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EA201992285A1 - Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами - Google Patents

Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами

Info

Publication number
EA201992285A1
EA201992285A1 EA201992285A EA201992285A EA201992285A1 EA 201992285 A1 EA201992285 A1 EA 201992285A1 EA 201992285 A EA201992285 A EA 201992285A EA 201992285 A EA201992285 A EA 201992285A EA 201992285 A1 EA201992285 A1 EA 201992285A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polymerases
dna
reading
available
libraries containing
Prior art date
Application number
EA201992285A
Other languages
English (en)
Inventor
Энтони Д. Кееф
Александр Литовчик
Мэтью А. Кларк
Original Assignee
Икс-Чем, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49916571&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201992285(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Икс-Чем, Инк. filed Critical Икс-Чем, Инк.
Publication of EA201992285A1 publication Critical patent/EA201992285A1/ru

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Настоящее изобретение относится к комплексам кодированных олигонуклеотидами библиотек и способов мечения и использования таких библиотек. В частности, олигонуклеотиды и способы могут включать в себя комплексы, содержащие по меньшей мере одну связь, для которой полимераза обладает пониженной способностью считывать или перемещаться.
EA201992285A 2012-07-13 2013-07-12 Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами EA201992285A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261671406P 2012-07-13 2012-07-13

Publications (1)

Publication Number Publication Date
EA201992285A1 true EA201992285A1 (ru) 2020-05-31

Family

ID=49916571

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201992285A EA201992285A1 (ru) 2012-07-13 2013-07-12 Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами
EA201590195A EA034141B1 (ru) 2012-07-13 2013-07-12 Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201590195A EA034141B1 (ru) 2012-07-13 2013-07-12 Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами

Country Status (16)

Country Link
US (1) US11674135B2 (ru)
EP (3) EP3851529A1 (ru)
JP (3) JP6426604B2 (ru)
KR (2) KR102146721B1 (ru)
CN (2) CN110257493A (ru)
AU (3) AU2013289993B2 (ru)
CA (1) CA2879018A1 (ru)
DK (2) DK3392338T3 (ru)
EA (2) EA201992285A1 (ru)
ES (2) ES2675167T3 (ru)
IL (1) IL236633B (ru)
MX (1) MX2015000598A (ru)
NZ (3) NZ703766A (ru)
SG (2) SG11201500250VA (ru)
WO (1) WO2014012010A1 (ru)
ZA (2) ZA201500328B (ru)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101789216B1 (ko) 2009-02-13 2017-10-23 엑스-켐, 인크. Ｄｎａ―코딩된 라이브러리의 생성 및 스크리닝 방법
EP3828271A1 (en) 2011-09-07 2021-06-02 X-Chem, Inc. Methods for tagging dna-encoded libraries
SG11201500250VA (en) 2012-07-13 2015-03-30 Chem Inc X Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
EP3174980A4 (en) 2014-08-01 2018-01-17 Dovetail Genomics, LLC Tagging nucleic acids for sequence assembly
MA41298A (fr) * 2014-12-30 2017-11-07 X Chem Inc Procédés de marquage de banques codées par de l'adn
NZ734854A (en) 2015-02-17 2022-11-25 Dovetail Genomics Llc Nucleic acid sequence assembly
WO2016154540A1 (en) 2015-03-26 2016-09-29 Dovetail Genomics Llc Physical linkage preservation in dna storage
CN106048736B (zh) * 2015-04-14 2019-09-03 成都先导药物开发股份有限公司 一种固相合成dna编码化合物库的方法
WO2017070123A1 (en) 2015-10-19 2017-04-27 Dovetail Genomics, Llc Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection
DK3386550T3 (da) 2015-12-07 2021-04-26 Arc Bio Llc Fremgangsmåder til fremstilling og anvendelse af guide nukleinsyrer
CA3014911A1 (en) 2016-02-23 2017-08-31 Dovetail Genomics, Llc Generation of phased read-sets for genome assembly and haplotype phasing
SG11201810088SA (en) 2016-05-13 2018-12-28 Dovetail Genomics Llc Recovering long-range linkage information from preserved samples
CN109312492B (zh) 2016-06-16 2022-10-04 哈斯达克科学公司 寡核苷酸指导和记录的编码探针分子的组合合成
US11198903B2 (en) * 2016-09-15 2021-12-14 Roche Molecular Systems, Inc. Methods for performing multiplexed real-time PCR
CN107130300A (zh) * 2016-10-08 2017-09-05 深圳劲宇生物科技有限公司 一种dna编码分子库的合成方法及dna模板
AU2018256367A1 (en) * 2017-04-18 2019-11-28 X-Chem, Inc. Methods for identifying compounds
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
WO2018227025A1 (en) * 2017-06-07 2018-12-13 Arc Bio, Llc Creation and use of guide nucleic acids
WO2019060856A1 (en) * 2017-09-25 2019-03-28 Haystack Sciences Corporation MULTINOMIAL CODING FOR COMBINATION CHEMISTRY DIRECTED BY OLIGONUCLEOTIDES
JP7264206B2 (ja) * 2020-09-30 2023-04-25 株式会社三洋物産 遊技機
WO2024020395A2 (en) 2022-07-19 2024-01-25 Digital Biology Inc. Barcode diffusion-based spatial omics

Family Cites Families (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5292967A (en) 1976-01-30 1977-08-04 Hanshin Diesel Works Separated matter accummulation takeout device for centrifugal separators
DE3788914T2 (de) 1986-09-08 1994-08-25 Ajinomoto Kk Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere.
US5585481A (en) 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5025388A (en) 1988-08-26 1991-06-18 Cramer Richard D Iii Comparative molecular field analysis (CoMFA)
US5670633A (en) 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
ATE148889T1 (de) 1991-09-18 1997-02-15 Affymax Tech Nv Verfahren zur synthese der verschiedenen sammlungen von oligomeren
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5633360A (en) 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
US6503759B1 (en) 1992-10-01 2003-01-07 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
ATE244769T1 (de) 1992-10-01 2003-07-15 Univ Columbia Komplexe kombinatorische chemische banken, die mit markierungen versehen sind
US5807683A (en) 1992-11-19 1998-09-15 Combichem, Inc. Combinatorial libraries and methods for their use
AU684279B2 (en) 1993-04-12 1997-12-11 Northwestern University Method of forming oligonucleotides
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
EP0705279B1 (en) 1993-05-27 2003-02-19 Selectide Corporation Topologically segregated, encoded solid phase libraries
US5840485A (en) 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
WO1995001365A1 (en) 1993-07-02 1995-01-12 Lynx Therapeutics, Inc. Synthesis of branched nucleic acids
US5571903A (en) 1993-07-09 1996-11-05 Lynx Therapeutics, Inc. Auto-ligating oligonucleotide compounds
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
DK96093D0 (da) 1993-08-25 1993-08-25 Symbicom Ab Improvements in molecular modelling and drug design
US5658782A (en) 1993-10-20 1997-08-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A Non-Profit Organization Amino acid transporters and uses
WO1995012608A1 (en) 1993-11-02 1995-05-11 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US6117976A (en) 1993-11-04 2000-09-12 Medical Research Council Manufacture and use of polypeptides tagged using binding molecules
AU692212B2 (en) 1993-12-17 1998-06-04 Roger S. Cubicciotti Nucleotide-directed assembly of bimolecular and multimolecular drugs and devices
US6936477B2 (en) 1994-04-13 2005-08-30 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
JPH08268A (ja) 1994-06-16 1996-01-09 Koichi Nishigaki 連結した２本鎖ｄｎａの製造方法
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5525734A (en) 1994-06-22 1996-06-11 Affymax Technologies N.V. Methods for synthesizing diverse collections of pyrrolidine compounds
US20030059826A1 (en) 1994-07-26 2003-03-27 Kim Janda Soluble combinatorial libraries
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US6654505B2 (en) 1994-10-13 2003-11-25 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5780613A (en) 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
DE19646372C1 (de) 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
US5780231A (en) 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5962228A (en) 1995-11-17 1999-10-05 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US5846839A (en) 1995-12-22 1998-12-08 Glaxo Group Limited Methods for hard-tagging an encoded synthetic library
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
DE19642751A1 (de) 1996-10-16 1998-04-23 Deutsches Krebsforsch Saccharid-Bibliothek
ES2268763T3 (es) 1997-01-21 2007-03-16 The General Hospital Corporation Seleccion de proteinas usando fusiones de arn-proteina.
US5888737A (en) 1997-04-15 1999-03-30 Lynx Therapeutics, Inc. Adaptor-based sequence analysis
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
JP4294740B2 (ja) 1997-05-23 2009-07-15 ソレクサ・インコーポレイテッド 分析物の系列的プロセシングのためのシステムおよび装置
US20020034732A1 (en) 1997-07-30 2002-03-21 Daniel J. Capon Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
EP1009819A1 (en) 1997-08-29 2000-06-21 Selective Genetics, Inc. Methods using phage display for selecting internalizing ligands for gene delivery
US6607878B2 (en) 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
EP1090137B1 (de) 1998-06-22 2002-04-03 Larova Biochemie GmbH Herstellung von polymeren aus nukleotidischen und/oder nicht-nukleotidischen bausteinen auf enzymatischem weg
US6846655B1 (en) 1998-06-29 2005-01-25 Phylos, Inc. Methods for generating highly diverse libraries
WO2000020639A1 (en) 1998-10-05 2000-04-13 Lynx Therapeutics, Inc. Enzymatic synthesis of oligonucleotide tags
EP1123305A1 (en) 1998-10-19 2001-08-16 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
US5942609A (en) 1998-11-12 1999-08-24 The Porkin-Elmer Corporation Ligation assembly and detection of polynucleotides on solid-support
KR20010099821A (ko) 1998-12-02 2001-11-09 추후기재 Ｄｎａ-단백질 융합체 및 그의 용도
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US7033753B1 (en) 1999-01-15 2006-04-25 University Of Rochester Compositions and methods for nonenzymatic ligation of oligonucleotides and detection of genetic polymorphisms
EP1208219A1 (en) 1999-04-08 2002-05-29 Pavel Sergeev Synthesis of biologically active compounds in cells
WO2000075302A2 (en) 1999-04-30 2000-12-14 Cyclops Genome Sciences Limited Isolation of nucleic acid
US7270969B2 (en) 1999-05-05 2007-09-18 Phylogica Limited Methods of constructing and screening diverse expression libraries
CA2382545C (en) 1999-08-27 2013-08-13 Phylos, Inc. Methods for encoding and sorting in vitro translated proteins
AU7703400A (en) 1999-09-14 2001-04-17 Xenoport, Inc. Substrates and screening methods for transport proteins
DE60042338D1 (de) 1999-10-04 2009-07-16 Univ New Jersey Med TAR RNA bindende Peptide
US6844324B1 (en) 1999-11-12 2005-01-18 Massachusetts Institute Of Technology Modular peptide mediated intracellular delivery system and uses therefore
EP1259823A2 (en) 2000-02-23 2002-11-27 Xenoport, Inc. Self-encoded combinatorial synthesis of compound multiplets
US6936467B2 (en) 2000-03-27 2005-08-30 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
US7998673B2 (en) 2000-03-29 2011-08-16 Lgc Limited Hybridisation beacon and method of rapid sequence detection and discrimination
US6479262B1 (en) 2000-05-16 2002-11-12 Hercules, Incorporated Solid phase enzymatic assembly of polynucleotides
US6994963B1 (en) 2000-07-10 2006-02-07 Ambion, Inc. Methods for recombinatorial nucleic acid synthesis
US20020072887A1 (en) 2000-08-18 2002-06-13 Sandor Szalma Interaction fingerprint annotations from protein structure models
US6627748B1 (en) 2000-09-11 2003-09-30 The Trustees Of Columbia University In The City Of New York Combinatorial fluorescence energy transfer tags and their applications for multiplex genetic analyses
EP2187317B1 (en) 2000-09-20 2012-12-05 ARKRAY, Inc. Client support system requesting a page of the manual in accordance with the status of a client
US6706481B2 (en) 2000-10-27 2004-03-16 Research Development Foundation In vitro selection of signaling aptamers
JP2002315577A (ja) 2000-11-14 2002-10-29 Gencom Co 核酸ライブラリーの作製方法
US20030049616A1 (en) 2001-01-08 2003-03-13 Sydney Brenner Enzymatic synthesis of oligonucleotide tags
ATE335754T1 (de) 2001-03-19 2006-09-15 Harvard College Entwicklung neuer molekularer funktionen
WO2004001042A2 (en) 2002-06-20 2003-12-31 Nuevolution A/S Microarrays displaying encoded molecules
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
US20030143561A1 (en) 2001-06-20 2003-07-31 Nuevolution A/S Nucleoside derivatives for library preparation
US20060234231A1 (en) 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
CA2451524A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Templated molecules and methods for using such molecules
US20070213519A1 (en) 2002-03-01 2007-09-13 Nuevolution A/S Building Block Forming A C=C Double Bond Upon Reaction
KR100916889B1 (ko) 2002-03-08 2009-09-09 아이드게노쉬쉐 테흐니쉐 호흐슐레 쥬리히 암호화된 자가-조립 화학적 라이브러리(ｅｓａｃｈｅｌ)
EP1487850A2 (en) 2002-03-15 2004-12-22 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
AU2003218630A1 (en) 2002-03-15 2003-09-29 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
US20050221318A1 (en) 2002-03-15 2005-10-06 Gouliaev Alex H Building block forming a c-c bond upon reaction
EP1487978B1 (en) 2002-03-15 2008-11-19 Nuevolution A/S An improved method for synthesising templated molecules
EP1543156A4 (en) 2002-07-18 2005-12-21 Univ Leland Stanford Junior DETECTION OF CHEMICAL LIGATION USING FLUORESCENCE QUENCHER SUB-GROUPS
WO2004009814A1 (en) 2002-07-23 2004-01-29 Nuevolution A/S Gene shuffling by template switching
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
JP4657919B2 (ja) 2002-08-19 2011-03-23 プレジデント アンド フェローズ オブ ハーバード カレッジ 進化する新しい分子機能
EP1539953A2 (en) 2002-09-12 2005-06-15 Nuevolution A/S Proximity-aided synthesis of templated molecules
DK3299463T3 (da) 2002-10-30 2020-12-07 Nuevolution As Enzymatisk kodning
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597395A2 (en) 2003-02-21 2005-11-23 Nuevolution A/S Method for producing second-generation library
WO2004074501A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S A method for obtaining structural information about an encoded molecule
ATE424455T1 (de) 2003-03-20 2009-03-15 Nuevolution As Ligationsvermittelnde codierung von kleinen molekülen
US20070134662A1 (en) 2003-07-03 2007-06-14 Juswinder Singh Structural interaction fingerprint
EP1668157A4 (en) 2003-07-07 2007-10-24 One Cell Systems Inc HAIRPIN MARKED PROBES AND METHOD OF USE
EP1533385A1 (en) 2003-09-05 2005-05-25 Nuevolution A/S Templated compounds for generation of encoded molecules and directional methods using such compounds
WO2005026686A2 (en) 2003-09-09 2005-03-24 Compass Genetics, Llc Multiplexed analytical platform
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
US20050255491A1 (en) 2003-11-13 2005-11-17 Lee Frank D Small molecule and peptide arrays and uses thereof
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
EP1694693A2 (en) 2003-12-17 2006-08-30 Praecis Pharmaceuticals Inc. Methods for synthesis of encoded libraries
JP2007521833A (ja) 2004-02-12 2007-08-09 コンパス ジェネティクス エルエルシー 配列特異的分類による遺伝的分析
US20090239211A1 (en) 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
DK1730277T3 (da) 2004-03-22 2010-03-01 Nuevolution As Kodning ved ligering under anvendelse af byggebloksoligonukleotider
US7405287B2 (en) 2004-08-03 2008-07-29 Board Of Regents, The University Of Texas System Method of treating a cancer
US7745614B2 (en) 2004-09-03 2010-06-29 The Board Of Trustees Of The Leland Stanford Junior University Universal linker compositions for the release or transfer of chemical agents from a polynucleotide
WO2006047791A2 (en) 2004-10-27 2006-05-04 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library device and method for use
CN101914528B (zh) 2004-11-08 2013-04-03 威泊根私人有限公司 结构型核酸指导的化学合成
ATE420170T1 (de) 2004-11-22 2009-01-15 Peter Birk Rasmussen Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle
CA2591582A1 (en) 2004-12-17 2006-06-22 Dynavax Technologies Corporation Methods and compositions for induction or promotion of immune tolerance
WO2006079061A2 (en) 2005-01-21 2006-07-27 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
US7407757B2 (en) 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
WO2006099604A2 (en) 2005-03-16 2006-09-21 Compass Genetics, Llc Methods and compositions for assay readouts on multiple analytical platforms
CN101233235B (zh) 2005-06-09 2012-10-03 葛兰素史克有限责任公司 合成编码文库的方法
US20090035824A1 (en) 2005-06-17 2009-02-05 Liu David R Nucleic acid-templated chemistry in organic solvents
AU2006272626B2 (en) 2005-07-26 2010-12-09 Oregon Health & Science University Nanoparticle probes for capture, sorting and placement of targets
US20090005256A1 (en) 2005-07-29 2009-01-01 Bittker Joshua A Analysis of Encoded Chemical Libraries
CN103215248B (zh) 2005-10-03 2016-05-18 应用生物系统有限责任公司 用于扩增核酸的组合物、方法和试剂盒
JP2009513135A (ja) 2005-10-28 2009-04-02 プリーシス・ファーマシューティカルズ・インコーポレイテッド エンコードされたライブラリーを用いて興味のある化合物を同定する方法
LT2336315T (lt) 2005-12-01 2017-11-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti efektyviai didelių bibliotekų sintezei
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
US7928211B2 (en) 2006-05-03 2011-04-19 Vipergen Pharmaceuticals Aps Method for preparing compounds by nucleic acid directed synthesis
WO2008050661A1 (fr) 2006-10-26 2008-05-02 Sumitomo Chemical Company, Limited Procédé servant à produire un cristal de complexe asymétrique du cuivre
CN101219219B (zh) 2007-01-10 2013-02-13 北京普罗吉生物科技发展有限公司 包含血管抑素或其片段的复合物、其制备方法及应用
CN101896623B (zh) 2007-10-22 2013-12-18 Lgc有限公司 寡核苷酸及其应用
JP4940311B2 (ja) 2007-11-19 2012-05-30 国立大学法人北陸先端科学技術大学院大学 光クロスリンク能を有する光応答性人工ヌクレオチド
WO2009077173A2 (en) * 2007-12-19 2009-06-25 Philochem Ag Dna-encoded chemical libraries
US20120107840A1 (en) 2008-04-09 2012-05-03 Sru Biosystems, Inc Methods for Label Free Testing of Cells
JP4814904B2 (ja) 2008-04-16 2011-11-16 国立大学法人北陸先端科学技術大学院大学 核酸類の配列選択的な精製方法
CA2723265C (en) 2008-05-02 2015-11-24 Epicentre Technologies Corporation Selective 5' ligation tagging of rna
TW201011006A (en) 2008-06-16 2010-03-16 Nuevolution As IAP binding compounds
EP3629022A1 (en) 2008-07-25 2020-04-01 Richard W. Wagner Protein screening methods
AU2010209508C1 (en) 2009-01-30 2017-10-19 Oxford Nanopore Technologies Limited Hybridization linkers
WO2010094027A1 (en) 2009-02-13 2010-08-19 X-Body, Inc. Identification of nucleic acid delivery vehicles using dna display
KR101789216B1 (ko) 2009-02-13 2017-10-23 엑스-켐, 인크. Ｄｎａ―코딩된 라이브러리의 생성 및 스크리닝 방법
DK2396430T3 (da) 2009-02-16 2013-07-15 Epict Technologies Corp Template-uafhængig ligering af enkelt-strenget dna
EP2464755B1 (en) 2009-11-05 2016-03-09 Epicentre Technologies Corporation Methods and kits for 3'-end-tagging of rna
DE102009058769A1 (de) 2009-12-16 2011-06-22 MagForce Nanotechnologies AG, 10589 Temperaturabhängige Aktivierung von katalytischen Nukleinsäuren zur kontrollierten Wirkstofffreisetzung
EP2553151A4 (en) 2010-03-26 2013-07-31 X Body Inc USE OF INDUCED PLURIPOTENTIAL CELLS AND OTHER CELLS FOR SCREENING COMPOSITE LIBRARIES
LT2558577T (lt) * 2010-04-16 2019-03-12 Nuevolution A/S Bifunkciniai kompleksai ir tokių kompleksų gamybos ir naudojimo būdai
US9880160B2 (en) 2011-03-15 2018-01-30 X-Body, Inc. Antibody screening methods
EP3828271A1 (en) * 2011-09-07 2021-06-02 X-Chem, Inc. Methods for tagging dna-encoded libraries
SG11201500250VA (en) 2012-07-13 2015-03-30 Chem Inc X Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
EP2883972A4 (en) * 2012-08-10 2016-04-06 Nippon Steel & Sumitomo Metal Corp TITANIUM ALLOY MATERIAL
GB201322692D0 (en) * 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries

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