DZ2788A1 - Agonistes et antagonistes selectifs à IL-2. - Google Patents

Agonistes et antagonistes selectifs à IL-2.

Info

Publication number: DZ2788A1
Authority: DZ; Algeria
Prior art keywords: agonists; antagonists; selective
Prior art date: 1998-05-15

Application number

DZ990088A

Other languages

English (en)

French (fr)

Inventor

Armen B Shanafelt

Jeffrey M Greve

Jesmok Gary

Kenneth J Lembach

Gayle D Wetzel

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-15

Filing date

1999-05-12

Publication date

2003-12-01

1999-05-12 Application filed by Bayer Ag filed Critical Bayer Ag

2003-12-01 Application granted granted Critical

2003-12-01 Publication of DZ2788A1 publication Critical patent/DZ2788A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Gastroenterology & Hepatology (AREA)
Oncology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Toxicology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

DZ990088A 1998-05-15 1999-05-12 Agonistes et antagonistes selectifs à IL-2. DZ2788A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US8008098A	1998-05-15	1998-05-15

Publications (1)

Publication Number	Publication Date
DZ2788A1 true DZ2788A1 (fr)	2003-12-01

Family

ID=22155135

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DZ990088A DZ2788A1 (fr)	1998-05-15	1999-05-12	Agonistes et antagonistes selectifs à IL-2.

Country Status (39)

Country	Link
EP (1)	EP1076704B1 (xx)
JP (1)	JP4276783B2 (xx)
KR (1)	KR100607609B1 (xx)
CN (2)	CN100366742C (xx)
AR (1)	AR020322A1 (xx)
AT (1)	ATE351907T1 (xx)
AU (1)	AU759697B2 (xx)
BG (1)	BG65139B1 (xx)
BR (1)	BRPI9910504B1 (xx)
CA (1)	CA2327349C (xx)
CO (1)	CO5070701A1 (xx)
CU (2)	CU23273B7 (xx)
CY (1)	CY1107533T1 (xx)
CZ (1)	CZ302071B6 (xx)
DE (1)	DE69934881T2 (xx)
DK (1)	DK1076704T3 (xx)
DZ (1)	DZ2788A1 (xx)
ES (1)	ES2281175T3 (xx)
HK (1)	HK1039963B (xx)
HN (1)	HN1999000075A (xx)
HU (1)	HU226142B1 (xx)
IL (2)	IL139136A0 (xx)
MY (1)	MY130274A (xx)
NO (1)	NO329235B1 (xx)
NZ (1)	NZ508098A (xx)
PA (1)	PA8472601A1 (xx)
PE (1)	PE20000475A1 (xx)
PL (1)	PL201675B1 (xx)
PT (1)	PT1076704E (xx)
RO (1)	RO122150B1 (xx)
RU (1)	RU2235729C2 (xx)
SI (1)	SI20643B (xx)
SK (1)	SK288100B6 (xx)
SV (1)	SV1999000061A (xx)
TN (1)	TNSN99090A1 (xx)
TR (1)	TR200003354T2 (xx)
TW (1)	TWI223663B (xx)
UA (1)	UA73719C2 (xx)
WO (1)	WO1999060128A1 (xx)

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WO2000058456A2 (en) *	1999-03-30	2000-10-05	Board Of Regents, The University Of Texas System	Compositions and methods for modifying toxic effects of proteinacious compounds
EP1935431A3 (en)	2000-05-15	2008-08-13	Health Research, Inc.	Cancer treatments by using a combination of an antibody against her2 and interleukin-2
US6689353B1 (en) *	2000-06-28	2004-02-10	Bayer Pharmaceuticals Corporation	Stabilized interleukin 2
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US6992174B2 (en)	2001-03-30	2006-01-31	Emd Lexigen Research Center Corp.	Reducing the immunogenicity of fusion proteins
EP2354791A1 (en) *	2001-12-04	2011-08-10	Merck Patent GmbH	Immunocytokines with modulated selectivity
WO2005007121A2 (en)	2003-07-18	2005-01-27	Massachusetts Institute Of Technology	Mutant interleukin-2(il-2) polypeptides
DE602004031341D1 (de)	2003-07-21	2011-03-24	Transgene Sa	Multifunktionelle cytokine
DK1944318T3 (da)	2003-07-21	2011-06-14	Transgene Sa	Multifunktionelle cytokiner
SI1682180T1 (sl)	2003-11-04	2010-03-31	Novartis Vaccines & Diagnostic	Antagonist anti cd monoklonskih antiteles in postopek za njihovo uporabo
ATE516305T1 (de) *	2004-02-27	2011-07-15	Inst Nat Sante Rech Med	Il-15-bindungsstelle für il-15-ralpha und spezifische il-15-mutanten mit wirkung als agonisten/antagonisten
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CN101244261B (zh) *	2008-03-10	2010-09-15	山东大学	一种含未复性重组蛋白的生物制剂及其制备方法与应用
DE102008023820A1 (de)	2008-05-08	2009-11-12	Aicuris Gmbh & Co. Kg	Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen
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CN102101885B (zh) *	2010-09-01	2013-06-05	南京发士达生物科技有限公司	低诱导抑制性t细胞的人白细胞介素ⅱ突变体及其用途
IL226267B (en)	2010-11-12	2022-09-01	Nektar Therapeutics	Conjugations of a part of il-2 and a polymer, preparations containing them and their uses
CU23923B1 (es) *	2010-11-12	2013-07-31	Ct De Inmunología Molecular	Polipéptidos derivados de la il-2 con actividad agonista
WO2012088446A1 (en)	2010-12-22	2012-06-28	Board Of Trustees Of The Leland Stanford Junior University	Superagonists and antagonists of interleukin-2
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WO2012119093A1 (en) *	2011-03-03	2012-09-07	Board Of Trustees Of The Leland Stanford Junior University	Superagonists and antagonists of interleukin-2
EA201892619A1 (ru)	2011-04-29	2019-04-30	Роше Гликарт Аг	Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
US20140044675A1 (en)	2012-08-10	2014-02-13	Roche Glycart Ag	Interleukin-2 fusion proteins and uses thereof
JP2016533167A (ja)	2013-09-24	2016-10-27	メディシナセラピューティクスピーティーイーリミテッド	インターロイキン−２融合タンパク質及びその使用
ES2704731T3 (es)	2014-02-06	2019-03-19	Hoffmann La Roche	Proteínas de fusión de interleucina 2 y usos de las mismas
GB201403775D0 (en)	2014-03-04	2014-04-16	Kymab Ltd	Antibodies, uses & methods
CA2946398A1 (en)	2014-04-24	2015-10-29	The Board Of Trustees Of The Leland Stanford Junior University	Superagonists, partial agonists and antagonists of interleukin-2
MA40094B1 (fr)	2014-08-06	2022-05-31	Univ Miami	Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation
ES2717831T3 (es)	2014-08-11	2019-06-25	Delinia Inc	Variantes de IL-2 modificadas que activan selectivamente las células T reguladoras para el tratamiento de enfermedades autoinmunes
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US9567399B1 (en)	2016-06-20	2017-02-14	Kymab Limited	Antibodies and immunocytokines
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EP3534947A1 (en)	2016-11-03	2019-09-11	Kymab Limited	Antibodies, combinations comprising antibodies, biomarkers, uses & methods
CA3041334A1 (en)	2016-11-08	2018-05-17	Delinia, Inc.	Il-2 variants for the treatment of autoimmune diseases
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US10961310B2 (en)	2017-03-15	2021-03-30	Pandion Operations, Inc.	Targeted immunotolerance
JOP20190271A1 (ar) *	2017-05-24	2019-11-21	Novartis Ag	بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة
US12006354B2 (en)	2017-05-24	2024-06-11	Novartis Ag	Antibody-IL2 engrafted proteins and methods of use in the treatment of cancer
US20200362058A1 (en) *	2017-05-24	2020-11-19	Novartis Ag	Antibody-cytokine engrafted proteins and methods of use
EP3630163A4 (en)	2017-05-24	2021-06-09	Pandion Operations, Inc.	TARGETED IMMUNTOLERANCE
CA3067909A1 (en)	2017-06-19	2018-12-27	Medicenna Therapeutics Inc.	Uses and methods for il-2 superagonists, agonists, and fusions thereof
BR112020002271A2 (pt) *	2017-08-03	2020-07-28	Synthorx, Inc.	conjugados de citocina para o tratamento de doenças proliferativas e infecciosas
CN111615396A (zh) *	2017-11-21	2020-09-01	小利兰·斯坦福大学董事会	白介素-2的部分激动剂
US10946068B2 (en)	2017-12-06	2021-03-16	Pandion Operations, Inc.	IL-2 muteins and uses thereof
US10174092B1 (en)	2017-12-06	2019-01-08	Pandion Therapeutics, Inc.	IL-2 muteins
CA3086199A1 (en)	2017-12-19	2019-06-27	Xencor, Inc.	Engineered il-2 fc fusion proteins
EP3752178A1 (en)	2018-02-16	2020-12-23	Iltoo Pharma	Use of interleukin 2 for treating sjögren's syndrome
KR20200136453A (ko)	2018-03-28	2020-12-07	브리스톨-마이어스 스큅 컴퍼니	인터루킨-2/인터루킨-2 수용체 알파 융합 단백질 및 사용 방법
MA52662A (fr)	2018-03-28	2021-02-17	Ascendis Pharma Oncology Div A/S	Conjugués d'il-2
WO2020007937A1 (en)	2018-07-03	2020-01-09	Iltoo Pharma	Use of interleukin-2 for treating systemic sclerosis
JP7550745B2 (ja) *	2018-07-24	2024-09-13	バイオエヌテックエスエー	Ｉｌ２アゴニスト
WO2020035482A1 (en)	2018-08-13	2020-02-20	Iltoo Pharma	Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof
SG11202005873QA (en) *	2018-09-17	2020-07-29	Gi Innovation Inc	Fusion protein comprising il-2 protein and cd80 protein, and use thereof
CN113383013B (zh)	2018-12-21	2022-11-04	江苏恒瑞医药股份有限公司	一种人白细胞介素2变体或其衍生物
AU2020279240A1 (en)	2019-05-20	2021-12-23	Pandion Operations, Inc.	MAdCAM targeted immunotolerance
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CN114867749A (zh)	2019-12-17	2022-08-05	安进公司	用于疗法中的双重白介素-2/tnf受体激动剂
KR20220140514A (ko)	2020-01-10	2022-10-18	브라이트 피크 테라퓨틱스 아게	변형된 il-2 폴리펩타이드 및 그의 용도
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CN114507643A (zh) *	2020-10-29	2022-05-17	未来智人再生医学研究院(广州)有限公司	一种表达il-2的多能干细胞衍生物及应用
IL302114A (en)	2020-10-29	2023-06-01	Bristol Myers Squibb Co	Fusion proteins for the treatment of diseases
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Family Cites Families (1)

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1999
- 1999-05-12 DZ DZ990088A patent/DZ2788A1/xx active
- 1999-05-13 PE PE1999000399A patent/PE20000475A1/es not_active Application Discontinuation
- 1999-05-13 ES ES99924232T patent/ES2281175T3/es not_active Expired - Lifetime
- 1999-05-13 HU HU0101948A patent/HU226142B1/hu unknown
- 1999-05-13 RU RU2000131593/04A patent/RU2235729C2/ru active
- 1999-05-13 WO PCT/US1999/010643 patent/WO1999060128A1/en active IP Right Grant
- 1999-05-13 IL IL13913699A patent/IL139136A0/xx unknown
- 1999-05-13 RO ROA200001123A patent/RO122150B1/ro unknown
- 1999-05-13 DE DE69934881T patent/DE69934881T2/de not_active Expired - Lifetime
- 1999-05-13 AR ARP990102269A patent/AR020322A1/es active IP Right Grant
- 1999-05-13 TN TNTNSN99090A patent/TNSN99090A1/fr unknown
- 1999-05-13 TR TR2000/03354T patent/TR200003354T2/xx unknown
- 1999-05-13 PL PL344407A patent/PL201675B1/pl unknown
- 1999-05-13 KR KR1020007012747A patent/KR100607609B1/ko not_active IP Right Cessation
- 1999-05-13 AU AU40784/99A patent/AU759697B2/en not_active Expired
- 1999-05-13 EP EP99924232A patent/EP1076704B1/en not_active Expired - Lifetime
- 1999-05-13 SI SI9920034A patent/SI20643B/sl active Search and Examination
- 1999-05-13 PA PA19998472601A patent/PA8472601A1/es unknown
- 1999-05-13 CN CNB998086509A patent/CN100366742C/zh not_active Expired - Lifetime
- 1999-05-13 PT PT99924232T patent/PT1076704E/pt unknown
- 1999-05-13 CZ CZ20004213A patent/CZ302071B6/cs not_active IP Right Cessation
- 1999-05-13 NZ NZ508098A patent/NZ508098A/en not_active IP Right Cessation
- 1999-05-13 DK DK99924232T patent/DK1076704T3/da active
- 1999-05-13 SK SK1724-2000A patent/SK288100B6/sk not_active IP Right Cessation
- 1999-05-13 AT AT99924232T patent/ATE351907T1/de active
- 1999-05-13 UA UA2000127206A patent/UA73719C2/uk unknown
- 1999-05-13 CA CA2327349A patent/CA2327349C/en not_active Expired - Lifetime
- 1999-05-13 CN CN2007101609093A patent/CN101319247B/zh not_active Expired - Lifetime
- 1999-05-13 BR BRPI9910504A patent/BRPI9910504B1/pt not_active IP Right Cessation
- 1999-05-13 JP JP2000549735A patent/JP4276783B2/ja not_active Expired - Lifetime
- 1999-05-14 SV SV1999000061A patent/SV1999000061A/es active IP Right Grant
- 1999-05-14 HN HN1999000075A patent/HN1999000075A/es unknown
- 1999-05-14 CO CO99030158A patent/CO5070701A1/es unknown
- 1999-05-14 MY MYPI99001912A patent/MY130274A/en unknown
- 1999-05-14 TW TW088107812A patent/TWI223663B/zh not_active IP Right Cessation
2000
- 2000-10-18 IL IL139136A patent/IL139136A/en not_active IP Right Cessation
- 2000-11-08 BG BG104929A patent/BG65139B1/bg unknown
- 2000-11-14 NO NO20005762A patent/NO329235B1/no not_active IP Right Cessation
- 2000-11-15 CU CU20000257A patent/CU23273B7/es not_active IP Right Cessation
2002
- 2002-02-21 HK HK02101283.2A patent/HK1039963B/zh not_active IP Right Cessation
- 2002-06-19 CU CU20020125A patent/CU23272A1/es not_active IP Right Cessation
2007
- 2007-03-09 CY CY20071100330T patent/CY1107533T1/el unknown

Also Published As

Publication number	Publication date
DE69934881D1 (de)	2007-03-08
EP1076704B1 (en)	2007-01-17
CA2327349C (en)	2010-10-26
DK1076704T3 (da)	2007-03-12
HK1039963B (zh)	2008-09-05
NO329235B1 (no)	2010-09-20
SK17242000A3 (sk)	2001-07-10
SK288100B6 (sk)	2013-07-02
BRPI9910504B1 (pt)	2016-08-09
NO20005762L (no)	2001-01-11
KR20010043602A (ko)	2001-05-25
CA2327349A1 (en)	1999-11-25
CU23273B7 (es)	2008-04-09
AU759697B2 (en)	2003-04-17
CY1107533T1 (el)	2013-03-13
PT1076704E (pt)	2007-02-28
JP2002515247A (ja)	2002-05-28
AR020322A1 (es)	2002-05-08
WO1999060128A1 (en)	1999-11-25
IL139136A (en)	2009-05-04
EP1076704A1 (en)	2001-02-21
BG65139B1 (bg)	2007-03-30
TR200003354T2 (tr)	2001-03-21
SV1999000061A (es)	2000-03-14
KR100607609B1 (ko)	2006-08-02
CN1309705A (zh)	2001-08-22
SI20643B (sl)	2008-02-29
NO20005762D0 (no)	2000-11-14
UA73719C2 (en)	2005-09-15
CN101319247B (zh)	2012-12-12
ATE351907T1 (de)	2007-02-15
PE20000475A1 (es)	2000-07-07
CU23272A1 (es)	2008-04-09
PL344407A1 (en)	2001-11-05
SI20643A (sl)	2002-02-28
CN101319247A (zh)	2008-12-10
AU4078499A (en)	1999-12-06
CZ20004213A3 (en)	2001-05-16
RO122150B1 (ro)	2009-01-30
PA8472601A1 (es)	2000-09-29
CN100366742C (zh)	2008-02-06
CO5070701A1 (es)	2001-08-28
PL201675B1 (pl)	2009-04-30
HN1999000075A (es)	1999-09-29
NZ508098A (en)	2003-09-26
HUP0101948A3 (en)	2003-08-28
HUP0101948A2 (hu)	2001-09-28
DE69934881T2 (de)	2007-11-08
RU2235729C2 (ru)	2004-09-10
BG104929A (en)	2001-09-28
TWI223663B (en)	2004-11-11
TNSN99090A1 (fr)	2005-11-10
JP4276783B2 (ja)	2009-06-10
MY130274A (en)	2007-06-29
BR9910504A (pt)	2001-01-09
ES2281175T3 (es)	2007-09-16
IL139136A0 (en)	2001-11-25
HK1039963A1 (en)	2002-05-17
HU226142B1 (en)	2008-05-28
CZ302071B6 (cs)	2010-09-29

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