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DK3578563T3 - Guanin-analoger som telomerase-substrater og påvirkere af telomerlængde - Google Patents

Guanin-analoger som telomerase-substrater og påvirkere af telomerlængde Download PDF

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Publication number
DK3578563T3
DK3578563T3 DK19173147.0T DK19173147T DK3578563T3 DK 3578563 T3 DK3578563 T3 DK 3578563T3 DK 19173147 T DK19173147 T DK 19173147T DK 3578563 T3 DK3578563 T3 DK 3578563T3
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DK
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Prior art keywords
influencers
telomere length
guanine analogs
telomerase substrates
telomerase
Prior art date
Application number
DK19173147.0T
Other languages
English (en)
Inventor
Sergei M Gryaznov
Ronald A Pruzan
Krisztina Pongracz
Original Assignee
Geron Corp
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Publication of DK3578563T3 publication Critical patent/DK3578563T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK19173147.0T 2011-12-22 2012-12-21 Guanin-analoger som telomerase-substrater og påvirkere af telomerlængde DK3578563T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161579575P 2011-12-22 2011-12-22
EP12859248.2A EP2794624B1 (en) 2011-12-22 2012-12-21 Guanine analogs as telomerase substrates and telomere length affectors

Publications (1)

Publication Number Publication Date
DK3578563T3 true DK3578563T3 (da) 2021-05-31

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
DK19173147.0T DK3578563T3 (da) 2011-12-22 2012-12-21 Guanin-analoger som telomerase-substrater og påvirkere af telomerlængde
DK12859248.2T DK2794624T3 (da) 2011-12-22 2012-12-21 Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK12859248.2T DK2794624T3 (da) 2011-12-22 2012-12-21 Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde

Country Status (8)

Country Link
US (5) US9593137B2 (da)
EP (2) EP3578563B1 (da)
JP (2) JP6113185B2 (da)
CA (1) CA2857490C (da)
DK (2) DK3578563T3 (da)
ES (2) ES2874774T3 (da)
HK (1) HK1205515A1 (da)
WO (1) WO2013095684A1 (da)

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CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
CN107849071B (zh) 2015-08-10 2021-03-09 默沙东公司 抗病毒的β氨基酸酯膦酰二胺化合物
EP3386512B1 (en) 2015-12-10 2023-11-22 Merck Sharp & Dohme LLC Antiviral phosphodiamide prodrugs of tenofovir
US10450335B2 (en) 2015-12-15 2019-10-22 Merck Sharp & Dohme Corp. Antiviral oxime phosphoramide compounds
US10736908B2 (en) 2016-10-26 2020-08-11 Merck Sharp & Dohme Corp. Antiviral aryl-amide phosphodiamide compounds
BR112019012511A2 (pt) 2016-12-22 2019-11-19 Idenix Pharmaceuticals Llc compostos antivirais de benzil-amina fosfodiamida, composição farmacêutica e uso do composto
TWI714820B (zh) * 2017-01-31 2021-01-01 美商基利科學股份有限公司 替諾福韋艾拉酚胺(tenofovir alafenamide)之晶型
US11826375B2 (en) 2018-07-19 2023-11-28 Merck Sharp & Dohme Llc Phosphinic amide prodrugs of tenofovir
CN111205326B (zh) * 2020-02-13 2020-09-22 南京道尔医药科技有限公司 一种绿色环保的泰诺福韦制备方法

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Publication number Publication date
US20170233419A1 (en) 2017-08-17
CA2857490A1 (en) 2013-06-27
US20200283461A1 (en) 2020-09-10
JP2015502979A (ja) 2015-01-29
CA2857490C (en) 2020-03-31
JP2017081961A (ja) 2017-05-18
US20190106447A1 (en) 2019-04-11
ES2734495T3 (es) 2019-12-10
JP6113185B2 (ja) 2017-04-12
EP2794624B1 (en) 2019-05-15
EP3578563A1 (en) 2019-12-11
HK1205515A1 (en) 2015-12-18
WO2013095684A1 (en) 2013-06-27
US9593137B2 (en) 2017-03-14
US10562926B2 (en) 2020-02-18
ES2874774T3 (es) 2021-11-05
EP3578563B1 (en) 2021-04-14
US20220306660A1 (en) 2022-09-29
DK2794624T3 (da) 2019-07-22
US11279720B2 (en) 2022-03-22
EP2794624A4 (en) 2015-04-29
US10035814B2 (en) 2018-07-31
US20150299232A1 (en) 2015-10-22
EP2794624A1 (en) 2014-10-29

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