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EA200000749A1 - Ароматические амиды, способ их получения и их применение в качестве лекарственных средств - Google Patents

Ароматические амиды, способ их получения и их применение в качестве лекарственных средств

Info

Publication number
EA200000749A1
EA200000749A1 EA200000749A EA200000749A EA200000749A1 EA 200000749 A1 EA200000749 A1 EA 200000749A1 EA 200000749 A EA200000749 A EA 200000749A EA 200000749 A EA200000749 A EA 200000749A EA 200000749 A1 EA200000749 A1 EA 200000749A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
hydrogen
halogen
medicine
production
Prior art date
Application number
EA200000749A
Other languages
English (en)
Other versions
EA003275B1 (ru
Inventor
Жан-Люк Асслейн
Мишель Клиш
Патрик Лорэн
Бранислав Мусицки
Анн-Мари Перье
Original Assignee
Хехст Марион Руссель
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9800116A external-priority patent/FR2773369B1/fr
Priority claimed from FR9812936A external-priority patent/FR2784681B1/fr
Application filed by Хехст Марион Руссель filed Critical Хехст Марион Руссель
Publication of EA200000749A1 publication Critical patent/EA200000749A1/ru
Publication of EA003275B1 publication Critical patent/EA003275B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Объектом настоящего изобретения являются соединения формулы (I), в которой: Y - кислород, N-Nалкили NOалкX - водород, гидроксил, алкил, алкенил, алкинил, алкокси CONOR или NRcRd, Rc и Rd - водород или алкил; Z - водород, галоген или свободный, превращенный в простой или сложный эфир OH; R- водород или галоген; R- водород, алкил или галоген; R - водород или алкил; R- водород, алкил или алкинил; R- водород или O-алкил; R- алкил или CH-O-алкил и R- водород или алкил, или Rи Rобразуют с атомом углерода, который их несет, циклический радикал, содержащий до 8 атомов углерода. Соединения формулы (I) имеют антибиотические свойства.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000749A 1998-01-08 1999-01-07 Ароматические амиды, способ их получения и их применение в качестве лекарственных средств EA003275B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9800116A FR2773369B1 (fr) 1998-01-08 1998-01-08 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments
FR9812936A FR2784681B1 (fr) 1998-10-15 1998-10-15 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments
PCT/FR1999/000014 WO1999035155A1 (fr) 1998-01-08 1999-01-07 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
EA200000749A1 true EA200000749A1 (ru) 2000-12-25
EA003275B1 EA003275B1 (ru) 2003-04-24

Family

ID=26234055

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000749A EA003275B1 (ru) 1998-01-08 1999-01-07 Ароматические амиды, способ их получения и их применение в качестве лекарственных средств

Country Status (36)

Country Link
US (2) US6420538B1 (ru)
EP (1) EP1045856B1 (ru)
JP (1) JP2002500229A (ru)
KR (1) KR100604290B1 (ru)
CN (2) CN1269833C (ru)
AP (1) AP2000001857A0 (ru)
AR (1) AR015211A1 (ru)
AT (1) ATE236918T1 (ru)
AU (1) AU750742B2 (ru)
BR (1) BR9906819A (ru)
CA (1) CA2317951A1 (ru)
CO (1) CO4810298A1 (ru)
CZ (1) CZ299840B6 (ru)
DE (1) DE69906684T2 (ru)
DK (1) DK1045856T3 (ru)
DZ (1) DZ2702A1 (ru)
EA (1) EA003275B1 (ru)
ES (1) ES2192031T3 (ru)
HU (1) HUP0100847A3 (ru)
ID (1) ID27558A (ru)
IL (1) IL137201A0 (ru)
MA (1) MA26593A1 (ru)
NO (1) NO20003496L (ru)
NZ (1) NZ505523A (ru)
PA (1) PA8466601A1 (ru)
PE (1) PE20000175A1 (ru)
PL (1) PL193130B1 (ru)
PT (1) PT1045856E (ru)
RS (1) RS50047B (ru)
SA (1) SA99191247B1 (ru)
SI (1) SI1045856T1 (ru)
SK (1) SK284734B6 (ru)
TN (1) TNSN99003A1 (ru)
TR (1) TR200002009T2 (ru)
TW (1) TW538046B (ru)
WO (1) WO1999035155A1 (ru)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2749585B1 (fr) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
TW538046B (en) * 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof
US6916846B2 (en) 2000-05-12 2005-07-12 Merck & Co. Inc. Coumermycin analogs as chemical dimerizers of chimeric proteins
BR0116216A (pt) 2000-12-15 2004-08-17 Vertex Pharma Inibidores de girase e seus usos
FR2844273B1 (fr) * 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US7618974B2 (en) 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7582641B2 (en) 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8404852B2 (en) 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8193352B2 (en) 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (es) 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
US7569591B2 (en) 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
TW201026694A (en) 2008-12-12 2010-07-16 Astrazeneca Ab Compound 468
US8071605B2 (en) 2008-12-12 2011-12-06 Astrazeneca Ab Piperidine compounds for use in the treatment of bacterial infections
TW201102065A (en) 2009-05-29 2011-01-16 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
UY32856A (es) 2009-08-26 2011-03-31 Astrazeneca Ab Derivados heterocíclicos de urea y métodos de uso de los mismos
US8859620B2 (en) 2009-08-31 2014-10-14 University Of Notre Dame Du Lac Phthalanilate compounds and methods of use
TWI535714B (zh) 2011-01-14 2016-06-01 維泰克斯製藥公司 旋轉酶抑制劑（ｒ）－１－乙基－３－［６－氟－５－［２－（１－羥基－１－甲基－乙基）嘧啶－５－基］－７－（四氫呋喃－２－基）－１ｈ－苯并咪唑－２－基］脲之固體形式
EP2663556B1 (en) 2011-01-14 2014-10-15 Vertex Pharmaceuticals Incorporated Process of making gyrase and topoisomerase iv inhibitors
CN103384666A (zh) 2011-01-14 2013-11-06 沃泰克斯药物股份有限公司 固体形式的促旋酶抑制剂（r）-1-乙基-3-[5-[2-（1-羟基-1-甲基-乙基）嘧啶-5-基]-7-（四氢呋喃-2-基）-1氢-苯并咪唑-2-基]脲
CA2824516C (en) 2011-01-14 2019-02-26 Vertex Pharmaceuticals Incorporated Pyrimidine gyrase and topoisomerase iv inhibitors
CN103702994B (zh) 2011-06-20 2016-03-23 沃泰克斯药物股份有限公司 旋转酶和拓扑异构酶抑制剂的磷酸酯
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
US9018216B2 (en) 2012-07-18 2015-04-28 Vertex Pharmaceuticals Incorporated Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
WO2020048949A1 (en) 2018-09-03 2020-03-12 Univerza V Ljubljani New class of dna gyrase and/or topoisomerase iv inhibitors with activity against gram-positive and gram-negative bacteria
EP4263503A1 (en) 2020-12-17 2023-10-25 Univerza V Ljubljani New n-phenylpyrrolamide inhibitors of dna gyrase and topoisomerase iv with antibacterial activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226978A (en) 1978-03-13 1980-10-07 Miles Laboratories, Inc. β-Galactosyl-umbelliferone-labeled aminoglycoside antibiotics and intermediates in their preparation
CA2249471A1 (fr) 1996-03-20 1997-09-25 Hoechst Marion Roussel Composes tricycliques ayant une activite vis-a-vis des integrines notamment vis-a-vis de l'integrine alphavbeta3, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
FR2749585B1 (fr) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
TW538046B (en) * 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof

Also Published As

Publication number Publication date
ID27558A (id) 2001-04-12
BR9906819A (pt) 2000-10-17
AP2000001857A0 (en) 2000-09-30
KR20010033939A (ko) 2001-04-25
CN1502617A (zh) 2004-06-09
US20030060609A1 (en) 2003-03-27
MA26593A1 (fr) 2004-12-20
WO1999035155A1 (fr) 1999-07-15
HUP0100847A1 (hu) 2001-07-30
EP1045856B1 (fr) 2003-04-09
TNSN99003A1 (fr) 2005-11-10
PL341590A1 (en) 2001-04-23
PL193130B1 (pl) 2007-01-31
EA003275B1 (ru) 2003-04-24
SK10152000A3 (sk) 2001-07-10
CZ20002523A3 (cs) 2000-11-15
CN1269833C (zh) 2006-08-16
NO20003496L (no) 2000-09-08
PT1045856E (pt) 2003-08-29
TR200002009T2 (tr) 2001-05-21
NO20003496D0 (no) 2000-07-07
HUP0100847A3 (en) 2003-07-28
SK284734B6 (sk) 2005-10-06
IL137201A0 (en) 2001-07-24
CN1257164C (zh) 2006-05-24
ATE236918T1 (de) 2003-04-15
PE20000175A1 (es) 2000-03-09
CN1291988A (zh) 2001-04-18
KR100604290B1 (ko) 2006-07-28
CO4810298A1 (es) 1999-06-30
CA2317951A1 (fr) 1999-07-15
PA8466601A1 (es) 2000-05-24
DZ2702A1 (fr) 2003-09-01
CZ299840B6 (cs) 2008-12-10
TW538046B (en) 2003-06-21
ES2192031T3 (es) 2003-09-16
AU1973699A (en) 1999-07-26
US6420538B1 (en) 2002-07-16
US6583119B2 (en) 2003-06-24
JP2002500229A (ja) 2002-01-08
SI1045856T1 (en) 2003-08-31
NZ505523A (en) 2003-01-31
AU750742B2 (en) 2002-07-25
YU42700A (sh) 2002-12-10
DE69906684T2 (de) 2003-11-06
EP1045856A1 (fr) 2000-10-25
AR015211A1 (es) 2001-04-18
RS50047B (sr) 2008-11-28
DE69906684D1 (de) 2003-05-15
SA99191247B1 (ar) 2006-09-20
DK1045856T3 (da) 2003-07-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU