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EA200870555A1 - Слитые белки, их применение и способы их получения - Google Patents

Слитые белки, их применение и способы их получения

Info

Publication number
EA200870555A1
EA200870555A1 EA200870555A EA200870555A EA200870555A1 EA 200870555 A1 EA200870555 A1 EA 200870555A1 EA 200870555 A EA200870555 A EA 200870555A EA 200870555 A EA200870555 A EA 200870555A EA 200870555 A1 EA200870555 A1 EA 200870555A1
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EA
Eurasian Patent Office
Prior art keywords
proteins
amino acids
peptide
present
peptide linker
Prior art date
Application number
EA200870555A
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English (en)
Inventor
Йорам Рейтер
Рой Ной
Кфир Овед
Original Assignee
Тева Фармасьютикал Индастриз, Лтд.
Текнион Рисерч Энд Дивелопмент Фаундейшн Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Тева Фармасьютикал Индастриз, Лтд., Текнион Рисерч Энд Дивелопмент Фаундейшн Лтд. filed Critical Тева Фармасьютикал Индастриз, Лтд.
Publication of EA200870555A1 publication Critical patent/EA200870555A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Настоящее изобретение относится к слитому белку, содержащему последовательные аминокислоты, которые, начиная с аминоконца белка, соответствуют последовательным аминокислотам, присутствующим в (i) пептиде цитомегаловируса человека, рестриктированному по МНС, (ii) первом пептидном линкере, (iii) β-2-микроглобулине человека, (iv) втором пептидном линкере, (v) цепи HLA-A2 молекулы МНС человека класса I, (vi) третьем пептидном линкере, (vii) вариабельной области тяжелой цепи фрагмента scFv антитела и (viii) вариабельной области легкой цепи такого фрагмента scFv, причем последовательные аминокислоты, соответствующие (vii) и (viii), непосредственно связаны друг с другом пептидной связью или с помощью последовательных аминокислот, соответствующих четвертому пептидному линкеру, и антитело, из которого происходит фрагмент scFv, специфически связывается с мезотелином. Настоящее изобретение относится к конструкции нуклеиновых кислот, кодирующих указанные слитые белки, способам продуцирования указанных слитых белов, композиции и применению указанных слитых белов.
EA200870555A 2006-05-19 2007-05-17 Слитые белки, их применение и способы их получения EA200870555A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80179806P 2006-05-19 2006-05-19
PCT/US2007/011953 WO2007136778A2 (en) 2006-05-19 2007-05-17 Fusion proteins, uses thereof and processes for producing same

Publications (1)

Publication Number Publication Date
EA200870555A1 true EA200870555A1 (ru) 2009-04-28

Family

ID=38723866

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870555A EA200870555A1 (ru) 2006-05-19 2007-05-17 Слитые белки, их применение и способы их получения

Country Status (16)

Country Link
US (4) US7977457B2 (ru)
EP (1) EP2024507B1 (ru)
JP (1) JP5225266B2 (ru)
KR (1) KR101442209B1 (ru)
CN (1) CN101448951B (ru)
AU (1) AU2007254167B2 (ru)
BR (1) BRPI0712716A2 (ru)
CA (1) CA2652538C (ru)
EA (1) EA200870555A1 (ru)
ES (1) ES2549128T3 (ru)
HK (1) HK1122335A1 (ru)
IL (1) IL195191A (ru)
MX (1) MX2008014722A (ru)
NO (1) NO342211B1 (ru)
WO (1) WO2007136778A2 (ru)
ZA (1) ZA200810677B (ru)

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