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EA201400914A1 - Ротавирусная субъединичная вакцина и способы ее получения и применения - Google Patents

Ротавирусная субъединичная вакцина и способы ее получения и применения

Info

Publication number
EA201400914A1
EA201400914A1 EA201400914A EA201400914A EA201400914A1 EA 201400914 A1 EA201400914 A1 EA 201400914A1 EA 201400914 A EA201400914 A EA 201400914A EA 201400914 A EA201400914 A EA 201400914A EA 201400914 A1 EA201400914 A1 EA 201400914A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
production
rotavirus
subunit vaccine
rotavirus subunit
Prior art date
Application number
EA201400914A
Other languages
English (en)
Other versions
EA034564B1 (ru
Inventor
Рассел Ф. Бей
Рэнди Р. Симонсон
Камеш Редди Сириджиредди
Бенджамин Мэтью Хаус
Original Assignee
Мериал Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мериал Лимитед filed Critical Мериал Лимитед
Publication of EA201400914A1 publication Critical patent/EA201400914A1/ru
Publication of EA034564B1 publication Critical patent/EA034564B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Данным изобретением предлагаются антигенные полипептиды или антигены ротавирусов, вызывающие у животных или человека иммунный ответ, направленный против ротавирусов; композиции, содержащие указанные ротавирусные полипептиды; способы вакцинации от ротавирусов и наборы для применения таких способов и композиций. Также предлагаются новые экспрессионные векторы для получения антигенных полипептидов для вакцины.
EA201400914A 2012-02-14 2013-02-14 Ротавирусная субъединичная вакцина, способ ее получения и применение EA034564B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261598624P 2012-02-14 2012-02-14
PCT/US2013/026179 WO2013123219A1 (en) 2012-02-14 2013-02-14 Rotavirus subunit vaccines and methods of making and use thereof

Publications (2)

Publication Number Publication Date
EA201400914A1 true EA201400914A1 (ru) 2014-12-30
EA034564B1 EA034564B1 (ru) 2020-02-20

Family

ID=47755047

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400914A EA034564B1 (ru) 2012-02-14 2013-02-14 Ротавирусная субъединичная вакцина, способ ее получения и применение

Country Status (22)

Country Link
US (1) US9446117B2 (ru)
EP (1) EP2814508B1 (ru)
JP (1) JP6149240B2 (ru)
KR (1) KR102087458B1 (ru)
CN (1) CN104203274B (ru)
AR (2) AR089995A1 (ru)
AU (1) AU2013221479B2 (ru)
BR (1) BR112014020025B1 (ru)
CA (1) CA2864106C (ru)
DK (1) DK2814508T5 (ru)
EA (1) EA034564B1 (ru)
ES (1) ES2632429T3 (ru)
HK (1) HK1200326A1 (ru)
HU (1) HUE033858T2 (ru)
LT (1) LT2814508T (ru)
MX (1) MX353786B (ru)
NZ (1) NZ628282A (ru)
PH (1) PH12014501795A1 (ru)
PL (1) PL2814508T3 (ru)
PT (1) PT2814508T (ru)
SI (1) SI2814508T1 (ru)
WO (1) WO2013123219A1 (ru)

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US10004797B2 (en) 2010-10-27 2018-06-26 Harrisvaccines, Inc. Method of rapidly producing improved vaccines for animals
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CN109306007B (zh) * 2018-09-26 2021-10-08 华中农业大学 抗猪繁殖与呼吸综合征病毒nsp4蛋白基因工程抗体及应用
JP2023544403A (ja) * 2020-10-05 2023-10-23 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド サーコウイルス科カプシドタンパク質を含む融合タンパク質、及びそれから構成されるキメラウイルス様粒子
CN114875047A (zh) * 2022-05-27 2022-08-09 江苏三仪生物工程有限公司 一种优化的猪轮状病毒外衣壳蛋白vp4的重组表达及应用

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Also Published As

Publication number Publication date
AU2013221479A1 (en) 2014-08-28
PL2814508T3 (pl) 2017-09-29
PT2814508T (pt) 2017-07-19
MX353786B (es) 2018-01-29
MX2014009722A (es) 2015-02-20
CN104203274A (zh) 2014-12-10
HK1200326A1 (en) 2015-08-07
BR112014020025B1 (pt) 2022-09-27
ES2632429T3 (es) 2017-09-13
US20130209507A1 (en) 2013-08-15
US9446117B2 (en) 2016-09-20
DK2814508T5 (da) 2017-06-12
PH12014501795B1 (en) 2014-11-17
EP2814508B1 (en) 2017-04-12
KR102087458B1 (ko) 2020-03-10
DK2814508T3 (da) 2017-05-22
WO2013123219A1 (en) 2013-08-22
SI2814508T1 (sl) 2017-10-30
CA2864106A1 (en) 2013-08-22
LT2814508T (lt) 2017-06-26
JP6149240B2 (ja) 2017-06-21
AU2013221479B2 (en) 2017-06-08
CA2864106C (en) 2017-10-17
EP2814508A1 (en) 2014-12-24
HUE033858T2 (en) 2018-01-29
NZ628282A (en) 2016-08-26
BR112014020025A8 (pt) 2022-07-12
KR20140123592A (ko) 2014-10-22
EA034564B1 (ru) 2020-02-20
AR126891A2 (es) 2023-11-29
BR112014020025A2 (pt) 2017-07-04
AR089995A1 (es) 2014-10-01
PH12014501795A1 (en) 2014-11-17
JP2015508776A (ja) 2015-03-23
CN104203274B (zh) 2017-09-08

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