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EA201891294A1 - Способ, в котором используется биспецифический белковый комплекс - Google Patents

Способ, в котором используется биспецифический белковый комплекс

Info

Publication number
EA201891294A1
EA201891294A1 EA201891294A EA201891294A EA201891294A1 EA 201891294 A1 EA201891294 A1 EA 201891294A1 EA 201891294 A EA201891294 A EA 201891294A EA 201891294 A EA201891294 A EA 201891294A EA 201891294 A1 EA201891294 A1 EA 201891294A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cell
protein complex
identifying
binding specificity
bispecific protein
Prior art date
Application number
EA201891294A
Other languages
English (en)
Inventor
Стефен Эдвард Рапецки
Original Assignee
Юсб Биофарма Спрл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юсб Биофарма Спрл filed Critical Юсб Биофарма Спрл
Publication of EA201891294A1 publication Critical patent/EA201891294A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к способу идентификации, разделения и характеристики клетки или популяции клеток путем захвата на поверхности клетки секретированных растворимых соединений (таких как иммуноглобулин), которые клетки или популяции клетки секретируют. Это достигается объединением мультиспецифического белкового комплекса, объединяющего специфичность связывания для секретированной молекулы и специфичность связывания для поверхностного антигена, специфичного для этой клетки или популяции клеток. Данный способ может использоваться в исследовательских и экспериментальных целях, таких как стратификация пациентов при подготовке клинических испытаний или персонализированные методы лечения, идентификацией популяций клеток, имеющих отношение к патологии и/или прогнозу.
EA201891294A 2015-12-03 2016-12-01 Способ, в котором используется биспецифический белковый комплекс EA201891294A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1521383.8A GB201521383D0 (en) 2015-12-03 2015-12-03 Method
PCT/EP2016/079440 WO2017093408A1 (en) 2015-12-03 2016-12-01 Method employing bispecific antibodies

Publications (1)

Publication Number Publication Date
EA201891294A1 true EA201891294A1 (ru) 2018-11-30

Family

ID=55234381

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891294A EA201891294A1 (ru) 2015-12-03 2016-12-01 Способ, в котором используется биспецифический белковый комплекс

Country Status (9)

Country Link
US (1) US10829566B2 (ru)
EP (1) EP3383900A1 (ru)
JP (1) JP2019507104A (ru)
CN (1) CN108473553A (ru)
BR (1) BR112018010939A2 (ru)
CA (1) CA3005994A1 (ru)
EA (1) EA201891294A1 (ru)
GB (1) GB201521383D0 (ru)
WO (1) WO2017093408A1 (ru)

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US20210017247A1 (en) 2017-07-03 2021-01-21 Torque Therapeutics, Inc. Fusion Molecules Targeting Immune Regulatory Cells and Uses Thereof
EP3864392A4 (en) * 2018-10-08 2022-08-10 Bioelectronica Corporation OPTICAL SAMPLE PROCESSING SYSTEMS AND METHODS
KR20220025698A (ko) * 2019-01-07 2022-03-03 토마스 제퍼슨 유니버시티 다기능 융합 단백질 및 이의 용도
CN115776897A (zh) * 2020-06-30 2023-03-10 和铂医药(上海)有限责任公司 具有H2L2与HCAb结构的结合蛋白
CN116178541A (zh) * 2020-08-06 2023-05-30 熙源安健医药（上海）有限公司 抗ngf抗体及其抗原结合片段、其制备方法和应用
CN114149508B (zh) * 2021-11-25 2023-04-28 苏州普乐康医药科技有限公司 一种结合cd40l的融合蛋白及其应用
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Also Published As

Publication number Publication date
EP3383900A1 (en) 2018-10-10
BR112018010939A2 (pt) 2018-12-04
US20180346604A1 (en) 2018-12-06
CA3005994A1 (en) 2017-06-08
JP2019507104A (ja) 2019-03-14
CN108473553A (zh) 2018-08-31
US10829566B2 (en) 2020-11-10
GB201521383D0 (en) 2016-01-20
WO2017093408A1 (en) 2017-06-08

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