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DOP2020000123A - Análogos de incretina y sus usos - Google Patents

Análogos de incretina y sus usos

Info

Publication number
DOP2020000123A
DOP2020000123A DO2020000123A DO2020000123A DOP2020000123A DO P2020000123 A DOP2020000123 A DO P2020000123A DO 2020000123 A DO2020000123 A DO 2020000123A DO 2020000123 A DO2020000123 A DO 2020000123A DO P2020000123 A DOP2020000123 A DO P2020000123A
Authority
DO
Dominican Republic
Prior art keywords
incretine
analogues
activity
receptors
incretin analogs
Prior art date
Application number
DO2020000123A
Other languages
English (en)
Inventor
Guo Lili
Alsina-Fernandez Jorge
Coskun Tamer
Qu Hongchang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DOP2020000123A publication Critical patent/DOP2020000123A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Details Of Garments (AREA)

Abstract

Se proporcionan análogos de incretina que tienen actividad en cada uno de los receptores de GIP, GLP-1 y glucagón. Los análogos de incretina tienen características estructurales que dan como resultado una actividad equilibrada y una duración de acción extendida en cada uno de estos receptores. También se proporcionan métodos para tratar enfermedades tales como diabetes mellitus, dislipidemia, hepatopatía grasa, síndrome metabólico, esteatohepatitis no alcohólica y obesidad.
DO2020000123A 2017-12-21 2020-06-17 Análogos de incretina y sus usos DOP2020000123A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762608613P 2017-12-21 2017-12-21
PCT/US2018/065663 WO2019125938A1 (en) 2017-12-21 2018-12-14 Incretin analogs and uses thereof

Publications (1)

Publication Number Publication Date
DOP2020000123A true DOP2020000123A (es) 2020-08-31

Family

ID=65003519

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2020000123A DOP2020000123A (es) 2017-12-21 2020-06-17 Análogos de incretina y sus usos

Country Status (25)

Country Link
US (2) US11542313B2 (es)
EP (1) EP3727426A1 (es)
JP (2) JP6961838B2 (es)
KR (2) KR102444783B1 (es)
CN (1) CN111491658B (es)
AR (1) AR113486A1 (es)
AU (1) AU2018388962B2 (es)
BR (1) BR112020010244A2 (es)
CA (1) CA3084005C (es)
CL (1) CL2020001635A1 (es)
CO (1) CO2020006255A2 (es)
CR (1) CR20200255A (es)
DO (1) DOP2020000123A (es)
EA (1) EA202091290A1 (es)
EC (1) ECSP20032650A (es)
IL (1) IL275468A (es)
JO (1) JOP20200137A1 (es)
MA (1) MA51288A (es)
MX (2) MX2020006548A (es)
NZ (1) NZ765277A (es)
PE (1) PE20210162A1 (es)
PH (1) PH12020551025A1 (es)
SG (1) SG11202005606VA (es)
TW (3) TWI744579B (es)
WO (1) WO2019125938A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI744579B (zh) * 2017-12-21 2021-11-01 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
JP7350851B2 (ja) * 2018-11-12 2023-09-26 天津薬物研究院有限公司 グルカゴン由来ペプチド及びその用途
WO2021034815A1 (en) * 2019-08-19 2021-02-25 Eli Lilly And Company Methods of making incretin analogs
AR120714A1 (es) * 2019-12-18 2022-03-09 Lilly Co Eli Análogos de incretina y sus usos
AR121650A1 (es) * 2020-03-25 2022-06-22 Takeda Pharmaceuticals Co Dosificación qd de compuestos peptídicos agonistas del receptor de gip y sus usos
EP4236991A1 (en) 2020-10-30 2023-09-06 Novo Nordisk A/S Glp-1, gip and glucagon receptor triple agonists
CN114685642B (zh) * 2020-12-29 2024-03-29 浙江和泽医药科技股份有限公司 一种肠促胰岛素类似物药学上可接受盐及制备方法和用途
CN116710462A (zh) 2021-01-20 2023-09-05 维京治疗公司 用于治疗代谢病症和肝病的组合物和方法
AR125086A1 (es) 2021-03-23 2023-06-07 Lilly Co Eli Composiciones que contienen análogos de incretina y usos de estas
EP4353249A1 (en) 2021-05-26 2024-04-17 The United Bio-Technology (Hengqin) Co., Ltd. Multi-agonist and use thereof
WO2022268029A1 (zh) * 2021-06-21 2022-12-29 广东东阳光药业有限公司 Glp-1、gcg和gip受体的三重激动剂
MX2024000213A (es) 2021-06-23 2024-04-16 Lilly Co Eli Métodos de uso y composiciones que incluyen un análogo de incretina.
TWI828434B (zh) * 2021-11-19 2024-01-01 大陸商南京明德新藥研發有限公司 釘合肽及其應用
KR20240099485A (ko) * 2021-11-19 2024-06-28 메드샤인 디스커버리 아이엔씨. 스테이플화 펩타이드 및 이의 용도
CN116162147B (zh) * 2021-11-24 2023-10-03 成都奥达生物科技有限公司 一种长效胰岛素类似物
CN114957387B (zh) * 2022-05-18 2023-06-20 华南理工大学 一种具有降血糖作用的巴旦木多肽及其制备方法与应用
WO2024050289A1 (en) 2022-08-29 2024-03-07 Eli Lilly And Company Compositions for oral delivery
WO2024067662A1 (zh) * 2022-09-28 2024-04-04 广东东阳光药业股份有限公司 Glp-1/gcg/gip三受体激动剂及其用途
WO2024077149A2 (en) 2022-10-05 2024-04-11 Eli Lilly And Company Peptides for incretin synthesis
WO2024141760A1 (en) 2022-12-30 2024-07-04 Algipharma As Compositions and methods to increase the systemic bioavailability of a polypeptide therapeutic agent undergoing oral administration
WO2024163535A1 (en) 2023-01-31 2024-08-08 Eli Lilly And Company Gip/glp1/gcg tri-receptor agonists and uses thereof
WO2024213022A1 (zh) * 2023-04-11 2024-10-17 上海多米瑞生物技术有限公司 肠促胰素类似物及其制备方法和应用
CN117024528B (zh) * 2023-07-07 2024-03-22 杭州信海医药科技有限公司 一种Retatrutide的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ603445A (en) * 2008-06-17 2014-03-28 Univ Indiana Res & Tech Corp Gip-based mixed agonists for treatment of metabolic disorders and obesity
JP2012521971A (ja) 2009-03-27 2012-09-20 グラクソ グループ リミテッド 薬物融合体および複合体
JP2013517307A (ja) * 2010-01-20 2013-05-16 ジーランド ファーマ アクティーゼルスカブ 心臓病の処置
AR080592A1 (es) * 2010-03-26 2012-04-18 Lilly Co Eli Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso
WO2012153196A2 (en) * 2011-05-10 2012-11-15 Zealand Pharma A/S Glu-glp-1 dual agonist signaling-selective compounds
AR092873A1 (es) 2012-09-26 2015-05-06 Cadila Healthcare Ltd Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon
CN105829339B (zh) * 2013-11-06 2021-03-12 西兰制药公司 胰高血糖素-glp-1-gip三重激动剂化合物
WO2015067715A2 (en) * 2013-11-06 2015-05-14 Zealand Pharma A/S Gip-glp-1 dual agonist compounds and methods
JOP20200119A1 (ar) * 2015-01-09 2017-06-16 Lilly Co Eli مركبات مساعد مشترك من gip وglp-1
WO2016198624A1 (en) 2015-06-12 2016-12-15 Sanofi Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
TWI669309B (zh) * 2015-06-22 2019-08-21 美商美國禮來大藥廠 升糖素及ｇｌｐ－１共激動劑化合物
TWI622596B (zh) * 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
DK3398961T3 (da) 2015-12-31 2022-08-22 Hanmi Pharm Ind Co Ltd Tredobbelt aktivator, der aktiverer glukagon, glp 1 og gip-receptor
EP3217027A1 (de) 2016-03-08 2017-09-13 HILTI Aktiengesellschaft Breites einlageelement zum einfassen einer ankerstange
TWI810937B (zh) * 2017-12-21 2023-08-01 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
TWI744579B (zh) * 2017-12-21 2021-11-01 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途

Also Published As

Publication number Publication date
CA3084005A1 (en) 2019-06-27
TWI744579B (zh) 2021-11-01
AU2018388962B2 (en) 2020-11-19
US20200331980A1 (en) 2020-10-22
KR20200088419A (ko) 2020-07-22
CO2020006255A2 (es) 2020-05-29
US11542313B2 (en) 2023-01-03
EA202091290A1 (ru) 2020-09-10
TW202415675A (zh) 2024-04-16
ECSP20032650A (es) 2020-07-31
MX2020006548A (es) 2020-09-14
AU2018388962A1 (en) 2020-06-04
MA51288A (fr) 2021-03-31
MX2024010201A (es) 2024-08-26
JP2021506955A (ja) 2021-02-22
WO2019125938A1 (en) 2019-06-27
IL275468A (en) 2020-08-31
PE20210162A1 (es) 2021-01-26
TW202202518A (zh) 2022-01-16
JP6961838B2 (ja) 2021-11-05
TWI809515B (zh) 2023-07-21
CL2020001635A1 (es) 2020-10-16
KR102622642B1 (ko) 2024-01-10
PH12020551025A1 (en) 2021-09-06
EP3727426A1 (en) 2020-10-28
CN111491658B (zh) 2024-04-26
BR112020010244A2 (pt) 2020-10-13
NZ765277A (en) 2024-08-30
KR20220133304A (ko) 2022-10-04
CN111491658A (zh) 2020-08-04
CA3084005C (en) 2024-01-02
SG11202005606VA (en) 2020-07-29
TW201938188A (zh) 2019-10-01
JP2022033724A (ja) 2022-03-02
CR20200255A (es) 2020-07-12
KR102444783B1 (ko) 2022-09-19
AR113486A1 (es) 2020-05-06
JOP20200137A1 (ar) 2022-10-30
US20230203121A1 (en) 2023-06-29

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