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EA201590022A1 - Новые производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса - Google Patents

Новые производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса

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Publication number
EA201590022A1
EA201590022A1 EA201590022A EA201590022A EA201590022A1 EA 201590022 A1 EA201590022 A1 EA 201590022A1 EA 201590022 A EA201590022 A EA 201590022A EA 201590022 A EA201590022 A EA 201590022A EA 201590022 A1 EA201590022 A1 EA 201590022A1
Authority
EA
Eurasian Patent Office
Prior art keywords
virus
benzimidazol
heterocycles
dihydro
new derivatives
Prior art date
Application number
EA201590022A
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English (en)
Other versions
EA028240B1 (ru
Inventor
Абделлах Тахри
Тим Хьюго Мария Йонкерс
Пьер Жан-Мари Бернар Рабуассон
Сандрин Мари Элен Вендевилль
Лили Ху
Самюэль Доминик Демэн
Людвиг Поль Коиманс
Original Assignee
ЯНССЕН Ар ЭНД Ди АЙРЛЭНД
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Publication of EA201590022A1 publication Critical patent/EA201590022A1/ru
Publication of EA028240B1 publication Critical patent/EA028240B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Настоящее изобретение относится к новым производным 1,3-дигидро-2H-бензимидазол-2-она, замещенных гетероциклами, характеризующимся формулой (I)их стереоизомерным формам, а также их фармацевтически приемлемым солям присоединения и сольватам, где R, R, Z и Het имеют значение, определенное в формуле изобретения. Соединения по настоящему изобретению применяются в качестве ингибиторов репликации респираторного синцитиального вируса (RSV). Настоящее изобретение дополнительно относится к получению таких новых соединений, композиций, содержащих эти соединения, а также к соединениям для применения при лечении инфекции, вызванной респираторным синцитиальным вирусом.
EA201590022A 2012-06-15 2013-06-14 Производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса EA028240B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12172271 2012-06-15
EP12182550 2012-08-31
PCT/EP2013/062322 WO2013186333A1 (en) 2012-06-15 2013-06-14 1,3 -dihydro- 2h-benzimidazol- 2 -one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents

Publications (2)

Publication Number Publication Date
EA201590022A1 true EA201590022A1 (ru) 2015-04-30
EA028240B1 EA028240B1 (ru) 2017-10-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590022A EA028240B1 (ru) 2012-06-15 2013-06-14 Производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса

Country Status (20)

Country Link
US (2) US20150111868A1 (ru)
EP (1) EP2864323B1 (ru)
JP (1) JP6259451B2 (ru)
KR (1) KR102092612B1 (ru)
CN (1) CN104540817B (ru)
AR (1) AR091455A1 (ru)
AU (1) AU2013276519B2 (ru)
CA (1) CA2873920C (ru)
CY (1) CY1119289T1 (ru)
DK (1) DK2864323T3 (ru)
EA (1) EA028240B1 (ru)
ES (1) ES2632914T3 (ru)
HR (1) HRP20171050T1 (ru)
HU (1) HUE033848T2 (ru)
LT (1) LT2864323T (ru)
PL (1) PL2864323T3 (ru)
PT (1) PT2864323T (ru)
SI (1) SI2864323T1 (ru)
TW (1) TWI643850B (ru)
WO (1) WO2013186333A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
DK2864323T3 (en) 2012-06-15 2017-08-14 Janssen Sciences Ireland Uc 1,3-DIHYDRO-2H-BENZIMIDAZOLE-2 UNDERIVATIVES SUBSTITUTED BY HETEROCYCLES AS ANTIVIRUS AGENTS AGAINST RESPIRATORY SYNCYTIAL VIRUS
BR112016003348B1 (pt) 2013-08-21 2023-03-07 Alios Biopharma, Inc Compostos antivirais ou sais farmaceuticamente aceitáveis dos mesmos, composição farmacêutica e seus usos
PE20170673A1 (es) * 2014-08-05 2017-05-22 Alios Biopharma Inc Terapia de combinacion para tratar una paramixovirus
MA41614A (fr) 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
CN111386118B (zh) 2017-09-29 2023-05-09 英安塔制药有限公司 作为rsv抑制剂的组合药物剂
JP2023500214A (ja) * 2019-10-30 2023-01-05 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ３－（｛５－クロロ－１－［３－（メチルスルホニル）プロピル］－１Ｈ－インドール－２イル｝メチル）－１－（２，２，２－トリフルオロエチル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オンの合成
WO2024174953A1 (zh) * 2023-02-21 2024-08-29 苏州隆博泰药业有限公司 苯并咪唑类衍生物及其医药用途

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3645697A (en) 1996-07-08 1998-02-02 Du Pont Pharmaceuticals Company Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of factor xa and of thrombin
AU1099000A (en) 1998-10-05 2000-04-26 Axys Pharmaceuticals, Inc. Novel compounds and compositions for treating hepatitis c infections
IL143801A0 (en) 1998-12-18 2002-04-21 Axys Pharm Inc (hetero) aryl-bicyclic heteroaryl derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US6747028B1 (en) 1999-06-28 2004-06-08 Hanssen Pharmaceutica, N.V. Respiratory syncytial virus replication inhibitors
EP1418175A1 (en) 1999-06-28 2004-05-12 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
WO2001012600A1 (en) 1999-08-12 2001-02-22 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa
WO2001057019A1 (en) 2000-02-01 2001-08-09 Cor Therapeutics, Inc. INDALONE AND BENZIMIDAZOLONE INHIBITORS OF FACTOR Xa
WO2001057020A1 (en) 2000-02-01 2001-08-09 Cor Therapeutics, Inc. INDOLE AND BENZIMIDAZOLE INHIBITORS OF FACTOR Xa
US6489338B2 (en) * 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
EP1461036A4 (en) * 2001-12-10 2005-11-16 Bristol Myers Squibb Co BIS HYDROCHLORIDE SALT MONOHYDRATE OF A SYNCYTIAL RESPIRATORY VIRUS FUSION INHIBITOR (RSV)
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
US20030180957A1 (en) 2001-12-21 2003-09-25 Sense Proteomic Limited Target and method
WO2004043913A2 (en) 2002-11-08 2004-05-27 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
PE20050068A1 (es) * 2003-02-06 2005-03-11 Novartis Ag 2-cianopirrolopirimidinas como inhibidores de la catepsina s
US7343930B2 (en) 2004-12-03 2008-03-18 Masco Corporation Of Indiana Sprayer with non-faucet control
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
ATE518840T1 (de) * 2007-05-22 2011-08-15 Boehringer Ingelheim Int Benzimidazolonchymasehemmer
FR2926556B1 (fr) 2008-01-22 2010-02-19 Sanofi Aventis Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
JP6145044B2 (ja) 2010-12-17 2017-06-07 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬剤投与
KR20150028969A (ko) 2012-06-15 2015-03-17 얀센 알 앤드 디 아일랜드 호흡기 합포체 바이러스의 항바이러스제로서의 벤즈이미다졸로 치환된 4-치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체
EA201590020A1 (ru) 2012-06-15 2015-03-31 ЯНССЕН Ар ЭНД Ди АЙРЛЭНД Новые производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса
AU2013276521A1 (en) 2012-06-15 2014-12-04 Janssen Sciences Ireland Uc 1,3 -dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents
DK2864323T3 (en) 2012-06-15 2017-08-14 Janssen Sciences Ireland Uc 1,3-DIHYDRO-2H-BENZIMIDAZOLE-2 UNDERIVATIVES SUBSTITUTED BY HETEROCYCLES AS ANTIVIRUS AGENTS AGAINST RESPIRATORY SYNCYTIAL VIRUS
SI2909195T1 (sl) 2012-10-16 2017-10-30 Janssen Sciences Ireland Uc RSV protivirusni sestavki

Also Published As

Publication number Publication date
PT2864323T (pt) 2017-07-14
HUE033848T2 (en) 2018-01-29
CA2873920C (en) 2021-07-20
CN104540817A (zh) 2015-04-22
HRP20171050T1 (hr) 2017-10-06
JP2015519386A (ja) 2015-07-09
PL2864323T3 (pl) 2017-09-29
AU2013276519A1 (en) 2014-12-04
CN104540817B (zh) 2017-03-01
WO2013186333A1 (en) 2013-12-19
ES2632914T3 (es) 2017-09-18
TWI643850B (zh) 2018-12-11
JP6259451B2 (ja) 2018-01-10
US20160122346A1 (en) 2016-05-05
AU2013276519B2 (en) 2017-05-25
EA028240B1 (ru) 2017-10-31
EP2864323A1 (en) 2015-04-29
CA2873920A1 (en) 2013-12-19
SI2864323T1 (sl) 2017-08-31
AR091455A1 (es) 2015-02-04
US9845321B2 (en) 2017-12-19
LT2864323T (lt) 2017-07-25
EP2864323B1 (en) 2017-04-19
CY1119289T1 (el) 2018-02-14
DK2864323T3 (en) 2017-08-14
US20150111868A1 (en) 2015-04-23
KR20150033646A (ko) 2015-04-01
KR102092612B1 (ko) 2020-03-25
TW201410669A (zh) 2014-03-16

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