EA201891999A1 - КОМПОЗИЦИИ РЕКОМБИНАНТНЫХ ВНУТРИВЕННЫХ ИММУНОГЛОБУЛИНОВ (rIVIG) И СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ - Google Patents
КОМПОЗИЦИИ РЕКОМБИНАНТНЫХ ВНУТРИВЕННЫХ ИММУНОГЛОБУЛИНОВ (rIVIG) И СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯInfo
- Publication number
- EA201891999A1 EA201891999A1 EA201891999A EA201891999A EA201891999A1 EA 201891999 A1 EA201891999 A1 EA 201891999A1 EA 201891999 A EA201891999 A EA 201891999A EA 201891999 A EA201891999 A EA 201891999A EA 201891999 A1 EA201891999 A1 EA 201891999A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- rivig
- immune
- proteins
- compositions
- transplants
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 229940008228 intravenous immunoglobulins Drugs 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 208000026278 immune system disease Diseases 0.000 abstract 3
- 241000282465 Canis Species 0.000 abstract 2
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 abstract 2
- 208000028622 Immune thrombocytopenia Diseases 0.000 abstract 2
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 abstract 2
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 241000282472 Canis lupus familiaris Species 0.000 abstract 1
- 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 abstract 1
- 102000009109 Fc receptors Human genes 0.000 abstract 1
- 108010087819 Fc receptors Proteins 0.000 abstract 1
- 208000003807 Graves Disease Diseases 0.000 abstract 1
- 208000015023 Graves' disease Diseases 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 208000011200 Kawasaki disease Diseases 0.000 abstract 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 abstract 1
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 abstract 1
- 201000001981 dermatomyositis Diseases 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 206010028417 myasthenia gravis Diseases 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 201000003067 thrombocytopenia due to platelet alloimmunization Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Композиции рекомбинантных внутривенных иммуноглобулиновых (rIVIG) белков и способы очистки и применения белков rIVIG. Указанные композиции содержат олигомерные молекулы Fc, которые связываются с рецепторами Fc с высокой авидностью. Белки rIVIG полезны в качестве иммуномодулирующих молекул для лечения иммунных нарушений, включающих аутоиммунные заболевания, такие как трудно поддающаяся лечению иммунная тромбоцитопения, хроническая воспалительная демиелинизирующая полинейропатия, рассеянный склероз, волчанка, болезнь Грейвса, болезнь Кавасаки, дерматомиозит, миастения гравис, синдром Гийена-Барре, аутоиммунная гемолитическая анемия, и другие иммунные и воспалительные патологии. Указанные белки rIVIG могут также применяться в качестве иммуномодуляторов у пациентов для снижения иммунного отторжения трансплантатов органов, трансплантатов стволовых клеток и трансплантатов костного мозга. Кроме того, данное изобретение предлагает белки rIVIG нечеловеческого происхождения, для применения при ветеринарных иммунных нарушениях, такие как собачьи белки rIVIG для лечения собак, страдающих аутоиммунной гемолитической анемией, иммунной тромбоцитопенической пурпурой, ревматоидным артритом или другим собачьим иммунным нарушением.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662315483P | 2016-03-30 | 2016-03-30 | |
| PCT/US2017/024650 WO2017172853A1 (en) | 2016-03-30 | 2017-03-29 | Recombinant intravenous immunoglobulin (rivig) compositions and methods for their production and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201891999A1 true EA201891999A1 (ru) | 2019-08-30 |
Family
ID=59965144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201891999A EA201891999A1 (ru) | 2016-03-30 | 2017-03-29 | КОМПОЗИЦИИ РЕКОМБИНАНТНЫХ ВНУТРИВЕННЫХ ИММУНОГЛОБУЛИНОВ (rIVIG) И СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11304994B2 (ru) |
| EP (1) | EP3436484A4 (ru) |
| JP (1) | JP7075100B2 (ru) |
| KR (1) | KR102477536B1 (ru) |
| CN (1) | CN109312000A (ru) |
| AU (1) | AU2017245143B2 (ru) |
| BR (1) | BR112018070022A2 (ru) |
| CA (1) | CA3019530A1 (ru) |
| CL (1) | CL2018002769A1 (ru) |
| CO (1) | CO2018011457A2 (ru) |
| EA (1) | EA201891999A1 (ru) |
| IL (1) | IL261968A (ru) |
| MA (1) | MA44517A (ru) |
| MX (1) | MX2018011865A (ru) |
| SG (1) | SG11201808541VA (ru) |
| TW (1) | TWI801336B (ru) |
| WO (1) | WO2017172853A1 (ru) |
| ZA (1) | ZA201806767B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3085385A1 (en) | 2017-12-14 | 2019-06-20 | CSL Behring Lengnau AG | Recombinant igg fc multimers for the treatment of neuromyelitis optica |
| JP2022502466A (ja) * | 2018-10-11 | 2022-01-11 | モメンタ ファーマシューティカルズ インコーポレイテッド | 高度にシリル化されたＩｇＧ組成物による処理 |
| CA3114796A1 (en) * | 2018-10-18 | 2020-04-23 | Kindred Biosciences, Inc. | Fc variants with altered binding to neonatal fc receptor (fcrn) for veterinary use |
| CN109793894A (zh) * | 2019-04-03 | 2019-05-24 | 长春西诺生物科技有限公司 | 犬免疫球蛋白在制备犬溶血性贫血药物中的应用 |
| CA3150680A1 (en) | 2019-09-13 | 2021-03-18 | Helen Zhihui CAO | RECOMBINANT IGG FC MULTIMERS FOR THE TREATMENT OF IMMUNE COMPLEX-MEDIATED KIDNEY DISORDERS |
| CN112899301B (zh) * | 2021-01-29 | 2023-04-11 | 中国热带农业科学院热带生物技术研究所 | 一种木薯普通花叶病毒诱导的基因沉默系统及其应用 |
| CN117964777A (zh) * | 2021-08-26 | 2024-05-03 | 瑅安生物医药（杭州）有限公司 | 一种接近天然分子的多肽融合分子 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE345139T1 (de) | 1997-08-21 | 2006-12-15 | Takara Bio Inc | Karzinostatische wirkstoffe |
| DE19963859A1 (de) | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
| GB0015426D0 (en) * | 2000-06-24 | 2000-08-16 | Univ Southampton | Method for generating soluble highly multimeric proteins |
| AU2002250293B2 (en) | 2001-03-09 | 2007-10-11 | Arnason, Barry G. Mr | Polymeric immunoglobulin fusion proteins that target low-affinity FCGammaReceptors |
| US7279329B2 (en) | 2005-10-17 | 2007-10-09 | Industrial Technology Research Institute | Expression system for producing collagen |
| US20070264687A1 (en) * | 2005-12-15 | 2007-11-15 | Min-Yuan Chou | Recombinant triplex scaffold-based polypeptides |
| GB0614780D0 (en) | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
| EP2144930A1 (en) * | 2007-04-18 | 2010-01-20 | ZymoGenetics, Inc. | Single chain fc, methods of making and methods of treatment |
| CN101802197A (zh) | 2007-05-14 | 2010-08-11 | 比奥根艾迪克Ma公司 | 单链FC（ScFc）区、包含其的结合多肽及与其相关的方法 |
| WO2008151088A2 (en) * | 2007-06-01 | 2008-12-11 | University Of Maryland, Baltimore | Immunoglobulin constant region fc receptor binding agents |
| WO2010065578A2 (en) | 2008-12-04 | 2010-06-10 | Leukosight Inc. | POLYPEPTIDES COMPRISING Fc FRAGMENTS OF IMMUNOGLOBULIN G (IgG) AND METHODS OF USING THE SAME |
| MX347343B (es) * | 2010-07-28 | 2017-04-21 | Gliknik Inc | Proteinas de fusion de fragmentos de proteinas humanas naturales para crear composiciones de fc de inmunoglobulinas multimerizadas ordenadamente. |
| EP2561888A1 (en) | 2011-08-23 | 2013-02-27 | Deutsches Krebsforschungszentrum | Protein comprising NC-1 for treating angiogenesis-related diseases |
| TWI476001B (zh) | 2011-12-26 | 2015-03-11 | Ind Tech Res Inst | 三倍體Ｆｃ融合蛋白及其用途 |
| JP6373836B2 (ja) | 2012-07-26 | 2018-08-15 | ザ・ヘンリー・エム・ジャクソン・ファンデイション・フォー・ジ・アドヴァンスメント・オヴ・ミリタリー・メディシン、インコーポレイテッド | 多量体融合タンパク質ワクチン及び免疫療法 |
| US9683044B2 (en) * | 2012-08-20 | 2017-06-20 | Gliknik Inc. | Molecules with antigen binding and polyvalent FC gamma receptor binding activity |
| WO2014060712A1 (en) * | 2012-10-17 | 2014-04-24 | Liverpool School Of Tropical Medicine | Immunomodulatory proteins |
| LT2968461T (lt) | 2013-03-13 | 2022-12-27 | Genzyme Corporation | Sulieti baltymai, apimantys pdgf ir vegf surišančius fragmentus, ir jų panaudojimo būdai |
| US20150038682A1 (en) | 2013-08-02 | 2015-02-05 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via homomultimerizing peptide |
| CA2945882A1 (en) * | 2014-04-16 | 2015-10-22 | Ucb Biopharma Sprl | Multimeric fc proteins |
| CN108289928B (zh) | 2015-08-06 | 2024-09-17 | 哈佛大学校长及研究员协会 | 改进的微生物-结合分子和其用途 |
-
2017
- 2017-03-29 EP EP17776516.1A patent/EP3436484A4/en active Pending
- 2017-03-29 AU AU2017245143A patent/AU2017245143B2/en active Active
- 2017-03-29 CN CN201780033114.8A patent/CN109312000A/zh active Pending
- 2017-03-29 SG SG11201808541VA patent/SG11201808541VA/en unknown
- 2017-03-29 MX MX2018011865A patent/MX2018011865A/es unknown
- 2017-03-29 EA EA201891999A patent/EA201891999A1/ru unknown
- 2017-03-29 WO PCT/US2017/024650 patent/WO2017172853A1/en active Application Filing
- 2017-03-29 CA CA3019530A patent/CA3019530A1/en active Pending
- 2017-03-29 BR BR112018070022A patent/BR112018070022A2/pt unknown
- 2017-03-29 JP JP2019503393A patent/JP7075100B2/ja active Active
- 2017-03-29 KR KR1020187030960A patent/KR102477536B1/ko active IP Right Grant
- 2017-03-29 US US16/089,042 patent/US11304994B2/en active Active
- 2017-03-29 MA MA044517A patent/MA44517A/fr unknown
- 2017-03-30 TW TW106110897A patent/TWI801336B/zh active
-
2018
- 2018-09-26 IL IL261968A patent/IL261968A/en unknown
- 2018-09-28 CL CL2018002769A patent/CL2018002769A1/es unknown
- 2018-10-11 ZA ZA2018/06767A patent/ZA201806767B/en unknown
- 2018-10-26 CO CONC2018/0011457A patent/CO2018011457A2/es unknown
-
2022
- 2022-03-29 US US17/707,243 patent/US11801286B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019513024A (ja) | 2019-05-23 |
| KR102477536B1 (ko) | 2022-12-13 |
| MA44517A (fr) | 2019-02-06 |
| KR20180132731A (ko) | 2018-12-12 |
| US11304994B2 (en) | 2022-04-19 |
| CO2018011457A2 (es) | 2019-02-08 |
| AU2017245143B2 (en) | 2024-01-11 |
| US20220233658A1 (en) | 2022-07-28 |
| AU2017245143A1 (en) | 2018-10-18 |
| IL261968A (en) | 2018-10-31 |
| CL2018002769A1 (es) | 2018-12-28 |
| TWI801336B (zh) | 2023-05-11 |
| US20190111115A1 (en) | 2019-04-18 |
| JP7075100B2 (ja) | 2022-05-25 |
| ZA201806767B (en) | 2023-04-26 |
| CA3019530A1 (en) | 2017-10-05 |
| EP3436484A1 (en) | 2019-02-06 |
| US11801286B2 (en) | 2023-10-31 |
| TW201741335A (zh) | 2017-12-01 |
| CN109312000A (zh) | 2019-02-05 |
| WO2017172853A1 (en) | 2017-10-05 |
| SG11201808541VA (en) | 2018-10-30 |
| BR112018070022A2 (pt) | 2019-02-05 |
| EP3436484A4 (en) | 2019-12-04 |
| MX2018011865A (es) | 2019-03-28 |
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