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EA200702604A1 - Derivatives of benzofuranone as a non-steroidal modulator of the progesterone receptor - Google Patents

Derivatives of benzofuranone as a non-steroidal modulator of the progesterone receptor

Info

Publication number
EA200702604A1
EA200702604A1 EA200702604A EA200702604A EA200702604A1 EA 200702604 A1 EA200702604 A1 EA 200702604A1 EA 200702604 A EA200702604 A EA 200702604A EA 200702604 A EA200702604 A EA 200702604A EA 200702604 A1 EA200702604 A1 EA 200702604A1
Authority
EA
Eurasian Patent Office
Prior art keywords
progesterone receptor
steroidal
benzofuranone
modulator
derivatives
Prior art date
Application number
EA200702604A
Other languages
Russian (ru)
Inventor
Вольфганг Шведе
Карстен Мёллер
Аня Шмидт
Ульрике Фурманн
Норберт Шмеес
Ульрих Боте
Original Assignee
Байер Шеринг Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байер Шеринг Фарма Акциенгезельшафт filed Critical Байер Шеринг Фарма Акциенгезельшафт
Publication of EA200702604A1 publication Critical patent/EA200702604A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)

Abstract

Это изобретение касается нестероидных модуляторов рецептора прогестерона общей формулы Iспособа их получения, применения модуляторов рецептора прогестерона для получения фармацевтических агентов и фармацевтических композиций содержащих эти соединения. Соединения в соответствии с изобретением пригодны для лечения и профилактики гинекологических расстройств, таких как эндометриоз, леиомиома матки, дисфункциональное кровотечение и дисменорея, а также для лечения и профилактики гормонозависимых опухолей и для применения для контроля женской фертильности и для гормонзаместительной терапии.This invention relates to non-steroidal progesterone receptor modulators of the general formula I of the method for their preparation, the use of progesterone receptor modulators to obtain pharmaceutical agents and pharmaceutical compositions containing these compounds. The compounds of the invention are suitable for the treatment and prevention of gynecological disorders such as endometriosis, uterine leiomyoma, dysfunctional bleeding and dysmenorrhea, as well as for the treatment and prevention of hormone-dependent tumors and for use in controlling female fertility and hormone replacement therapy.

EA200702604A 2005-06-24 2006-06-22 Derivatives of benzofuranone as a non-steroidal modulator of the progesterone receptor EA200702604A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005030294A DE102005030294A1 (en) 2005-06-24 2005-06-24 Nonsteroidal progesterone receptor modulators
PCT/EP2006/006532 WO2006136462A1 (en) 2005-06-24 2006-06-22 Benzofuranone derivatives as nonsteroidal progesterone receptor modulators

Publications (1)

Publication Number Publication Date
EA200702604A1 true EA200702604A1 (en) 2008-06-30

Family

ID=36716643

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702604A EA200702604A1 (en) 2005-06-24 2006-06-22 Derivatives of benzofuranone as a non-steroidal modulator of the progesterone receptor

Country Status (22)

Country Link
EP (1) EP1899315A1 (en)
JP (1) JP2008543911A (en)
KR (1) KR20080018275A (en)
CN (1) CN101248056A (en)
AR (1) AR057409A1 (en)
AU (1) AU2006261049A1 (en)
BR (1) BRPI0612305A2 (en)
CA (1) CA2611900A1 (en)
CR (1) CR9595A (en)
DE (1) DE102005030294A1 (en)
DO (1) DOP2006000150A (en)
EA (1) EA200702604A1 (en)
EC (1) ECSP078043A (en)
GT (1) GT200600272A (en)
IL (1) IL188022A0 (en)
MX (1) MX2008000070A (en)
NO (1) NO20080441L (en)
PE (1) PE20070170A1 (en)
TW (1) TW200738665A (en)
UY (1) UY29626A1 (en)
WO (1) WO2006136462A1 (en)
ZA (1) ZA200800689B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30805A1 (en) * 2006-12-21 2008-07-31 Bayer Schering Pharma Ag NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS
DE102007032800A1 (en) * 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nonsteroidal progesterone receptor modulators
DE102007058747A1 (en) 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nonsteroidal progesterone receptor modulators
TWI477276B (en) * 2008-04-28 2015-03-21 Repros Therapeutics Inc Antiprogestin dosing regimens
WO2013181449A1 (en) 2012-05-31 2013-12-05 Repros Therapeutics Inc. Formulations and methods for vaginal delivery of antiprogestins
EP2914268B1 (en) 2012-11-02 2018-07-04 Repros Therapeutics Inc. Methods and compositions for treating progesterone-dependent conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19723722A1 (en) * 1997-05-30 1998-12-10 Schering Ag Nonsteroidal progestogens
AU4501800A (en) * 1999-05-04 2000-11-17 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods
US6358948B1 (en) * 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
AU2003202216A1 (en) * 2002-01-14 2003-07-30 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof
EP1482925B1 (en) * 2002-03-11 2007-01-17 Schering AG 5-(2-hydroxy-3-'1-(3-trifluoromethylphenyl)-cyclopropl]-propionylamino)-phtalide and related compounds with progesterone receptor modulating activity for use in fertility control and hormone replacement therapy
DE10346939A1 (en) * 2003-10-06 2005-05-19 Schering Ag New arylalkanol derivatives used for treating e.g. respiratory diseases, joint diseases, vascular inflammations, skin disorders, kidney and liver diseases and neurological diseases

Also Published As

Publication number Publication date
CN101248056A (en) 2008-08-20
MX2008000070A (en) 2008-03-19
AR057409A1 (en) 2007-12-05
AU2006261049A1 (en) 2006-12-28
GT200600272A (en) 2007-08-20
TW200738665A (en) 2007-10-16
UY29626A1 (en) 2007-01-31
ZA200800689B (en) 2009-07-29
IL188022A0 (en) 2008-03-20
EP1899315A1 (en) 2008-03-19
DOP2006000150A (en) 2006-12-31
WO2006136462A1 (en) 2006-12-28
KR20080018275A (en) 2008-02-27
ECSP078043A (en) 2008-01-23
JP2008543911A (en) 2008-12-04
BRPI0612305A2 (en) 2010-11-03
DE102005030294A1 (en) 2007-01-04
NO20080441L (en) 2008-03-07
PE20070170A1 (en) 2007-03-02
CA2611900A1 (en) 2006-12-28
CR9595A (en) 2008-05-05

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