DK276683A - Carbapenemer og fremgangsmaade til fremstilling deraf - Google Patents

Carbapenemer og fremgangsmaade til fremstilling deraf Download PDF

Info

Publication number: DK276683A
Authority: DK; Denmark
Prior art keywords: carbapenemes; procedures; preparing
Prior art date: 1982-06-18

Application number

DK276683A

Other languages

English (en)

Other versions

DK276683D0 (da

Inventor

Choung Un Kim

Jr Peter Francis Misco

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-06-18

Filing date

1983-06-15

Publication date

1983-12-19

1983-06-15 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1983-06-15 Publication of DK276683D0 publication Critical patent/DK276683D0/da

1983-12-19 Publication of DK276683A publication Critical patent/DK276683A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

DK276683A 1982-06-18 1983-06-15 Carbapenemer og fremgangsmaade til fremstilling deraf DK276683A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US38965282A	1982-06-18	1982-06-18
US06/499,690 US4536335A (en)	1982-06-18	1983-06-07	Carbapenem antibiotics

Publications (2)

Publication Number	Publication Date
DK276683D0 DK276683D0 (da)	1983-06-15
DK276683A true DK276683A (da)	1983-12-19

Family

ID=27012789

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK276683A DK276683A (da)	1982-06-18	1983-06-15	Carbapenemer og fremgangsmaade til fremstilling deraf

Country Status (23)

Country	Link
US (1)	US4536335A (da)
KR (1)	KR890000192B1 (da)
AT (1)	AT381941B (da)
AU (1)	AU567294B2 (da)
CA (1)	CA1273009A (da)
CH (1)	CH658657A5 (da)
DE (1)	DE3321864A1 (da)
DK (1)	DK276683A (da)
ES (1)	ES8407489A1 (da)
FI (1)	FI77036C (da)
FR (1)	FR2528847B1 (da)
GB (1)	GB2122196B (da)
GR (1)	GR78375B (da)
HU (1)	HU191052B (da)
IE (1)	IE55432B1 (da)
IL (1)	IL69002A (da)
IT (1)	IT1206324B (da)
LU (1)	LU84864A1 (da)
MY (1)	MY8800124A (da)
NL (1)	NL8302183A (da)
OA (1)	OA07468A (da)
PT (1)	PT76887B (da)
SE (1)	SE460791B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1198440A (en) *	1982-04-08	1985-12-24	Choung U. Kim	Carbapenem antibiotics
US4683301A (en) *	1982-04-08	1987-07-28	Bristol-Myers Company	Carbapenem antibiotics
US4552696A (en) *	1982-04-09	1985-11-12	Bristol-Myers Company	Carbapenem antibiotics
US4640799A (en) *	1982-06-18	1987-02-03	Bristol-Myers Company	Carbapenem antibiotics
US4746736A (en) *	1982-09-28	1988-05-24	Bristol-Myers Company	Carbapenem antibiotics
DK140584A (da) *	1983-03-08	1984-09-09	Bristol Myers Co	Fremgangsmaade til fremstilling af carbapenemderivater
GB8416651D0 (en) *	1984-06-29	1984-08-01	Erba Farmitalia	Penem derivatives
IE851586L (en) *	1984-07-02	1986-01-02	Interchem Internat S A	I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent
US4757066A (en) *	1984-10-15	1988-07-12	Sankyo Company Limited	Composition containing a penem or carbapenem antibiotic and the use of the same
US4680292A (en) *	1984-12-13	1987-07-14	Merck & Co., Inc.	Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
US4729993A (en) *	1984-12-13	1988-03-08	Merck & Co., Inc.	Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
US4725594A (en) *	1984-12-13	1988-02-16	Merck & Co., Inc.	Carbapenems having an internally or externally alkylated mono- or bicyclic 2-quaternary heteroarylalxyl heteromethyl substituent
GB8509181D0 (en) *	1985-04-10	1985-05-15	Erba Farmitalia	Penem derivatives
US4788282A (en) *	1985-06-07	1988-11-29	Bristol-Myers Company	Deprotection of allylic esters and ethers
US4665169A (en) *	1985-09-11	1987-05-12	Bristol-Myers Company	Carbapenem antibiotics
US4880922A (en) *	1985-11-22	1989-11-14	Bristol-Myers Company	Carbapenems with quaternized heterothioalkylthio substitution at position 2
CA1272719A (en) *	1986-03-06	1990-08-14	Pierre Dextraze	Carbapenem antibiotics
US4894450A (en) *	1987-05-11	1990-01-16	Merck & Co., Inc.	Process for 2-(aminoalkylthio) carbapenems
US5362723A (en) *	1991-07-29	1994-11-08	Merck & Co., Inc.	2-(heterocyclylheteroaryliumalkyl) phenyl carbapenem antibacterial agents
WO2004089954A1 (ja) *	2003-04-08	2004-10-21	Sumitomo Pharmaceuticals Co., Ltd.	新規なカルバペネム化合物
EP2623821A1 (de)	2012-02-06	2013-08-07	Siemens Aktiengesellschaft	Getriebegehäuse, Getriebeeinheit mit einem solchen Getriebegehäuse und Getriebemotor mit einer solchen Getriebeeinheit
US11040947B2 (en)	2017-03-22	2021-06-22	The Research Foundation For The State University Of New York	Substituted quinazolines as matrix metalloproteinase-9 hemopexin domain inhibitors

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4235920A (en) *	1975-11-21	1980-11-25	Merck & Co., Inc.	N-Alkylated derivatives of thienamycin
GB1570988A (en) *	1975-11-21	1980-07-09	Merck & Co Inc	Antibiotics of the thienamycin class
US4226870A (en) *	1975-11-21	1980-10-07	Merck & Co., Inc.	O-, N- and carboxyl derivatives of thienamycin
GB1591439A (en) *	1976-10-01	1981-06-24	Glaxo Operations Ltd	7-syn (oxyimino -acylamido) cephalosporins
US4234596A (en) *	1976-11-19	1980-11-18	Merck & Co., Inc.	3-(2-Aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4235917A (en) *	1977-05-05	1980-11-25	Merck & Co., Inc.	N-Alkyl-N-acyl derivatives of thienamycin
AU531084B2 (en) *	1977-10-19	1983-08-11	Merck & Co., Inc.	Azetidine derivatives
AU4061378A (en) *	1977-10-19	1980-04-17	Merck & Co., Inc.	1-azabicyclo (3.2.0) hept-2-enes
US4218463A (en) *	1977-12-28	1980-08-19	Merck & Co., Inc.	3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4189493A (en) *	1977-12-28	1980-02-19	Merck & Co., Inc.	N-heterocyclic derivatives of thienamycin
US4174316A (en) *	1978-08-14	1979-11-13	Merck & Co., Inc.	4-Iodomethylazetidin-2-one
EP0010317B1 (en) *	1978-10-24	1983-12-21	Merck & Co. Inc.	6-, 1- and 2-substituted-1-carbapen-2-em-3-carboxylic acids, processes for the preparation of such compounds and pharmaceutical composition comprising such compounds
US4318912A (en) *	1979-01-02	1982-03-09	Merck & Co., Inc.	6-(1-Hydroxyethyl)-3-substituted-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid
EP0082133A3 (en) *	1979-04-19	1983-07-20	Merck & Co. Inc.	A process for preparing intermediates useful for preparing 2-substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4290947A (en) *	1979-04-27	1981-09-22	Merck & Co., Inc.	Process for the preparation of thienamycin and intermediates
US4376774A (en) *	1979-05-29	1983-03-15	Merck & Co., Inc.	Antibiotic N-heterocyclyl thienamycin
US4273709A (en) *	1979-07-23	1981-06-16	Merck & Co., Inc.	Process for the preparation of thienamycin and intermediates
DE3070269D1 (en) *	1979-08-10	1985-04-18	Beecham Group Plc	Beta-lactam antibiotics, their preparation, pharmaceutical compositions containing them and their preparation
US4287123A (en) *	1980-01-14	1981-09-01	Merck & Co., Inc.	Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
US4282148A (en) *	1980-01-14	1981-08-04	Merck & Co., Inc.	Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
US4269772A (en) *	1980-01-14	1981-05-26	Merck & Co., Inc.	Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline
DE3169321D1 (en) *	1980-03-27	1985-04-25	Merck & Co Inc	Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals
US4309346A (en) *	1980-03-27	1982-01-05	Merck & Co., Inc.	Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates
IE52147B1 (en) *	1980-03-27	1987-07-08	Merck & Co Inc	4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
EP0038869A1 (en) *	1980-04-30	1981-11-04	Merck & Co. Inc.	Process for the preparation of 1-carbapenems, and intermediates for their preparation
JPS56161393A (en) *	1980-05-16	1981-12-11	Sanraku Inc	Beta-lactam compound
EP0044170A1 (en) *	1980-07-11	1982-01-20	Beecham Group Plc	Beta-lactam antibiotics, their preparation and use
PT73791B (en) *	1980-10-17	1983-10-14	Merck & Co Inc	Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
US4552873A (en) *	1981-08-19	1985-11-12	Sankyo Company Limited	Carbapenem compounds, and compositions containing them
EP0074599A1 (en) *	1981-09-09	1983-03-23	Takeda Chemical Industries, Ltd.	5,6-cis-Carbapenem derivatives, their production and use
CA1198440A (en) *	1982-04-08	1985-12-24	Choung U. Kim	Carbapenem antibiotics
US4552696A (en) *	1982-04-09	1985-11-12	Bristol-Myers Company	Carbapenem antibiotics

1983
- 1983-06-07 US US06/499,690 patent/US4536335A/en not_active Expired - Fee Related
- 1983-06-14 FR FR8309814A patent/FR2528847B1/fr not_active Expired
- 1983-06-15 DK DK276683A patent/DK276683A/da not_active Application Discontinuation
- 1983-06-15 IL IL69002A patent/IL69002A/xx unknown
- 1983-06-15 GR GR71689A patent/GR78375B/el unknown
- 1983-06-15 FI FI832175A patent/FI77036C/fi not_active IP Right Cessation
- 1983-06-15 CA CA000430410A patent/CA1273009A/en not_active Expired - Lifetime
- 1983-06-16 ES ES523315A patent/ES8407489A1/es not_active Expired
- 1983-06-16 DE DE3321864A patent/DE3321864A1/de active Granted
- 1983-06-17 LU LU84864A patent/LU84864A1/fr unknown
- 1983-06-17 GB GB08316617A patent/GB2122196B/en not_active Expired
- 1983-06-17 PT PT76887A patent/PT76887B/pt not_active IP Right Cessation
- 1983-06-17 KR KR8302711A patent/KR890000192B1/ko not_active IP Right Cessation
- 1983-06-17 HU HU832173A patent/HU191052B/hu not_active IP Right Cessation
- 1983-06-17 SE SE8303502A patent/SE460791B/sv not_active IP Right Cessation
- 1983-06-17 AU AU15891/83A patent/AU567294B2/en not_active Ceased
- 1983-06-17 OA OA58035A patent/OA07468A/xx unknown
- 1983-06-17 NL NL8302183A patent/NL8302183A/xx not_active Application Discontinuation
- 1983-06-17 IT IT8321682A patent/IT1206324B/it active
- 1983-06-17 IE IE1431/83A patent/IE55432B1/en not_active IP Right Cessation
- 1983-06-20 AT AT0226583A patent/AT381941B/de not_active IP Right Cessation
- 1983-06-20 CH CH3372/83A patent/CH658657A5/de not_active IP Right Cessation
1988
- 1988-12-30 MY MY8316617A patent/MY8800124A/xx unknown

Also Published As

Publication number	Publication date
IE831431L (en)	1983-12-18
DK276683D0 (da)	1983-06-15
FR2528847A1 (fr)	1983-12-23
US4536335A (en)	1985-08-20
PT76887A (en)	1983-07-01
AU1589183A (en)	1983-12-22
SE8303502D0 (sv)	1983-06-17
ES523315A0 (es)	1984-10-01
SE460791B (sv)	1989-11-20
HU191052B (en)	1986-12-28
KR840005145A (ko)	1984-11-03
ATA226583A (de)	1986-05-15
AU567294B2 (en)	1987-11-19
DE3321864C2 (da)	1992-03-26
IT8321682A0 (it)	1983-06-17
GR78375B (da)	1984-09-26
FI77036B (fi)	1988-09-30
GB2122196A (en)	1984-01-11
KR890000192B1 (en)	1989-03-10
LU84864A1 (fr)	1984-03-07
ES8407489A1 (es)	1984-10-01
AT381941B (de)	1986-12-10
IL69002A (en)	1988-02-29
IE55432B1 (en)	1990-09-12
SE8303502L (sv)	1984-02-10
OA07468A (fr)	1984-12-31
CA1273009A (en)	1990-08-21
FI832175L (fi)	1983-12-19
FR2528847B1 (fr)	1988-03-25
NL8302183A (nl)	1984-01-16
FI77036C (fi)	1989-01-10
CH658657A5 (de)	1986-11-28
FI832175A0 (fi)	1983-06-15
GB2122196B (en)	1986-01-15
MY8800124A (da)	1988-12-31
PT76887B (en)	1986-04-09
DE3321864A1 (de)	1983-12-22
IT1206324B (it)	1989-04-14
GB8316617D0 (en)	1983-07-20

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DK563083D0 (da)	1983-12-07	5-(aryl-alifatiske)-3-lavere-alkylisoxazoler og fremgangsmaade til fremstilling heraf
DK302983D0 (da)	1983-06-30	Phenyl alpha-acyloxyacetamid-derivater og fremgangsmader til fremstilling deraf
DK276683A (da)	1983-12-19	Carbapenemer og fremgangsmaade til fremstilling deraf
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DK157683A (da)	1983-12-26	N-phosphonomethylglycinderivater og fremgangsmaade til fremstilling og anvendelse deraf
DK567781A (da)	1982-06-23	Phenoxyalkoxysilaner og fremgangsmaade til fremstilling heraf
DK315085D0 (da)	1985-07-10	Isoinsolinyl-alkyl-piperaziner og fremgangsmaade til fremstilling deraf
DK537481A (da)	1982-06-06	5-amino-1-phenyl-4-cyanpyrazoler og fremgangsmaade til fremstilling heraf
DK621484D0 (da)	1984-12-21	Acylaminomitosaner og fremgangsmaade til fremstilling deraf
DK404783A (da)	1984-03-08	Octahydrobenz(f)isoquinoliner og fremgangsmaade til fremstilling heraf
DK160744C (da)	1991-09-30	Oxychloreringskatalysator-praekursor til oxychlorering og fremgangsmaade til fremstilling heraf
DK271281A (da)	1982-02-03	Haardfeldt og fremgangsmaade til fremstilling deraf
DK343183A (da)	1984-05-04	Ketoquinoliner og fremgangsmaade til fremstilling deraf
DK129983D0 (da)	1983-03-22	2-beta-d-ribofuranosylselenazol-4-carboxamidforbindelser og fremgangsmader til fremstilling deraf
DK81192D0 (da)	1992-06-18	Substituerede ethandiimidamider og fremgangsmaade til fremstilling deraf
DK372582A (da)	1983-02-21	Immunogent kompleks og fremgangsmaade til fremstilling deraf
DK26384A (da)	1984-07-22	Toxoplasmosefaktor og fremgangsmaade til fremstilling deraf
DK454684A (da)	1985-03-29	7beta-acylamino-3-azido-cephalosporiner og fremgangsmaade til fremstilling heraf
DK454784A (da)	1985-03-27	6-oxodecahydroquinoliner og fremgangsmaade til fremstilling heraf
DK90083D0 (da)	1983-02-25	Isoxazolopyrimidinderivater og fremgangsmade til fremstilling deraf
DK112682A (da)	1982-09-17	Azaspiroalkandioner og fremgangsmaade til fremstilling deraf

Legal Events

Date	Code	Title	Description
1994-02-28	AHB	Application shelved due to non-payment