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EP0072284B1 - Multiple receptacle reaction support for testing liquid doses - Google Patents

Multiple receptacle reaction support for testing liquid doses Download PDF

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Publication number
EP0072284B1
EP0072284B1 EP82401379A EP82401379A EP0072284B1 EP 0072284 B1 EP0072284 B1 EP 0072284B1 EP 82401379 A EP82401379 A EP 82401379A EP 82401379 A EP82401379 A EP 82401379A EP 0072284 B1 EP0072284 B1 EP 0072284B1
Authority
EP
European Patent Office
Prior art keywords
disc
rotatable support
support according
eccentric
recesses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP82401379A
Other languages
German (de)
French (fr)
Other versions
EP0072284A2 (en
EP0072284A3 (en
Inventor
Alain Charles Albert Benajam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Le Materiel Biomedical A Responsabilite Dite Ltee Ste
Original Assignee
Le Materiel Biomedical A Responsabilite Dite Ltee Ste
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Le Materiel Biomedical A Responsabilite Dite Ltee Ste filed Critical Le Materiel Biomedical A Responsabilite Dite Ltee Ste
Priority to AT82401379T priority Critical patent/ATE30215T1/en
Publication of EP0072284A2 publication Critical patent/EP0072284A2/en
Publication of EP0072284A3 publication Critical patent/EP0072284A3/en
Application granted granted Critical
Publication of EP0072284B1 publication Critical patent/EP0072284B1/en
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/111666—Utilizing a centrifuge or compartmented rotor

Definitions

  • the present invention relates to a reaction vessel with multiple containers for testing liquid doses, allowing both agitation and / or centrifugation and automation of the test processes.
  • the rotary reaction support between liquid doses of samples and reagents in the form of a transparent disc in which are provided a plurality of flat-bottomed cells closed upwards and communicating with the outside each via an eccentric orifice opening into the upper face of the disc, is characterized in that said cells have no communication with each other.
  • the eccentric hole and the socket can communicate by an inclined face from top to bottom and from the inside of the disc to the outside. They can also communicate by a flat-bottom extension of said cell towards the orifice.
  • the rotary support according to the invention is of the type consisting of superimposed plates, it is advantageous for the disc to be formed by the superposition and the joining of two coaxial circular plates, one of which comprises said cells and the other of the through holes each forming one of said eccentric orifices.
  • the disc is pierced in its center with a hole allowing it to be mounted on a rotary vertical axis, or else it is integral with an axis orthogonal to its plane capable of being connected to rotation drive means.
  • the disc it is possible to subject the disc to rotary agitation or centrifugation movements.
  • the eccentric orifice is closer to the center of the disc than the corresponding socket, so that during centrifugation, the liquid cannot escape through said orifice.
  • the embodiment of the reaction vessel with multiple receptacles according to the invention comprises an upper disc 1 (FIG. 1) and a lower disc 2 (FIG. 3) superimposed and assembled by example by collage.
  • the discs 1 and 2 are made of a transparent synthetic material and are provided in their center with holes 3 or 4, respectively, to allow the passage of a rotary drive shaft when the discs 1 and 2 are superimposed.
  • the upper disc 1 is provided with a plurality of through holes 5 whose axes 6, orthogonal to the plane of the disc 1 are distributed at a plurality of points 7 located at the intersection of spokes 8 and concentric circles 9. Furthermore , each hole 5 widens upwards thanks to a portion 10 in the form of a funnel, of axis 6.
  • the lower transparent disc 2 comprises a plurality of blind holes 11 whose axes 12 are distributed at a plurality of points 13 located at the intersection of spokes 14 and concentric circles 15.
  • each blind hole 11 is associated with an inclined notch 16, symmetrical with respect to the corresponding diameter 14 and arranged with respect to the hole 11, on the side of the center of the disc 2.
  • the disc 1 is superimposed on the disc 2, so that the axis 6 of the holes 5 and 10 comes into correspondence with the median axis 17 of the oblique notches 16.
  • each blind hole 11 is closed by the disc 1, but it is in communication with the outside, at its upper part, via the oblique notch 16 and holes 5 and 10.
  • the radial length of the notches 16 is equal to the diameter of the holes 5 (see FIG. 6).
  • the disc was composed of two plates 1, superimposed.
  • the disc according to the invention could be composed, for example, of three superposed plates.
  • provision could be made for the holes 11 to pass completely through the plate 2 and for them to be closed off by a third plate disposed on the side opposite the disk 1 relative to the disk 2, as symbolized in FIG. 6 by the line in mixed line 18.
  • the upper disc 1 only has the portions 10, in the form of a funnel, with holes 5.
  • the blind holes 11 are, in the lower disc 2, extended in the direction portions 10, by a communication hole 11 ′ with a flat bottom, sufficiently elongated so that the upper edge of the funnels 10 is outside the container 11, or at least gives off on the bottom thereof vision 19 covering practically the greater part of said bottom.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Packages (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Optical Measuring Cells (AREA)

Abstract

The invention relates to a reaction support incorporating multiple recipients for testing liquid doses, comprising a transparent plate provided with a plurality of recesses of which each forms one of the recipient. According to the invention, this support is characterized in that the plate is in the form of a disc and in that the recesses are obturated at the top and are each in communication with the outside via an eccentric orifice opening on the upper face of the disc. The invention is particularly applicable in the domain of biology.

Description

La présente invention concerne un support de réaction à récipients multiples pourtests de doses liquides, permettant à la fois l'agitation et/ou la centrifugation et l'automatisation des processus de tests.The present invention relates to a reaction vessel with multiple containers for testing liquid doses, allowing both agitation and / or centrifugation and automation of the test processes.

On sait que, par exemple en biologie, immunologie, etc. il est nécessaire de soumettre simultanément une pluralité de doses de liquides, tels que sang, sérum, etc. à l'action de réactifs, pour permettre de classifier ces liquides.We know that, for example in biology, immunology, etc. it is necessary to simultaneously submit a plurality of doses of liquids, such as blood, serum, etc. to the action of reagents, to allow to classify these liquids.

On connaît déjà, par le brevet US-A-3 873 217 un support rotatif de réaction entre des doses liquides d'échantillons et de réactifs, présentant la forme d'un disque transparent pourvu d'une pluralité de paires de récipients à fond plat obturés vers le haut et en communication avec l'extérieur par l'intermédiaire d'orifices excentrés débouchant dans la face supérieure du disque, les deux récipients d'une paire communiquant entre eux et servant respectivement au stockage temporaire d'une dose liquide d'échantillon et d'une dose liquide de réactif et l'un desdits récipients d'une paire servant de récipient de réaction lorsque la dose contenue dans l'autre récipient y a été transférée par action des forces centrifuges.Already known, from US-A-3 873 217 a rotary support for reacting between liquid doses of samples and reagents, having the shape of a transparent disc provided with a plurality of pairs of flat-bottomed containers closed upwards and in communication with the outside by means of eccentric orifices opening into the upper face of the disc, the two receptacles of a pair communicating with each other and respectively serving for the temporary storage of a liquid dose of sample and a liquid dose of reagent and one of said containers of a pair serving as a reaction container when the dose contained in the other container has been transferred to it by the action of centrifugal forces.

Selon l'invention, le support rotatif de réaction entre des doses liquides d'échantillons et de réactifs présentant la forme d'un disque transparent dans lequel sont prévus une pluralité d'alvéoles à fond plat obturés vers le haut et communiquant avec l'extérieur chacun par l'intermédiaire d'un orifice excentrée débouchant dans la face supérieure du disque, est caractérisé en ce que lesdits alvéoles n'ont pas de communication entre eux.According to the invention, the rotary reaction support between liquid doses of samples and reagents in the form of a transparent disc in which are provided a plurality of flat-bottomed cells closed upwards and communicating with the outside each via an eccentric orifice opening into the upper face of the disc, is characterized in that said cells have no communication with each other.

L'orifice excentré et l'alvéole peuvent communiquer par une face inclinée du haut vers le bas et de l'intérieur du disque vers l'extérieur. Ils peuvent également communiquer par un prolongement à fond plat dudit alvéole vers l'orifice.The eccentric hole and the socket can communicate by an inclined face from top to bottom and from the inside of the disc to the outside. They can also communicate by a flat-bottom extension of said cell towards the orifice.

Lorsque le support rotatif selon l'invention est du type constitué de plaques superposées, il est avantageux que le disque soit formé par la superposition et la solidarisation de deux plaques circulaires coaxiales, dont l'une comporte lesdits alvéoles et l'autre des trous traversants formant chacun un desdits orifices excentrés.When the rotary support according to the invention is of the type consisting of superimposed plates, it is advantageous for the disc to be formed by the superposition and the joining of two coaxial circular plates, one of which comprises said cells and the other of the through holes each forming one of said eccentric orifices.

Avantageusement, le disque est percé en son centre d'un trou permettant son montage sur un axe vertical rotatif, ou bien il est solidaire d'un axe orthogonal à son plan susceptible d'être relié à des moyens d'entraînement en rotation. Ainsi, il est possible de soumettre le disque à des mouvements d'agitation en rotation ou de centrifugation.Advantageously, the disc is pierced in its center with a hole allowing it to be mounted on a rotary vertical axis, or else it is integral with an axis orthogonal to its plane capable of being connected to rotation drive means. Thus, it is possible to subject the disc to rotary agitation or centrifugation movements.

De préférence, l'orifice excentré es plus proche du centre du disque que l'alvéole correspondant, afin qu'au cours d'une centrifugation, le liquide ne puisse s'échapper par ledit orifice.Preferably, the eccentric orifice is closer to the center of the disc than the corresponding socket, so that during centrifugation, the liquid cannot escape through said orifice.

Les différents alvéoles et orifices sont de préférence rangés selon des rayons et des cercles concentriques.

  • Les figures du dessin annexé feront bien comprendre comment l'invention peut être réalisée.
  • La figure 1 est une vue de dessus de la plaque supérieure d'un exemple de réalisation de supports de réaction selon l'invention.
  • La figure 2 est une vue en coupe agrandie selon la ligne II-II de la figure 1.
  • La figure 3 est une vue de dessus du disque inférieur associé au disque supérieur des figures 1 et 2.
  • La figure 4 est une vue de dessus agrandie d'un orifice du disque inférieur de la figure 3.
  • La figure 5 est une vue en coupe agrandie selon la ligne V-V de la figure 3.
  • La figure 6 est une vue en coupe diamétrale agrandie partielle du support selon l'invention, au niveau d'un récipient de réaction.
  • La figure 7 illustre en vue de dessus agrandie une variante de réalisation de supports de réaction selon l'invention.
  • La figure 8 est une coupe longitudinale de la figure 7 et peut être comparée à la figure 6.
The various cells and orifices are preferably arranged according to radii and concentric circles.
  • The figures of the appended drawing will make it clear how the invention can be implemented.
  • Figure 1 is a top view of the upper plate of an exemplary embodiment of reaction supports according to the invention.
  • Figure 2 is an enlarged sectional view along line II-II of Figure 1.
  • FIG. 3 is a top view of the lower disk associated with the upper disk of FIGS. 1 and 2.
  • FIG. 4 is an enlarged top view of an orifice of the lower disc of FIG. 3.
  • FIG. 5 is an enlarged sectional view along the line VV of FIG. 3.
  • Figure 6 is a partial enlarged diametral sectional view of the support according to the invention, at a reaction vessel.
  • FIG. 7 illustrates in enlarged top view an alternative embodiment of reaction supports according to the invention.
  • Figure 8 is a longitudinal section of Figure 7 and can be compared to Figure 6.

Le mode de réalisation du support de réaction à récipients multiples selon l'invention, décrit ci-après en regard des figures 1 à 6, comporte un disque supérieur 1 (figure 1) et un disque inférieur 2 (figure 3) superposés et assemblés par exemple par collage. Les disques 1 et 2 sont dans une matière synthétique transparente et sont pourvus en leur centre de trous 3 ou 4, respectivement, pour permettre le passage d'un arbre rotatif d'entraînement lorsque les disques 1 et 2 sont superposés.The embodiment of the reaction vessel with multiple receptacles according to the invention, described below with reference to FIGS. 1 to 6, comprises an upper disc 1 (FIG. 1) and a lower disc 2 (FIG. 3) superimposed and assembled by example by collage. The discs 1 and 2 are made of a transparent synthetic material and are provided in their center with holes 3 or 4, respectively, to allow the passage of a rotary drive shaft when the discs 1 and 2 are superimposed.

Le disque supérieur 1 est pourvu d'une pluralité de trous traversants 5 dont les axes 6, orthogonaux au plan du disque 1 sont répartis en une pluralité de points 7 se trouvant à l'intersection de rayons 8 et de cercles concentriques 9. Par ailleurs, chaque trou 5 s'évase vers le haut grâce à une portion 10 en forme d'entonnoir, d'axe 6.The upper disc 1 is provided with a plurality of through holes 5 whose axes 6, orthogonal to the plane of the disc 1 are distributed at a plurality of points 7 located at the intersection of spokes 8 and concentric circles 9. Furthermore , each hole 5 widens upwards thanks to a portion 10 in the form of a funnel, of axis 6.

A des fins de clarté du dessin, sur la figure 1, seuls quelques trous 5 ont été représentés.For the sake of clarity of the drawing, in FIG. 1, only a few holes 5 have been shown.

Le disque transparent inférieur 2 comporte une pluralité de trous borgnes 11 dont les axes 12 sont répartis en une pluralité de points 13 se trouvant à l'intersection de rayons 14 et de cercles concentriques 15.The lower transparent disc 2 comprises a plurality of blind holes 11 whose axes 12 are distributed at a plurality of points 13 located at the intersection of spokes 14 and concentric circles 15.

Par ailleurs, à chaque trou borgne 11 est associé une échancrure 16 inclinée, symétrique par rapport au diamètre 14 correspondant et disposée par rapport au trou 11, du côté du centre du disque 2.Furthermore, each blind hole 11 is associated with an inclined notch 16, symmetrical with respect to the corresponding diameter 14 and arranged with respect to the hole 11, on the side of the center of the disc 2.

Pour obtenir un support de réaction selon l'invention, on superpose le disque 1 au disque 2, de façon que l'axe 6 des trous 5 et 10 vienne en correspondance avec l'axe médian 17 des échancrures obliques 16. Dans cette position, représentée sur la figure 6, chaque trou borgne 11 est obturé par le disque 1, mais il est en communication avec l'extérieur, à sa partie supérieure, par l'intermédiaire de l'échancrure oblique 16 et des trous 5 et 10. De préférence, la longueur radiale des échancrures 16 est égale au diamètre des trous 5 (voir la figure 6).To obtain a reaction support according to the invention, the disc 1 is superimposed on the disc 2, so that the axis 6 of the holes 5 and 10 comes into correspondence with the median axis 17 of the oblique notches 16. In this position, shown in Figure 6, each blind hole 11 is closed by the disc 1, but it is in communication with the outside, at its upper part, via the oblique notch 16 and holes 5 and 10. From preferably, the radial length of the notches 16 is equal to the diameter of the holes 5 (see FIG. 6).

Ainsi, il est possible de remplir le trou borgne 11 (ou récipient 11) en doses de liquide en introduisant, par exemple, l'aiguille d'une seringue dans l'entonnoir 10, le liquide traversant alors le trou 10 et l'échancrure 16 pour parvenir jusqu'au récipient 11. De la même façon, il est possible d'introduire un ou plusieurs réactifs dans les récipients 11. Lorsqu'une agitation ou une centrifugation est nécessaire, il suffit de soumettre le disque 1, 2 à ce mouvement et, puisque les récipients 11 sont obturés par le disque 1 et que les échancrures 6 et les trous 10 se trouvent plus près du diamètre du disque 1, que les récipients 11, il n'y a aucun risque que le liquide contenu dans ces récipients 11 s'échappe vers l'extérieur.So it is possible to fill the blind hole 11 (or container 11) in doses of liquid by introducing, for example, the needle of a syringe into the funnel 10, the liquid then passing through the hole 10 and the notch 16 to reach the container 11. From in the same way, it is possible to introduce one or more reagents into the containers 11. When agitation or centrifugation is necessary, it suffices to subject the disc 1, 2 to this movement and, since the containers 11 are closed by the disc 1 and that the notches 6 and the holes 10 are closer to the diameter of the disc 1, than the containers 11, there is no risk that the liquid contained in these containers 11 escapes towards the outside.

Dans l'exemple de réalisation représenté, on a supposé que le disque était composé de deux plaques 1, superposées. Bien entendu, le disque selon l'invention pourrait être composé, par exemple, de trois plaques superposées. Pour cela, on pourrait prévoir que les trous 11 traversent complètement la plaque 2 et qu'ils sont obturés par une troisième plaque disposée du côté opposé au disque 1 par rapport au disque 2, comme cela est symbolisé sur la figure 6 par la ligne en trait mixte 18.In the embodiment shown, it was assumed that the disc was composed of two plates 1, superimposed. Of course, the disc according to the invention could be composed, for example, of three superposed plates. For this, provision could be made for the holes 11 to pass completely through the plate 2 and for them to be closed off by a third plate disposed on the side opposite the disk 1 relative to the disk 2, as symbolized in FIG. 6 by the line in mixed line 18.

Dans la variante de réalisation des figures 7 et 8, le disque supérieur 1 ne comporte que les portions 10, en forme d'entonnoir, des trous 5. En revanche, les trous borgnes 11 sont, dans le disque inférieur 2, prolongés en direction des portions 10, par un trou de communication 11' à fond plat, suffisamment allongé pour que le bord supérieur des entonnoirs 10 se trouve à l'extérieur du récipient 11, ou tout au moins dégage sur le fond de celui-ci un champ de vision 19 recouvrant pratiquement la plus grande partie dudit fond.In the alternative embodiment of FIGS. 7 and 8, the upper disc 1 only has the portions 10, in the form of a funnel, with holes 5. On the other hand, the blind holes 11 are, in the lower disc 2, extended in the direction portions 10, by a communication hole 11 ′ with a flat bottom, sufficiently elongated so that the upper edge of the funnels 10 is outside the container 11, or at least gives off on the bottom thereof vision 19 covering practically the greater part of said bottom.

Claims (10)

1. Rotatable support for reaction between liquid doses of samples and of reagents having the form of a transparent disc provided with a plurality of recesses having a flat bottom which are obturated at the top and are in communication with the outside each via an eccentric orifice opening on the upper face of the disc, characterized in that said recesses (11) do not intercommunicate.
2. Rotatable support according to claim 1, characterized in that the eccentric orifice (5, 10) and the recess (11) communicate by a face (16) inclined from top to bottom and from the inside of the disc towards the outside.
3. Rotatable support according to claim 1, characterized in that the eccentric orifice (10) and the recess (11) communicate by a flat-bottomed extension (11') of said recess (11) towards the orifice (10).
4. Rotatable support according to any one of claims 1 to 3, of the type constituted by superposed plates, characterized in that the disc is formed by the superposition and connection of two coaxial circular plates (1 and 2) of which one comprises said recesses (11) and the other through-holes (5, 10) each forming one of said eccentric orifices.
5. Rotatable support according to claims 3 and 4, characterized in that said extensions (11') are made in the lower plate (2).
6. Rotatable support according to any one of the preceding claims, characterized in that the eccentric orifices are disposed in order to clear to the maximum, in projection, the bottom of said recesses.
7. Rotatable support according to any one of claims 1 to 6, characterized in that the eccentric orifices (5, 10) are flared out upwardly.
8. Rotatable support according to any one of claims 1 to 7, characterized in that each eccentric orifice (5, 10) is nearer the centre of the disc than the corresponding recess.
9. Rotatable support according to any one of claims 1 to 8, characterized in that the different recesses (11) and orifices (5, 10) are arranged in radii (8, 14) and concentric circles (9, 13).
10. Rotatable support according to any one of claims 1 to 9, characterized in that the disc is pierced at its centre with a hole (3,4) allowing it to be assembled on a rotating vertical shaft.
EP82401379A 1981-08-05 1982-07-26 Multiple receptacle reaction support for testing liquid doses Expired EP0072284B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT82401379T ATE30215T1 (en) 1981-08-05 1982-07-26 MULTIPLE REACTION VESSEL HOLDER FOR TESTING LIQUID SAMPLES.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8115163A FR2511153B1 (en) 1981-08-05 1981-08-05 MULTIPLE CONTAINER REACTION HOLDER FOR TESTING LIQUID DOSES
FR8115163 1981-08-05

Publications (3)

Publication Number Publication Date
EP0072284A2 EP0072284A2 (en) 1983-02-16
EP0072284A3 EP0072284A3 (en) 1985-01-16
EP0072284B1 true EP0072284B1 (en) 1987-10-14

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US (1) US4656009A (en)
EP (1) EP0072284B1 (en)
JP (1) JPS5830669A (en)
AT (1) ATE30215T1 (en)
DE (1) DE3277454D1 (en)
FR (1) FR2511153B1 (en)

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FR2418673A1 (en) * 1978-03-01 1979-09-28 Nal Transfusion Sanguine Centr DEVICE FOR CENTRIFUGATION OF LIQUIDS CONTAINING PARTICLES OR CELLS IN SUSPENSION
JPS55121150A (en) * 1979-03-14 1980-09-18 Hitachi Ltd Plural items analyzing unit
JPS5644852A (en) * 1979-09-21 1981-04-24 Hitachi Ltd Centrifugal sampler for automatic chemical analysis device

Also Published As

Publication number Publication date
FR2511153A1 (en) 1983-02-11
DE3277454D1 (en) 1987-11-19
FR2511153B1 (en) 1986-01-10
US4656009A (en) 1987-04-07
ATE30215T1 (en) 1987-10-15
EP0072284A2 (en) 1983-02-16
JPS5830669A (en) 1983-02-23
EP0072284A3 (en) 1985-01-16

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