DK3535290T5 - Manipuleret todelt celleindretning til opdagelse og karakterisering af t-celle-receptorinteraktion med beslægtet antigen - Google Patents
Manipuleret todelt celleindretning til opdagelse og karakterisering af t-celle-receptorinteraktion med beslægtet antigen Download PDFInfo
- Publication number
- DK3535290T5 DK3535290T5 DK17801380.1T DK17801380T DK3535290T5 DK 3535290 T5 DK3535290 T5 DK 3535290T5 DK 17801380 T DK17801380 T DK 17801380T DK 3535290 T5 DK3535290 T5 DK 3535290T5
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- A—HUMAN NECESSITIES
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
- C12N2015/859—Animal models comprising reporter system for screening tests
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- General Physics & Mathematics (AREA)
- Virology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Computational Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201670874 | 2016-11-07 | ||
PCT/EP2017/078474 WO2018083339A1 (en) | 2016-11-07 | 2017-11-07 | An engineered two-part cellular device for discovery and characterisation of t-cell receptor interaction with cognate antigen |
Publications (2)
Publication Number | Publication Date |
---|---|
DK3535290T3 DK3535290T3 (da) | 2024-03-11 |
DK3535290T5 true DK3535290T5 (da) | 2024-09-02 |
Family
ID=57460293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17801380.1T DK3535290T5 (da) | 2016-11-07 | 2017-11-07 | Manipuleret todelt celleindretning til opdagelse og karakterisering af t-celle-receptorinteraktion med beslægtet antigen |
Country Status (12)
Country | Link |
---|---|
US (2) | US20200115432A1 (da) |
EP (3) | EP4332226A3 (da) |
JP (2) | JP7582779B2 (da) |
KR (1) | KR102606929B1 (da) |
CN (1) | CN110036026B (da) |
AU (3) | AU2017352661B2 (da) |
CA (1) | CA3039422A1 (da) |
DK (1) | DK3535290T5 (da) |
ES (1) | ES2970535T3 (da) |
FI (1) | FI3535290T3 (da) |
LT (1) | LT3535290T (da) |
WO (1) | WO2018083339A1 (da) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11293021B1 (en) | 2016-06-23 | 2022-04-05 | Inscripta, Inc. | Automated cell processing methods, modules, instruments, and systems |
AU2017352591B2 (en) | 2016-11-07 | 2024-07-11 | Genovie Ab | A two-part device for T-cell receptor synthesis and stable genomic integration to TCR-presenting cells |
ES2968633T3 (es) | 2016-11-07 | 2024-05-13 | Genovie Ab | Sistema multicomponente modificado por ingeniería para la identificación y caracterización de receptores de linfocitos T y antígenos de linfocitos T |
US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
HRP20220615T1 (hr) | 2017-06-30 | 2022-06-24 | Inscripta, Inc. | Postupci, moduli, instrumenti i sustavi za automatiziranu obradu stanica |
WO2019200004A1 (en) | 2018-04-13 | 2019-10-17 | Inscripta, Inc. | Automated cell processing instruments comprising reagent cartridges |
US10858761B2 (en) | 2018-04-24 | 2020-12-08 | Inscripta, Inc. | Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells |
US10557216B2 (en) | 2018-04-24 | 2020-02-11 | Inscripta, Inc. | Automated instrumentation for production of T-cell receptor peptide libraries |
US10501738B2 (en) | 2018-04-24 | 2019-12-10 | Inscripta, Inc. | Automated instrumentation for production of peptide libraries |
CA3108767A1 (en) | 2018-06-30 | 2020-01-02 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
US11142740B2 (en) | 2018-08-14 | 2021-10-12 | Inscripta, Inc. | Detection of nuclease edited sequences in automated modules and instruments |
US10532324B1 (en) | 2018-08-14 | 2020-01-14 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
WO2020081149A2 (en) | 2018-08-30 | 2020-04-23 | Inscripta, Inc. | Improved detection of nuclease edited sequences in automated modules and instruments |
US11214781B2 (en) | 2018-10-22 | 2022-01-04 | Inscripta, Inc. | Engineered enzyme |
US10604746B1 (en) | 2018-10-22 | 2020-03-31 | Inscripta, Inc. | Engineered enzymes |
US10815467B2 (en) | 2019-03-25 | 2020-10-27 | Inscripta, Inc. | Simultaneous multiplex genome editing in yeast |
US11001831B2 (en) | 2019-03-25 | 2021-05-11 | Inscripta, Inc. | Simultaneous multiplex genome editing in yeast |
WO2020247587A1 (en) | 2019-06-06 | 2020-12-10 | Inscripta, Inc. | Curing for recursive nucleic acid-guided cell editing |
WO2020257395A1 (en) | 2019-06-21 | 2020-12-24 | Inscripta, Inc. | Genome-wide rationally-designed mutations leading to enhanced lysine production in e. coli |
US10927385B2 (en) | 2019-06-25 | 2021-02-23 | Inscripta, Inc. | Increased nucleic-acid guided cell editing in yeast |
WO2021102059A1 (en) | 2019-11-19 | 2021-05-27 | Inscripta, Inc. | Methods for increasing observed editing in bacteria |
AU2020402526B2 (en) | 2019-12-10 | 2025-01-23 | Inscripta, Inc. | Novel MAD nucleases |
US10704033B1 (en) | 2019-12-13 | 2020-07-07 | Inscripta, Inc. | Nucleic acid-guided nucleases |
EP4069851A4 (en) | 2019-12-18 | 2023-11-22 | Inscripta, Inc. | Cascade/dcas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells |
US10689669B1 (en) | 2020-01-11 | 2020-06-23 | Inscripta, Inc. | Automated multi-module cell processing methods, instruments, and systems |
CA3157061A1 (en) | 2020-01-27 | 2021-08-05 | Christian SILTANEN | Electroporation modules and instrumentation |
US20210332388A1 (en) | 2020-04-24 | 2021-10-28 | Inscripta, Inc. | Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells |
CN115867312B (zh) | 2020-04-27 | 2025-06-27 | 杰诺维有限公司 | 产生引发针对病毒的非病毒粒子组成衍生表位的人白细胞抗原i类限制性cd8 t细胞应答的疫苗组合物的方法 |
US11787841B2 (en) | 2020-05-19 | 2023-10-17 | Inscripta, Inc. | Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli |
EP4214314A4 (en) | 2020-09-15 | 2024-10-16 | Inscripta, Inc. | Crispr editing to embed nucleic acid landing pads into genomes of live cells |
US11512297B2 (en) | 2020-11-09 | 2022-11-29 | Inscripta, Inc. | Affinity tag for recombination protein recruitment |
WO2022146497A1 (en) | 2021-01-04 | 2022-07-07 | Inscripta, Inc. | Mad nucleases |
EP4274890A4 (en) | 2021-01-07 | 2024-11-27 | Inscripta, Inc. | MAD-NUCLEASES |
US11884924B2 (en) | 2021-02-16 | 2024-01-30 | Inscripta, Inc. | Dual strand nucleic acid-guided nickase editing |
CN116286982B (zh) * | 2022-09-09 | 2024-01-30 | 广州凯普医药科技有限公司 | 一种hpv基因分型检测阳性参考品及其制备方法和应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6816194A (en) * | 1993-04-20 | 1994-11-08 | Robinson, William S. | Methods and materials for treatment of individuals infected with intracellular infectious agents |
EP1458241A4 (en) * | 2001-11-20 | 2005-11-09 | Dana Farber Cancer Inst Inc | MODIFIED ANTIGEN-PRESENTING CELLS |
US9678061B2 (en) * | 2010-08-06 | 2017-06-13 | Ludwig-Maximilians-Universität München | Identification of T cell target antigens |
JP6126804B2 (ja) * | 2012-07-25 | 2017-05-10 | 国立大学法人富山大学 | T細胞受容体のクローニング方法 |
CA2906970C (en) * | 2013-03-21 | 2021-05-18 | Ospedale San Raffaele Srl | Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases |
HK1243441A1 (zh) * | 2014-11-05 | 2018-07-13 | Board Of Regents, The University Of Texas System | 基因修飾的免疫效應細胞和用於擴增免疫效應細胞的工程化細胞 |
CN105316362B (zh) * | 2015-08-19 | 2020-03-17 | 暨南大学 | 一种Dual-RMCE介导的TCR基因置换系统及其方法 |
-
2017
- 2017-11-07 LT LTEPPCT/EP2017/078474T patent/LT3535290T/lt unknown
- 2017-11-07 EP EP24150956.1A patent/EP4332226A3/en active Pending
- 2017-11-07 CN CN201780068529.9A patent/CN110036026B/zh active Active
- 2017-11-07 JP JP2019546065A patent/JP7582779B2/ja active Active
- 2017-11-07 EP EP24150943.9A patent/EP4365296A3/en active Pending
- 2017-11-07 US US16/347,716 patent/US20200115432A1/en not_active Abandoned
- 2017-11-07 WO PCT/EP2017/078474 patent/WO2018083339A1/en active Search and Examination
- 2017-11-07 EP EP17801380.1A patent/EP3535290B1/en active Active
- 2017-11-07 FI FIEP17801380.1T patent/FI3535290T3/fi active
- 2017-11-07 DK DK17801380.1T patent/DK3535290T5/da active
- 2017-11-07 ES ES17801380T patent/ES2970535T3/es active Active
- 2017-11-07 AU AU2017352661A patent/AU2017352661B2/en active Active
- 2017-11-07 KR KR1020197013903A patent/KR102606929B1/ko active Active
- 2017-11-07 CA CA3039422A patent/CA3039422A1/en active Pending
-
2022
- 2022-12-02 JP JP2022193613A patent/JP2023027162A/ja active Pending
-
2023
- 2023-05-19 US US18/320,900 patent/US20230322896A1/en active Pending
- 2023-12-22 AU AU2023285984A patent/AU2023285984A1/en active Pending
- 2023-12-22 AU AU2023285982A patent/AU2023285982A1/en active Pending
Also Published As
Publication number | Publication date |
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AU2023285984A1 (en) | 2024-02-01 |
CN110036026B (zh) | 2024-01-05 |
AU2017352661B2 (en) | 2023-09-28 |
NZ753806A (en) | 2023-10-27 |
CN110036026A (zh) | 2019-07-19 |
EP4365296A3 (en) | 2024-07-24 |
EP3535290A1 (en) | 2019-09-11 |
ES2970535T3 (es) | 2024-05-29 |
AU2017352661A1 (en) | 2019-06-13 |
LT3535290T (lt) | 2024-02-12 |
JP2023027162A (ja) | 2023-03-01 |
EP4332226A2 (en) | 2024-03-06 |
CA3039422A1 (en) | 2018-05-11 |
US20200115432A1 (en) | 2020-04-16 |
JP2020513249A (ja) | 2020-05-14 |
EP4332226A3 (en) | 2024-05-08 |
JP7582779B2 (ja) | 2024-11-13 |
WO2018083339A1 (en) | 2018-05-11 |
US20230322896A1 (en) | 2023-10-12 |
AU2023285982A1 (en) | 2024-02-01 |
EP4365296A2 (en) | 2024-05-08 |
KR102606929B1 (ko) | 2023-11-27 |
EP3535290B1 (en) | 2024-01-10 |
KR20190076993A (ko) | 2019-07-02 |
DK3535290T3 (da) | 2024-03-11 |
FI3535290T3 (fi) | 2024-02-05 |
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