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EA201400064A1 - Офтальмологическая фармацевтическая композиция для местного применения, которая содержит регорафениб - Google Patents

Офтальмологическая фармацевтическая композиция для местного применения, которая содержит регорафениб

Info

Publication number
EA201400064A1
EA201400064A1 EA201400064A EA201400064A EA201400064A1 EA 201400064 A1 EA201400064 A1 EA 201400064A1 EA 201400064 A EA201400064 A EA 201400064A EA 201400064 A EA201400064 A EA 201400064A EA 201400064 A1 EA201400064 A1 EA 201400064A1
Authority
EA
Eurasian Patent Office
Prior art keywords
regoraphenib
pharmaceutical composition
ophthalmic pharmaceutical
local application
ophthalmic
Prior art date
Application number
EA201400064A
Other languages
English (en)
Inventor
Михаэль Бёттгер
Жорж Фон-Дегенфельд
Юлия Фройндлиб
Клаудиа Хирт-Дитрих
Йёрг Кельдених
Йюрген Клар
Уве Мюнстер
Андреас Ом
Аннетт Рихтер
Бернд Ридль
Original Assignee
Байер Хелфкеэ Ллк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46456546&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201400064(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байер Хелфкеэ Ллк filed Critical Байер Хелфкеэ Ллк
Publication of EA201400064A1 publication Critical patent/EA201400064A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение относится к офтальмологическим фармацевтическим композициям для местного применения, которые содержат регорафениб, гидрат, сольват или его фармацевтически приемлемую соль или их полиморф, а также процесс их получения для использования при лечении офтальмологических расстройств.
EA201400064A 2011-06-28 2012-06-26 Офтальмологическая фармацевтическая композиция для местного применения, которая содержит регорафениб EA201400064A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11171719 2011-06-28
EP12155281 2012-02-14
PCT/EP2012/062365 WO2013000917A1 (en) 2011-06-28 2012-06-26 Topical ophthalmological pharmaceutical composition containing regorafenib

Publications (1)

Publication Number Publication Date
EA201400064A1 true EA201400064A1 (ru) 2014-05-30

Family

ID=46456546

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400064A EA201400064A1 (ru) 2011-06-28 2012-06-26 Офтальмологическая фармацевтическая композиция для местного применения, которая содержит регорафениб

Country Status (25)

Country Link
US (1) US20140296301A1 (ru)
EP (1) EP2726059A1 (ru)
JP (1) JP5998213B2 (ru)
KR (1) KR20140048218A (ru)
CN (1) CN103889399A (ru)
AP (1) AP2013007335A0 (ru)
AR (1) AR086800A1 (ru)
AU (1) AU2012277905A1 (ru)
BR (1) BR112013033831A2 (ru)
CA (1) CA2840329A1 (ru)
CL (1) CL2013003700A1 (ru)
CO (1) CO6920289A2 (ru)
CR (1) CR20130693A (ru)
CU (1) CU24163B1 (ru)
DO (1) DOP2013000314A (ru)
EA (1) EA201400064A1 (ru)
EC (1) ECSP13013106A (ru)
GT (1) GT201300322A (ru)
HK (1) HK1197176A1 (ru)
MX (1) MX2013015287A (ru)
PE (1) PE20141031A1 (ru)
TN (1) TN2013000533A1 (ru)
UY (1) UY34166A (ru)
WO (1) WO2013000917A1 (ru)
ZA (1) ZA201400646B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1797038E (pt) 2004-09-29 2012-08-14 Bayer Pharma AG Forma termodinamicamente estável de tosilato de bay 43-9006
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
UY35183A (es) * 2012-12-21 2014-07-31 Bayer Healthcare Llc Composición farmacéutica oftalmológica tópica que contiene regorafenib
WO2015011659A1 (en) * 2013-07-24 2015-01-29 Dr. Reddys Laboratories Limited Crystalline polymorphic forms of regorafenib and processes for the preparation of polymorph i of regorafenib
CN103923000A (zh) * 2014-01-29 2014-07-16 苏州晶云药物科技有限公司 几种新晶型及其制备方法
CN104546776B (zh) * 2015-02-10 2017-08-22 杭州朱养心药业有限公司 瑞戈非尼片剂药物组合物和制法
CN114010787A (zh) 2015-06-06 2022-02-08 拨云生物医药科技(广州)有限公司 用于治疗翼状胬肉的组合物和方法
US11246864B2 (en) 2016-06-02 2022-02-15 Ads Therapeutics Llc Compositions and methods of using nintedanib for treating ocular diseases with abnormal neovascularization

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732222B1 (fr) * 1995-03-28 1997-04-25 Oreal Utilisation d'un antagoniste de cgrp pour le traitement des prurits et des dysesthesies oculaires et palpebraux
DK2020243T3 (en) * 2002-05-28 2018-11-19 Astrazeneca Ab Pharmaceutical composition which can be applied topically
DE602004010407T2 (de) 2003-07-23 2008-10-16 Bayer Pharmaceuticals Corp., West Haven Fluorsubstituierter omega-carboxyaryldiphenylharnstoff zur behandlung und prävention von krankheiten und leiden
BRPI0609227A2 (pt) 2005-05-10 2010-03-09 Alcon Inc composições de suspensão de nepafenac e outros fármacos oftálmicos, bem como uso das referidas composições no tratamento tópico de distúrbios oftálmicos
EP1893216A4 (en) 2005-06-08 2012-08-08 Targegen Inc METHOD AND COMPOSITIONS FOR THE TREATMENT OF EYE DISEASES
DK1968594T3 (da) 2005-11-29 2010-12-13 Glaxosmithkline Llc Behandling af okulære neovaskulære lidelser, såsom makulær degeneration, striae angioides og makulært ødem
EP1962828A1 (en) * 2005-12-15 2008-09-03 Bayer HealthCare AG Diaryl urea for treating inflammatory skin, eye and/or ear diseases
WO2007076358A1 (en) 2005-12-23 2007-07-05 Alcon, Inc. PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
WO2008027341A2 (en) 2006-08-30 2008-03-06 Merck & Co., Inc. Topical ophthalmic formulations
AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
US20100130569A1 (en) * 2007-05-11 2010-05-27 Saten Pharmaceutical Co., Ltd. Prophylactic or therapeutic agent for posterior ocular disease comprising non-ergot selective d2 receptor agonist as active ingredient
DE102007055341A1 (de) * 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
WO2010127029A1 (en) 2009-05-01 2010-11-04 Ophthotech Corporation Methods for treating or preventing ophthalmological diseases
SG178032A1 (en) 2009-07-16 2012-03-29 Glaxo Wellcome Mfg Pte Ltd Treatment method

Also Published As

Publication number Publication date
US20140296301A1 (en) 2014-10-02
WO2013000917A1 (en) 2013-01-03
JP5998213B2 (ja) 2016-09-28
CL2013003700A1 (es) 2014-07-18
BR112013033831A2 (pt) 2017-02-14
AR086800A1 (es) 2014-01-22
CA2840329A1 (en) 2013-01-03
AU2012277905A1 (en) 2014-01-16
AP2013007335A0 (en) 2013-12-31
TN2013000533A1 (en) 2015-03-30
GT201300322A (es) 2014-11-13
CO6920289A2 (es) 2014-04-10
JP2014518233A (ja) 2014-07-28
AU2012277905A8 (en) 2014-01-30
UY34166A (es) 2013-01-31
KR20140048218A (ko) 2014-04-23
EP2726059A1 (en) 2014-05-07
CN103889399A (zh) 2014-06-25
CU24163B1 (es) 2016-03-31
ECSP13013106A (es) 2014-01-31
ZA201400646B (en) 2015-11-25
PE20141031A1 (es) 2014-08-21
NZ619229A (en) 2016-04-29
HK1197176A1 (en) 2015-01-09
MX2013015287A (es) 2014-03-31
CR20130693A (es) 2016-05-02
CU20130168A7 (es) 2014-04-24
DOP2013000314A (es) 2014-04-15

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