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EA200801220A1 - 3-аминоциклопентанекарбоксамиды в качестве модуляторов хемокиновых рецепторов - Google Patents

3-аминоциклопентанекарбоксамиды в качестве модуляторов хемокиновых рецепторов

Info

Publication number
EA200801220A1
EA200801220A1 EA200801220A EA200801220A EA200801220A1 EA 200801220 A1 EA200801220 A1 EA 200801220A1 EA 200801220 A EA200801220 A EA 200801220A EA 200801220 A EA200801220 A EA 200801220A EA 200801220 A1 EA200801220 A1 EA 200801220A1
Authority
EA
Eurasian Patent Office
Prior art keywords
chemokine receptor
aminocyclopentanecarboxamides
receptor modulators
compounds
modulators
Prior art date
Application number
EA200801220A
Other languages
English (en)
Inventor
Чу-Бьяо Ксуе
Original Assignee
Инсайт Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38126410&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200801220(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Инсайт Корпорейшн filed Critical Инсайт Корпорейшн
Publication of EA200801220A1 publication Critical patent/EA200801220A1/ru

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  • Chemical & Material Sciences (AREA)
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Abstract

Настоящее изобретение направлено на соединения формулы I, которые являются модуляторами хемокиновых рецепторов. Соединения по изобретению и их композиции полезны в лечении заболеваний, связанных с экспрессией и/или активностью хемокинового рецептора.
EA200801220A 2005-12-21 2006-12-18 3-аминоциклопентанекарбоксамиды в качестве модуляторов хемокиновых рецепторов EA200801220A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75247705P 2005-12-21 2005-12-21
US75232005P 2005-12-21 2005-12-21
PCT/IB2006/003739 WO2007072201A2 (en) 2005-12-21 2006-12-18 3-aminocyclopentanecarboxamides as modulators of chemokine receptors

Publications (1)

Publication Number Publication Date
EA200801220A1 true EA200801220A1 (ru) 2008-12-30

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ID=38126410

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801220A EA200801220A1 (ru) 2005-12-21 2006-12-18 3-аминоциклопентанекарбоксамиды в качестве модуляторов хемокиновых рецепторов

Country Status (21)

Country Link
US (2) US7700624B2 (ru)
EP (1) EP1971576A2 (ru)
JP (1) JP2009520809A (ru)
KR (1) KR20080070868A (ru)
AP (1) AP2008004487A0 (ru)
AR (1) AR058402A1 (ru)
AU (1) AU2006327823A1 (ru)
BR (1) BRPI0620073A2 (ru)
CA (1) CA2634636A1 (ru)
CR (1) CR10060A (ru)
EA (1) EA200801220A1 (ru)
EC (1) ECSP088527A (ru)
IL (1) IL191602A0 (ru)
MA (1) MA30077B1 (ru)
ME (1) MEP1008A (ru)
NL (1) NL2000380C2 (ru)
NO (1) NO20082285L (ru)
RS (1) RS20080246A (ru)
TW (1) TW200734323A (ru)
UY (1) UY30052A1 (ru)
WO (1) WO2007072201A2 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1565436B1 (en) * 2002-11-27 2012-04-25 Incyte Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
HU229709B1 (en) * 2004-04-13 2014-05-28 Incyte Corp Wilmington Piperazinyilpiperidine derivatives as chemokine receptor antagonists
ES2614117T3 (es) * 2004-06-28 2017-05-29 Incyte Holdings Corporation Minociclopentanecarboxamidas como moduladores de receptores de chemokina
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
WO2007053498A1 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
MEP1008A (xx) * 2005-12-21 2010-02-10 Incyte Corp 3-aminociklopentankarboksamidi kao modulatori receptora hemokina
US7910108B2 (en) 2006-06-05 2011-03-22 Incyte Corporation Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases
NZ592919A (en) 2008-11-26 2013-05-31 Pfizer 3-aminocyclopentanecarboxamides as chemokine receptor modulators
EP2721025B1 (en) * 2011-06-16 2015-11-25 Boehringer Ingelheim International Gmbh New selective ccr2 antagonists
TW201613864A (en) 2014-02-20 2016-04-16 Takeda Pharmaceutical Novel compounds
PL3177612T3 (pl) 2014-08-04 2022-08-08 Nuevolution A/S Opcjonalnie skondensowane pochodne pirymidyny podstawione heterocyklilem, użyteczne w leczeniu chorób zapalnych, metabolicznych, onkologicznych i autoimmunologicznych
AU2020405446A1 (en) 2019-12-20 2022-05-26 Nuevolution A/S Compounds active towards nuclear receptors
EP4126874A1 (en) 2020-03-31 2023-02-08 Nuevolution A/S Compounds active towards nuclear receptors
AU2021249530A1 (en) 2020-03-31 2022-12-01 Nuevolution A/S Compounds active towards nuclear receptors

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811310A (en) 1986-09-30 1998-09-22 Albert Einstein College Of Medicine Of Yeshiva Univ. The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease
AU693143B2 (en) 1993-12-06 1998-06-25 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
US5510332A (en) * 1994-07-07 1996-04-23 Texas Biotechnology Corporation Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor
JPH10506608A (ja) 1994-07-11 1998-06-30 アセナ ニューロサイエンシーズ，インコーポレイテッド 白血球接着のインヒビター
GB9524630D0 (en) 1994-12-24 1996-01-31 Zeneca Ltd Chemical compounds
WO1996031206A2 (en) 1995-04-07 1996-10-10 Warner-Lambert Company Flavones and coumarins as agents for the treatment of atherosclerosis
EP1001764A4 (en) 1997-05-29 2005-08-24 Merck & Co Inc Heterocyclic amides as cell adhesion inhibitors
AU726585B2 (en) 1997-05-29 2000-11-09 Merck & Co., Inc. Biarylalkanoic acids as cell adhesion inhibitors
ATE256699T1 (de) 1997-05-30 2004-01-15 Celltech Therapeutics Ltd Entzündungshemmende tyrosin-derivate
US7557120B2 (en) * 2003-02-24 2009-07-07 Merck & Co., Inc. Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity
CA2532102A1 (en) * 2003-07-15 2005-02-03 Merck & Co., Inc. 7 and 8 membered heterocyclic cyclopentyl benzylamide modulators of chemokine receptor activity
AU2004313486A1 (en) 2004-01-02 2005-07-28 Merck & Co., Inc. Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
CA2564499A1 (en) * 2004-04-26 2005-12-22 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahy-dropyridopyridine modulators of chemokine receptor activity
WO2005115392A2 (en) * 2004-05-11 2005-12-08 Incyte Corporation 3-(4-heteroarylcyclohexylamino) cyclopentanecarboxamides as modulators of chemokine receptors
NZ551673A (en) * 2004-06-28 2010-11-26 Incyte Corp 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors
ES2614117T3 (es) * 2004-06-28 2017-05-29 Incyte Holdings Corporation Minociclopentanecarboxamidas como moduladores de receptores de chemokina
MEP1008A (xx) * 2005-12-21 2010-02-10 Incyte Corp 3-aminociklopentankarboksamidi kao modulatori receptora hemokina

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TW200734323A (en) 2007-09-16
JP2009520809A (ja) 2009-05-28
NO20082285L (no) 2008-06-18
MA30077B1 (fr) 2008-12-01
US20100203039A1 (en) 2010-08-12
RS20080246A (en) 2009-07-15
US7700624B2 (en) 2010-04-20
EP1971576A2 (en) 2008-09-24
BRPI0620073A2 (pt) 2011-11-01
ECSP088527A (es) 2008-07-30
KR20080070868A (ko) 2008-07-31
CR10060A (es) 2008-07-17
MEP1008A (xx) 2010-02-10
AR058402A1 (es) 2008-01-30
UY30052A1 (es) 2007-07-31
WO2007072201A2 (en) 2007-06-28
CA2634636A1 (en) 2007-06-28
IL191602A0 (en) 2009-02-11
NL2000380C2 (nl) 2007-11-28
AU2006327823A1 (en) 2007-06-28
US20070149532A1 (en) 2007-06-28
WO2007072201A3 (en) 2007-10-04

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