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EA202190298A1 - Циклические динуклеотиды в качестве агонистов sting - Google Patents

Циклические динуклеотиды в качестве агонистов sting

Info

Publication number
EA202190298A1
EA202190298A1 EA202190298A EA202190298A EA202190298A1 EA 202190298 A1 EA202190298 A1 EA 202190298A1 EA 202190298 A EA202190298 A EA 202190298A EA 202190298 A EA202190298 A EA 202190298A EA 202190298 A1 EA202190298 A1 EA 202190298A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sting agonists
cyclic dinucleotides
compounds
sting
dinucleotides
Prior art date
Application number
EA202190298A
Other languages
English (en)
Inventor
Стюарт Эмануэл
Марк Рихтер
Питер Дж. Коннолли
Джеймс П. Эдвардс
Гуани Ван
Сантош Кумар Татиконда
Леонид Бейгельман
Жилль Биньян
Вим Берт Грит Схепенс
Марсель Вьейевуа
Йоханнес Вильхельмус Й.Ф. Тюринг
Original Assignee
Янссен Байотек, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Байотек, Инк. filed Critical Янссен Байотек, Инк.
Publication of EA202190298A1 publication Critical patent/EA202190298A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Описаны соединения, композиции и способы лечения заболеваний, синдромов или расстройств, на которые влияет модулирование STING. Такие соединения представлены формулой (I)причем R1, R1', X1, B1, R2, R2', B2, X2, R3, Z-M-Y и Y1-M1-Z1 определены в настоящем документе.
EA202190298A 2018-07-17 2019-07-16 Циклические динуклеотиды в качестве агонистов sting EA202190298A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862699001P 2018-07-17 2018-07-17
PCT/IB2019/056075 WO2020016782A1 (en) 2018-07-17 2019-07-16 Cyclic dinucleotides as sting agonists

Publications (1)

Publication Number Publication Date
EA202190298A1 true EA202190298A1 (ru) 2021-04-16

Family

ID=67999987

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190298A EA202190298A1 (ru) 2018-07-17 2019-07-16 Циклические динуклеотиды в качестве агонистов sting

Country Status (20)

Country Link
US (2) US11597746B2 (ru)
EP (1) EP3823976A1 (ru)
JP (1) JP2021531277A (ru)
KR (1) KR20210033026A (ru)
CN (1) CN112424212A (ru)
AR (1) AR122240A1 (ru)
AU (1) AU2019304230B2 (ru)
BR (1) BR112021000693A2 (ru)
CA (1) CA3106602A1 (ru)
EA (1) EA202190298A1 (ru)
EC (1) ECSP21003171A (ru)
IL (1) IL280105A (ru)
MA (1) MA53178A (ru)
MX (1) MX2021000625A (ru)
PE (1) PE20211636A1 (ru)
PH (1) PH12020552172A1 (ru)
SG (1) SG11202012624RA (ru)
TW (1) TW202030199A (ru)
UY (1) UY38304A (ru)
WO (1) WO2020016782A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020006290A (es) * 2017-12-15 2020-12-03 Janssen Biotech Inc Dinucleotidos ciclicos como agonistas de sting.
TW202030199A (zh) * 2018-07-17 2020-08-16 美商健生生物科技公司 作為ｓｔｉｎｇ促效劑之環狀二核苷酸
TW202200136A (zh) 2020-04-10 2022-01-01 日商小野藥品工業股份有限公司 癌治療方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6411676B2 (ja) * 2015-12-03 2018-10-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｓｔｉｎｇの調節因子としての環状プリンジヌクレオチド
US10723756B2 (en) * 2016-01-11 2020-07-28 Innate Tumor Immunity Inc. Cyclic dinucleotides for treating conditions associated with STING activity such as cancer
EA036421B1 (ru) * 2016-01-11 2020-11-09 Иннэйт Тьюмор Иммьюнити, Инк. Соединения и композиции для лечения состояний, ассоциированных с активностью sting
HUE060396T2 (hu) 2016-03-18 2023-02-28 Immune Sensor Llc Ciklikus DI-nukleotid vegyületek és azok felhasználási módszerei
CA3029644A1 (en) * 2016-07-06 2018-01-11 Sperovie Biosciences, Inc. Compounds, compositions, and methods for the treatment of disease
WO2018045204A1 (en) * 2016-08-31 2018-03-08 Ifm Therapeutics, Inc Cyclic dinucleotide analogs for treating conditions associated with sting (stimulator of interferon genes) activity
JOP20170188A1 (ar) * 2016-11-25 2019-01-30 Janssen Biotech Inc ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
TW202030199A (zh) * 2018-07-17 2020-08-16 美商健生生物科技公司 作為ｓｔｉｎｇ促效劑之環狀二核苷酸

Also Published As

Publication number Publication date
CA3106602A1 (en) 2020-01-23
CN112424212A (zh) 2021-02-26
WO2020016782A1 (en) 2020-01-23
US11597746B2 (en) 2023-03-07
IL280105A (en) 2021-03-01
TW202030199A (zh) 2020-08-16
US20230287034A1 (en) 2023-09-14
AR122240A1 (es) 2022-08-31
AU2019304230B2 (en) 2023-08-31
SG11202012624RA (en) 2021-02-25
BR112021000693A2 (pt) 2021-04-13
PE20211636A1 (es) 2021-08-24
JP2021531277A (ja) 2021-11-18
EP3823976A1 (en) 2021-05-26
AU2019304230A1 (en) 2021-01-14
MX2021000625A (es) 2021-03-25
UY38304A (es) 2020-01-31
US20210277046A1 (en) 2021-09-09
MA53178A (fr) 2021-05-26
PH12020552172A1 (en) 2021-06-07
ECSP21003171A (es) 2021-02-26
KR20210033026A (ko) 2021-03-25

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