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EE04526B1 - Halogeenasendatud tetratsklilise tetrahdrofuraani derivaadid, nende valmistamismeetod, kasutamineja farmatseutiline kompositsioon - Google Patents

Halogeenasendatud tetratsklilise tetrahdrofuraani derivaadid, nende valmistamismeetod, kasutamineja farmatseutiline kompositsioon

Info

Publication number
EE04526B1
EE04526B1 EEP200000161A EEP200000161A EE04526B1 EE 04526 B1 EE04526 B1 EE 04526B1 EE P200000161 A EEP200000161 A EE P200000161A EE P200000161 A EEP200000161 A EE P200000161A EE 04526 B1 EE04526 B1 EE 04526B1
Authority
EE
Estonia
Prior art keywords
halogen
preparation
methods
pharmaceutical composition
tetrahydrofuran derivatives
Prior art date
Application number
EEP200000161A
Other languages
English (en)
Inventor
Javier Fernndez-Gadea Francisco
Ignacio Andr�s-Gil Jos�
Gil-Lopetegui Pilar
D�az-Mart�nez Adolfo
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200000161A publication Critical patent/EE200000161A/et
Publication of EE04526B1 publication Critical patent/EE04526B1/et

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EEP200000161A 1997-10-10 1998-10-06 Halogeenasendatud tetratsklilise tetrahdrofuraani derivaadid, nende valmistamismeetod, kasutamineja farmatseutiline kompositsioon EE04526B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97203154 1997-10-10
PCT/EP1998/006352 WO1999019317A1 (en) 1997-10-10 1998-10-06 Halogen substituted tetracyclic tetrahydrofuran derivatives

Publications (2)

Publication Number Publication Date
EE200000161A EE200000161A (et) 2001-04-16
EE04526B1 true EE04526B1 (et) 2005-08-15

Family

ID=8228817

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000161A EE04526B1 (et) 1997-10-10 1998-10-06 Halogeenasendatud tetratsklilise tetrahdrofuraani derivaadid, nende valmistamismeetod, kasutamineja farmatseutiline kompositsioon

Country Status (36)

Country Link
US (2) US6511976B1 (et)
EP (1) EP1021432B1 (et)
JP (1) JP3248902B2 (et)
KR (1) KR100366014B1 (et)
CN (1) CN100340554C (et)
AP (1) AP1239A (et)
AR (1) AR017325A1 (et)
AT (1) ATE235479T1 (et)
AU (1) AU737334B2 (et)
BG (1) BG64387B1 (et)
BR (1) BR9812871A (et)
CA (1) CA2305612C (et)
CZ (1) CZ296928B6 (et)
DE (1) DE69812668T2 (et)
DK (1) DK1021432T3 (et)
EA (1) EA003698B1 (et)
EE (1) EE04526B1 (et)
ES (1) ES2195403T3 (et)
HK (1) HK1029106A1 (et)
HR (1) HRP20000189A2 (et)
HU (1) HU225161B1 (et)
ID (1) ID23903A (et)
IL (1) IL135538A (et)
MY (1) MY117783A (et)
NO (1) NO317159B1 (et)
NZ (1) NZ503294A (et)
OA (1) OA11898A (et)
PL (1) PL339833A1 (et)
PT (1) PT1021432E (et)
SI (1) SI1021432T1 (et)
SK (1) SK284028B6 (et)
TR (1) TR200000918T2 (et)
TW (1) TW567186B (et)
UA (1) UA52778C2 (et)
WO (1) WO1999019317A1 (et)
ZA (1) ZA989204B (et)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA79248C2 (en) * 2001-11-09 2007-06-11 Janssen Pharmaceutica Nv Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
CA2468038C (en) * 2001-12-07 2011-04-26 Janssen Pharmaceutica Nv Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
US7205335B2 (en) * 2001-12-07 2007-04-17 Mao Hua Preparation of cis-fused 3,3a,8,12b-tetrahydro-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
HRP20020305A8 (en) * 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030959A2 (et) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o.
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
TW200612899A (en) * 2004-06-14 2006-05-01 Janssen Pharmaceutica Nv Novel tetracyclic tetrahydrofuran derivatives
WO2006000555A2 (en) 2004-06-23 2006-01-05 Janssen Pharmaceutica N.V. Novel unsaturated tetracyclic tetrahydrofuran derivatives
WO2006061392A2 (en) 2004-12-07 2006-06-15 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
AU2011202995B2 (en) * 2004-12-07 2012-02-02 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
ES2391780T3 (es) * 2005-01-27 2012-11-29 Janssen Pharmaceutica Nv Derivados de tetrahidrofurano tetracíclicos como inhibidores de 5HT2 en el tratamiento de trastornos de SNC
AU2006248956C1 (en) * 2005-05-19 2012-02-02 Janssen Pharmaceutica N.V. Selected tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain
CA2604165A1 (en) * 2005-05-26 2006-11-30 Janssen Pharmaceutica N.V. Novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives and their use as a medicament
ES2342110T3 (es) * 2005-06-17 2010-07-01 Janssen Pharmaceutica Nv Nuevos derivados tetraciclicos de tetrahidrofurano que contienen una cadena lateral de amina ciclica.
US9125866B1 (en) 2015-01-28 2015-09-08 King Saud University Antidepressant compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552399A (en) * 1994-11-02 1996-09-03 Janssen Pharmaceutica N.V. Substituted tetracyclic azepine derivatives
JP3887785B2 (ja) 1994-11-02 2007-02-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 5−ht2レセプター親和性を有する置換四環状オキサゼピン及びチアゼピン誘導体
NZ329953A (en) 1996-04-12 1999-06-29 Janssen Pharmaceutica Nv Substituted tetracyclic n-oxide tetrahydrofuran derivatives, salts and stereoisomeric forms thereof for the treatment of cns cardiovascular or gastrointestinal disorders
HUP9902901A3 (en) 1996-08-28 2002-01-28 Lilly Co Eli Substituted 1,2,3,4-tetrahydro-2-dibenzofuranamines and 2-aminocyclohepta[b]benzofurans

Also Published As

Publication number Publication date
PT1021432E (pt) 2003-08-29
NO20001792L (no) 2000-04-06
AR017325A1 (es) 2001-09-05
CN1274353A (zh) 2000-11-22
KR20010023292A (ko) 2001-03-26
EP1021432B1 (en) 2003-03-26
EE200000161A (et) 2001-04-16
UA52778C2 (uk) 2003-01-15
MY117783A (en) 2004-08-30
CN100340554C (zh) 2007-10-03
IL135538A0 (en) 2001-05-20
ID23903A (id) 2000-05-25
US20030134852A1 (en) 2003-07-17
US6511976B1 (en) 2003-01-28
AU737334B2 (en) 2001-08-16
TR200000918T2 (tr) 2000-07-21
EA003698B1 (ru) 2003-08-28
ES2195403T3 (es) 2003-12-01
HU225161B1 (en) 2006-07-28
SI1021432T1 (en) 2003-08-31
HUP0003748A2 (hu) 2002-01-28
HRP20000189A2 (en) 2001-02-28
IL135538A (en) 2005-07-25
OA11898A (en) 2006-04-10
BG64387B1 (bg) 2004-12-30
KR100366014B1 (ko) 2002-12-26
ATE235479T1 (de) 2003-04-15
NZ503294A (en) 2001-08-31
DE69812668D1 (de) 2003-04-30
TW567186B (en) 2003-12-21
EA200000400A1 (ru) 2000-10-30
AP2000001784A0 (en) 2000-06-30
HUP0003748A3 (en) 2002-02-28
CZ296928B6 (cs) 2006-07-12
SK284028B6 (sk) 2004-08-03
BR9812871A (pt) 2000-08-08
AP1239A (en) 2004-01-15
ZA989204B (en) 2000-04-10
WO1999019317A1 (en) 1999-04-22
EP1021432A1 (en) 2000-07-26
NO317159B1 (no) 2004-08-30
NO20001792D0 (no) 2000-04-06
BG104287A (en) 2000-11-30
JP3248902B2 (ja) 2002-01-21
SK4712000A3 (en) 2000-10-09
AU9629698A (en) 1999-05-03
US6699858B2 (en) 2004-03-02
DE69812668T2 (de) 2004-01-29
CZ20001136A3 (cs) 2000-08-16
CA2305612C (en) 2007-07-31
HK1029106A1 (en) 2001-03-23
DK1021432T3 (da) 2003-07-14
CA2305612A1 (en) 1999-04-22
JP2001519425A (ja) 2001-10-23
PL339833A1 (en) 2001-01-02

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KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

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KB4A Valid patent at the end of a year

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