EA018196B1 - Double packing materials for infusion solution - Google Patents

Abstract

The present invention relates to a double packing material for packing infusion solution, comprising: primarily packing the infusion solution with a polypropylene packing material includes a double-layer structure of an outer layer consisting of a polypropylene homopolymer, a copolymer of propylene with alpha-olefin or a mixture thereof, and an inner layer consisting of 40-65 parts by weight of a polypropylene, 30-50 parts by weight of amorphous polypropylene resin and 1-15 parts by weight of hydrogenated styrene butadiene rubber; and secondarily packing the packed polypropylene packing material with a packing material containing an aluminum foil. The packing material ensures safety of the content therein from light and has high thermal resistance and excellent preservation properties that resists to the damage and tearing by external force on long-term storage despite that it is not stored in dark place, and thus is very useful as the packing material for storing expensive infusion solution such as the contrast medium which is radiological diagnostic solution.

Description

Technical field

The present invention relates to packaging materials for double packaging an infusion solution.

State of the art

The present invention relates to packaging materials for double packaging an infusion solution. In particular, the present invention relates to packaging materials for double packaging an infusion solution, wherein the infusion solution is initially packaged in a polypropylene packaging material, and the polypropylene packaging is secondarily packaged under vacuum and hermetically sealed in a material containing aluminum foil, thereby increasing the storage capacity of the infusion solution their qualities.

Among the packaging materials for the infusion solution, glass bottles with a rubber stopper were widely used, but a glass bottle with a rubber stopper is not convenient to handle in that it has considerable weight and impact strength when dropped, and it is also easy to break. Therefore, recently, taking into account the ease of handling, cost of sale and ease of disposal, packaging in the form of a bag using a polymer material, an example of which is polyvinyl chloride (PVC), has been used. PVC was widely used previously due to its lightness and smoothness, but the safety of PVC bags has been questioned for a long time, since it contains a plasticizing additive (plasticizer) diethylhexyl phthalate (ΌΕΗΡ), which is a phthalate known as a hormonal environmental factor that emits toxic substances during combustion. such as dioxin, and showing reproductive toxicity in experiments on mice.

Accordingly, it was recommended that medical instruments for medical treatment and intended for special patients, including newborns, pregnant women and the elderly, be sure to use non-PVC products or not contain не products. According to this voluntary agreement, various non-polyvinyl chloride products have been developed, and currently polyethylene (PE), a multilayer film made of a polymer composite polyethylene terephthalate (ΡΕΤ) and polypropylene (PP) are used as non-vinyl packaging for the infusion solution.

In particular, the PE- and ΡΕΤ-composite films are mainly used in Korea, and polypropylene has not yet been developed with the lightness, flexibility, transparency, chemical resistance and excellent strength required for packaging material for the infusion solution. However, polypropylene is still not ready for use as a packaging material for a contrast medium, which is more expensive compared to another infusion solution.

Disclosure of invention

Technical problem.

Although the packaging material made of polypropylene for the infusion solution is smoother than the glass bottle or polyvinylethylene (ΡνΕ), the problem with the packaging material made of polypropylene for the infusion solution is that the packaging material may burst or burst due to shock during prolonged storage or transportation. (shock), because it has less heat resistance and strength than a traditional product. In addition, in the case of polypropylene packaging material, there is a high risk of deterioration of the infusion solution or deterioration of its quality due to exposure to sunlight or other types of light or heat.

Technical solution.

The author of the present invention has supplemented the present invention, on the basis that the heat resistance of the infusion solution increases significantly and the ability of the infusion solution to maintain its qualities is increased while preventing the packaging from breaking when exposed to external forces or damage due to exposure to sunlight or other types of light, through primary packaging infusion solution in polypropylene packaging material and secondary vacuum packaging and hermetic sealing of packaged polypropylene of material in the material containing aluminum foil. In particular, the present invention is intended for packaging and transporting an expensive contrast agent, which is a medicine for radiological diagnostics according to the method mentioned above, thereby improving the ability of the contrast agent to retain its properties in order to protect the contrast agent from damage or deterioration.

Benefits.

Double-packaging packaging materials according to the present invention, in which the infusion solution is first packaged in a polypropylene packaging material, and then the packaged polypropylene material is vacuum packed and hermetically sealed in a material containing aluminum foil, ensure its contents are protected by light and have high heat resistance and excellent retention capacity, which prevents damage or tearing when exposed to external force during long-term storage enii, even if the package is not stored in a dark place, and thus extremely useful as a packaging Part 1 018196 rial storage expensive infusion solution such as a contrast agent, which is a drug for radiological diagnostics.

Brief Description of the Drawings

The drawing is a front view with a partially enlarged sectional view illustrating packaging materials for double packaging for an infusion solution according to a preferred embodiment of the present invention.

Description of the main elements:

- polypropylene packaging material,

- outer layer

- inner layer,

- packaging material containing aluminum foil,

- polyester,

- aluminium foil,

- polyethylene.

Preferred Embodiment

The present invention relates to packaging materials for double packaging an infusion solution. Specifically, the present invention relates to packaging materials for double packaging for an infusion solution, as shown in the drawing, in which the infusion solution is initially packed in a polypropylene packaging material 10, and the polypropylene packaging is secondarily vacuum packed and sealed in a material 20 containing aluminum foil, thereby increasing the ability of the infusion solution to maintain its properties.

The polypropylene packaging material 10, which directly contains the infusion solution, is made of polypropylene synthetic resin. Polypropylene synthetic resin is a material that has recently been developed as a material for an infusion solution, since it does not have the properties of a hormonal environmental factor and is not toxic to the human body. In the present invention, the polypropylene synthetic resin can be used as a polypropylene homopolymer or as a copolymer of propylene with an alpha olefin to increase heat resistance and transparency. Preferably, in order to increase both the transparency and flexibility of the resin, the polypropylene synthetic resin is made in the form of a two-layer structure, and it is possible to obtain a multilayer structure without the use of an additional adhesive resin for fixing the outer layer 11 and the inner layer 12.

Therefore, the polypropylene packaging material 10 according to the invention is made by gluing an outer layer 11 consisting of a polypropylene homopolymer, a copolymer of propylene with an alpha olefin, or a mixture thereof; and the inner layer 12, consisting of 40-65 parts by weight polypropylene, 30-50 parts by weight amorphous polypropylene resin and 1-15 parts by weight hydrogenated styrene butadiene rubber in the form of a two-layer structure.

The transparency of the polypropylene material is at least 80%, preferably at least 85%, and the flexibility is a flexural modulus of less than 300 kg / cm ² . Preferably, the melting point is 150-160 ° C for the outer layer and 140-150 ° C for the inner layer, and the melt index (230 ° C, 2.16 kg) is 0.5-10 g / 10 min for the outer layer and 2.0-10 g / 10 min for the inner layer.

In most cases, medical packaging materials for the infusion solution are sterilized at 121 ° C after filling with the infusion solution, and they must have good heat resistance, since the deformation and leakage of the substance must be less than the controlled volume. In addition, the medical packaging material must have high transparency in order to be able to visually judge whether the drug stored in the packaging material has deteriorated or become contaminated during use of the medical infusion solution, and also have high flexibility to facilitate application and increase strength relative to external influences.

Therefore, in an embodiment of the present invention, hydrogenated styrene butadiene rubber as well as amorphous polypropylene having a crystallization rate of less than 30% are added to the polymerization of the polypropylene synthetic resin, thereby increasing the transparency and flexibility of the resin.

Moreover, in the polymerization of a polypropylene synthetic resin, a resin layer is required that has not only heat resistance, but also increased transparency and flexibility, since the higher the content of the polypropylene resin, the more the flexibility decreases, and the more the content of amorphous polypropylene resin increases, the more the heat resistance decreases . However, while the content of polypropylene resin and amorphous polypropylene resin is determined by the above contents, since the ability to undergo processing is reduced due to the adhesiveness (adhesive property) when using amorphous polypropylene resin in larger volumes than specified, the contents of the compositions (mixtures) are not too limited by them and may vary, as well as the type of infusion solution or shelf life.

- 2 018196

A packaging material 20 comprising aluminum foil according to an embodiment of the present invention relates to a packaging material of a multilayer structure in which polyester and polyethylene cover an aluminum foil, and it constitutes a three-layer structure of polyester 21, aluminum foil 22 and polyethylene 23. Also packaging material, having a three-layer structure, is subjected to thermal welding (joining) of its edges in order to accommodate the initially packaged polypropylene packaging material, and then odvergaetsya nitrogen charge and sealing a hermetic pouch-shaped. The packaging method and packaging size may vary, as well as the size and capacity of the contents.

A packaging material 20 containing aluminum foil prepared by the aforementioned method enables long-term safe storage of the infusion solution and minimizes damage and deterioration of contents when exposed to external pressure and light during transportation.

In the present description, the polyester is related to all polymers having an ester group as a bond group, and it is widely used for the manufacture of sterilized bags, since it has high strength and heat resistance, and, in addition to packaging, is used for various purposes, for example, for magnetic tapes or capacitors.

Aluminum foil is made by repeatedly rolling a sheet of industrial aluminum so that the aluminum sheet gradually becomes thinner, and finally the aluminum sheet is placed on a foil rolling mill, where it acquires a thickness of the order of several microns. Aluminum foil has a moisture insulating effect and is used for packaging cookies and cigarettes or for cooking or decoration. Recently, it has become possible to glue aluminum foil with paper or to arbitrarily print on its surface, and, therefore, the volume of aluminum foil used as packaging material is increasing dramatically.

In the present description, the infusion solution includes all of the various infusion solutions distributed as a medical solution, including physiological (saline) solution, glucose solution, Hartmann solution, Ringer's solution, amino acid solution and diagnostic solution, and preferably a diagnostic solution, more preferably contrast agent.

As described above, the packaging materials for double packaging for the infusion solution have a double sealing structure consisting of polypropylene packaging material and packaging material containing aluminum foil, for packaging polypropylene packaging material, and packaging material containing aluminum foil has a triple structure consisting of PET 21, aluminum foil 22 and PE 23. Therefore, it is possible to increase the retention period of the contents for a long period of more than 2 years and, thus, reliability to save the contents during storage and transportation period the infusion solution.

Specialists in this field will appreciate the idea of the present invention, and the specific embodiments disclosed in the description can be easily used as the basis for modifying or creating other embodiments to achieve the same objectives of the present invention. Those skilled in the art will also appreciate that such equivalent embodiments are within the spirit and scope of the invention as set forth in the appended claims.

Claims (9)

CLAIM 1. Double packaging material for packaging an infusion solution, including polypropylene packaging material for the primary packaging of an infusion solution, where the polypropylene packaging material has a two-layer structure consisting of an outer layer and an inner layer, where the outer layer consists of a polypropylene homopolymer, propylene copolymer with alpha -olefin or their mixtures and the inner layer consists of 40-65 weight.h. polypropylene, 30-50 weight.h. amorphous polypropylene resin and 1-15 weight.h. hydrogenated styrene butadiene rubber; packaging material containing aluminum foil for the secondary packaging of polypropylene packaging material. 2. Double packaging material according to claim 1, in which the packaging material containing aluminum foil has a three-layer structure of polyester, aluminum foil and polyethylene. 3. Dual packaging material according to claim 1, in which the infusion solution, packaged in polypropylene packaging material, is a diagnostic solution. 4. The dual packaging material of claim 3, wherein the diagnostic solution packaged in polypropylene packaging material is a contrast agent. 5. Dual packaging material according to claim 1, in which the melting point of the outer layer of polypropylene packaging material is from 150 to 160 ° C. - 3 018196 6. Dual packaging material according to claim 1, in which the melting point of the inner layer of polypropylene packaging material is from 140 to 150 ° C. 7. Dual packaging material according to claim 1, in which the amorphous polypropylene resin has a degree of crystallization of less than 30%. 8. Double packaging material according to claim 2, in which the packaging material containing aluminum foil has a ternary structure consisting of an inner layer of polyethylene, a middle layer of aluminum foil and an outer layer of a complex polyester. 9. Double packaging material for packaging an infusion solution that includes primary packaging material for the primary packaging of an infusion solution, where the primary packaging material has a two-layer structure consisting of an outer and an inner layer, where the outer layer consists of a polypropylene homopolymer, propylene copolymer with alpha olefin or their mixtures and the inner layer consists of 40-65 weight parts. polypropylene, 30-50 weight.h. amorphous polypropylene resin having a degree of crystallization of less than 30%, and 1-15 weight.h. hydrogenated styrene butadiene rubber; secondary packaging material for the secondary packaging of the primary packaging material, where the secondary packaging material has a triple structure consisting of an inner layer of polyethylene, a middle layer of aluminum foil and an outer layer of polyester.