DK3041862T3 - Modificerede bispecifikke, penta- og hexavalente ig-m-antistoffer med konstant kæde - Google Patents
Modificerede bispecifikke, penta- og hexavalente ig-m-antistoffer med konstant kæde Download PDFInfo
- Publication number
- DK3041862T3 DK3041862T3 DK14766628.3T DK14766628T DK3041862T3 DK 3041862 T3 DK3041862 T3 DK 3041862T3 DK 14766628 T DK14766628 T DK 14766628T DK 3041862 T3 DK3041862 T3 DK 3041862T3
- Authority
- DK
- Denmark
- Prior art keywords
- hexavalent
- penta
- antibodies
- constant chain
- modified bispecific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/528—CH4 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361874284P | 2013-09-05 | 2013-09-05 | |
| US201361874277P | 2013-09-05 | 2013-09-05 | |
| PCT/US2014/054079 WO2015053887A1 (en) | 2013-09-05 | 2014-09-04 | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3041862T3 true DK3041862T3 (da) | 2020-07-27 |
Family
ID=51542496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14766628.3T DK3041862T3 (da) | 2013-09-05 | 2014-09-04 | Modificerede bispecifikke, penta- og hexavalente ig-m-antistoffer med konstant kæde |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10351631B2 (da) |
| EP (1) | EP3041862B1 (da) |
| JP (1) | JP6721505B2 (da) |
| KR (1) | KR102306492B1 (da) |
| CN (1) | CN105722855B (da) |
| AU (1) | AU2014332458B2 (da) |
| CA (1) | CA2922830A1 (da) |
| DK (1) | DK3041862T3 (da) |
| WO (1) | WO2015053887A1 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| KR101638224B1 (ko) | 2011-02-28 | 2016-07-08 | 에프. 호프만-라 로슈 아게 | 항원 결합 단백질 |
| RU2013141078A (ru) | 2011-02-28 | 2015-04-10 | Ф. Хоффманн-Ля Рош Аг | Одновалентные антигенсвязывающие белки |
| EP3055329B1 (en) * | 2013-10-11 | 2018-06-13 | F. Hoffmann-La Roche AG | Multispecific domain exchanged common variable light chain antibodies |
| BR112016018313A8 (pt) | 2014-02-10 | 2018-06-12 | Igm Biosciences Inc | Moléculas de ligação multiespecíficas iga |
| SG10201909716RA (en) | 2014-04-03 | 2019-11-28 | Igm Biosciences Inc | Modified j-chain |
| NZ732922A (en) | 2015-01-20 | 2022-07-29 | Igm Biosciences Inc | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
| EP3957738A1 (en) | 2015-03-04 | 2022-02-23 | IGM Biosciences, Inc. | Cd20 binding molecules and uses thereof |
| JP6882184B2 (ja) | 2015-03-25 | 2021-06-02 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多価ｂ型肝炎ウイルス抗原結合分子およびその使用 |
| US10570191B2 (en) | 2015-04-17 | 2020-02-25 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| EP3355913B1 (en) * | 2015-09-30 | 2024-10-30 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| ES2819870T3 (es) * | 2015-09-30 | 2021-04-19 | Igm Biosciences Inc | Moléculas de unión con cadena J modificada |
| IL262295B2 (en) | 2016-05-09 | 2023-09-01 | Igm Biosciences Inc | Antibodies against pd–l1 |
| JP2020512820A (ja) | 2017-04-07 | 2020-04-30 | アイジーエム バイオサイエンシズ インコーポレイテッド | 補体依存性細胞溶解のエフェクター機能の調節のための修飾されたヒトＩｇＭ定常領域 |
| KR20200128391A (ko) | 2018-03-01 | 2020-11-12 | 아이쥐엠 바이오사이언스 인코포레이티드 | IgM 혈청 반감기에 영향을 미치는 IgM Fc 및 J-쇄 돌연변이 |
| MX2022001934A (es) | 2019-08-15 | 2022-03-11 | Igm Biosciences Inc | Moleculas de union multimericas inmunoestimuladoras. |
| KR20230005228A (ko) | 2020-04-22 | 2023-01-09 | 아이쥐엠 바이오사이언스 인코포레이티드 | Pd-1 효능제 다량체 결합 분자 |
| WO2023196995A1 (en) | 2022-04-07 | 2023-10-12 | Repertoire Immune Medicines, Inc. | T cell receptor multimers and uses thereof |
| WO2024073482A1 (en) * | 2022-09-28 | 2024-04-04 | Dren Bio, Inc. | Multispecific antibodies and methods of use thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8719963D0 (en) | 1987-08-24 | 1987-09-30 | Cattaneo A | Recombinant dna products |
| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| CA2521490C (en) | 2003-05-23 | 2013-07-30 | Crucell Holland B.V. | Production of recombinant igm in per.c6 cells |
| RU2398882C2 (ru) | 2004-07-22 | 2010-09-10 | Эрасмус Юниверсити Медикал Сентр Роттердам | СПОСОБ ПОЛУЧЕНИЯ АНТИГЕН-СВЯЗЫВАЮЩЕГО ДОМЕНА Vh ИСПОЛЬЗОВАНИЕ |
| US8377435B2 (en) | 2004-11-05 | 2013-02-19 | The Board Of Trustees Of The Leland Stanford Junior University | Antibody induced cell membrane wounding |
| US8349332B2 (en) * | 2005-04-06 | 2013-01-08 | Ibc Pharmaceuticals, Inc. | Multiple signaling pathways induced by hexavalent, monospecific and bispecific antibodies for enhanced toxicity to B-cell lymphomas and other diseases |
| DK2235064T3 (da) | 2008-01-07 | 2016-01-11 | Amgen Inc | Fremgangsmåde til fremstilling af Fc-heterodimeriske molekyler under anvendelse af elektrostatiske styringseffekter |
| US9676845B2 (en) * | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| US20130129723A1 (en) * | 2009-12-29 | 2013-05-23 | Emergent Product Development Seattle, Llc | Heterodimer Binding Proteins and Uses Thereof |
| EP2760891B1 (en) | 2011-09-26 | 2018-11-07 | JN Biosciences LLC | Hybrid constant regions |
| DK2794905T3 (da) * | 2011-12-20 | 2020-07-06 | Medimmune Llc | Modificerede polypeptider til bispecifikke antistofgrundstrukturer |
| CA2863714C (en) | 2012-02-08 | 2022-07-05 | Igm Biosciences, Inc. | Cdim binding proteins and uses thereof |
| EP3094644B1 (en) | 2014-01-16 | 2019-07-24 | Mondelli, Mario Umberto Franceso | Neutralizing human monoclonal antibodies against hepatitis b virus surface antigen |
| BR112016018313A8 (pt) | 2014-02-10 | 2018-06-12 | Igm Biosciences Inc | Moléculas de ligação multiespecíficas iga |
| SG10201909716RA (en) | 2014-04-03 | 2019-11-28 | Igm Biosciences Inc | Modified j-chain |
| NZ732922A (en) | 2015-01-20 | 2022-07-29 | Igm Biosciences Inc | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
| EP3957738A1 (en) | 2015-03-04 | 2022-02-23 | IGM Biosciences, Inc. | Cd20 binding molecules and uses thereof |
| JP6882184B2 (ja) | 2015-03-25 | 2021-06-02 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多価ｂ型肝炎ウイルス抗原結合分子およびその使用 |
| US10570191B2 (en) | 2015-04-17 | 2020-02-25 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| ES2819870T3 (es) | 2015-09-30 | 2021-04-19 | Igm Biosciences Inc | Moléculas de unión con cadena J modificada |
| EP3355913B1 (en) | 2015-09-30 | 2024-10-30 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| IL262295B2 (en) | 2016-05-09 | 2023-09-01 | Igm Biosciences Inc | Antibodies against pd–l1 |
| JP2019528683A (ja) | 2016-07-20 | 2019-10-17 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多量体ｇｉｔｒ結合分子及びその使用 |
| AU2017298483A1 (en) | 2016-07-20 | 2019-02-07 | Igm Biosciences, Inc. | Multimeric OX40 binding molecules and uses thereof |
| EP3487298A4 (en) | 2016-07-20 | 2020-03-11 | IGM Biosciences, Inc. | MOLECULES FIXING PDK137 / 4 AND USES THEREOF |
| US20190338041A1 (en) | 2016-07-20 | 2019-11-07 | Igm Biosciences, Inc. | Multimeric cd40 binding molecules and uses thereof |
-
2014
- 2014-09-04 DK DK14766628.3T patent/DK3041862T3/da active
- 2014-09-04 KR KR1020167007082A patent/KR102306492B1/ko active IP Right Grant
- 2014-09-04 CN CN201480051238.5A patent/CN105722855B/zh active Active
- 2014-09-04 US US14/916,166 patent/US10351631B2/en active Active
- 2014-09-04 AU AU2014332458A patent/AU2014332458B2/en active Active
- 2014-09-04 EP EP14766628.3A patent/EP3041862B1/en active Active
- 2014-09-04 CA CA2922830A patent/CA2922830A1/en active Pending
- 2014-09-04 WO PCT/US2014/054079 patent/WO2015053887A1/en active Application Filing
- 2014-09-04 JP JP2016540383A patent/JP6721505B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014332458A1 (en) | 2016-04-07 |
| EP3041862B1 (en) | 2020-05-06 |
| BR112016004768A2 (da) | 2017-09-05 |
| JP6721505B2 (ja) | 2020-07-15 |
| CA2922830A1 (en) | 2015-04-16 |
| JP2016531924A (ja) | 2016-10-13 |
| US10351631B2 (en) | 2019-07-16 |
| KR20160077036A (ko) | 2016-07-01 |
| US20160222132A1 (en) | 2016-08-04 |
| BR112016004768A8 (pt) | 2018-06-12 |
| KR102306492B1 (ko) | 2021-09-29 |
| EP3041862A1 (en) | 2016-07-13 |
| WO2015053887A1 (en) | 2015-04-16 |
| CN105722855B (zh) | 2021-04-23 |
| CN105722855A (zh) | 2016-06-29 |
| AU2014332458B2 (en) | 2020-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3041862T3 (da) | Modificerede bispecifikke, penta- og hexavalente ig-m-antistoffer med konstant kæde | |
| HK1232243A1 (zh) | 抗- 抗體及其用途 | |
| DK3026062T3 (da) | Anti-pd-1-antistof og anvendelse deraf | |
| EP2970505A4 (en) | SPECIFIC ANTIBODIES AND USES THEREOF | |
| DK3083694T3 (da) | Caniniserede, murine anti-canin-pd-1-antistoffer | |
| DK3683235T3 (da) | Anti-IL-33-antistoffer og anvendelser deraf | |
| DK3336106T3 (da) | Anti-fcrh5-antistoffer | |
| DK3027209T3 (da) | Anti-Activin A-antistoffer og anvendelser deraf | |
| ZA201506568B (en) | Anti-tnf-anti-il-17 bispecific antibodies | |
| DK3071595T3 (da) | Humaniseret anti-kallikrein-2-antistof | |
| EP2981286A4 (en) | ANTI-IL-4 ANTIBODIES AND BISPECIFIC ANTIBODIES AND USES THEREOF | |
| DK3708583T3 (da) | Ikke-fucosylerede anti-fgfr2iiib-antistoffer | |
| SG11201509284VA (en) | Anti-cxcl1, cxcl7 and cxcl8 antibodies and their applications | |
| DK3079719T3 (da) | ANTI-SIGLEC-8-antistoffer og fremgangsmåder til anvendelse deraf | |
| DK3272997T3 (da) | Choker | |
| DE112014003170A5 (de) | Kettenrad | |
| PL3549599T3 (pl) | Przeciwciała przeciwko csf-1r | |
| EP2970438A4 (en) | MONOCLONAL MELATONIN ANTIBODY, DETECTION, METHOD AND USES THEREOF | |
| DK3068800T3 (da) | FcRn-specifikke antistoffer | |
| BR112016000450A2 (pt) | oscilador, e método | |
| DK3155304T3 (da) | Rørledning med kompositholdestrimmel | |
| DE112014004310A5 (de) | Kettenführungselement | |
| DK3065774T3 (da) | Anti-CCL17-antistoffer | |
| DE112014005606A5 (de) | CVT-Getriebe | |
| DK2951208T3 (da) | Anti-cd83 antistoffer og anvendelse deraf |