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EA201290894A1 - Азетидиновые производные пиперидин-4-ила как ингибиторы jak1 - Google Patents

Азетидиновые производные пиперидин-4-ила как ингибиторы jak1

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Publication number
EA201290894A1
EA201290894A1 EA201290894A EA201290894A EA201290894A1 EA 201290894 A1 EA201290894 A1 EA 201290894A1 EA 201290894 A EA201290894 A EA 201290894A EA 201290894 A EA201290894 A EA 201290894A EA 201290894 A1 EA201290894 A1 EA 201290894A1
Authority
EA
Eurasian Patent Office
Prior art keywords
piperidin
ila
azetidine derivatives
jak1
jak1 inhibitors
Prior art date
Application number
EA201290894A
Other languages
English (en)
Other versions
EA030376B1 (ru
Inventor
Тайшэн Хуан
Чу-Бяо Сюэ
Аньлай Ван
Лин Кун
Хай Фэнь Е
Вэньцин Яо
Джеймс Д. Роджерс
Стейси Шепард
Хайшэн Ван
Лисинь Шао
Хой-Инь Ли
Цюнь Ли
Original Assignee
Инсайт Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44065466&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201290894(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Инсайт Корпорейшн filed Critical Инсайт Корпорейшн
Publication of EA201290894A1 publication Critical patent/EA201290894A1/ru
Publication of EA030376B1 publication Critical patent/EA030376B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
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    • A61K9/0048—Eye, e.g. artificial tears
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В изобретении представлены азетидиновые производные пиперидин-4-ила, а также их композиции и способы их применения, которые модулируют активность Янус-киназы 1 (JAK1) и являются полезными для лечения заболеваний, связанных с активностью JAK1, включая, например, воспалительные нарушения, аутоиммунные нарушения, рак и другие заболевания.
EA201290894A 2010-03-10 2011-03-09 Азетидиновые производные пиперидин-4-ила как ингибиторы jak1 EA030376B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31258810P 2010-03-10 2010-03-10
US41560210P 2010-11-19 2010-11-19
PCT/US2011/027665 WO2011112662A1 (en) 2010-03-10 2011-03-09 Piperidin-4-yl azetidine derivatives as jak1 inhibitors

Publications (2)

Publication Number Publication Date
EA201290894A1 true EA201290894A1 (ru) 2013-04-30
EA030376B1 EA030376B1 (ru) 2018-07-31

Family

ID=44065466

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290894A EA030376B1 (ru) 2010-03-10 2011-03-09 Азетидиновые производные пиперидин-4-ила как ингибиторы jak1

Country Status (38)

Country Link
US (6) US8765734B2 (ru)
EP (6) EP2545045B1 (ru)
JP (6) JP5858484B2 (ru)
KR (7) KR102283091B1 (ru)
CN (1) CN102985417B (ru)
AR (1) AR081315A1 (ru)
AU (1) AU2011224484A1 (ru)
BR (1) BR112012022513A2 (ru)
CA (1) CA2792508C (ru)
CL (1) CL2012002501A1 (ru)
CO (1) CO6602158A2 (ru)
CR (1) CR20120510A (ru)
CY (2) CY1120154T1 (ru)
DK (3) DK3354652T3 (ru)
EA (1) EA030376B1 (ru)
EC (1) ECSP12012218A (ru)
ES (5) ES2982015T3 (ru)
HK (2) HK1177741A1 (ru)
HR (3) HRP20160326T1 (ru)
HU (3) HUE028723T2 (ru)
IL (1) IL221823A (ru)
LT (2) LT3050882T (ru)
ME (2) ME02386B (ru)
MX (5) MX364636B (ru)
MY (2) MY175156A (ru)
NO (1) NO3050882T3 (ru)
NZ (1) NZ602313A (ru)
PE (1) PE20130038A1 (ru)
PH (1) PH12015502575A1 (ru)
PL (3) PL3050882T3 (ru)
PT (2) PT3354652T (ru)
RS (3) RS60680B1 (ru)
SG (1) SG183551A1 (ru)
SI (3) SI2545045T1 (ru)
SM (1) SMT201600085B (ru)
TW (6) TWI592413B (ru)
WO (1) WO2011112662A1 (ru)
ZA (1) ZA201207420B (ru)

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