151239B1 (en)
JP (2) JPH0616717B2 (en)
AU (1) AU576788B2 (en)
CA (1) CA1248472A (en)
DE (1) DE3486030T2 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU572125B2 (en) * 1983-03-17 1988-05-05 Mabco Limited Monoclonal antibodies with specificity for crosslinked fibrin and their diagnotic uses
DE3400434A1 (en) * 1984-01-09 1985-09-26 Behringwerke Ag, 3550 Marburg DETERMINATION OF FIBRINE WITH FIBRINE-SPECIFIC ANTIBODY
US5357042A (en) * 1984-04-23 1994-10-18 The General Hospital Corporation Synthetic peptides capable of eliciting fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity
US4927916A (en) * 1984-04-23 1990-05-22 The General Hospital Corporation Method of producing fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity using fibrin-specific peptides
JPS60233553A (en) * 1984-05-04 1985-11-20 Dai Ichi Pure Chem Co Ltd Method for measuring decomposed product of fibrinogen and fibrin
JPS60257363A (en) * 1984-06-05 1985-12-19 Dai Ichi Pure Chem Co Ltd Measuring method of fdp
JPS60257364A (en) * 1984-06-05 1985-12-19 Dai Ichi Pure Chem Co Ltd Measuring method of fibrinogen/fibrin degradation product
US5256413A (en) * 1985-01-08 1993-10-26 The General Hospital Corporation Method and use for site-specific activation of substances
US5116613A (en) * 1985-01-08 1992-05-26 The General Hospital Corporation Antibody-thrombolytic agent product and method of use
CA1302919C (en) * 1985-07-03 1992-06-09 Robert T. Buckler Histamine derivatives, immunogen conjugates and antibodies raised thereto
JPS6393800A (en) * 1986-10-08 1988-04-25 Mitsubishi Gas Chem Co Inc Antihuman fibrin monoclonal antibody and use thereof
SE8701437L (en) * 1987-04-06 1988-10-07 Rolf Kenth Sigvard Wallin IN VITRO DIAGNOSTIC PROCEDURE AND MEASURES THAT CAN BE USED IN THE PROCEDURE
US5679583A (en) * 1987-05-02 1997-10-21 Hoechst Aktiengesellschaft Monoclonal antibodies for the selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids
US5382522A (en) * 1987-07-21 1995-01-17 International Immunoassay Laboratories, Inc. Immunoassay for creatine kinase-MB and creatine kinase-BB isoforms and reagents
US5382515A (en) * 1987-07-21 1995-01-17 International Immunoassay Laboratories, Inc. Creative kinase-MB immunoassay for myocardial infarction and reagents
US4900662A (en) * 1987-07-21 1990-02-13 International Immunoassay Laboratories, Inc. CK-MM myocardial infarction immunoassay
DE3727610A1 (en) 1987-08-19 1989-03-02 Behringwerke Ag SYNTHETIC PEPTIDES, AGAINST THESE ANTIBODIES AND THEIR USE
DE3730059A1 (en) * 1987-09-08 1989-03-30 Behringwerke Ag METHOD FOR DETERMINING "SOLUBLE" FIBRINE
US6541275B1 (en) 1988-02-03 2003-04-01 Dade Behring Inc. Immunoassay for F1.2 prothrombin fragment
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
US5582862A (en) * 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
NL8801227A (en) * 1988-05-10 1989-12-01 Tno ANTIBODIES AGAINST FIBRINE; IMMUNOGEN, METHOD FOR DETERMINING FIBRIN WITH THE ANTIBODIES AND PHARMACEUTICAL PREPARATION BASED ON THE ANTIBODIES FOR THE PREPARATION OF THE ANTIBODIES.
US5120834A (en) * 1988-06-13 1992-06-09 American Biogenetic Sciences, Inc. Fibrin-specific monoclonal antibody
US5453359A (en) 1988-06-13 1995-09-26 American Biogenetic Sciences, Inc. Immunoassay and kit for in vitro detection of soluble DesAABB fibrin polymers
US5811265A (en) * 1988-08-19 1998-09-22 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
US5609869A (en) * 1988-08-19 1997-03-11 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
WO1990004634A1 (en) * 1988-10-03 1990-05-03 Scripps Clinic And Research Foundation Monoclonal antibodies against receptor-induced binding sites
US5487892A (en) * 1994-02-24 1996-01-30 American Biogenetic Sciences, Inc. Method for treating thrombotic disease using a fibrin specific monoclonal antibody
US5817768A (en) * 1995-06-07 1998-10-06 The New York Blood Center, Inc. Monospecific antibodies against a subunit of fibrinogen
CA2266341A1 (en) * 1996-09-20 1998-03-26 The General Hospital Corporation Composition and method for enhancing fibrinolysis using antibodies to alpha-2-antiplasmin
US20030003515A1 (en) * 2000-12-05 2003-01-02 Farrell David H. Monocloral antibody-based diagnostic assay for gamma fibrinogen
CN103025871B (en) * 2010-07-30 2016-05-18 希森美康株式会社 Anti-FDP monoclonal antibody, use its FDP to measure with reagent and kit and FDP assay method
US9987416B2 (en) * 2015-01-09 2018-06-05 BioQuiddity Inc. Sterile assembled liquid medicament dosage control and delivery device
US11338082B2 (en) 2019-09-04 2022-05-24 BloQ Pharma, Inc. Variable rate dispenser with aseptic spike connector assembly

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4090846A (en) * 1976-10-20 1978-05-23 Fisher Scientific Company Indirect latex test for determination of fibrinogen degradation products
US4438209A (en) * 1981-07-17 1984-03-20 Mallinckrodt, Inc. Radioimmunoassay for fibrinopeptide A
US4443549A (en) * 1981-10-19 1984-04-17 Molecular Genetics, Inc. Production of monoclonal antibodies against bacterial adhesins
US4487833A (en) * 1982-03-01 1984-12-11 The General Hospital Corporation Method of preparing hybridomas and of purifying immunogenic materials
US4487829A (en) * 1982-03-23 1984-12-11 Massachusetts Institute Of Technology Production and use of monoclonal antibodies against adenoviruses
US4443427A (en) * 1982-06-21 1984-04-17 Sidney Farber Cancer Institute, Inc. Monoclonal antibody
US4465776A (en) * 1982-09-27 1984-08-14 Research Corporation Monoclonal antibodies to vitamin B6 and immunoassay method
AU572125B2 (en) * 1983-03-17 1988-05-05 Mabco Limited Monoclonal antibodies with specificity for crosslinked fibrin and their diagnotic uses
US4468346A (en) * 1983-10-27 1984-08-28 The United States Of America As Represented By The Secretary Of Agriculture Monoclonal antibodies to porcine immunoglobulins

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BIOLOGICAL ABSTRACTS, vol. 76, 1983, abstract no. 62261; B.P.R. SOLA et al.: "Isolation and characterization of a monoclonal antibody specific for fibrinogen and fibrin of human origin", & THROMB. RES. 29(6): 643-654, 1983 *
BIOLOGICAL ABSTRACTS, vol. 76, 1983, abstract no. 69855; S.J. KENNEL et al.: "Solid-phase radioimmunoassay of fragment D of human fibrinogen by use of a low-affinity monoclonal antibody", & CLIN. CHEM. 29(5): 778-781, 1983 *
BIOLOGICAL ABSTRACTS, vol. 77, 1984, abstract no. 40751; M.J.I.H. ELMS et al.: "Measurement of crosslinked fibrin degradation products: An immunoassay using monoclonal antibodies", & THROMB. HAEMOSTASIS. 50(2); 591-594, 1983 *
BIOLOGICAL ABSTRACTS, vol. 77, 1984, abstract no. 80886; D.B.RYLATT et al.: "An immunoassay for human D dimer using monoclonal antibodies", & THROMB. RES 31(6): 767-778, 1983 *
BIOLOGICAL ABSTRACTS, vol. 78, 1984, abstract no. 24799; B. KUDRYK et al.: "A monoclonal antibody with ability to distinguish between amino-terminal fragments derived from fibrinogen and fibrin", & MOL. IMMUNOL. 20(11): 1191-1200, 1983 *
BIOLOGICAL ABSTRACTS, vol. 78, 1984, abstract no. 8595; B. KUDRYK et al.: "Specifity of a monoclonal antibody for the amino terminal region of fibrin", & MOL. IMMUNOL. 21(1): 89-94, 1984 *
CHEMICAL ABSTRACTS, vol. 95, 1981, page 573, abstract no. 78340s, Columbus, Ohio, US; S.J. KENNEL et al.: "Monoclonal antibodies from rats immunized with fragment D of human fibrinogen" , & THROMB. RES. 1981, 22(3), 309-20 *
SCIENCE, vol. 222, 9th December 1983, pages 1129-1132; K.Y. HUI et al.: "Monoclonal antibodies to a synthetic fibrin-like peptide bind to human fibrin but not fibrinogen" *

Also Published As

Publication number Publication date
DE3486030T2 (en) 1993-05-19
CA1248472A (en) 1989-01-10
AU3487284A (en) 1985-05-23
EP0151239B1 (en) 1993-01-07
JPH06237786A (en) 1994-08-30
US4722903A (en) 1988-02-02
AU576788B2 (en) 1988-09-08
JPH0616717B2 (en) 1994-03-09
DE3486030D1 (en) 1993-02-18
EP0151239A2 (en) 1985-08-14
JPH0772200B2 (en) 1995-08-02
JPS60185800A (en) 1985-09-21

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