EA201692269A1 - Новые композиции, их использование и способы получения - Google Patents
Новые композиции, их использование и способы полученияInfo
- Publication number
- EA201692269A1 EA201692269A1 EA201692269A EA201692269A EA201692269A1 EA 201692269 A1 EA201692269 A1 EA 201692269A1 EA 201692269 A EA201692269 A EA 201692269A EA 201692269 A EA201692269 A EA 201692269A EA 201692269 A1 EA201692269 A1 EA 201692269A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- obtaining
- new compositions
- present
- compounds
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
В целом, настоящее изобретение предоставляет новые соединения хинолонов и их фармацевтическую композицию, которые могут ингибировать клеточную пролиферацию и/или индуцировать апоптоз клеток. Настоящее изобретение также относится к способам получения таких соединений и композиций, а также к способам их создания и использования.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461991282P | 2014-05-09 | 2014-05-09 | |
US201462050202P | 2014-09-15 | 2014-09-15 | |
US201462054054P | 2014-09-23 | 2014-09-23 | |
US201562128208P | 2015-03-04 | 2015-03-04 | |
PCT/US2015/030046 WO2015172123A1 (en) | 2014-05-09 | 2015-05-09 | Novel compositions, uses and methods for making them |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201692269A1 true EA201692269A1 (ru) | 2017-04-28 |
EA034235B1 EA034235B1 (ru) | 2020-01-20 |
Family
ID=54393079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201692269A EA034235B1 (ru) | 2014-05-09 | 2015-05-09 | Новые композиции, их использование и способы получения |
Country Status (33)
Country | Link |
---|---|
US (1) | US9512123B2 (ru) |
EP (2) | EP3219716B1 (ru) |
JP (2) | JP6188179B2 (ru) |
KR (3) | KR102044648B1 (ru) |
CN (2) | CN106459068B (ru) |
AU (3) | AU2015255738C1 (ru) |
BR (1) | BR112016026150B1 (ru) |
CA (2) | CA2948173C (ru) |
CL (2) | CL2016002798A1 (ru) |
CY (1) | CY1120935T1 (ru) |
DK (1) | DK3140305T3 (ru) |
EA (1) | EA034235B1 (ru) |
EC (3) | ECSP16088687A (ru) |
ES (1) | ES2679628T3 (ru) |
HR (1) | HRP20181105T1 (ru) |
HU (1) | HUE039733T2 (ru) |
IL (2) | IL248638B (ru) |
LT (1) | LT3140305T (ru) |
MX (1) | MX2016014555A (ru) |
NI (1) | NI201600168A (ru) |
NZ (1) | NZ725917A (ru) |
PE (2) | PE20170678A1 (ru) |
PH (2) | PH12016502213B1 (ru) |
PL (1) | PL3140305T3 (ru) |
PT (1) | PT3140305T (ru) |
RS (1) | RS57493B1 (ru) |
SG (2) | SG10201703658SA (ru) |
SI (1) | SI3140305T1 (ru) |
SM (1) | SMT201800418T1 (ru) |
TR (1) | TR201809990T4 (ru) |
UA (1) | UA117182C2 (ru) |
WO (1) | WO2015172123A1 (ru) |
ZA (1) | ZA201607573B (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
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US9758518B2 (en) | 2015-03-04 | 2017-09-12 | Pimera, Inc. | Compositions, uses and methods for making them |
CA3057741A1 (en) | 2017-03-28 | 2018-10-04 | Pimera, Inc. | Novel crystal forms of a pol1 inhibitor |
US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
WO2020180959A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
CN112300173B (zh) * | 2019-07-30 | 2021-10-01 | 上海凌达生物医药有限公司 | 一类含氮多环类化合物、制备方法和用途 |
US11427567B2 (en) | 2019-08-14 | 2022-08-30 | Incyte Corporation | Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors |
CN110606850A (zh) * | 2019-09-11 | 2019-12-24 | 中山大学 | 一种3-苯并[4,5]咪唑[1,2-a]吡嗪-1-胺类化合物及其制备方法和应用 |
CA3157681A1 (en) | 2019-10-11 | 2021-04-15 | Incyte Corporation | Bicyclic amines as cdk2 inhibitors |
US20240254117A1 (en) * | 2020-12-27 | 2024-08-01 | Shanghai Ringene Biopharma Co., Ltd. | Pyrimido-heterocyclic compounds, and preparation method therefor and use thereof |
US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
CN113416197B (zh) * | 2021-08-25 | 2021-12-28 | 北京鑫开元医药科技有限公司 | 甲酰胺类衍生物、制备方法、药物组合物及应用 |
US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
CN114276354B (zh) * | 2022-01-07 | 2023-06-02 | 中山大学 | 1-氨基苯并[4,5]咪唑并[1,2-a]吡嗪-3-甲酰胺类化合物及其制备和应用 |
CN114539265B (zh) * | 2022-03-02 | 2023-07-21 | 中山大学 | 靶向a2a的苯并咪唑并吡嗪-3-甲酰胺及其肿瘤免疫功能 |
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NL7709746A (nl) * | 1976-09-09 | 1978-03-13 | Hoechst Ag | Werkwijze ter bereiding van benzimidazo-(1,2-a)-chi- nolinen. |
DE2929414A1 (de) * | 1979-07-20 | 1981-02-05 | Hoechst Ag | Pyrimido- eckige klammer auf 5',4' zu 5,6 eckige klammer zu -pyrido- eckige klammer auf 1,2-a eckige klammer zu -benzimidazole, verfahren zu ihrer herstellung und deren verwendung |
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JP3468520B2 (ja) * | 1992-06-22 | 2003-11-17 | ベーリンガー インゲルハイム コマンディトゲゼルシャフト | 9−アミノ−ピリダジノ〔4′,5′:3,4〕ピローロ〔2,1−a〕イソキノリンと該化合物の医薬製剤製造への使用 |
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WO2011156698A2 (en) | 2010-06-11 | 2011-12-15 | Abbott Laboratories | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS |
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KR101561730B1 (ko) * | 2012-02-06 | 2015-10-22 | 주식회사 엘지화학 | 질소원소를 함유한 헤테로고리 유도체 및 이를 이용한 유기 전자 소자 |
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2015
- 2015-05-09 CN CN201580031811.0A patent/CN106459068B/zh active Active
- 2015-05-09 NZ NZ725917A patent/NZ725917A/en unknown
- 2015-05-09 KR KR1020187030648A patent/KR102044648B1/ko active IP Right Grant
- 2015-05-09 CA CA2948173A patent/CA2948173C/en active Active
- 2015-05-09 PT PT157900168T patent/PT3140305T/pt unknown
- 2015-05-09 KR KR1020167033915A patent/KR101890505B1/ko active IP Right Grant
- 2015-05-09 SI SI201530315T patent/SI3140305T1/sl unknown
- 2015-05-09 DK DK15790016.8T patent/DK3140305T3/en active
- 2015-05-09 SM SM20180418T patent/SMT201800418T1/it unknown
- 2015-05-09 KR KR1020177009732A patent/KR20170042821A/ko active Application Filing
- 2015-05-09 EP EP17166200.0A patent/EP3219716B1/en active Active
- 2015-05-09 RS RS20180827A patent/RS57493B1/sr unknown
- 2015-05-09 PE PE2017000488A patent/PE20170678A1/es unknown
- 2015-05-09 SG SG10201703658SA patent/SG10201703658SA/en unknown
- 2015-05-09 EA EA201692269A patent/EA034235B1/ru unknown
- 2015-05-09 US US14/708,230 patent/US9512123B2/en active Active
- 2015-05-09 PL PL15790016T patent/PL3140305T3/pl unknown
- 2015-05-09 JP JP2016575683A patent/JP6188179B2/ja active Active
- 2015-05-09 SG SG11201609171XA patent/SG11201609171XA/en unknown
- 2015-05-09 WO PCT/US2015/030046 patent/WO2015172123A1/en active Application Filing
- 2015-05-09 TR TR2018/09990T patent/TR201809990T4/en unknown
- 2015-05-09 CA CA2974960A patent/CA2974960A1/en not_active Abandoned
- 2015-05-09 CN CN201710268769.5A patent/CN106995443B/zh active Active
- 2015-05-09 UA UAA201612474A patent/UA117182C2/uk unknown
- 2015-05-09 HU HUE15790016A patent/HUE039733T2/hu unknown
- 2015-05-09 MX MX2016014555A patent/MX2016014555A/es unknown
- 2015-05-09 PE PE2016002189A patent/PE20170131A1/es unknown
- 2015-05-09 AU AU2015255738A patent/AU2015255738C1/en active Active
- 2015-05-09 LT LTEP15790016.8T patent/LT3140305T/lt unknown
- 2015-05-09 EP EP15790016.8A patent/EP3140305B1/en active Active
- 2015-05-09 BR BR112016026150-0A patent/BR112016026150B1/pt active IP Right Grant
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2016
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