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DK214878A - PROCEDURE FOR THE PREPARATION OF AMINOAL CYLBENZENE DERIVATIVES - Google Patents

PROCEDURE FOR THE PREPARATION OF AMINOAL CYLBENZENE DERIVATIVES

Info

Publication number
DK214878A
DK214878A DK214878A DK214878A DK214878A DK 214878 A DK214878 A DK 214878A DK 214878 A DK214878 A DK 214878A DK 214878 A DK214878 A DK 214878A DK 214878 A DK214878 A DK 214878A
Authority
DK
Denmark
Prior art keywords
cylbenzene
aminoal
derivatives
procedure
preparation
Prior art date
Application number
DK214878A
Other languages
Danish (da)
Inventor
B J Price
J W Clitherow
J Bradshaw
M Martin-Smith
Original Assignee
Allen & Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB20660/77A external-priority patent/GB1604674A/en
Application filed by Allen & Hanburys Ltd filed Critical Allen & Hanburys Ltd
Publication of DK214878A publication Critical patent/DK214878A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/08—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
DK214878A 1977-05-17 1978-05-16 PROCEDURE FOR THE PREPARATION OF AMINOAL CYLBENZENE DERIVATIVES DK214878A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB20660/77A GB1604674A (en) 1977-05-17 1977-05-17 Aminoalkyl-benzene derivatives
GB4012977 1977-09-27
GB1744478 1978-05-03

Publications (1)

Publication Number Publication Date
DK214878A true DK214878A (en) 1978-11-18

Family

ID=27257503

Family Applications (1)

Application Number Title Priority Date Filing Date
DK214878A DK214878A (en) 1977-05-17 1978-05-16 PROCEDURE FOR THE PREPARATION OF AMINOAL CYLBENZENE DERIVATIVES

Country Status (13)

Country Link
JP (1) JPS53149936A (en)
AU (2) AU523496B2 (en)
CH (2) CH643238A5 (en)
DE (1) DE2821410A1 (en)
DK (1) DK214878A (en)
ES (1) ES469953A1 (en)
FI (1) FI781490A (en)
FR (2) FR2401135A1 (en)
IE (1) IE46886B1 (en)
IT (1) IT1156755B (en)
NL (1) NL7805344A (en)
NZ (1) NZ187235A (en)
SE (1) SE443558B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233302A (en) * 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them
AR228941A1 (en) * 1978-04-26 1983-05-13 Glaxo Group Ltd PROCEDURE FOR PREPARING NEW DERIVATIVES OF 3,5-DIAMINO-1,2,4-TRIAZOLE WHICH ARE ACTIVE AGAINST HISTAMINIC RECEPTORS
PT70884A (en) * 1979-03-02 1980-03-01 Glaxo Group Ltd Process for preparing heterocyclic derivatives
US4293557A (en) 1979-07-03 1981-10-06 Teikoku Hormone Mfg. Co., Ltd. Antiulcer phenoxypropylamine derivatives
JPS609750B2 (en) * 1979-07-03 1985-03-12 帝国臓器製薬株式会社 Novel N-substituted phenoxypropylamide compounds
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
EP0029303B1 (en) * 1979-10-22 1985-01-30 Glaxo Group Limited 1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them
US4238487A (en) * 1979-10-31 1980-12-09 Merck & Co., Inc. Aminoalkyl benzofuran derivatives
FR2477537A1 (en) * 1980-03-07 1981-09-11 Francaise Sucrerie NOVEL ACYLATED GUANIDINES, UREAS AND SUBSTITUTED UREAS, THEIR MANUFACTURING PROCESS AND THEIR APPLICATION AS MEDICAMENTS
US4490533A (en) * 1980-12-22 1984-12-25 Merck & Co., Inc. Aminoalkyl pyridine derivatives
EP0057981A3 (en) 1981-02-09 1982-08-25 Beecham Group Plc Aromatic compounds, processes for their preparation and their use
JPS57165348A (en) * 1981-04-06 1982-10-12 Teikoku Hormone Mfg Co Ltd Novel aminoalkylbenzene derivative
US4522943A (en) * 1981-05-18 1985-06-11 Bristol-Myers Company Chemical compounds
US4526973A (en) * 1981-05-18 1985-07-02 Bristol-Myers Company Chemical compounds
IE53068B1 (en) * 1981-06-15 1988-05-25 Merck & Co Inc Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
DE3275291D1 (en) * 1981-07-24 1987-03-05 Glaxo Group Ltd Heterocyclic derivatives
US4411899A (en) * 1981-12-21 1983-10-25 Merck & Co., Inc. Substituted derivatives of amino alkane diols as gastric secretion inhibitors
JPS5988458A (en) * 1982-11-12 1984-05-22 Toyama Chem Co Ltd Amine derivative and its salt
JPH0639466B2 (en) * 1987-08-03 1994-05-25 杏林製薬株式会社 Urea derivative
JPH01131172A (en) * 1987-08-28 1989-05-24 Toyama Chem Co Ltd Amine derivative and salt thereof and antiulcer agent containing said derivative and salt
EP0641763B1 (en) * 1992-05-12 1997-01-08 Zeria Pharmaceutical Co., Ltd. Novel quaternary ammonium salts and use thereof as medicine
TWI328009B (en) 2003-05-21 2010-08-01 Glaxo Group Ltd Quinoline derivatives as phosphodiesterase inhibitors
AR070950A1 (en) * 2007-11-01 2010-05-19 Acucela Inc COMPOUNDS DERIVED FROM AMINA, PHARMACEUTICAL COMPOSITIONS OF THEM, INHIBITING PRODUCTION COMPOUNDS OF 11-CIS-RETINOL AND METHODS TO TREAT DISEASES AND OPHTHALMIC DISORDERS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE636468A (en) *
US2785201A (en) * 1953-12-24 1957-03-12 Personnes A Responsabilite Lim Compounds of bis quaternary ammonium derivatives of phenylethylamine
US3047628A (en) * 1957-02-19 1962-07-31 Hoffmann La Roche Benzylamine derivatives
GB993581A (en) * 1960-03-03 1965-05-26 Wellcome Found Phenoxyalkylguanidines and their synthesis and pharmaceutical preparations containing them
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
JPS5227757A (en) * 1975-08-26 1977-03-02 Kyowa Hakko Kogyo Co Ltd Preparation of 6-aminomethylnaphthalene derivatives

Also Published As

Publication number Publication date
IE46886B1 (en) 1983-10-19
CH643233A5 (en) 1984-05-30
AU541144B2 (en) 1984-12-20
FR2398718B1 (en) 1982-10-15
ES469953A1 (en) 1979-09-16
FR2398718A1 (en) 1979-02-23
CH643238A5 (en) 1984-05-30
IE780940L (en) 1978-11-17
NL7805344A (en) 1978-11-21
JPH0112744B2 (en) 1989-03-02
DE2821410A1 (en) 1978-11-30
IT1156755B (en) 1987-02-04
NZ187235A (en) 1981-10-19
SE443558B (en) 1986-03-03
IT7849419A0 (en) 1978-05-17
FR2401135B1 (en) 1983-08-19
AU8411782A (en) 1982-08-26
AU523496B2 (en) 1982-07-29
FI781490A (en) 1978-11-18
FR2401135A1 (en) 1979-03-23
JPS53149936A (en) 1978-12-27
AU3606778A (en) 1979-11-15
SE7805591L (en) 1978-11-18

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