ECSP20070185A - Análogos novedosos de glp-1 - Google Patents
Análogos novedosos de glp-1Info
- Publication number
- ECSP20070185A ECSP20070185A ECSENADI202070185A ECDI202070185A ECSP20070185A EC SP20070185 A ECSP20070185 A EC SP20070185A EC SENADI202070185 A ECSENADI202070185 A EC SENADI202070185A EC DI202070185 A ECDI202070185 A EC DI202070185A EC SP20070185 A ECSP20070185 A EC SP20070185A
- Authority
- EC
- Ecuador
- Prior art keywords
- analogs
- glp
- action
- new
- present disclosure
- Prior art date
Links
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 title abstract 2
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 abstract 2
- 101800000224 Glucagon-like peptide 1 Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 102100040918 Pro-glucagon Human genes 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transmission And Conversion Of Sensor Element Output (AREA)
Abstract
La presente descripción se refiere a análogos novedosos del péptido similar al glucagón-1 (GLP-1) (7-37) que tienen una secuencia de aminoácidos con Leu o Ile en el C-terminal. Los nuevos análogos son potentes agonistas de GLP-1 con efecto adverso reducido y duración de la acción mejorada. La presente descripción se refiere además a derivados acilados de los nuevos análogos que tienen una potencia y duración de la acción mejoradas adicionalmente y son adecuados para la administración oral. Los análogos de la presente descripción pueden ser útiles en el tratamiento de la diabetes y la obesidad.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201821013109 | 2018-04-05 | ||
| IN201821040474 | 2018-10-26 | ||
| IN201821040468 | 2018-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP20070185A true ECSP20070185A (es) | 2021-01-29 |
Family
ID=66589592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202070185A ECSP20070185A (es) | 2018-04-05 | 2020-11-05 | Análogos novedosos de glp-1 |
Country Status (31)
| Country | Link |
|---|---|
| US (7) | US11447535B2 (es) |
| EP (3) | EP4364751A3 (es) |
| JP (2) | JP7250814B2 (es) |
| KR (1) | KR20200141469A (es) |
| CN (2) | CN117964735A (es) |
| AU (2) | AU2019247936C1 (es) |
| BR (1) | BR112020020419A2 (es) |
| CA (1) | CA3095988A1 (es) |
| CL (1) | CL2020002574A1 (es) |
| CO (1) | CO2020012425A2 (es) |
| DK (2) | DK4122954T3 (es) |
| EC (1) | ECSP20070185A (es) |
| ES (2) | ES2925678T3 (es) |
| FI (1) | FI4122954T3 (es) |
| HR (2) | HRP20240749T1 (es) |
| HU (2) | HUE060135T2 (es) |
| IL (1) | IL277483A (es) |
| JO (1) | JOP20200251A1 (es) |
| LT (2) | LT3774862T (es) |
| MX (2) | MX2020010505A (es) |
| PE (1) | PE20211417A1 (es) |
| PH (1) | PH12020551591A1 (es) |
| PL (2) | PL4122954T3 (es) |
| PT (2) | PT4122954T (es) |
| RS (2) | RS63523B1 (es) |
| SG (1) | SG11202009467YA (es) |
| SI (2) | SI4122954T1 (es) |
| SM (2) | SMT202200352T1 (es) |
| UA (1) | UA128210C2 (es) |
| WO (1) | WO2019193576A1 (es) |
| ZA (1) | ZA202306729B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020010505A (es) * | 2018-04-05 | 2021-01-15 | Sun Pharmaceutical Ind Ltd | Analogos novedosos de glp-1. |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| TW202216746A (zh) * | 2020-06-22 | 2022-05-01 | 印度商太陽製藥工業有限公司 | 長效型ｇｌｐ－１／ｇｉｐ雙重促效劑 |
| WO2022079639A1 (en) * | 2020-10-17 | 2022-04-21 | Sun Pharmaceutical Industries Limited | Glp-1/gip dual agonists |
| CN114685646B (zh) * | 2020-12-31 | 2023-04-07 | 厦门赛诺邦格生物科技股份有限公司 | 一种多肽侧链类似物的制备方法及其应用 |
| JP7604666B2 (ja) | 2021-01-20 | 2024-12-23 | バイキング・セラピューティクス・インコーポレイテッド | 代謝及び肝臓障害の処置のための組成物及び方法 |
| CN116514952B (zh) * | 2022-10-13 | 2024-02-02 | 江苏师范大学 | 一类glp-1类似物及其应用 |
| WO2024252366A1 (en) | 2023-06-09 | 2024-12-12 | Sun Pharmaceutical Industries Limited | Glp-1/gip dual, glp-1/gcg dual and glp-1/gip/gcg triple receptor agonists |
| WO2024261580A1 (en) | 2023-06-20 | 2024-12-26 | Sun Pharmaceutical Industries Limited | Glp-1 analog for use in the treatment of metabolic disorders |
| CN117756914B (zh) * | 2023-12-15 | 2024-09-03 | 瀚晖制药有限公司 | 依柯胰岛素的制备方法 |
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| HU227021B1 (en) | 1996-08-30 | 2010-05-28 | Novo Nordisk As | Glp-1 derivatives |
| AU3247799A (en) | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
| WO1999043706A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Derivatives of glp-1 analogs |
| EP1056774A1 (en) | 1998-02-27 | 2000-12-06 | Novo Nordisk A/S | N-terminally truncated glp-1 derivatives |
| ATE466028T1 (de) | 1998-02-27 | 2010-05-15 | Novo Nordisk As | N-terminal veränderte glp-1 abkömmlinge |
| FR2777283B1 (fr) | 1998-04-10 | 2000-11-24 | Adir | Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP2322545A1 (en) | 1998-12-07 | 2011-05-18 | Ipsen Pharma | Analogues of GLP-1 |
| ATE346093T1 (de) | 2000-06-16 | 2006-12-15 | Lilly Co Eli | Analoge des glucagon ähnlichen peptid-1 |
| EA005584B1 (ru) | 2000-12-07 | 2005-04-28 | Эли Лилли Энд Компани | Слитые белки glp-1 |
| BR0306706A (pt) | 2002-01-08 | 2007-03-27 | Lilly Co Eli | peptìdeo glp-1 estendido, métodos de estimulação do receptor de glp-1 em um indivìduo necessitando de normalização de glicose sanguìnea, de tratamento de um indivìduo profilaticamente para diabetes independente de insulina, de redução ou de manutenção do peso corporal, de tratamento da obesidade, e de tratamento de doenças, em um indivìduo necessitando do mesmo, uso de um composto de glp-1, processo de preparação de uma formulação farmacêutica, e, formulação farmacêutica |
| AU2003272970B2 (en) | 2002-10-11 | 2009-05-28 | Sanwa Kagaku Kenkyusho Co. Ltd. | GLP-1 derivatives and transmicosal absorption preparations thereof |
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| AU2006287562B2 (en) | 2005-09-08 | 2012-05-10 | Trustees Of Tufts College | Stabilized GLP-1 analogs |
| ES2397289T3 (es) | 2005-09-22 | 2013-03-06 | Biocompatibles Uk Ltd. | Polipéptidos de fusión de GLP-1 (péptido 1 de tipo glucagón) con resistencia a peptidasa incrementada |
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| CA2702289A1 (en) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Compounds exhibiting glucagon antagonist and glp-1 agonist activity |
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-
2019
- 2019-04-05 MX MX2020010505A patent/MX2020010505A/es unknown
- 2019-04-05 HR HRP20240749TT patent/HRP20240749T1/hr unknown
- 2019-04-05 PT PT221774037T patent/PT4122954T/pt unknown
- 2019-04-05 SM SM20220352T patent/SMT202200352T1/it unknown
- 2019-04-05 AU AU2019247936A patent/AU2019247936C1/en active Active
- 2019-04-05 JP JP2020553627A patent/JP7250814B2/ja active Active
- 2019-04-05 SG SG11202009467YA patent/SG11202009467YA/en unknown
- 2019-04-05 LT LTEPPCT/IB2019/052835T patent/LT3774862T/lt unknown
- 2019-04-05 DK DK22177403.7T patent/DK4122954T3/da active
- 2019-04-05 PL PL22177403.7T patent/PL4122954T3/pl unknown
- 2019-04-05 US US16/376,190 patent/US11447535B2/en active Active
- 2019-04-05 CA CA3095988A patent/CA3095988A1/en active Pending
- 2019-04-05 PT PT197249154T patent/PT3774862T/pt unknown
- 2019-04-05 KR KR1020207031696A patent/KR20200141469A/ko active IP Right Grant
- 2019-04-05 ES ES19724915T patent/ES2925678T3/es active Active
- 2019-04-05 SI SI201930764T patent/SI4122954T1/sl unknown
- 2019-04-05 PL PL19724915.4T patent/PL3774862T3/pl unknown
- 2019-04-05 HR HRP20221054TT patent/HRP20221054T1/hr unknown
- 2019-04-05 SM SM20240241T patent/SMT202400241T1/it unknown
- 2019-04-05 DK DK19724915.4T patent/DK3774862T3/da active
- 2019-04-05 RS RS20220814A patent/RS63523B1/sr unknown
- 2019-04-05 FI FIEP22177403.7T patent/FI4122954T3/fi active
- 2019-04-05 CN CN202311777728.0A patent/CN117964735A/zh active Pending
- 2019-04-05 JO JOP/2020/0251A patent/JOP20200251A1/ar unknown
- 2019-04-05 HU HUE19724915A patent/HUE060135T2/hu unknown
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