DK163243C - Fremgangsmaade til fremstilling af cephalosporinderivater - Google Patents

Fremgangsmaade til fremstilling af cephalosporinderivater

Info

Publication number: DK163243C
Authority: DK; Denmark
Prior art keywords: procedure; preparation; cephalosporine derivatives; cephalosporine; derivatives
Prior art date: 1980-03-28

Application number

DK138781A

Other languages

English (en)

Other versions

DK163243B (da

DK138781A (da

Inventor

Gerd Ascher

Original Assignee

Biochemie Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-03-28

Filing date

1981-03-27

Publication date

1992-06-29

1981-03-27 Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh

1981-09-29 Publication of DK138781A publication Critical patent/DK138781A/da

1992-02-10 Publication of DK163243B publication Critical patent/DK163243B/da

1992-06-29 Application granted granted Critical

1992-06-29 Publication of DK163243C publication Critical patent/DK163243C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK138781A 1980-03-28 1981-03-27 Fremgangsmaade til fremstilling af cephalosporinderivater DK163243C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT168080		1980-03-28
AT168080		1980-03-28

Publications (3)

Publication Number	Publication Date
DK138781A DK138781A (da)	1981-09-29
DK163243B DK163243B (da)	1992-02-10
DK163243C true DK163243C (da)	1992-06-29

Family

ID=3518666

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK138781A DK163243C (da)	1980-03-28	1981-03-27	Fremgangsmaade til fremstilling af cephalosporinderivater
DK157291A DK167680B1 (da)	1980-03-28	1991-09-06	Syn-isomere 2-pyridyl- og 2-benzothiazolylthioestere samt fremgangsmaade til fremstilling deraf

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK157291A DK167680B1 (da)	1980-03-28	1991-09-06	Syn-isomere 2-pyridyl- og 2-benzothiazolylthioestere samt fremgangsmaade til fremstilling deraf

Country Status (19)

Country	Link
US (2)	US4767852A (da)
EP (1)	EP0037380B1 (da)
JP (2)	JPS56152488A (da)
AU (2)	AU550168B1 (da)
CA (1)	CA1172627A (da)
CY (1)	CY1365A (da)
DE (1)	DE3165922D1 (da)
DK (2)	DK163243C (da)
ES (2)	ES500792A0 (da)
FI (1)	FI74019C (da)
HK (1)	HK80687A (da)
IE (1)	IE51831B1 (da)
IL (1)	IL62506A (da)
NZ (2)	NZ206261A (da)
PH (1)	PH17071A (da)
PT (1)	PT72736B (da)
SG (1)	SG35287G (da)
YU (2)	YU43764B (da)
ZA (1)	ZA812083B (da)

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EP0096297B1 (de) *	1982-06-03	1988-06-15	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Verfahren zur Herstellung von 1-Sulfo-2-oxoazetidinderivaten
DK162718C (da) *	1982-09-30	1992-05-11	Fujisawa Pharmaceutical Co	Analogifremgangsmaade til fremstilling af 7-substitueret-3-vinyl-3-cephemforbindelser
US4652651A (en) *	1983-05-31	1987-03-24	Hoffmann-La Roche Inc.	Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
IT8448798A0 (it) *	1983-09-12	1984-09-05	Biochemie Gmbh	Procedimento per la preparazione di antibiotici del tipo cefalosporina
JPS6064986A (ja) *	1983-09-20	1985-04-13	Toyama Chem Co Ltd	セファロスポリン類の製造法
JPS60142987A (ja) *	1983-12-29	1985-07-29	Mochida Pharmaceut Co Ltd	セフアロスポリン誘導体
DE3485860T2 (de) *	1983-12-29	1993-01-14	Mochida Pharm Co Ltd	Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
AR243192A1 (es) *	1984-03-23	1993-07-30	Toyama Chemical Co Ltd	Procedimiento de preparacion de una cefalosporina y de un intermediario para su preparacion.
AT392792B (de) *	1984-03-23	1991-06-10	Toyama Chemical Co Ltd	Verfahren zur herstellung von cephalosporinderivaten
EP0156771A3 (en) *	1984-03-29	1986-03-19	Biochemie Gesellschaft M.B.H.	Cephalosporins
EP0312844B1 (de) *	1984-04-10	1994-06-22	Biochemie Gesellschaft M.B.H.	Cephalosporinzwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung
DE3587866D1 (de) *	1984-04-10	1994-07-28	Biochemie Gmbh	Cephalosporinzwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung.
AT381496B (de) *	1984-04-10	1986-10-27	Biochemie Gmbh	Verfahren zur herstellung von cephalosporinantibiotika
GB2161476B (en) *	1984-05-25	1988-01-27	Toyama Chemical Co Ltd	2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins
US4840945A (en) *	1985-04-01	1989-06-20	Mochida Pharmaceutical Co., Ltd.	Cephalosporin derivatives
US4675398A (en) *	1985-08-16	1987-06-23	E. R. Squibb & Sons, Inc.	Copper-mediated oximation reaction
US5359057A (en) *	1986-02-07	1994-10-25	Hoffmann-La Roche Inc.	Acylation of amines
DE3779768D1 (de) *	1986-02-07	1992-07-23	Hoffmann La Roche	Verfahren zur herstellung von carbonsaeureamiden.
GB8614710D0 (en) *	1986-06-17	1986-07-23	Ici Plc	Process
JPS63132893A (ja) *	1986-11-25	1988-06-04	Mochida Pharmaceut Co Ltd	新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
US4880798A (en) *	1986-11-25	1989-11-14	Mochida Pharmaceutical Co., Ltd.	Cephalosporin derivatives
SI8711089A8 (en) *	1987-06-11	1996-08-31	Krka Tovarna Zdravil	Process for preparation of 6-/d(-)-alpha-(4-ethyl-2,3-dioxo-1- piperazine-carboxyamido)-phenylacetamido/-penicillanic acid
IT1234385B (it) *	1989-05-23	1992-05-18	Sbd Synthetic And Biolog Devel	Procedimento migliorato per la produzione di una sostanza antibiotica appartenente al gruppo delle cefalosporine
KR950014571B1 (ko) *	1991-11-18	1995-12-08	제일제당주식회사	세펨 유도체의 제조방법
AT398764B (de) *	1992-01-28	1995-01-25	Lek Tovarna Farmacevtskih	Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat
AT399877B (de) *	1992-02-20	1995-08-25	Biochemie Gmbh	Neues verfahren zur herstellung von ceftriaxon
KR970006247B1 (en) *	1992-09-28	1997-04-25	Lg Chemical Ltd	Novel benzothiazole derivatives and process for preparing the same
JPH08142052A (ja) *	1994-11-18	1996-06-04	Fuji Car Mfg Co Ltd	減容押出成形機
GB9423459D0 (en) *	1994-11-21	1995-01-11	Biochemie Gmbh	Silylation process
AT402928B (de) *	1994-12-23	1997-09-25	Biochemie Gmbh	Neues verfahren zur herstellung von cefotaxim
KR100197788B1 (ko) *	1995-06-30	1999-06-15	김충환	세펨 유도체의 제조방법
IN181459B (da) *	1995-12-26	1998-06-20	Lupin Lab Ltd
AU690482B2 (en) *	1996-03-18	1998-04-23	Ranbaxy Laboratories Limited	Process for producing cephalosporin antibiotics
IN184690B (da) *	1996-03-18	2000-09-23	Ranbaxy Lab Ltd
KR100361829B1 (ko) *	1997-04-16	2005-08-17	주식회사 엘지생명과학	반응성 유기산 유도체로 부터 세프트리악손을 제조하는 방법
KR100361828B1 (ko) *	1997-04-16	2005-08-12	주식회사 엘지생명과학	반응성 유기산 유도체로 부터 세포탁심을 제조하는방법
IT1295935B1 (it) *	1997-10-30	1999-05-28	Acs Dobfar Spa	Derivati aminotiazolici utili nella preparazione di antibiotici b -lattamici
EP1178992A2 (en)	1999-05-07	2002-02-13	Ranbaxy Laboratories, Limited	Process for the preparation of cefpodoxime acid
US6388070B1 (en) *	2001-01-05	2002-05-14	Orchid Chemicals & Pharmaceuticals Ltd.	Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
EP1399429A1 (en) *	2001-06-14	2004-03-24	Orchid Chemicals and Pharmaceuticals Ltd	1,3,4-oxadiazol-2-yl thioesters and their use for acylating 7-aminocephalosporins
US6610845B1 (en)	2002-01-04	2003-08-26	Orchid Chemicals & Pharmaceuticals Limited, India	Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
WO2003099826A1 (en) *	2002-05-23	2003-12-04	Orchid Chemicals And Pharmaceuticals Limited	A new process for the preparation of cefditoren using the thioester of thiazolylacetic acid
US20040002600A1 (en) *	2002-06-20	2004-01-01	Orchid Chemicals And Pharmaceuticals Limited	Process for the conversion of penam ring system to cepham ring system
US7847093B2 (en) *	2003-04-16	2010-12-07	Sandoz Ag	Processes for the preparations of cefepime
DE602004028111D1 (de)	2003-04-16	2010-08-26	Sandoz Ag	Verfahren zur herstellung von cefepim
US7098329B2 (en) *	2003-06-19	2006-08-29	Orchid Chemicals & Pharmaceuticals Ltd.	Process for the preparation of a cephalosporin antibiotic
US7459550B2 (en)	2003-07-04	2008-12-02	Orchid Chemicals & Pharmaceuticals Ltd.	Process for the preparation of Cefditoren
EP1704153A2 (en) *	2004-01-16	2006-09-27	Wockhardt Limited	Improved process for the production of cefotaxime sodium
CN100448856C (zh) *	2006-06-26	2009-01-07	山东金城医药化工股份有限公司	一种催化合成ae-活性酯的工艺
CN101418015B (zh) *	2007-10-24	2011-04-27	山东轩竹医药科技有限公司	头孢曲松磷酰化衍生物
KR20120016662A (ko)	2009-05-25	2012-02-24	산도즈 아게	세프토비프롤 메도카릴의 제조 방법
KR101139431B1 (ko) *	2011-05-30	2012-04-27	(주)비씨월드제약	이매티닙 염기의 신규한 제조방법

Family Cites Families (15)

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Publication number	Priority date	Publication date	Assignee	Title
JPS4823401B1 (da) *	1969-11-19	1973-07-13
US3659237A (en) *	1971-03-30	1972-04-25	Westinghouse Electric Corp	Contactor
GB1576625A (en) *	1976-04-12	1980-10-08	Fujisawa Pharmaceutical Co	Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
JPS5936891B2 (ja) *	1977-12-09	1984-09-06	武田薬品工業株式会社	保護基の脱離方法
DE2758000A1 (de) *	1977-12-24	1979-07-05	Hoechst Ag	Verfahren zur herstellung von penicillinen und cephalosporinen
EP0004570B1 (en) *	1978-03-09	1982-04-14	Asahi Kasei Kogyo Kabushiki Kaisha	Thiol esters, process for their preparation, pharmaceutical compositions containing them and a process for preparing cephalosporin compounds using the same
JPS6058239B2 (ja) *	1978-07-20	1985-12-19	山之内製薬株式会社	新規セフアロスポリン誘導体
US4220761A (en) *	1978-09-12	1980-09-02	Fujisawa Pharmaceutical Co., Ltd.	7-[Substituted oximinoacetamido]-3-[hydroxy alkyltetrazolo]cephalosporin derivatives
FI800381A (fi) *	1979-02-16	1980-08-17	Sandoz Ag	Nya kefalosporinderivat deras framstaellning och anvaendning som antimikrobiella aemnen
HU184771B (en) *	1979-05-23	1984-10-29	Rhone Poulenc Ind	Process for producing new 3-thiovinyl-cepheme-carboxylic acid derivatives
NL8100539A (nl) *	1980-02-12	1981-09-01	Rhone Poulenc Ind	Nieuwe thiolesters, de bereiding daarvan en hun gebruik bij syntheses.
EP0137227B1 (en) *	1980-09-02	1987-12-16	Asahi Kasei Kogyo Kabushiki Kaisha	Process for the preparation of cephalosporin derivatives using novel thioesters
CH648038A5 (de) *	1981-01-19	1985-02-28	Sandoz Ag	7-((carboxymethoxyimino)-1h-pyrazol-3-yl-acetyl)amino-3-desacetoxy-3-(1-methyl-1h-tetrazol-5-yl-thio)cephalosporansaeure und salze, verfahren zur herstellung und verwendung.
EP0115770B2 (en) *	1983-01-07	1996-06-19	Takeda Chemical Industries, Ltd.	Thiazole Derivatives
US4652651A (en) *	1983-05-31	1987-03-24	Hoffmann-La Roche Inc.	Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage

1981
- 1981-03-25 CY CY136581A patent/CY1365A/xx unknown
- 1981-03-25 EP EP81810118A patent/EP0037380B1/en not_active Expired
- 1981-03-25 DE DE8181810118T patent/DE3165922D1/de not_active Expired
- 1981-03-26 YU YU798/81A patent/YU43764B/xx unknown
- 1981-03-26 PT PT72736A patent/PT72736B/pt unknown
- 1981-03-27 AU AU68859/81A patent/AU550168B1/en not_active Expired
- 1981-03-27 AU AU68859/81D patent/AU6885981A/en active Granted
- 1981-03-27 DK DK138781A patent/DK163243C/da not_active IP Right Cessation
- 1981-03-27 NZ NZ206261A patent/NZ206261A/en unknown
- 1981-03-27 ES ES500792A patent/ES500792A0/es active Granted
- 1981-03-27 PH PH25445A patent/PH17071A/en unknown
- 1981-03-27 NZ NZ196642A patent/NZ196642A/en unknown
- 1981-03-27 JP JP4610481A patent/JPS56152488A/ja active Granted
- 1981-03-27 FI FI810948A patent/FI74019C/fi not_active IP Right Cessation
- 1981-03-27 ZA ZA00812083A patent/ZA812083B/xx unknown
- 1981-03-27 IL IL62506A patent/IL62506A/xx not_active IP Right Cessation
- 1981-03-27 IE IE697/81A patent/IE51831B1/en not_active IP Right Cessation
- 1981-03-30 CA CA000374191A patent/CA1172627A/en not_active Expired
1982
- 1982-02-26 ES ES509957A patent/ES8307007A1/es not_active Expired
1983
- 1983-06-02 YU YU1227/83A patent/YU43179B/xx unknown
1986
- 1986-11-19 US US06/932,759 patent/US4767852A/en not_active Expired - Lifetime
1987
- 1987-04-16 SG SG352/87A patent/SG35287G/en unknown
- 1987-10-29 HK HK806/87A patent/HK80687A/xx not_active IP Right Cessation
1988
- 1988-12-29 JP JP63332733A patent/JPH02177A/ja active Granted
1989
- 1989-07-24 US US07/384,349 patent/US5003073A/en not_active Expired - Lifetime
1991
- 1991-09-06 DK DK157291A patent/DK167680B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPS56152488A (en)	1981-11-26
YU43764B (en)	1989-12-31
IE51831B1 (en)	1987-04-15
PH17071A (en)	1984-05-24
YU43179B (en)	1989-04-30
NZ206261A (en)	1984-07-31
US4767852A (en)	1988-08-30
IL62506A (en)	1986-01-31
CY1365A (en)	1987-08-07
PT72736A (en)	1981-04-01
SG35287G (en)	1988-05-20
ES8205228A1 (es)	1982-06-01
YU122783A (en)	1986-12-31
DK163243B (da)	1992-02-10
JPH02177A (ja)	1990-01-05
ES509957A0 (es)	1983-06-16
EP0037380B1 (en)	1984-09-12
DK157291D0 (da)	1991-09-06
EP0037380A2 (en)	1981-10-07
JPH0567632B2 (da)	1993-09-27
YU79881A (en)	1983-12-31
AU550168B1 (en)	1986-03-06
DK138781A (da)	1981-09-29
PT72736B (en)	1982-07-13
IL62506A0 (en)	1981-05-20
DK157291A (da)	1991-09-06
EP0037380A3 (en)	1981-12-02
AU6885981A (en)	1981-10-01
US5003073A (en)	1991-03-26
IE810697L (en)	1981-09-28
DK167680B1 (da)	1993-12-06
ZA812083B (en)	1982-11-24
FI74019B (fi)	1987-08-31
FI810948L (fi)	1981-09-29
HK80687A (en)	1987-11-06
ES500792A0 (es)	1982-06-01
FI74019C (fi)	1987-12-10
NZ196642A (en)	1984-07-31
DE3165922D1 (en)	1984-10-18
JPH0313237B2 (da)	1991-02-22
ES8307007A1 (es)	1983-06-16
CA1172627A (en)	1984-08-14

Publication	Publication Date	Title
DK163243C (da)	1992-06-29	Fremgangsmaade til fremstilling af cephalosporinderivater
DK534481A (da)	1982-06-06	Fremgangsmaade til fremstilling af 1-sulfo-2-oxoazetidinderivater
DK99781A (da)	1981-09-07	Fremgangsmaade til fremstilling af carboxtyrilderivater
DK2281A (da)	1981-07-08	Fremgangsmaade til fremstilling af tiazolinderivater
DK300981A (da)	1982-02-22	Fremgangsmaade til fremstilling af imidazolderivater
DK157876C (da)	1990-07-30	Analogifremgangsmaade til fremstilling af imidazo-rifamycin-derivater
DK161581A (da)	1981-12-07	Fremgangsmaade til fremstilling af imidazolderivater
DK162524C (da)	1992-03-30	Analogifremgangsmaade til fremstilling af 5-alkylthio-tetrazolderivater
DK95383A (da)	1983-09-30	Fremgangsmaade til fremstilling af cephalosporinderivater
DK100281A (da)	1981-09-09	Fremgangsmaade til fremstilling af imidazolderivater
DK399282A (da)	1983-03-09	Fremgangsmaade til fremstilling af cephalosporinderivater
DK86283A (da)	1983-09-05	Fremgangsmaade til fremstilling af cephalosporinderivater
DK564781A (da)	1982-06-27	Fremgangsmaade til fremstilling af pyrazoloindazolderivater
DK53780A (da)	1980-08-17	Fremgangsmaade til fremstilling af cephalosporinderivater
DK554581A (da)	1982-06-16	Fremgangsmaade til fremstilling af alkylendioxybenzenderivater
DK172181A (da)	1981-10-18	Fremgangsmaade til fremstilling af 9-carbamoyl-9-aminoalkylfluoren-derivater
DK565281A (da)	1982-06-20	Fremgangsmaade til fremstilling af quinolon-derivater
DK151956C (da)	1988-08-15	Analogifremgangsmaade til fremstilling af carbostyrilderivater
DK85281A (da)	1981-08-26	Fremgangsmaade til fremstilling af phenoxyderivater
DK424781A (da)	1982-03-27	Fremgangsmaade til fremstilling af quinolonderivater
DK448981A (da)	1982-04-12	Fremgangsmaade til fremstilling af 4-chinolinmethanderivater
DK551481A (da)	1982-06-14	Fremgangsmaade til fremstilling af triazolderivater
DK406579A (da)	1981-03-28	Fremgangsmaade til fremstilling af cephalosporinderivater
DK396482A (da)	1983-03-24	Fremgangsmaade til fremstilling af cephalosporinderivater
DK406781A (da)	1982-03-14	Fremgangsmaade til fremstilling af imidazolderivater

Legal Events

Date	Code	Title	Description
2001-04-23	PUP	Patent expired