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EA201792612A1 - 6-аминохинолин-3-карбонитрилы в качестве модуляторов cot - Google Patents

6-аминохинолин-3-карбонитрилы в качестве модуляторов cot

Info

Publication number
EA201792612A1
EA201792612A1 EA201792612A EA201792612A EA201792612A1 EA 201792612 A1 EA201792612 A1 EA 201792612A1 EA 201792612 A EA201792612 A EA 201792612A EA 201792612 A EA201792612 A EA 201792612A EA 201792612 A1 EA201792612 A1 EA 201792612A1
Authority
EA
Eurasian Patent Office
Prior art keywords
aminohinolin
carbonitriles
cot
modulators
cot modulators
Prior art date
Application number
EA201792612A
Other languages
English (en)
Inventor
Элизабет М. Бейкон
Гаятри Балан
Чиэнь-хун Чоу
Кристофер Т. Кларк
Джероми Дж. Коттелл
Мусон Ким
Торстен А. Киршберг
Джон О. Линк
Гэри Филлипс
Скотт Д. Шрёдер
Нил Х. Сквайерс
Кирк Л. Стивенс
Джеймс Г. Тэйлор
Уильям Дж. Уоткинс
Натан И. Райт
Шейла М. Зипфель
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201792612A1 publication Critical patent/EA201792612A1/ru

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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

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Abstract

Изобретение, в целом, относится к модуляторам Cot (рак щитовидной железы типа Осака) и способам их применения и получения.
EA201792612A 2015-07-06 2016-06-30 6-аминохинолин-3-карбонитрилы в качестве модуляторов cot EA201792612A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562189155P 2015-07-06 2015-07-06
US201562269061P 2015-12-17 2015-12-17
PCT/US2016/040552 WO2017007694A1 (en) 2015-07-06 2016-06-30 6-amino-quinoline-3-carbonitrils as cot modulators

Publications (1)

Publication Number Publication Date
EA201792612A1 true EA201792612A1 (ru) 2018-07-31

Family

ID=56497863

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201792612A EA201792612A1 (ru) 2015-07-06 2016-06-30 6-аминохинолин-3-карбонитрилы в качестве модуляторов cot

Country Status (19)

Country Link
US (2) US9815818B2 (ru)
EP (1) EP3319955B1 (ru)
JP (1) JP6525362B2 (ru)
KR (2) KR20200022527A (ru)
CN (1) CN108026067B (ru)
AU (1) AU2016289817B2 (ru)
BR (1) BR112018000187A2 (ru)
CA (1) CA2991572A1 (ru)
EA (1) EA201792612A1 (ru)
ES (1) ES2849953T3 (ru)
HK (1) HK1252613A1 (ru)
IL (1) IL256432A (ru)
MX (1) MX2017017124A (ru)
NZ (1) NZ738538A (ru)
PL (1) PL3319955T3 (ru)
PT (1) PT3319955T (ru)
SI (1) SI3319955T1 (ru)
TW (1) TWI711611B (ru)
WO (1) WO2017007694A1 (ru)

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WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
KR101974793B1 (ko) * 2015-07-06 2019-05-02 길리애드 사이언시즈, 인코포레이티드 Cot 조정제 및 그의 사용 방법
EP3319955B1 (en) 2015-07-06 2020-11-25 Gilead Sciences, Inc. 6-amino-quinoline-3-carbonitrils as cot modulators
CA3029457A1 (en) 2016-06-30 2018-01-04 Gilead Sciences, Inc. 4,6-diaminoquinazolines as cot modulators and methods of use thereof
CN108329306A (zh) * 2017-07-09 2018-07-27 曹艳 一种用于治疗艾滋病药物的制备方法
US20200275661A1 (en) * 2017-09-26 2020-09-03 Nippon Soda Co., Ltd. Quinoline compound, and agricultural and horticultural fungicide
TWI770527B (zh) * 2019-06-14 2022-07-11 美商基利科學股份有限公司 Cot 調節劑及其使用方法
WO2021202224A1 (en) 2020-03-30 2021-10-07 Gilead Sciences, Inc. Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound
JP7446475B2 (ja) 2020-04-02 2024-03-08 ギリアード サイエンシーズ， インコーポレイテッド Ｃｏｔ阻害剤化合物を調製するためのプロセス
TW202304435A (zh) 2021-06-04 2023-02-01 美商基利科學股份有限公司 治療ｎａｓｈ之方法
CN115433096B (zh) * 2022-09-16 2024-02-06 浙江省农业科学院 一种抗臭氧剂的制备方法

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MX2007014258A (es) 2005-05-18 2008-01-22 Wyeth Corp Inhibidores de 4,6-diamino-[1,7]naftiridin-3-carbonitrilo de la tpl2 cinasa y metodos de fabricacion y uso de los mismos.
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KR101974793B1 (ko) 2015-07-06 2019-05-02 길리애드 사이언시즈, 인코포레이티드 Cot 조정제 및 그의 사용 방법
EP3319955B1 (en) 2015-07-06 2020-11-25 Gilead Sciences, Inc. 6-amino-quinoline-3-carbonitrils as cot modulators
CA3029457A1 (en) 2016-06-30 2018-01-04 Gilead Sciences, Inc. 4,6-diaminoquinazolines as cot modulators and methods of use thereof

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KR20200022527A (ko) 2020-03-03
SI3319955T1 (sl) 2021-01-29
TW201713643A (zh) 2017-04-16
KR102082331B1 (ko) 2020-02-27
MX2017017124A (es) 2018-03-09
US10316017B2 (en) 2019-06-11
CN108026067B (zh) 2021-01-12
AU2016289817B2 (en) 2019-01-31
EP3319955B1 (en) 2020-11-25
CN108026067A (zh) 2018-05-11
JP6525362B2 (ja) 2019-06-05
JP2018520160A (ja) 2018-07-26
ES2849953T3 (es) 2021-08-24
US20170008873A1 (en) 2017-01-12
TWI711611B (zh) 2020-12-01
EP3319955A1 (en) 2018-05-16
PL3319955T3 (pl) 2021-05-04
BR112018000187A2 (pt) 2018-09-04
CA2991572A1 (en) 2017-01-12
US20170362201A1 (en) 2017-12-21
AU2016289817A1 (en) 2018-01-18
IL256432A (en) 2018-02-28
PT3319955T (pt) 2021-01-05
WO2017007694A1 (en) 2017-01-12
HK1252613A1 (zh) 2019-05-31
US9815818B2 (en) 2017-11-14
NZ738538A (en) 2019-06-28
KR20180022981A (ko) 2018-03-06

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