EA032938B1 - Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения - Google Patents
Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его полученияInfo
- Publication number
- EA032938B1 EA032938B1 EA201792597A EA201792597A EA032938B1 EA 032938 B1 EA032938 B1 EA 032938B1 EA 201792597 A EA201792597 A EA 201792597A EA 201792597 A EA201792597 A EA 201792597A EA 032938 B1 EA032938 B1 EA 032938B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical composition
- compound
- composition based
- preparing same
- glutarimide derivative
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Изобретение относится к соединению формулыили его фармацевтически приемлемой соли, его применению в качестве средства для лечения заболеваний дыхательных путей, способу лечения заболеваний дыхательных путей, включающему введение пациенту указанного соединения, фармацевтической композиции, содержащей указанное соединение, и способу получения указанного соединения путем нагревания моноамида дикарбоновой кислоты формулыгде m, R, R, R, R, R, R, Rи Rопределены в формуле изобретения с водоотнимающим агентом в органическом растворителе.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2013116826A RU2562773C3 (ru) | 2013-04-12 | Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения |
Publications (3)
Publication Number | Publication Date |
---|---|
EA201792597A2 EA201792597A2 (ru) | 2018-04-30 |
EA201792597A3 EA201792597A3 (ru) | 2018-09-28 |
EA032938B1 true EA032938B1 (ru) | 2019-08-30 |
Family
ID=51689819
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201792071A EA033054B1 (ru) | 2013-04-12 | 2014-04-10 | Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения |
EA201792072A EA032951B1 (ru) | 2013-04-12 | 2014-04-10 | Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения |
EA201591957A EA031392B1 (ru) | 2013-04-12 | 2014-04-10 | Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения |
EA201792597A EA032938B1 (ru) | 2013-04-12 | 2014-04-10 | Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201792071A EA033054B1 (ru) | 2013-04-12 | 2014-04-10 | Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения |
EA201792072A EA032951B1 (ru) | 2013-04-12 | 2014-04-10 | Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения |
EA201591957A EA031392B1 (ru) | 2013-04-12 | 2014-04-10 | Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения |
Country Status (15)
Country | Link |
---|---|
US (8) | US9815814B2 (ru) |
EP (3) | EP2985282A4 (ru) |
JP (4) | JP6529958B2 (ru) |
KR (3) | KR102254315B1 (ru) |
CN (4) | CN110128406B (ru) |
AU (5) | AU2014251442A1 (ru) |
BR (3) | BR122020010204B1 (ru) |
CA (1) | CA2909057C (ru) |
EA (4) | EA033054B1 (ru) |
IL (4) | IL266301B2 (ru) |
MX (4) | MX2015014336A (ru) |
SG (4) | SG10201802647QA (ru) |
UA (1) | UA121299C2 (ru) |
WO (1) | WO2014168522A1 (ru) |
ZA (3) | ZA201508278B (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2015014336A (es) * | 2013-04-12 | 2016-06-07 | Obschestvo S Ogranichennoi Otveststvennostiyu Pharmentpr | Derivados de glutarimida, uso de los mismos, composicion farmaceutica basada en los mismos y metodos para producir derivados de glutarimida. |
RU2552929C1 (ru) * | 2013-11-14 | 2015-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний |
RU2628800C2 (ru) * | 2014-03-12 | 2017-08-22 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Амидные соединения, способы получения, применение в качестве средств для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами |
CN106539792B (zh) * | 2016-11-07 | 2017-08-25 | 王晓旭 | 一种治疗高血脂症的药物 |
CN111093661B (zh) * | 2017-09-07 | 2023-10-27 | 化学免疫疗法有限责任公司 | 戊二酰亚胺衍生物用于治疗与细胞因子的异常活性相关的疾病的用途 |
EP3873890A4 (en) * | 2018-11-01 | 2022-09-07 | Ahammune Biosciences Private Limited | NEW IMIDAZOLE COMPOUNDS, PROCESS FOR SYNTHESIS AND ASSOCIATED USES |
RU2712281C1 (ru) | 2018-11-23 | 2020-01-28 | Общество С Ограниченной Ответственностью "Хемиммьюн Терапьютикс" | Применение производного глутаримида для преодоления резистентности к стероидам и терапии заболеваний, ассоциированных с аберрантным сигналингом интерферона гамма |
WO2021262040A1 (ru) * | 2020-06-26 | 2021-12-30 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Применение производного глутаримида для терапии заболеваний, ассоциированных с аберрантной активностью интерлейкина-6 |
WO2023121519A1 (ru) * | 2021-12-23 | 2023-06-29 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Применение 1-[2-(1-метилимидазол-4-ил)-этил]пергидроазин-2,6-диона для лечения covid-19 |
WO2023177329A1 (ru) * | 2022-03-18 | 2023-09-21 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Применение 1-(2-(1н-имидазол-4-ил)этил)пиперидин-2,6-диона для лечения кашля, вызванного вирусными инфекциями |
WO2023191666A1 (ru) * | 2022-03-29 | 2023-10-05 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Кристаллическая форма 1-(2-(1н-имидазол-4-ил)этил)пиперидин-2,6-диона и ее применение |
WO2023249516A1 (ru) * | 2022-06-24 | 2023-12-28 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Новая кристаллическая форма 1-[2-(1-метилимидазол-4-ил)этил]пергидроазин-2,6-диона и ее фармацевтическое применение |
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MX2015014336A (es) | 2013-04-12 | 2016-06-07 | Obschestvo S Ogranichennoi Otveststvennostiyu Pharmentpr | Derivados de glutarimida, uso de los mismos, composicion farmaceutica basada en los mismos y metodos para producir derivados de glutarimida. |
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RU2552929C1 (ru) * | 2013-11-14 | 2015-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний |
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2014
- 2014-04-10 MX MX2015014336A patent/MX2015014336A/es unknown
- 2014-04-10 KR KR1020207016268A patent/KR102254315B1/ko active IP Right Grant
- 2014-04-10 EP EP14782170.6A patent/EP2985282A4/en not_active Withdrawn
- 2014-04-10 IL IL266301A patent/IL266301B2/en unknown
- 2014-04-10 EP EP20178489.9A patent/EP3722290B1/en active Active
- 2014-04-10 JP JP2016507512A patent/JP6529958B2/ja active Active
- 2014-04-10 MX MX2020005736A patent/MX2020005736A/es unknown
- 2014-04-10 CN CN201910437242.XA patent/CN110128406B/zh active Active
- 2014-04-10 BR BR122020010204-7A patent/BR122020010204B1/pt active IP Right Grant
- 2014-04-10 WO PCT/RU2014/000264 patent/WO2014168522A1/ru active Application Filing
- 2014-04-10 CA CA2909057A patent/CA2909057C/en active Active
- 2014-04-10 CN CN201910437241.5A patent/CN110229140B/zh active Active
- 2014-04-10 KR KR1020157032457A patent/KR102255929B1/ko active IP Right Grant
- 2014-04-10 EA EA201792071A patent/EA033054B1/ru unknown
- 2014-04-10 BR BR112015025804-2A patent/BR112015025804B1/pt not_active IP Right Cessation
- 2014-04-10 CN CN201480032755.8A patent/CN106061962B/zh not_active Expired - Fee Related
- 2014-04-10 MX MX2020005738A patent/MX2020005738A/es unknown
- 2014-04-10 MX MX2020005735A patent/MX2020005735A/es unknown
- 2014-04-10 EP EP20178488.1A patent/EP3725785B1/en active Active
- 2014-04-10 CN CN201910437243.4A patent/CN110172055B/zh active Active
- 2014-04-10 US US14/783,911 patent/US9815814B2/en active Active
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Patent Citations (3)
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SU1836365A3 (ru) * | 1991-01-24 | 1993-08-23 | Физиko-Xиmичeckий Иhctиtуt Иm.A.B.Бoгatckoгo;Hии@ Фapmakoлoгии Poccийckoй Amh | Способ получения ν-0-пиперазинил)бутилглутаримидов |
WO2001005765A1 (en) * | 1999-07-15 | 2001-01-25 | Recordati Industria Chimica E Farmaceutica Spa | Cyclic amides and imides having selective antagonist activity at alpha-1d adrenergic receptor |
RU2278857C2 (ru) * | 2000-01-21 | 2006-06-27 | Грюненталь Гмбх | Замещенные глутаримиды, способы получения и лекарственное средство на их основе |
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