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EA199900187A1 - Лиганд, родственный фактору некроза опухоли - Google Patents

Лиганд, родственный фактору некроза опухоли

Info

Publication number
EA199900187A1
EA199900187A1 EA199900187A EA199900187A EA199900187A1 EA 199900187 A1 EA199900187 A1 EA 199900187A1 EA 199900187 A EA199900187 A EA 199900187A EA 199900187 A EA199900187 A EA 199900187A EA 199900187 A1 EA199900187 A1 EA 199900187A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tumor necrosis
necrosis factor
ligand
related tumor
trell
Prior art date
Application number
EA199900187A
Other languages
English (en)
Other versions
EA003187B1 (ru
Inventor
Ив Шишепортиш
Джеффри Л. Браунинг
Original Assignee
Байоджен, Инк.
Дзе Фэкелти Оф Медсин Оф Дзе Юниверсити Оф Женева
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байоджен, Инк., Дзе Фэкелти Оф Медсин Оф Дзе Юниверсити Оф Женева filed Critical Байоджен, Инк.
Publication of EA199900187A1 publication Critical patent/EA199900187A1/ru
Publication of EA003187B1 publication Critical patent/EA003187B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)

Abstract

Описаны лиганд, родственный фактору некроза опухоли (TRELL), новый член семейства факторов некроза опухоли (TNF), модифицированный TRELL, и содержащие их фармацевтические композиции.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900187A 1996-08-07 1997-08-07 Лиганд, родственный фактору некроза опухоли EA003187B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2354196P 1996-08-07 1996-08-07
US2851596P 1996-10-18 1996-10-18
US4082097P 1997-03-18 1997-03-18
PCT/US1997/013945 WO1998005783A1 (en) 1996-08-07 1997-08-07 A tumor necrosis factor related ligand

Publications (2)

Publication Number Publication Date
EA199900187A1 true EA199900187A1 (ru) 1999-08-26
EA003187B1 EA003187B1 (ru) 2003-02-27

Family

ID=27362110

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900187A EA003187B1 (ru) 1996-08-07 1997-08-07 Лиганд, родственный фактору некроза опухоли

Country Status (26)

Country Link
EP (2) EP0956351B1 (ru)
JP (3) JP4161084B2 (ru)
KR (1) KR100543730B1 (ru)
CN (2) CN101024831A (ru)
AT (1) ATE307204T1 (ru)
AU (1) AU736289B2 (ru)
BG (1) BG64779B1 (ru)
BR (1) BR9711046A (ru)
CA (1) CA2262756C (ru)
CZ (1) CZ297387B6 (ru)
DE (1) DE69734397T2 (ru)
DK (1) DK0956351T3 (ru)
EA (1) EA003187B1 (ru)
EE (1) EE05276B1 (ru)
ES (1) ES2251737T3 (ru)
HK (1) HK1025994A1 (ru)
HU (1) HU226787B1 (ru)
IL (1) IL128407A (ru)
IS (1) IS2606B (ru)
NO (2) NO326967B1 (ru)
NZ (1) NZ334107A (ru)
PL (1) PL188102B1 (ru)
SI (1) SI0956351T1 (ru)
SK (1) SK288012B6 (ru)
TR (1) TR199900903T2 (ru)
WO (1) WO1998005783A1 (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9376498A (en) * 1997-09-05 1999-03-22 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
JP2001522584A (ja) * 1997-10-10 2001-11-20 ジェネンテク・インコーポレイテッド Ａｐｏ−３リガンドポリペプチド
DE19829550C1 (de) * 1998-07-02 2000-01-27 Bosch Gmbh Robert Vorrichtung zum Verbinden von Bauteilen
SK10042001A3 (sk) * 1999-01-15 2001-12-03 Biogen, Inc. Farmaceutická kompozícia obsahujúca činidlo blokujúce proteín tweak alebo receptor tweak
WO2001035995A2 (en) * 1999-11-19 2001-05-25 Tittle Thomas V Tr3-specific binding agents and methods for their use
US6994976B1 (en) 1999-11-19 2006-02-07 Tittle Thomas V Tr3-specific binding agents and methods for their use
EP1239869B1 (en) * 1999-12-20 2013-08-28 Immunex Corporation Tweak receptor
US6727225B2 (en) 1999-12-20 2004-04-27 Immunex Corporation TWEAK receptor
US7495086B2 (en) 1999-12-20 2009-02-24 Immunex Corporation TWEAK receptor
NZ522741A (en) 2000-05-08 2005-06-24 Biogen Idec Inc Method for promoting neovascularization using a TWEAK agonist and an angiogenic factor, such as fibroblast growth factor and VEGF
US7208151B2 (en) 2001-09-12 2007-04-24 Biogen Idec Ma Inc. Tweak receptor agonists as anti-angiogenic agents
EP2301578A3 (en) 2002-04-09 2012-08-08 Biogen Idec MA Inc. Methods for treating TWEAK-related conditions
US20070010658A1 (en) * 2002-10-29 2007-01-11 Holtet Thor L Trimeric binding proteins for trimeric cytokines
EP2529619B1 (en) 2005-02-17 2015-09-23 Biogen MA Inc. Treating neurological disorders
EP1885388B1 (en) 2005-05-10 2013-09-11 Biogen Idec MA Inc. Treating and evaluating inflammatory disorders
DK1888113T3 (da) 2005-05-27 2014-09-01 Biogen Idec Inc Tweak-bindende antistoffer
WO2006138219A2 (en) 2005-06-13 2006-12-28 Biogen Idec Ma Inc. Methods of diagnosis / prognosis of inflammatory conditions
US8093006B2 (en) 2009-04-02 2012-01-10 Hoffmann-La Roche Inc. Antibodies against human tweak and uses thereof
MX343114B (es) 2010-10-05 2016-10-25 F Hoffmann-La Roche Ag * Anticuerpos contra la tweak humana y usos de los mismos.
EP2834273B1 (en) 2012-04-05 2018-08-22 F.Hoffmann-La Roche Ag Bispecific antibodies against human tweak and human il17 and uses thereof
US11028395B2 (en) * 2016-10-24 2021-06-08 Biois Co., Ltd. TNF-alpha-binding aptamer, and therapeutic use for same
US11447778B2 (en) * 2018-04-20 2022-09-20 Academia Sinica TNF-targeting aptamers and uses thereof for treatment or diagnosing TNF-related inflammatory diseases
JP2024516548A (ja) 2021-04-08 2024-04-16 ジョスリン ダイアビーティス センター インコーポレイテッド 腎機能低下の診断及び予測の方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5176996A (en) 1988-12-20 1993-01-05 Baylor College Of Medicine Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US5256775A (en) 1989-06-05 1993-10-26 Gilead Sciences, Inc. Exonuclease-resistant oligonucleotides
IE902820A1 (en) 1989-08-07 1991-02-27 Merck & Co Inc Peptide inhibitors of human papilloma virus protein binding¹to retinoblastoma gene proteins
US5264564A (en) 1989-10-24 1993-11-23 Gilead Sciences Oligonucleotide analogs with novel linkages
EP0531080A3 (en) 1991-09-04 1993-12-29 Merck & Co Inc Peptide inhibitors of human papilloma virus protein binding to retinoblastoma gene protein

Also Published As

Publication number Publication date
CN1308451C (zh) 2007-04-04
NO20084906L (no) 1999-04-06
TR199900903T2 (xx) 1999-06-21
KR100543730B1 (ko) 2006-01-23
NO326967B1 (no) 2009-03-23
AU736289B2 (en) 2001-07-26
SK288012B6 (sk) 2012-10-02
CZ40399A3 (cs) 1999-08-11
EP1591530A3 (en) 2009-04-08
JP2001505407A (ja) 2001-04-24
DE69734397T2 (de) 2006-07-06
IS4967A (is) 1999-02-05
EP0956351B1 (en) 2005-10-19
JP2009183294A (ja) 2009-08-20
CN101024831A (zh) 2007-08-29
NO990550L (no) 1999-04-06
HU226787B1 (en) 2009-10-28
EP0956351A1 (en) 1999-11-17
BR9711046A (pt) 2000-01-11
DE69734397D1 (de) 2006-03-02
EP1591530B8 (en) 2015-04-22
NZ334107A (en) 2000-06-23
ES2251737T3 (es) 2006-05-01
EE05276B1 (et) 2010-02-15
SI0956351T1 (sl) 2006-02-28
EP1591530B1 (en) 2015-02-25
EE9900043A (et) 1999-08-16
IL128407A (en) 2007-07-24
EP1591530A2 (en) 2005-11-02
AU3829497A (en) 1998-02-25
JP4411330B2 (ja) 2010-02-10
KR20000029877A (ko) 2000-05-25
DK0956351T3 (da) 2006-02-20
ATE307204T1 (de) 2005-11-15
IL128407A0 (en) 2000-01-31
WO1998005783A1 (en) 1998-02-12
JP4161084B2 (ja) 2008-10-08
CN1232503A (zh) 1999-10-20
PL331583A1 (en) 1999-07-19
NO990550D0 (no) 1999-02-05
BG64779B1 (bg) 2006-03-31
JP2007204480A (ja) 2007-08-16
HK1025994A1 (en) 2000-12-01
HUP9903921A2 (hu) 2000-03-28
HUP9903921A3 (en) 2000-08-28
CZ297387B6 (cs) 2006-11-15
SK15799A3 (en) 2000-03-13
IS2606B (is) 2010-04-15
EA003187B1 (ru) 2003-02-27
BG103169A (en) 2000-06-30
PL188102B1 (pl) 2004-12-31
CA2262756A1 (en) 1998-02-12
CA2262756C (en) 2012-06-12

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