DK3302527T3 - Manipuleret CCL20-låst-dimerpolypeptid - Google Patents
Manipuleret CCL20-låst-dimerpolypeptid Download PDFInfo
- Publication number
- DK3302527T3 DK3302527T3 DK16804201.8T DK16804201T DK3302527T3 DK 3302527 T3 DK3302527 T3 DK 3302527T3 DK 16804201 T DK16804201 T DK 16804201T DK 3302527 T3 DK3302527 T3 DK 3302527T3
- Authority
- DK
- Denmark
- Prior art keywords
- ccl20
- manipulated
- dimer polypeptide
- locked dimer
- locked
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562170347P | 2015-06-03 | 2015-06-03 | |
| PCT/US2016/034956 WO2016196429A1 (en) | 2015-06-03 | 2016-05-31 | An engineered ccl20 locked dimer polypeptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3302527T3 true DK3302527T3 (da) | 2020-03-30 |
Family
ID=57441846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16804201.8T DK3302527T3 (da) | 2015-06-03 | 2016-05-31 | Manipuleret CCL20-låst-dimerpolypeptid |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10738095B2 (da) |
| EP (2) | EP3302527B1 (da) |
| JP (1) | JP6786526B2 (da) |
| AU (1) | AU2016271292B2 (da) |
| CA (1) | CA2988086C (da) |
| DK (1) | DK3302527T3 (da) |
| ES (1) | ES2776243T3 (da) |
| WO (1) | WO2016196429A1 (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3533451B1 (en) | 2017-01-21 | 2022-07-27 | Guangzhou Hanfang Pharmaceuticals Co., Ltd. | Application of paeoniflorin-6'-o-benzene sulfonate in medicine for treating sjögren's syndrome |
Family Cites Families (49)
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| US4160452A (en) | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
| US6479258B1 (en) | 1995-12-07 | 2002-11-12 | Diversa Corporation | Non-stochastic generation of genetic vaccines |
| US7390619B1 (en) | 1998-02-11 | 2008-06-24 | Maxygen, Inc. | Optimization of immunomodulatory properties of genetic vaccines |
| US20030215421A1 (en) | 1999-07-21 | 2003-11-20 | Mcdonald John R. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
| US6645491B1 (en) | 1999-02-03 | 2003-11-11 | Schering Corporation | Method for treating inflammatory conditions using an antibody to MIP-3α |
| US20020004041A1 (en) | 1999-02-19 | 2002-01-10 | Albert Matthew L. | Methods for abrogating a cellular immune response |
| US6723538B2 (en) | 1999-03-11 | 2004-04-20 | Micromet Ag | Bispecific antibody and chemokine receptor constructs |
| GB9912350D0 (en) * | 1999-05-26 | 1999-07-28 | European Molecular Biology Lab Embl | Modified cytokine |
| AU6951300A (en) | 1999-09-08 | 2001-04-10 | Schering Corporation | Novel uses of mammalian ccr6 receptors and related reagents |
| US20020061599A1 (en) | 1999-12-30 | 2002-05-23 | Elling Christian E. | Method of identifying ligands of biological target molecules |
| US6843987B2 (en) | 2000-02-02 | 2005-01-18 | Schering Corporation | Mammalian cytokines; receptors; related reagents and methods |
| NZ521540A (en) | 2000-04-11 | 2004-09-24 | Genentech Inc | Multivalent antibodies and uses therefor |
| US20040197329A1 (en) | 2000-10-13 | 2004-10-07 | Yasunori Nakayama | Remedies or preventives for rheumatoid arthritis |
| US20020147312A1 (en) | 2001-02-02 | 2002-10-10 | O'keefe Theresa | Hybrid antibodies and uses thereof |
| US7468253B2 (en) | 2001-06-07 | 2008-12-23 | Chemocentryx, Inc. | Method for multiple chemokine receptor screening for antagonists using RAM assay |
| FI117667B (fi) * | 2001-07-05 | 2007-01-15 | Univ Zuerich | Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä |
| JP2005502723A (ja) | 2001-09-20 | 2005-01-27 | シェーリング コーポレイション | 免疫応答のアジュバントとしてのケモカイン |
| US20030140361A1 (en) | 2001-09-24 | 2003-07-24 | Brennan Thomas J. | CCR6 chemokine receptor disruptions, compositions and methods relating thereto |
| US7413866B2 (en) | 2001-11-30 | 2008-08-19 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| US7442512B2 (en) | 2001-11-30 | 2008-10-28 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| US7507787B2 (en) | 2001-12-03 | 2009-03-24 | The University Of British Columbia | Effectors of innate immunity |
| US20060240016A1 (en) | 2001-12-18 | 2006-10-26 | Luc Aguilar | Activity of THAP-family chemokine-binding domains |
| US7858297B2 (en) | 2001-12-18 | 2010-12-28 | Centre National De La Recherche Scientifique Cnrs | Chemokine-binding protein and methods of use |
| US20060275295A1 (en) | 2001-12-18 | 2006-12-07 | Denis Jullien | Activity of THAP-family chemokine-binding domains |
| WO2004024075A2 (en) | 2002-09-11 | 2004-03-25 | Medical College Of Georgia Research Institute, Inc. | Chemokine receptor antagonists as therapeutic agents |
| US20050148029A1 (en) | 2003-09-29 | 2005-07-07 | Biosite, Inc. | Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes |
| EP1771204A4 (en) | 2004-07-01 | 2008-08-13 | Univ New York | COMPOSITIONS AND METHODS FOR MODULATING ROR GAMMA T |
| WO2006047315A2 (en) | 2004-10-25 | 2006-05-04 | The Brigham And Women's Hospital, Inc. | Targeted delivery of biological factors using self-assembling peptide nanofibers |
| US8440627B2 (en) | 2004-11-04 | 2013-05-14 | Tufts Medical Center, Inc. | G protein coupled receptor agonists and antagonists and methods of use |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| EP1952150B1 (en) | 2005-11-23 | 2016-12-14 | Genentech, Inc. | Methods and compositions related to b cell assays |
| ATE437889T1 (de) | 2005-12-02 | 2009-08-15 | Apceth Gmbh & Co Kg | Chemokin-mucin fusionsproteine mit einer gpi- ankerdomäne und deren verwendung als tumor-immun- adjuvanzien oder in der geweberegeneration |
| EP3805269A1 (en) | 2006-06-12 | 2021-04-14 | Aptevo Research and Development LLC | Single-chain multivalent binding proteins with effector function |
| WO2008080218A1 (en) | 2006-12-29 | 2008-07-10 | Osprey Pharmaceuticals Usa, Inc. | Methods of selecting and producing modified toxins, conjugates containing modified toxins and uses thereof |
| US7923016B2 (en) * | 2008-02-27 | 2011-04-12 | Medical College Of Wisconsin | Engineered CXCL12 α locked dimer polypeptide |
| US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| CA2745439C (en) | 2008-12-03 | 2019-10-15 | Genmab A/S | Antibody variants having modifications in the constant region |
| JP2012517405A (ja) | 2009-02-09 | 2012-08-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器及び胃腸の疾患の治療のための新規医薬組成物 |
| EP2456787A4 (en) | 2009-07-24 | 2013-01-30 | Univ Leland Stanford Junior | CYTOKINE COMPOSITIONS AND METHODS OF USE |
| US8729058B2 (en) | 2009-10-27 | 2014-05-20 | Michael Zasloff | Methods and compositions for treating and preventing viral infections |
| EA029419B1 (ru) | 2010-11-19 | 2018-03-30 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Нейтрализующие антитела против ccl20 |
| UY33827A (es) | 2010-12-22 | 2012-07-31 | Abbott Lab | Proteínas de unión a media-inmunoglobulina y sus usos |
| EP2670847B1 (en) * | 2011-02-03 | 2016-10-05 | XOMA Technology Ltd. | Methods and materials for enhancing functional protein expression in bacteria |
| TWI671315B (zh) | 2011-03-28 | 2019-09-11 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| KR20140020321A (ko) | 2011-04-13 | 2014-02-18 | 레발레시오 코퍼레이션 | 염증성 신경변성 질환에 관여하는 작동자 ｔ 세포를 억제하고／하거나 조절하기 위한 조성물 및 방법 |
| SI2931738T1 (sl) | 2012-12-13 | 2019-05-31 | Aduro Biotech, Inc. | Sestave, ki vsebujejo ciklične purin dinukleotide z definirano stereokemijo, ter metode za njihovo pripravo in uporabo |
-
2016
- 2016-05-31 DK DK16804201.8T patent/DK3302527T3/da active
- 2016-05-31 AU AU2016271292A patent/AU2016271292B2/en active Active
- 2016-05-31 JP JP2017562777A patent/JP6786526B2/ja active Active
- 2016-05-31 US US15/579,114 patent/US10738095B2/en active Active
- 2016-05-31 WO PCT/US2016/034956 patent/WO2016196429A1/en active Application Filing
- 2016-05-31 EP EP16804201.8A patent/EP3302527B1/en active Active
- 2016-05-31 EP EP19212936.9A patent/EP3666282A1/en active Pending
- 2016-05-31 ES ES16804201T patent/ES2776243T3/es active Active
- 2016-05-31 CA CA2988086A patent/CA2988086C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3302527A4 (en) | 2018-12-12 |
| JP2018517707A (ja) | 2018-07-05 |
| CA2988086A1 (en) | 2016-12-08 |
| AU2016271292A1 (en) | 2017-12-21 |
| ES2776243T3 (es) | 2020-07-29 |
| WO2016196429A1 (en) | 2016-12-08 |
| EP3302527A1 (en) | 2018-04-11 |
| CA2988086C (en) | 2023-09-19 |
| US20180237486A1 (en) | 2018-08-23 |
| US10738095B2 (en) | 2020-08-11 |
| EP3666282A1 (en) | 2020-06-17 |
| AU2016271292B2 (en) | 2022-04-14 |
| JP6786526B2 (ja) | 2020-11-18 |
| EP3302527B1 (en) | 2020-01-08 |
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