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EA201000331A1 - 1',3-двузамещенные 4-(арил-х-фенил)-1h-пиридин-2-оны - Google Patents

1',3-двузамещенные 4-(арил-х-фенил)-1h-пиридин-2-оны

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Publication number
EA201000331A1
EA201000331A1 EA201000331A EA201000331A EA201000331A1 EA 201000331 A1 EA201000331 A1 EA 201000331A1 EA 201000331 A EA201000331 A EA 201000331A EA 201000331 A EA201000331 A EA 201000331A EA 201000331 A1 EA201000331 A1 EA 201000331A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
mglur2
diseases
involved
dublocated
Prior art date
Application number
EA201000331A
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English (en)
Other versions
EA019085B1 (ru
Inventor
Хосе Мария Сид-Нуньес
Андрес Авелино Трабанко-Суарес
Грегор Джеймс Макдональд
Гийом Альбер Жак Дювей
Роберт Иоганнес Лютьенс
Терри Патрик Финн
Original Assignee
Орто-Макнейл-Янссен Фармасьютикалз, Инк.
Аддекс Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Орто-Макнейл-Янссен Фармасьютикалз, Инк., Аддекс Фарма С.А. filed Critical Орто-Макнейл-Янссен Фармасьютикалз, Инк.
Publication of EA201000331A1 publication Critical patent/EA201000331A1/ru
Publication of EA019085B1 publication Critical patent/EA019085B1/ru

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

Настоящее изобретение относится к новым соединениям, в частности, к новым производным пиридинона формулы (I), где все радикалы такие, как определено в заявке и в формуле изобретения. Соединения по изобретению являются положительными аллостерическими модуляторами метаботропных рецепторов подтипа 2 ("mGluR2"), которые полезны для лечения или предупреждения неврологических и психиатрических расстройств, связанных с глутаматной дисфункцией, и заболеваний, в которые вовлечен подтип mGluR2 метаботропных рецепторов. В частности, такие заболевания представляют собой расстройства центральной нервной системы, выбранные из группы: тревога, шизофрения, мигрень, депрессия и эпилепсия. Изобретение также направлено на фармацевтические композиции и способы получения таких соединений и композиций, а также на использование таких соединений для предупреждения и лечения заболеваний, в которые вовлечен mGluR2.
EA201000331A 2007-09-14 2008-09-12 1',3-двузамещенные 4-(арил-х-фенил)-1н-пиридин-2-оны EA019085B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07116388 2007-09-14
PCT/EP2008/007549 WO2009033702A1 (en) 2007-09-14 2008-09-12 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones

Publications (2)

Publication Number Publication Date
EA201000331A1 true EA201000331A1 (ru) 2011-02-28
EA019085B1 EA019085B1 (ru) 2014-01-30

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US (2) US8252937B2 (ru)
EP (1) EP2200985B1 (ru)
JP (1) JP5366269B2 (ru)
KR (1) KR20100065191A (ru)
CN (1) CN101848893B (ru)
AR (1) AR068512A1 (ru)
AT (1) ATE516272T1 (ru)
AU (1) AU2008297876B2 (ru)
BR (1) BRPI0817101A2 (ru)
CA (1) CA2697399C (ru)
CL (1) CL2008002746A1 (ru)
DK (1) DK2200985T3 (ru)
EA (1) EA019085B1 (ru)
ES (1) ES2365966T3 (ru)
HK (1) HK1144159A1 (ru)
MX (1) MX2010002538A (ru)
NZ (1) NZ584152A (ru)
PL (1) PL2200985T3 (ru)
PT (1) PT2200985E (ru)
TW (1) TW200922566A (ru)
WO (1) WO2009033702A1 (ru)
ZA (1) ZA201001221B (ru)

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