DK418486D0 - 3,4-DIHYDRO-2H- (1) - (BENZOPYRANE AND BENZOTHIOPYRANE) -3-AMINES AND SALTS THEREOF AND THEIR PREPARATION AND USE - Google Patents
3,4-DIHYDRO-2H- (1) - (BENZOPYRANE AND BENZOTHIOPYRANE) -3-AMINES AND SALTS THEREOF AND THEIR PREPARATION AND USEInfo
- Publication number
- DK418486D0 DK418486D0 DK418486A DK418486A DK418486D0 DK 418486 D0 DK418486 D0 DK 418486D0 DK 418486 A DK418486 A DK 418486A DK 418486 A DK418486 A DK 418486A DK 418486 D0 DK418486 D0 DK 418486D0
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- lower alkyl
- denotes
- aryl
- sulphur
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Dental Preparations (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds of the formula: <IMAGE> in which Z denotes oxygen or sulphur, R denotes hydrogen or lower alkyl, R1 denotes hydrogen, lower alkyl or aryl(lower alkyl), R2 denotes hydrogen, lower alkyl or aryl(lower alkyl) or R1 and R2 together denote alkylene having 4-6 C atoms, R3 denotes hydrogen, hydroxyl, lower alkoxy, aryl(lower alkoxy), acyloxy or aryloxy in compounds having the meaning sulphur for Z, R3 denotes hydroxyl, lower alkoxy, aryl(lower alkoxy), acyloxy or aryloxy in compounds having the meaning oxygen for Z and R3 is bonded in position 5 or 8 in compounds having the meaning oxygen for Z, and R4 and R5 independently of one another denote hydrogen, lower alkyl or halogen, and pharmaceutically acceptable salts thereof, or mono- or di-S-oxides of compounds of the formula I in which Z denotes sulphur. The compounds can be used as modulators for the receptors of the central nervous system, for example as serotonin receptor antagonists in the treatment of disorders of the central nervous system.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77206885A | 1985-09-03 | 1985-09-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK418486D0 true DK418486D0 (en) | 1986-09-02 |
| DK418486A DK418486A (en) | 1987-03-04 |
Family
ID=25093804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK418486A DK418486A (en) | 1985-09-03 | 1986-09-02 | 3,4-DIHYDRO-2H- (1) - (BENZOPYRANE AND BENZOTHIOPYRANE) -3-AMINES AND SALTS THEREOF AND THEIR PREPARATION AND USE |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0222996B1 (en) |
| JP (1) | JPS6259273A (en) |
| KR (1) | KR900003883B1 (en) |
| AT (1) | ATE63744T1 (en) |
| AU (1) | AU596113B2 (en) |
| DD (1) | DD249480A5 (en) |
| DE (1) | DE3679378D1 (en) |
| DK (1) | DK418486A (en) |
| ES (1) | ES2001923A6 (en) |
| FI (1) | FI86720C (en) |
| GR (1) | GR862239B (en) |
| HU (1) | HU202853B (en) |
| IL (1) | IL79920A (en) |
| NO (1) | NO863507L (en) |
| NZ (1) | NZ217432A (en) |
| PH (1) | PH22522A (en) |
| PT (1) | PT83300B (en) |
| ZA (1) | ZA866685B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957928A (en) * | 1986-06-26 | 1990-09-18 | Ciba-Geigy Corporation | Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds |
| US4801605A (en) * | 1986-08-29 | 1989-01-31 | Ciba-Geigy Corporation | 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans |
| SE8605504D0 (en) * | 1986-12-19 | 1986-12-19 | Astra Laekemedel Ab | NOVEL CHROMAN DERIVATIVES |
| EP0322361A3 (en) * | 1987-12-23 | 1990-01-24 | Ciba-Geigy Ag | Hydrogenated 1-benzooxacycloalkyl pyridine-carboxylic-acid compounds |
| EP0375449B1 (en) * | 1988-12-23 | 1995-02-15 | Beecham Group Plc | Benzopyran-type compounds |
| DK0470176T3 (en) * | 1989-04-27 | 1994-04-25 | Upjohn Co | Substituted 3-amino-chromanes |
| SE8904127D0 (en) * | 1989-12-07 | 1989-12-07 | Astra Ab | NEW BIOCYCLIC AMINO-SUBSTITUTED COMPOUNDS |
| US5616610A (en) * | 1989-12-22 | 1997-04-01 | Astra Aktiebolag | (R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans |
| SE8904361D0 (en) | 1989-12-22 | 1989-12-22 | Astra Ab | NEW CHROMAN AND THIOCHROMAN DERIVATIVES |
| US5420151A (en) * | 1989-12-22 | 1995-05-30 | Aktiebolaget Astra | Chroman derivatives |
| FR2660657B1 (en) * | 1990-04-09 | 1993-05-07 | Adir | NOVEL 3-AMINOCHROMANE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| US5273994A (en) * | 1990-04-09 | 1993-12-28 | Adir Et Compagnie | 3-aminochroman compounds |
| FR2678617B1 (en) * | 1991-07-01 | 1995-01-20 | Adir | NEW PROCESS FOR THE SYNTHESIS OF ENANTIOMERS OF 3-AMINO CHROMAN DERIVATIVES. |
| FR2681325B1 (en) * | 1991-09-16 | 1993-12-17 | Fabre Medicament Pierre | DERIVATIVES OF AMINOMETHYL-4 PIPERIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION. |
| HRP920935A2 (en) * | 1991-10-08 | 1995-08-31 | Astra Ab | New therapeutically active compound |
| FR2689509B1 (en) * | 1992-04-01 | 1994-06-03 | Adir | NEW SPIRANIC DERIVATIVES OF 3-AMINO CHROMANE, THEIR PREPARATION METHODS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| CZ282172B6 (en) * | 1992-11-30 | 1997-05-14 | Smithkline Beecham Plc | Benzopyran analogs process for preparing such compounds, pharmaceutical composition containing such compounds and the use thereof |
| US7125904B2 (en) | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3629289A (en) * | 1969-04-24 | 1971-12-21 | Parke Davis & Co | Chromanamines |
| US3607886A (en) * | 1969-04-24 | 1971-09-21 | Parke Davis & Co | Chromanamines |
| US4203895A (en) * | 1978-04-14 | 1980-05-20 | Warner-Lambert Company | Process for the preparation of cis-(±)-3,4-dihydro-N,N,2-trimethyl-2H-1-benzopyran-3-amine and intermediates produced thereby |
-
1986
- 1986-09-01 PH PH34204A patent/PH22522A/en unknown
- 1986-09-01 AT AT86112104T patent/ATE63744T1/en not_active IP Right Cessation
- 1986-09-01 DE DE8686112104T patent/DE3679378D1/en not_active Expired - Lifetime
- 1986-09-01 EP EP86112104A patent/EP0222996B1/en not_active Expired - Lifetime
- 1986-09-01 GR GR862239A patent/GR862239B/en unknown
- 1986-09-02 DK DK418486A patent/DK418486A/en unknown
- 1986-09-02 NZ NZ217432A patent/NZ217432A/en unknown
- 1986-09-02 NO NO863507A patent/NO863507L/en unknown
- 1986-09-02 ZA ZA866685A patent/ZA866685B/en unknown
- 1986-09-02 IL IL79920A patent/IL79920A/en unknown
- 1986-09-02 ES ES8601568A patent/ES2001923A6/en not_active Expired
- 1986-09-02 DD DD86294093A patent/DD249480A5/en not_active IP Right Cessation
- 1986-09-02 HU HU863786A patent/HU202853B/en not_active IP Right Cessation
- 1986-09-03 KR KR1019860007357A patent/KR900003883B1/en not_active IP Right Cessation
- 1986-09-03 JP JP61206047A patent/JPS6259273A/en active Pending
- 1986-09-03 FI FI863558A patent/FI86720C/en not_active IP Right Cessation
- 1986-09-03 PT PT83300A patent/PT83300B/en not_active IP Right Cessation
- 1986-09-03 AU AU62317/86A patent/AU596113B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0222996A2 (en) | 1987-05-27 |
| FI86720B (en) | 1992-06-30 |
| PT83300B (en) | 1989-05-12 |
| IL79920A (en) | 1991-07-18 |
| FI86720C (en) | 1992-10-12 |
| HU202853B (en) | 1991-04-29 |
| ATE63744T1 (en) | 1991-06-15 |
| FI863558A (en) | 1987-03-04 |
| KR900003883B1 (en) | 1990-06-04 |
| EP0222996B1 (en) | 1991-05-22 |
| KR870003088A (en) | 1987-04-15 |
| FI863558A0 (en) | 1986-09-03 |
| ES2001923A6 (en) | 1988-07-01 |
| HUT44771A (en) | 1988-04-28 |
| ZA866685B (en) | 1987-04-29 |
| DK418486A (en) | 1987-03-04 |
| DD249480A5 (en) | 1987-09-09 |
| JPS6259273A (en) | 1987-03-14 |
| NZ217432A (en) | 1990-03-27 |
| NO863507L (en) | 1987-03-04 |
| PH22522A (en) | 1988-10-17 |
| AU596113B2 (en) | 1990-04-26 |
| GR862239B (en) | 1986-12-31 |
| IL79920A0 (en) | 1986-12-31 |
| DE3679378D1 (en) | 1991-06-27 |
| AU6231786A (en) | 1987-03-05 |
| NO863507D0 (en) | 1986-09-02 |
| PT83300A (en) | 1986-10-01 |
| EP0222996A3 (en) | 1987-12-02 |
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