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EA201590655A1 - Комбинация лахинимода и придопидина для лечения нейродегенеративных нарушений - Google Patents

Комбинация лахинимода и придопидина для лечения нейродегенеративных нарушений

Info

Publication number
EA201590655A1
EA201590655A1 EA201590655A EA201590655A EA201590655A1 EA 201590655 A1 EA201590655 A1 EA 201590655A1 EA 201590655 A EA201590655 A EA 201590655A EA 201590655 A EA201590655 A EA 201590655A EA 201590655 A1 EA201590655 A1 EA 201590655A1
Authority
EA
Eurasian Patent Office
Prior art keywords
combination
lachinimode
treatment
neurodegenerative disorder
patient suffering
Prior art date
Application number
EA201590655A
Other languages
English (en)
Other versions
EA201590655A8 (ru
Inventor
Майкл Хайден
Дэн Бар-Зохар
Original Assignee
Тева Фармасьютикал Индастриз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тева Фармасьютикал Индастриз Лтд. filed Critical Тева Фармасьютикал Индастриз Лтд.
Publication of EA201590655A1 publication Critical patent/EA201590655A1/ru
Publication of EA201590655A8 publication Critical patent/EA201590655A8/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Mechanical Engineering (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В изобретении предложен способ лечения пациента, страдающего нейродегенеративным нарушением, например болезнью Хантингтона (HD), включающий введение пациенту лахинимода в качестве дополнительной терапии или в комбинации с придопидином. В изобретении также предложены упаковка и фармацевтическая композиция, включающая лахинимод и придопидин, для лечения пациента, страдающего нейродегенеративным нарушением, например HD. В изобретении также предложен лахинимод для применения в качестве дополнительной терапии или в комбинации с придопидином для лечения пациента, страдающего нейродегенеративным нарушением, например HD. В изобретении также предложено применение лахинимода и придопидина в получении комбинации для лечения пациента, страдающего нейродегенеративным нарушением, например HD.
EA201590655A 2012-09-27 2013-09-27 Комбинация лахинимода и придопидина для лечения нейродегенеративных нарушений EA201590655A8 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261706695P 2012-09-27 2012-09-27
US201361879004P 2013-09-17 2013-09-17
PCT/US2013/062482 WO2014052933A1 (en) 2012-09-27 2013-09-27 Laquinimod and pridopidine for treating neurodegenerative disorders

Publications (2)

Publication Number Publication Date
EA201590655A1 true EA201590655A1 (ru) 2015-12-30
EA201590655A8 EA201590655A8 (ru) 2016-07-29

Family

ID=50339469

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590655A EA201590655A8 (ru) 2012-09-27 2013-09-27 Комбинация лахинимода и придопидина для лечения нейродегенеративных нарушений

Country Status (13)

Country Link
US (7) US20150209346A1 (ru)
EP (1) EP2900330A4 (ru)
CN (1) CN104902958A (ru)
AU (1) AU2013323131A1 (ru)
BR (1) BR112015006623A2 (ru)
CA (1) CA2884781A1 (ru)
EA (1) EA201590655A8 (ru)
HK (2) HK1211525A1 (ru)
IL (1) IL237742A0 (ru)
IN (1) IN2015DN03219A (ru)
MX (1) MX2015003608A (ru)
WO (1) WO2014052933A1 (ru)
ZA (1) ZA201502600B (ru)

Families Citing this family (21)

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USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
DK2146961T3 (da) * 2007-04-12 2014-04-28 Ivax Int Gmbh N-oxid- og/eller di-N-oxidderivater af dopaminreceptorstabilisatorer/modulatorer udvisende forbedrede cardiovaskulære bivirkningsprofiler
JP2013536825A (ja) 2010-09-03 2013-09-26 イバックス・インターナショナル・ゲーエムベーハー ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体
WO2013034622A1 (en) 2011-09-07 2013-03-14 Neurosearch A/S Polymorphic form of pridopidine hydrochloride
WO2013086425A1 (en) 2011-12-08 2013-06-13 IVAX International GmbH The hydrobromide salt of pridopidine
US11090297B2 (en) 2013-06-21 2021-08-17 Prilenia Neurotherapeutics Ltd. Pridopidine for treating huntington's disease
SG11201509729YA (en) 2013-06-21 2015-12-30 Teva Pharmaceuticals Int Gmbh Use of high dose pridopidine for treating huntington's disease
AR098832A1 (es) * 2013-12-20 2016-06-15 Teva Pharma Uso de laquinimod para retrasar la progresión de la enfermedad de huntington
TW201613859A (en) * 2014-06-30 2016-04-16 Teva Pharma Analogs of PRIDOPIDINE, their preparation and use
EP3193870A4 (en) * 2014-09-16 2018-04-25 Teva Pharmaceutical Industries Ltd. Treatment of neurodegenerative diseases with combination of laquinimod and fingolimod
MX2017008136A (es) 2014-12-22 2018-03-06 Teva Pharmaceuticals Int Gmbh Sal de l-tartrato de pridopidina.
US11471449B2 (en) 2015-02-25 2022-10-18 Prilenia Neurotherapeutics Ltd. Use of pridopidine to improve cognitive function and for treating Alzheimer's disease
HUE060353T2 (hu) * 2015-02-25 2023-02-28 Prilenia Neurotherapeutics Ltd Pridopidin alkalmazása memória javítására
AR105434A1 (es) 2015-07-22 2017-10-04 Teva Pharmaceuticals Int Gmbh Proceso para preparar pridopidina
US20170020854A1 (en) * 2015-07-22 2017-01-26 Teva Pharmaceuticals International Gmbh Pridopidine base formulations and their use
WO2017048457A1 (en) * 2015-09-18 2017-03-23 Teva Pharmaceuticals Industries Ltd. Combination of laquinimod and pridopidine to treat multiple sclerosis
AU2017315783C1 (en) 2016-08-24 2020-12-24 Prilenia Neurotherapeutics Ltd Use of pridopidine for treating a subject with early stage huntington disease
WO2019010491A1 (en) * 2017-07-07 2019-01-10 University Of Pittsburgh-Of The Commonwealth System Of Higher Education COMBINATIONS OF MEDICINES FOR THE PROTECTION AGAINST THE DEATH OF NEURONAL CELLS
PL3668509T3 (pl) * 2017-08-14 2023-03-20 Prilenia Neurotherapeutics Ltd. Sposób leczenia stwardnienia zanikowego bocznego pridopidiną
CA3128250C (en) * 2019-03-15 2024-01-16 Michael Hayden Treatment of mitochondrial associated diseases and disorders, including symptoms thereof using pridopidine
EP3982963A4 (en) * 2019-06-12 2023-06-21 Prilenia Neurotherapeutics Ltd. PRIDOPIDIN-CONTAINING COMPOSITION AND ANALOGUE THEREOF FOR THE TREATMENT OF HUNTINGTON'S DISEASE AND ITS SYMPTOMS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2170327B1 (en) * 2007-06-18 2014-10-22 A.Carlsson Research AB Use of dopamine stabilizers
CN102369202A (zh) * 2008-11-13 2012-03-07 链接医药公司 氮杂喹啉酮衍生物及其应用
PL2467372T3 (pl) * 2009-08-10 2017-04-28 Teva Pharmaceutical Industries Ltd. Leczenie zaburzeń związanych z BDNF z zastosowaniem lakwinimodu
WO2011107583A1 (en) * 2010-03-04 2011-09-09 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders
WO2012078591A1 (en) * 2010-12-07 2012-06-14 Teva Pharmaceutical Industries Ltd. Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients

Also Published As

Publication number Publication date
US20180133209A1 (en) 2018-05-17
MX2015003608A (es) 2015-06-05
BR112015006623A2 (pt) 2017-07-04
US20170319569A1 (en) 2017-11-09
HK1214553A1 (zh) 2016-07-29
EA201590655A8 (ru) 2016-07-29
HK1211525A1 (en) 2016-05-27
ZA201502600B (en) 2016-06-29
IL237742A0 (en) 2015-05-31
CN104902958A (zh) 2015-09-09
EP2900330A4 (en) 2016-05-25
AU2013323131A1 (en) 2015-05-07
EP2900330A1 (en) 2015-08-05
US20180250285A1 (en) 2018-09-06
WO2014052933A1 (en) 2014-04-03
IN2015DN03219A (ru) 2015-10-02
US20180369228A1 (en) 2018-12-27
US20190117639A1 (en) 2019-04-25
US20150209346A1 (en) 2015-07-30
CA2884781A1 (en) 2014-04-03
US20140088140A1 (en) 2014-03-27

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