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EA201200318A1 - Гетероциклические оксимы - Google Patents

Гетероциклические оксимы

Info

Publication number
EA201200318A1
EA201200318A1 EA201200318A EA201200318A EA201200318A1 EA 201200318 A1 EA201200318 A1 EA 201200318A1 EA 201200318 A EA201200318 A EA 201200318A EA 201200318 A EA201200318 A EA 201200318A EA 201200318 A1 EA201200318 A1 EA 201200318A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compound
treatment
diseases
heterocyclic oximes
Prior art date
Application number
EA201200318A
Other languages
English (en)
Inventor
Мяо Дай
Синнянь Фу
Фэн Хэ
Лэй Цзян
Юй Ли
Фан Лян
Лэй Лю
Юань Ми
Яочан Сюй
Гуолян Хунь
Сяокся Янь
Чжэнтянь Ю
Цзи Ю Чжан
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201200318A1 publication Critical patent/EA201200318A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В заявке описаны соединения формулы (I) и их соли:где заместители являются такими, как определено в описании; соединение формулы (I), предназначенное для применения для лечения организма человека или животного, в частности заболеваний или патологических состояний, опосредуемых тирозинкиназой c-Met; применение соединения формулы (I) для приготовления лекарственного средства, предназначенного для лечения таких заболеваний; фармацевтические композиции, включающие соединение формулы (I) необязательно в присутствии компонента комбинации, и способы получения соединения формулы (I).
EA201200318A 2009-08-20 2010-08-18 Гетероциклические оксимы EA201200318A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23544009P 2009-08-20 2009-08-20
CN2010071978 2010-04-21
CN2010074089 2010-06-18
PCT/EP2010/062057 WO2011020861A1 (en) 2009-08-20 2010-08-18 Heterocyclic oxime compounds

Publications (1)

Publication Number Publication Date
EA201200318A1 true EA201200318A1 (ru) 2012-09-28

Family

ID=43243152

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200318A EA201200318A1 (ru) 2009-08-20 2010-08-18 Гетероциклические оксимы

Country Status (14)

Country Link
US (2) US8410264B2 (ru)
EP (1) EP2467383A1 (ru)
JP (1) JP5775871B2 (ru)
KR (1) KR20120089463A (ru)
AR (1) AR079486A1 (ru)
AU (1) AU2010284972A1 (ru)
BR (1) BR112012008061A2 (ru)
CA (1) CA2771432A1 (ru)
EA (1) EA201200318A1 (ru)
IN (1) IN2012DN01453A (ru)
MX (1) MX2012002179A (ru)
TW (1) TW201113284A (ru)
UY (1) UY32848A (ru)
WO (1) WO2011020861A1 (ru)

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CN106432225B (zh) * 2009-12-31 2019-02-19 和记黄埔医药（上海）有限公司 某些三唑并吡啶化合物和三唑并吡嗪化合物、其组合物和其使用方法
EP3450432A1 (en) 2010-05-17 2019-03-06 Incozen Therapeutics Pvt. Ltd. Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued - 3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of protein kinases
CN103459396B (zh) * 2011-02-10 2015-08-19 诺瓦提斯公司 作为c-Met酪氨酸激酶抑制剂的[1,2,4]三唑并[4,3-b]哒嗪化合物
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US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
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US20120302570A1 (en) 2012-11-29
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TW201113284A (en) 2011-04-16
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BR112012008061A2 (pt) 2016-03-01
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US8410264B2 (en) 2013-04-02
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