DK45081A - Fremgangsmaade til fremstilling af 2-(2-(1,4-benzodioxanyl) )--imidazolin eller ikke-toxiske syreadditionssalte deraf - Google Patents

Fremgangsmaade til fremstilling af 2-(2-(1,4-benzodioxanyl) )--imidazolin eller ikke-toxiske syreadditionssalte deraf

Info

Publication number: DK45081A
Authority: DK; Denmark
Prior art keywords: benzodioxanyl; imidazoline; preparation; acid addition; addition salts
Prior art date: 1980-02-04

Application number

DK45081A

Other languages

English (en)

Other versions

DK160092B (da

DK160092C (da

Inventor

C B Chapleo

P L Myers

Original Assignee

Reckitt & Colmann Prod Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-02-04

Filing date

1981-02-02

Publication date

1981-08-05

1981-02-02 Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd

1981-08-05 Publication of DK45081A publication Critical patent/DK45081A/da

1991-01-28 Publication of DK160092B publication Critical patent/DK160092B/da

1991-06-24 Application granted granted Critical

1991-06-24 Publication of DK160092C publication Critical patent/DK160092C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

DK045081A 1980-02-04 1981-02-02 Analogifremgangsmaade til fremstilling af 2-(2-(1,4-benzodioxanyl))-2-imidazolin eller ikke-toxiske syreadditionssalte deraf DK160092C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8003636		1980-02-04
GB8003636		1980-02-04

Publications (3)

Publication Number	Publication Date
DK45081A true DK45081A (da)	1981-08-05
DK160092B DK160092B (da)	1991-01-28
DK160092C DK160092C (da)	1991-06-24

Family

ID=10511105

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK045081A DK160092C (da)	1980-02-04	1981-02-02	Analogifremgangsmaade til fremstilling af 2-(2-(1,4-benzodioxanyl))-2-imidazolin eller ikke-toxiske syreadditionssalte deraf

Country Status (26)

Country	Link
US (1)	US4818764A (da)
EP (1)	EP0033655B1 (da)
JP (1)	JPS56122378A (da)
AR (1)	AR225794A1 (da)
AT (1)	ATE7228T1 (da)
AU (1)	AU535320B2 (da)
CA (1)	CA1156241A (da)
CS (1)	CS254956B2 (da)
DD (1)	DD155991A5 (da)
DE (1)	DE3163256D1 (da)
DK (1)	DK160092C (da)
ES (1)	ES8202553A1 (da)
FI (1)	FI67543C (da)
GB (1)	GB2068376B (da)
GR (1)	GR73853B (da)
HU (1)	HU187295B (da)
IE (1)	IE51736B1 (da)
IL (1)	IL62039A (da)
NO (1)	NO154882C (da)
NZ (1)	NZ196162A (da)
PH (1)	PH16249A (da)
PL (1)	PL128368B1 (da)
PT (1)	PT72435B (da)
SU (1)	SU1128837A3 (da)
ZA (1)	ZA81666B (da)
ZW (1)	ZW2381A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ199469A (en) *	1981-01-30	1984-03-16	Reckitt & Colmann Prod Ltd	Benzodioxanyl-2-imidazoline derivatives and pharmaceutical compositions
US4436914A (en) *	1981-08-03	1984-03-13	Kluge Arthur F	Benzodioxane-imidazoline compounds as antihypertensives
NZ203680A (en) *	1982-04-17	1985-08-16	Reckitt & Colmann Prod Ltd	Imidazolines and pharmaceutical compositions
FR2527208B1 (fr) *	1982-05-19	1985-07-19	Inst Nat Sante Rech Med	Isomeres optiques de la (benzodioxanne-1,4 yl-2)-2d-2 imidazoline, leur preparation et leur application en therapeutique
EP0115142B1 (en) *	1982-12-23	1986-11-05	Ici Americas Inc.	Chroman compounds
US4634714A (en) *	1983-12-01	1987-01-06	American Home Products Corporation	Inhibition of prolactin release by a benzodioxinylimidazoline derivative
US4882343A (en) *	1987-08-28	1989-11-21	G. D. Searle & Co.	Biarylalkylimidazole derivatives as anti-depressants
GB8720600D0 (en) *	1987-09-02	1987-10-07	Saad Al Damluji	Pharmaceutical compositions
US5240930A (en) *	1987-09-02	1993-08-31	National Research Development Corporation	Pharmaceutical compositions for treatment of depression and low blood pressure
FR2698789B1 (fr) *	1992-12-07	1995-03-03	Pf Medicament	Utilisation de l'idazoxan et ses dérivés pour la préparation d'un médicament destiné au traitement de la maladie de Parkinson et de son évolution.
FR2700113B1 (fr) *	1993-01-07	1995-03-24	Pf Medicament	Utilisation de l'Idazoxan et ses dérivés pour la fabrication de médicaments destinés au traitement des maladies neurodégénératives et en particulier l'évolution de la maladie d'Alzheimer.
US5574059A (en) *	1995-10-27	1996-11-12	Cornell Research Foundation, Inc.	Treating disorders mediated by vascular smooth muscle cell proliferation
FR2795727B1 (fr) *	1999-06-29	2001-09-21	Pf Medicament	Nouveaux derives benzodioxanne imidazolines fluores, leur preparation et leurs applications en therapeutique
FR2801786B1 (fr) *	1999-12-01	2002-03-01	Fabre Pierre Cosmetique	Nouvelles compositions topiques a base d'idazoxan et de cafeine ou de ses derives solubles et leur utilisation comme amincissant et/ou dans le traitement de la cellulite
US20010049368A1 (en) *	2000-02-29	2001-12-06	Reines Scott A.	Method for treating or preventing depression
US7595335B2 (en) *	2003-10-28	2009-09-29	Pierre Fabre Medicament	Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
FR2861299B1 (fr) *	2003-10-28	2006-01-27	Pf Medicament	Compositions pharmaceutiques a base de derives d'idasoxan sous formes polymorphes
US8476307B2 (en) *	2003-10-28	2013-07-02	Pierre Fabre Medicament	Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
WO2023159145A1 (en) *	2022-02-16	2023-08-24	Terran Biosciences, Inc.	Deuterated idazoxan and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2641601A (en) *	1950-11-24	1953-06-09	Hoffmann La Roche	Furans and method of preparation
US2979511A (en) *	1959-03-25	1961-04-11	Olin Mathieson	Certain 1, 4-benzodioxanyl imidazolines and corresponding pyrimidines and process
JPS5276346A (en) *	1975-12-22	1977-06-27	Sumitomo Bakelite Co Ltd	Epoxy resin adhesive composition
EP0003732B1 (en) *	1978-02-01	1983-10-19	The Wellcome Foundation Limited	Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
US4302469A (en) *	1980-09-10	1981-11-24	Syntex (U.S.A.) Inc.	2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
US4315021A (en) *	1980-12-03	1982-02-09	Syntex (U.S.A.) Inc.	2-(1,4-Benzodioxan-2-ylalkyl)imidazoles
US4301171A (en) *	1980-12-03	1981-11-17	Syntex (U.S.A.) Inc.	2-(1,4-Benzodioxan-2-ylalkyl)benzimidazoles useful as anti-depressants
US4436914A (en) *	1981-08-03	1984-03-13	Kluge Arthur F	Benzodioxane-imidazoline compounds as antihypertensives
US4352809A (en) *	1981-09-04	1982-10-05	Smithkline Corporation	Method of producing alpha2 antagonism

1981
- 1981-01-22 PH PH25123A patent/PH16249A/en unknown
- 1981-01-30 AU AU66758/81A patent/AU535320B2/en not_active Ceased
- 1981-02-01 IL IL62039A patent/IL62039A/xx not_active IP Right Cessation
- 1981-02-02 PL PL1981229488A patent/PL128368B1/pl unknown
- 1981-02-02 ZA ZA00810666A patent/ZA81666B/xx unknown
- 1981-02-02 AR AR284181A patent/AR225794A1/es active
- 1981-02-02 CS CS81738A patent/CS254956B2/cs unknown
- 1981-02-02 NO NO810351A patent/NO154882C/no unknown
- 1981-02-02 FI FI810288A patent/FI67543C/fi not_active IP Right Cessation
- 1981-02-02 HU HU81233A patent/HU187295B/hu not_active IP Right Cessation
- 1981-02-02 IE IE199/81A patent/IE51736B1/en not_active IP Right Cessation
- 1981-02-02 DD DD81227377A patent/DD155991A5/de unknown
- 1981-02-02 EP EP81300427A patent/EP0033655B1/en not_active Expired
- 1981-02-02 NZ NZ196162A patent/NZ196162A/en unknown
- 1981-02-02 SU SU813241694A patent/SU1128837A3/ru active
- 1981-02-02 PT PT72435A patent/PT72435B/pt not_active IP Right Cessation
- 1981-02-02 ES ES499034A patent/ES8202553A1/es not_active Expired
- 1981-02-02 ZW ZW23/81A patent/ZW2381A1/xx unknown
- 1981-02-02 GR GR64021A patent/GR73853B/el unknown
- 1981-02-02 GB GB8103150A patent/GB2068376B/en not_active Expired
- 1981-02-02 JP JP1420281A patent/JPS56122378A/ja active Granted
- 1981-02-02 DE DE8181300427T patent/DE3163256D1/de not_active Expired
- 1981-02-02 DK DK045081A patent/DK160092C/da not_active IP Right Cessation
- 1981-02-02 CA CA000369899A patent/CA1156241A/en not_active Expired
- 1981-02-02 AT AT81300427T patent/ATE7228T1/de not_active IP Right Cessation
- 1981-02-02 US US06/230,195 patent/US4818764A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PH16249A (en)	1983-08-16
AR225794A1 (es)	1982-04-30
FI810288L (fi)	1981-08-05
FI67543B (fi)	1984-12-31
DK160092B (da)	1991-01-28
DE3163256D1 (en)	1984-05-30
HU187295B (en)	1985-12-28
ZA81666B (en)	1982-04-28
ATE7228T1 (de)	1984-05-15
IL62039A (en)	1985-01-31
PT72435B (pt)	1982-01-29
SU1128837A3 (ru)	1984-12-07
GB2068376B (en)	1983-06-22
GB2068376A (en)	1981-08-12
ES499034A0 (es)	1982-02-01
IL62039A0 (en)	1981-03-31
ZW2381A1 (en)	1981-06-24
DK160092C (da)	1991-06-24
NO154882B (no)	1986-09-29
CS254956B2 (en)	1988-02-15
NO810351L (no)	1981-08-05
US4818764A (en)	1989-04-04
JPS56122378A (en)	1981-09-25
PL229488A1 (da)	1981-10-16
ES8202553A1 (es)	1982-02-01
EP0033655B1 (en)	1984-04-25
EP0033655A2 (en)	1981-08-12
NO154882C (no)	1987-01-07
FI67543C (fi)	1985-04-10
AU535320B2 (en)	1984-03-15
AU6675881A (en)	1981-08-13
NZ196162A (en)	1983-06-17
PL128368B1 (en)	1984-01-31
GR73853B (da)	1984-05-07
CS73881A2 (en)	1987-07-16
DD155991A5 (de)	1982-07-21
IE810199L (en)	1981-08-04
CA1156241A (en)	1983-11-01
IE51736B1 (en)	1987-03-18
PT72435A (en)	1981-03-01
JPH0231077B2 (da)	1990-07-11
EP0033655A3 (en)	1981-11-25

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Legal Events

Date	Code	Title	Description
2000-09-25	PBP	Patent lapsed