Nothing Special   »   [go: up one dir, main page]

DK2649187T3 - Biokatalysatorer og fremgangsmåder til syntesen af armodafinil - Google Patents

Biokatalysatorer og fremgangsmåder til syntesen af armodafinil

Info

Publication number
DK2649187T3
DK2649187T3 DK11846568.1T DK11846568T DK2649187T3 DK 2649187 T3 DK2649187 T3 DK 2649187T3 DK 11846568 T DK11846568 T DK 11846568T DK 2649187 T3 DK2649187 T3 DK 2649187T3
Authority
DK
Denmark
Prior art keywords
armodafinil
synthesis
methods
polypeptides
biocatalators
Prior art date
Application number
DK11846568.1T
Other languages
English (en)
Inventor
Ee Lui Ang
Behnaz Behrouzian
Ellen Eberhard
Steven J Collier
Fan Jasyln Fu
Derek Smith
Shiwei Song
Oscar Alvizo
Magnus Widegren
Jun Zhu
Junye Xu
Robert Wilson
Michael D Clay
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Application granted granted Critical
Publication of DK2649187T3 publication Critical patent/DK2649187T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13022—Cyclohexanone monooxygenase (1.14.13.22)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK11846568.1T 2010-12-08 2011-12-07 Biokatalysatorer og fremgangsmåder til syntesen af armodafinil DK2649187T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42112310P 2010-12-08 2010-12-08
PCT/US2011/063809 WO2012078800A2 (en) 2010-12-08 2011-12-07 Biocatalysts and methods for the synthesis of armodafinil

Publications (1)

Publication Number Publication Date
DK2649187T3 true DK2649187T3 (da) 2018-01-29

Family

ID=46207723

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11846568.1T DK2649187T3 (da) 2010-12-08 2011-12-07 Biokatalysatorer og fremgangsmåder til syntesen af armodafinil

Country Status (6)

Country Link
US (12) US9267159B2 (da)
EP (1) EP2649187B1 (da)
DK (1) DK2649187T3 (da)
HU (1) HUE037616T2 (da)
IL (1) IL226571B (da)
WO (1) WO2012078800A2 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2649187T3 (da) 2010-12-08 2018-01-29 Codexis Inc Biokatalysatorer og fremgangsmåder til syntesen af armodafinil
WO2015048572A1 (en) 2013-09-27 2015-04-02 Codexis, Inc. Automated screening of enzyme variants
CN108690836B (zh) * 2017-04-12 2021-01-26 浙江京新药业股份有限公司 一种环己酮单加氧酶及其在合成拉唑中的应用
CN108586346B (zh) 2018-05-10 2019-10-01 北京富盛嘉华医药科技有限公司 一种生物催化合成西他列汀及其中间体的方法

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528041A1 (fr) 1982-06-04 1983-12-09 Lafon Labor Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique
AU596948B2 (en) 1984-08-03 1990-05-24 Gesellschaft Fur Biotechnologische Forschung Mbh Process and apparatus for the bubble-free gassing of liquids, especially of culture media for propagating tissue cultures
FR2593809B1 (fr) 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
JPH0717796B2 (ja) 1987-10-14 1995-03-01 丸善石油化学株式会社 ポリプロピレン系樹脂組成物
US5538867A (en) 1988-09-13 1996-07-23 Elf Aquitaine Process for the electrochemical regeneration of pyridine cofactors
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
GB9423970D0 (en) 1994-11-28 1995-01-11 Astra Ab Oxidation
FI104465B (fi) 1995-06-14 2000-02-15 Valio Oy Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö
SE510666C2 (sv) 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
SE510650C2 (sv) 1997-05-30 1999-06-14 Astra Ab Ny förening
DK1036198T3 (da) 1997-12-08 2013-01-02 California Inst Of Techn Fremgangsmåde til fremstilling af polynukleotid- og polypeptidsekvenser
US6495023B1 (en) 1998-07-09 2002-12-17 Michigan State University Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration
JP4221100B2 (ja) 1999-01-13 2009-02-12 エルピーダメモリ株式会社 半導体装置
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6498242B1 (en) * 1999-02-19 2002-12-24 E. I. Du Pont De Nemours And Company Biological method for the production of adipic acid and intermediates
CN1352681A (zh) 1999-03-11 2002-06-05 伊斯曼化学公司 通过金属催化的辅因子再生用氢气进行酶促还原
EP1272967A2 (en) 2000-03-30 2003-01-08 Maxygen, Inc. In silico cross-over site selection
US6670358B2 (en) 2000-05-16 2003-12-30 Cephalon, Inc. Substituted thioacetamides
US6492396B2 (en) 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
AU2001276210A1 (en) 2000-07-18 2002-01-30 National Research Council Of Canada Cloning, sequencing and expression of a comamonas cyclopentanone 1,2-monooxygenase-encoding gene in escherichia coli
US6478964B1 (en) 2001-05-18 2002-11-12 Midwest Water Management, Llp Floating fine-bubble aeration system
IL158959A (en) 2001-05-25 2010-06-30 Cephalon Inc Solid pharmaceutical formulations comprising modafinil
US7105296B2 (en) 2001-08-29 2006-09-12 E. I. Du Pont De Nemours And Company Genes encoding Baeyer-Villiger monooxygenases
US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
US7629157B2 (en) 2003-08-11 2009-12-08 Codexis, Inc. Ketoreductase polypeptides and related polynucleotides
JP2007502114A (ja) 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド
WO2005018579A2 (en) 2003-08-11 2005-03-03 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
US7824898B2 (en) 2003-08-11 2010-11-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
EP1516869A1 (en) 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
WO2007027328A2 (en) 2005-07-28 2007-03-08 University Of Iowa Research Foundation Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
ITMI20051971A1 (it) 2005-10-18 2007-04-19 Dipharma Spa Procedimento per la preparazione di - modafinil
US20080031939A1 (en) 2006-03-01 2008-02-07 Viviana Braude Process for the preparation of armodafinil
ATE518946T1 (de) 2007-02-08 2011-08-15 Codexis Inc Ketoreduktasen und anwendungen davon
EP2155667A1 (en) 2007-06-07 2010-02-24 Teva Pharmaceutical Industries Ltd. Reduction processes for the preparation of ezetimibe
CN101784669B (zh) 2007-08-24 2015-02-18 科德克希思公司 用于(r)-3-羟基四氢噻吩的立体选择性制备的改善的酮还原酶多肽
CN101855342B (zh) 2007-09-13 2013-07-10 科德克希思公司 用于还原苯乙酮的酮还原酶多肽
CN101889081B (zh) 2007-09-28 2014-06-18 科德克希思公司 酮还原酶多肽及其用途
HUE027683T2 (en) 2007-10-01 2016-10-28 Codexis Inc Ketoreductase polypeptides for the production of azetidinone
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
SI2329013T1 (sl) 2008-08-27 2016-03-31 Codexis, Inc. Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8288131B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
WO2010025085A2 (en) 2008-08-29 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
WO2011071982A2 (en) 2009-12-08 2011-06-16 Codexis, Inc. Synthesis of prazole compounds
DK2649187T3 (da) 2010-12-08 2018-01-29 Codexis Inc Biokatalysatorer og fremgangsmåder til syntesen af armodafinil

Also Published As

Publication number Publication date
HUE037616T2 (hu) 2018-09-28
IL226571B (en) 2018-11-29
US9765306B2 (en) 2017-09-19
US9365835B2 (en) 2016-06-14
WO2012078800A3 (en) 2012-09-07
US20170067036A1 (en) 2017-03-09
US10087426B2 (en) 2018-10-02
US20180371431A1 (en) 2018-12-27
EP2649187A4 (en) 2015-01-14
EP2649187B1 (en) 2017-11-22
US9267159B2 (en) 2016-02-23
US20180195053A1 (en) 2018-07-12
US20210198638A1 (en) 2021-07-01
US11384343B2 (en) 2022-07-12
US20220372452A1 (en) 2022-11-24
US10781429B2 (en) 2020-09-22
US10557126B2 (en) 2020-02-11
US20210002618A1 (en) 2021-01-07
WO2012078800A2 (en) 2012-06-14
EP2649187A2 (en) 2013-10-16
US20160130566A1 (en) 2016-05-12
US20180037872A1 (en) 2018-02-08
US10400223B2 (en) 2019-09-03
US9528095B2 (en) 2016-12-27
US20160264945A1 (en) 2016-09-15
US20200109376A1 (en) 2020-04-09
US20190345460A1 (en) 2019-11-14
US10961517B2 (en) 2021-03-30
US20130260426A1 (en) 2013-10-03
US9938509B2 (en) 2018-04-10

Similar Documents

Publication Publication Date Title
IT1401911B1 (it) Processo per la sintesi di acido 2,5-furandicarbossilico
DK2054502T3 (da) Nykonstrueret mikroorganisme, der producerer homo-ravsyre, og fremgangsmåde til fremstilling af ravsyre ved anvendelse af samme
BRPI0922854A2 (pt) processo contracorrente para conversão de biomassa
BRPI0913622A2 (pt) Processo para a produção fermentativa de eritropoietina
DK2329012T3 (da) Behandling af slagtilfælde under anvendelse af isolerede placentaceller
BRPI0809206A2 (pt) Processo de formação de membranas microporosas
DK2082054T3 (da) Fremgangsmåde til forbedring af udbyttet af celluloseomdannelsesprocesser
BRPI0922330A2 (pt) processo para operar uma torre de resfriamento
DK2328672T3 (da) Fremgangsmåde til indvinding af højren carbondioxid
DK2649187T3 (da) Biokatalysatorer og fremgangsmåder til syntesen af armodafinil
EP3330254A3 (en) Method and process for preparation and production of deuterated omega-diphenylurea
DK2080808T3 (da) Fremgangsmåde til fremstilling af l-aminosyre
WO2007139933A3 (en) Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
DK2151427T3 (da) Ny fremgangsmåde til syntetisering af agomelatin
DK1745136T3 (da) Fremgangsmåde til enzymatisk fremstilling af (S)-3-cyano-5-methylhexansyre
BRPI0908645A2 (pt) ''processo de purificação de glicerol bruto''
WO2013036861A8 (en) Biocatalysts and methods for the synthesis of substituted lactams
WO2010099441A3 (en) Synthesis of molecular sieve ssz-74 using a hydroxide-mediated gel
HRP20181437T1 (hr) Postupak proizvodnje (3s,3s') 4,4' disulfanedilbis (3-aminobutan-1-sulfonske kiseline)
FR2960230B1 (fr) Procede d'obtention de borazane, convenant pour l'obtention de borazane de grande, voire tres grande purete; borazane de tres grande purete
BRPI0823412A2 (pt) Torre metálica
ITMI20072262A1 (it) Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico
GB201101479D0 (en) Process for the manufacture of racemic 2-aryl-propionic acid
DK2349987T3 (da) Fremgangsmåde til fremstilling og oprensning af trifluormethansulfinsyre
SMT201400064B (it) Procedimento per la produzione di acido 2-[(3,5-difluoro-3'-metossi-1,1'-bifenil-4-il) amino] nicotinico