DK3310805T3 - Pd-1-cd28-fusionsproteiner og anvendelse deraf i medicin - Google Patents
Pd-1-cd28-fusionsproteiner og anvendelse deraf i medicin Download PDFInfo
- Publication number
- DK3310805T3 DK3310805T3 DK16736802.6T DK16736802T DK3310805T3 DK 3310805 T3 DK3310805 T3 DK 3310805T3 DK 16736802 T DK16736802 T DK 16736802T DK 3310805 T3 DK3310805 T3 DK 3310805T3
- Authority
- DK
- Denmark
- Prior art keywords
- medicine
- fusion proteins
- fusion
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15172913 | 2015-06-19 | ||
| PCT/EP2016/064195 WO2016203048A1 (en) | 2015-06-19 | 2016-06-20 | Pd-1-cd28 fusion proteins and their use in medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3310805T3 true DK3310805T3 (da) | 2021-05-03 |
Family
ID=53476720
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16736802.6T DK3310805T3 (da) | 2015-06-19 | 2016-06-20 | Pd-1-cd28-fusionsproteiner og anvendelse deraf i medicin |
| DK21155542.0T DK3909972T5 (da) | 2015-06-19 | 2016-06-20 | Pd1-cd28-fusionsproteiner og disses anvendelse i medicin |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK21155542.0T DK3909972T5 (da) | 2015-06-19 | 2016-06-20 | Pd1-cd28-fusionsproteiner og disses anvendelse i medicin |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11192935B2 (da) |
| EP (3) | EP3909972B1 (da) |
| JP (3) | JP7085988B2 (da) |
| CN (3) | CN115927474A (da) |
| AU (1) | AU2016277883B2 (da) |
| CA (1) | CA2989949A1 (da) |
| DK (2) | DK3310805T3 (da) |
| ES (2) | ES2870174T3 (da) |
| FI (1) | FI3909972T3 (da) |
| HU (1) | HUE054201T2 (da) |
| PL (1) | PL3310805T3 (da) |
| PT (1) | PT3310805T (da) |
| WO (1) | WO2016203048A1 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2978186A1 (en) | 2015-03-05 | 2016-09-09 | Fred Hutchinson Cancer Research Center | Immunomodulatory fusion proteins and uses thereof |
| BR112017024757A2 (pt) | 2015-05-18 | 2018-11-13 | TCR2 Therapeutics Inc. | composições e métodos para reprogramação de tcr utilizando proteínas de fusão |
| DK3310805T3 (da) * | 2015-06-19 | 2021-05-03 | Sebastian Kobold | Pd-1-cd28-fusionsproteiner og anvendelse deraf i medicin |
| JP2018520679A (ja) * | 2015-06-29 | 2018-08-02 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 免疫チェックポイントキメラ抗原受容体療法 |
| CN105331585A (zh) * | 2015-11-13 | 2016-02-17 | 科济生物医药（上海）有限公司 | 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞 |
| JP7250519B2 (ja) * | 2016-03-23 | 2023-04-03 | ヘルムホルツ ツェントゥルム ミュンヘン ドイチェス フォルシュングスツェントゥルム フューア ゲズントハイト ウント ウムヴェルト （ゲーエムベーハー） | Ｐｄ－１及び４－１ｂｂの融合タンパク質 |
| CN107523545A (zh) * | 2016-06-20 | 2017-12-29 | 上海细胞治疗研究院 | 一种高效稳定表达抗体的杀伤性细胞及其用途 |
| EP3478722A1 (en) * | 2016-06-30 | 2019-05-08 | F. Hoffmann-La Roche AG | Improved adoptive t-cell therapy |
| CN109715668A (zh) | 2016-08-02 | 2019-05-03 | T细胞受体治疗公司 | 用于使用融合蛋白进行tcr重编程的组合物和方法 |
| IL302917A (en) | 2016-10-07 | 2023-07-01 | Tcr2 Therapeutics Inc | Preparations and methods for reprogramming T-cell receptors using fusion proteins |
| US11851491B2 (en) | 2016-11-22 | 2023-12-26 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| EP3558348A1 (en) * | 2016-12-21 | 2019-10-30 | TCR2 Therapeutics Inc. | Engineered t cells for the treatment of cancer |
| WO2018140725A1 (en) * | 2017-01-26 | 2018-08-02 | Novartis Ag | Cd28 compositions and methods for chimeric antigen receptor therapy |
| CN110621335A (zh) | 2017-03-17 | 2019-12-27 | 弗雷德哈钦森癌症研究中心 | 免疫调节融合蛋白及其用途 |
| KR20200130709A (ko) * | 2018-03-06 | 2020-11-19 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 전립선-특이 막 항원 car 및 이의 사용 방법 |
| CN108727504B (zh) * | 2018-04-16 | 2021-08-27 | 泉州向日葵生物科技有限公司 | 一种ifn与抗pd-l1抗体的融合蛋白及其应用 |
| CN111606999B (zh) * | 2019-02-26 | 2022-09-06 | 南京惟亚德生物医药有限公司 | 兼具激活免疫共刺激信号通路和阻断免疫检查点的复制型溶瘤腺病毒及其应用 |
| KR20220035471A (ko) * | 2019-07-19 | 2022-03-22 | 메모리얼 슬로안 케터링 캔서 센터 | 면역치료법을 위한 융합 폴리펩티드 |
| CN113832111A (zh) * | 2020-06-23 | 2021-12-24 | 南京大学 | 一种类外泌体技术用于制备新型溶瘤病毒的方法 |
| CN113832114A (zh) * | 2020-06-23 | 2021-12-24 | 南京大学 | 一种新型溶瘤腺病毒EM/VSV-G Ad5-P及其在制备抗肿瘤药物中的应用 |
| CN115197314A (zh) * | 2021-04-11 | 2022-10-18 | 中国科学院分子细胞科学卓越创新中心 | 一种pd1变体及其用途 |
| JP2024519945A (ja) * | 2021-05-20 | 2024-05-21 | アチェロイス バイオファーマ，インク． | 免疫チェックポイント多価粒子の組成物、および使用方法 |
| WO2023235479A1 (en) * | 2022-06-02 | 2023-12-07 | TCR2 Therapeutics Inc. | Compositions and methods for treating cancer |
| WO2024107577A2 (en) * | 2022-11-14 | 2024-05-23 | Achelois Biopharma, Inc. | Immune checkpoint multivalent particles compositions and methods of use |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19822115B4 (de) | 1998-05-08 | 2004-04-08 | Heinrich-Pette-Institut | Retrovirale Gentransfervektoren |
| WO2007032255A1 (ja) | 2005-09-13 | 2007-03-22 | Mie University | Ｔ細胞レセプター及び該レセプターをコードする核酸 |
| WO2010012829A1 (en) | 2008-07-31 | 2010-02-04 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Her2/neu specific t cell receptors |
| ZA200807283B (en) | 2008-08-22 | 2009-10-28 | Mechlift Invest Pty Ltd | Data unit for a bin lifting device |
| MA34813B1 (fr) | 2010-12-09 | 2014-01-02 | Univ Pennsylvania | Utilisation de lymphocytes t modifies par un recepteur chimerique d'antigenes chimerique pour traiter le cancer |
| EP2694549B1 (en) | 2011-04-08 | 2018-08-15 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer |
| EA201490364A1 (ru) * | 2011-07-29 | 2014-08-29 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Костимулирующие рецепторы-переключатели |
| BR112014008849A2 (pt) | 2011-10-20 | 2017-09-12 | Us Health | receptores quiméricos de antígeno anti-cd22 |
| WO2013062365A2 (ko) * | 2011-10-26 | 2013-05-02 | 국립암센터 | 변이 ｃｔｌａ4 유전자 이입 ｔ 세포 및 이를 포함하는 항암 면역치료용 조성물 |
| US9688740B2 (en) * | 2011-10-26 | 2017-06-27 | National Cancer Center | Mutant CTLA4 gene transfected T cell and composition including same for anticancer immunotherapy |
| CA2868121C (en) | 2012-03-23 | 2021-06-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mesothelin chimeric antigen receptors |
| RU2766608C2 (ru) | 2012-04-11 | 2022-03-15 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток |
| GB201206559D0 (en) * | 2012-04-13 | 2012-05-30 | Ucl Business Plc | Polypeptide |
| US9657105B2 (en) | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| EP3995512A1 (en) | 2013-08-26 | 2022-05-11 | Hinrich Abken | Anti cd30 chimeric antigen receptor and its use |
| AU2015355084A1 (en) * | 2014-12-02 | 2017-06-29 | Prospect Chartercare Rwmc, Llc | Methods and compositons for treating cancer |
| DK3310805T3 (da) * | 2015-06-19 | 2021-05-03 | Sebastian Kobold | Pd-1-cd28-fusionsproteiner og anvendelse deraf i medicin |
| CA3071661A1 (en) * | 2017-09-06 | 2019-03-14 | Fred Hutchinson Cancer Research Center | Strep-tag specific chimeric receptors and uses thereof |
| CN115418362A (zh) * | 2019-12-02 | 2022-12-02 | 吉林凯莱英医药化学有限公司 | 共固定化酶、其制备方法及其应用 |
-
2016
- 2016-06-20 DK DK16736802.6T patent/DK3310805T3/da active
- 2016-06-20 EP EP21155542.0A patent/EP3909972B1/en active Active
- 2016-06-20 DK DK21155542.0T patent/DK3909972T5/da active
- 2016-06-20 HU HUE16736802A patent/HUE054201T2/hu unknown
- 2016-06-20 JP JP2018517487A patent/JP7085988B2/ja active Active
- 2016-06-20 CN CN202210834160.0A patent/CN115927474A/zh active Pending
- 2016-06-20 PL PL16736802T patent/PL3310805T3/pl unknown
- 2016-06-20 EP EP16736802.6A patent/EP3310805B1/en active Active
- 2016-06-20 AU AU2016277883A patent/AU2016277883B2/en active Active
- 2016-06-20 US US15/737,877 patent/US11192935B2/en active Active
- 2016-06-20 EP EP24156660.3A patent/EP4349854A3/en active Pending
- 2016-06-20 FI FIEP21155542.0T patent/FI3909972T3/fi active
- 2016-06-20 ES ES16736802T patent/ES2870174T3/es active Active
- 2016-06-20 ES ES21155542T patent/ES2976647T3/es active Active
- 2016-06-20 PT PT167368026T patent/PT3310805T/pt unknown
- 2016-06-20 CA CA2989949A patent/CA2989949A1/en active Pending
- 2016-06-20 CN CN201680048221.3A patent/CN108026151B/zh active Active
- 2016-06-20 WO PCT/EP2016/064195 patent/WO2016203048A1/en unknown
- 2016-06-20 CN CN202210854297.2A patent/CN115925971A/zh active Pending
-
2021
- 2021-10-29 US US17/515,250 patent/US20220169699A1/en active Pending
-
2022
- 2022-03-22 JP JP2022044885A patent/JP7460675B2/ja active Active
-
2024
- 2024-03-21 JP JP2024044396A patent/JP2024073636A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016277883A1 (en) | 2018-01-18 |
| JP2024073636A (ja) | 2024-05-29 |
| ES2870174T3 (es) | 2021-10-26 |
| US20220169699A1 (en) | 2022-06-02 |
| AU2016277883A8 (en) | 2018-01-25 |
| PT3310805T (pt) | 2021-05-19 |
| DK3909972T3 (da) | 2024-04-29 |
| DK3909972T5 (da) | 2024-08-05 |
| CA2989949A1 (en) | 2016-12-22 |
| EP3909972A1 (en) | 2021-11-17 |
| EP3310805A1 (en) | 2018-04-25 |
| CN108026151B (zh) | 2022-07-15 |
| HUE054201T2 (hu) | 2021-08-30 |
| US20190010207A1 (en) | 2019-01-10 |
| JP7085988B2 (ja) | 2022-06-17 |
| FI3909972T3 (fi) | 2024-05-03 |
| CN115927474A (zh) | 2023-04-07 |
| WO2016203048A1 (en) | 2016-12-22 |
| JP2022084787A (ja) | 2022-06-07 |
| EP4349854A3 (en) | 2024-07-10 |
| EP3310805B1 (en) | 2021-02-17 |
| EP4349854A2 (en) | 2024-04-10 |
| CN115925971A (zh) | 2023-04-07 |
| US11192935B2 (en) | 2021-12-07 |
| CN108026151A (zh) | 2018-05-11 |
| EP3909972B1 (en) | 2024-02-14 |
| JP7460675B2 (ja) | 2024-04-02 |
| PL3310805T3 (pl) | 2021-08-23 |
| ES2976647T3 (es) | 2024-08-06 |
| AU2016277883B2 (en) | 2020-09-17 |
| JP2018518990A (ja) | 2018-07-19 |
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