DK162601C - Analogifremgangsmaade til fremstilling af 8-oe4-oe4-(2,1-benzisothiazol-3-yl)-1-piperazinylaabutylaa-8-azaspirooe4.5aadecan-7,9-dion - Google Patents

Analogifremgangsmaade til fremstilling af 8-oe4-oe4-(2,1-benzisothiazol-3-yl)-1-piperazinylaabutylaa-8-azaspirooe4.5aadecan-7,9-dion

Info

Publication number: DK162601C
Authority: DK; Denmark
Prior art keywords: piperazinylaabutylaa; benzisothiazol; dion; analogue; preparation
Prior art date: 1981-12-23

Application number

DK307590A

Other languages

English (en)

Other versions

DK162601B (da

DK307590A (da

DK307590D0 (da

Inventor

Davis L Temple

Joseph P Yevich

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-12-23

Filing date

1990-12-28

Publication date

1992-05-11

1990-12-28 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1990-12-28 Publication of DK307590A publication Critical patent/DK307590A/da

1990-12-28 Publication of DK307590D0 publication Critical patent/DK307590D0/da

1991-11-18 Publication of DK162601B publication Critical patent/DK162601B/da

1992-05-11 Application granted granted Critical

1992-05-11 Publication of DK162601C publication Critical patent/DK162601C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK307590A 1981-12-23 1990-12-28 Analogifremgangsmaade til fremstilling af 8-oe4-oe4-(2,1-benzisothiazol-3-yl)-1-piperazinylaabutylaa-8-azaspirooe4.5aadecan-7,9-dion DK162601C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US33383081		1981-12-23
US06/333,830 US4411901A (en)	1981-12-23	1981-12-23	Benzisothiazole and benzisoxazole piperazine derivatives

Publications (4)

Publication Number	Publication Date
DK307590A DK307590A (da)	1990-12-28
DK307590D0 DK307590D0 (da)	1990-12-28
DK162601B DK162601B (da)	1991-11-18
DK162601C true DK162601C (da)	1992-05-11

Family

ID=23304433

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK566282A DK160939C (da)	1981-12-23	1982-12-21	Analogifremgangsmaade til fremstilling af benzisothiazol- og benzisoxazolpiperazinderivater, samt mellemprodukter til anvendelse ved fremgangsmaaden
DK307590A DK162601C (da)	1981-12-23	1990-12-28	Analogifremgangsmaade til fremstilling af 8-oe4-oe4-(2,1-benzisothiazol-3-yl)-1-piperazinylaabutylaa-8-azaspirooe4.5aadecan-7,9-dion

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK566282A DK160939C (da)	1981-12-23	1982-12-21	Analogifremgangsmaade til fremstilling af benzisothiazol- og benzisoxazolpiperazinderivater, samt mellemprodukter til anvendelse ved fremgangsmaaden

Country Status (26)

Country	Link
US (1)	US4411901A (da)
JP (2)	JPS58110576A (da)
KR (1)	KR870001022B1 (da)
AU (1)	AU550780B2 (da)
BE (1)	BE895469A (da)
CA (1)	CA1205806A (da)
CH (2)	CH659070A5 (da)
CY (1)	CY1376A (da)
DE (1)	DE3247530A1 (da)
DK (2)	DK160939C (da)
ES (4)	ES8401970A1 (da)
FI (1)	FI78697C (da)
FR (2)	FR2521561B1 (da)
GB (1)	GB2114119B (da)
GR (1)	GR77108B (da)
HK (1)	HK5088A (da)
HU (2)	HU195806B (da)
IE (1)	IE54789B1 (da)
IT (1)	IT1158037B (da)
KE (1)	KE3718A (da)
LU (1)	LU84550A1 (da)
NL (1)	NL8204910A (da)
PT (1)	PT76017B (da)
SE (2)	SE453502B (da)
SG (1)	SG30087G (da)
ZA (1)	ZA828544B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4452799A (en) *	1981-12-23	1984-06-05	Mead Johnson & Company	Benzisothiazole and benzisoxazole piperazine derivatives
US4524206A (en) *	1983-09-12	1985-06-18	Mead Johnson & Company	1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4656280A (en) *	1984-03-07	1987-04-07	E. I. Du Pont De Nemours And Company	Radioiodinated dopamine receptor ligand
US4590196A (en) *	1984-08-23	1986-05-20	Bristol-Myers Company	Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH0625181B2 (ja) *	1985-03-27	1994-04-06	住友製薬株式会社	新規なイミド誘導体
US4656173A (en) *	1985-04-24	1987-04-07	Bristol-Myers Company	Antipsychotic benzisothiazole S-oxide compound
US4677104A (en) *	1985-05-06	1987-06-30	Bristol-Myers Company	Antipsychotic fused-ring pyridinylpiperazine derivatives
AU593194B2 (en) *	1986-09-26	1990-02-01	Sumitomo Pharmaceuticals Company, Limited	Imide derivatives ,and their production and use
MX174210B (es) *	1987-02-17	1994-04-28	Pfizer	Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
CA1335289C (en) *	1987-10-26	1995-04-18	Fujio Antoku	Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
WO1989004311A1 (en) *	1987-11-12	1989-05-18	American Home Products Corporation	Polycyclicamines with psychotropic activity
US4855430A (en) *	1987-11-12	1989-08-08	American Home Products Corporation	Polycyclicamine with psychotropic activity
DE3875073T2 (de) *	1987-11-20	1993-03-11	Hoechst Roussel Pharma	3-(4(1-substituierte-4-piperazinyl)butyl)-4-thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
US5801186A (en)	1987-11-20	1998-09-01	Hoechst Marion Roussel, Inc.	3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
US4880930A (en) *	1987-11-30	1989-11-14	New James S	Psychotropic acyclic amide derivatives
US5116970A (en) *	1988-02-18	1992-05-26	New James S	Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
US5001130A (en) *	1988-02-18	1991-03-19	Bristol-Myers Company	Psychotropic heterobicycloalkylpiperazine derivatives
NZ230045A (en) *	1988-08-05	1990-11-27	Janssen Pharmaceutica Nv	3-piperazinylbenzazole derivatives and pharmaceutical compositions
US4957916A (en) *	1988-08-05	1990-09-18	Janssen Pharmaceutica N.V.	Antipsychotic 3-piperazinylbenzazole derivatives
US5015740A (en) *	1988-08-05	1991-05-14	Janssen Pharmaceutica N.V.	Antipsychotic 3-piperazinylbenzazole derivatives
WO1990002552A1 (en) *	1988-09-16	1990-03-22	Pfizer Inc.	Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides
US4847252A (en) *	1988-10-25	1989-07-11	Bristol-Myers Company	Method for alleviation of vascular headache
US5776963A (en) *	1989-05-19	1998-07-07	Hoechst Marion Roussel, Inc.	3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4956368A (en) *	1989-07-24	1990-09-11	Bristol-Myers Company	Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
US4968792A (en) *	1989-09-25	1990-11-06	American Home Products Corporation	Psychotropic benzisothiazole derivatives
FR2671350A1 (fr) *	1991-01-08	1992-07-10	Adir	Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
US5098904A (en) *	1990-06-27	1992-03-24	Bristol-Myers Squibb Company	Cerebral function enhancing pyrimidinyl derivatives
JP2800953B2 (ja) *	1990-07-06	1998-09-21	住友製薬株式会社	新規なイミド誘導体
US5266571A (en) *	1992-01-09	1993-11-30	Amer Moh Samir	Treatment of hemorrhoids with 5-HT2 antagonists
GB9226857D0 (en) *	1992-12-23	1993-02-17	Boyd Edward A	Pharmaceutical compositions
US5599815A (en) *	1993-02-04	1997-02-04	Meiji Seika Kabushiki Kaisha	Antipsychotic benzoisothiazolyl piperazine derivatives
HUT69376A (en) *	1993-05-04	1995-09-28	Egyt Gyogyszervegyeszeti Gyar	Process for preparing heterocyclic compounds
IL117295A (en)	1995-02-28	1999-11-30	Lundbeck & Co As H	4-Aminotetrahydro-benzisoxazole or-isothiazole compounds and pharmaceutical compositions comprising them
KR100304179B1 (ko) *	1995-06-06	2001-11-22	게리 디. 스트리트, 스티븐 엘. 네스비트	항정신병제로서의벤즈이속사졸및인다졸유도체,이의제조방법및이를함유하는약제학적조성물
EP1757292A1 (en)	1997-09-05	2007-02-28	Pfizer Products Inc.	Method of treating ocd and tic disorders
EP1165083A2 (en) *	1999-04-06	2002-01-02	Sepracor Inc.	Methods and compositions for the treatment of psychotic and related disorders using ziprasidone metabolites
US7030142B1 (en)	1999-04-06	2006-04-18	Sepracor Inc.	Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites
WO2004037820A1 (en) *	2002-10-28	2004-05-06	Warner-Lambert Company Llc	Oxindole substituted piperazine derivatives
WO2004041793A1 (en) *	2002-11-08	2004-05-21	Warner-Lambert Company Llc	Phenylalkyl and pyridylalkyl piperazine derivatives
ES2610508T3 (es)	2006-11-22	2017-04-27	Clinical Research Associates, Llc	Métodos para tratar el síndrome de Down, el síndrome del cromosoma X frágil y el autismo
WO2013014665A1 (en)	2011-07-28	2013-01-31	Mapi Pharma Ltd.	Intermediate compounds and process for the preparation of lurasidone and salts thereof
CN105669665A (zh) *	2016-03-15	2016-06-15	烟台贝森医药科技有限公司	哌罗匹隆的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1595920B2 (de) *	1964-11-04	1978-08-10	Merck Patent Gmbh, 6100 Darmstadt	4-(co-Piperazinoalkyl)-pyrazole, ihre Salze und Verfahren zu ihrer Herstellung
US3398151A (en) *	1966-02-01	1968-08-20	Mead Johnson & Co	Azaspirodecanediones and azaspiroundecanediones
DE1695410A1 (de) *	1967-04-20	1971-04-08	Merck Patent Gmbh	Verfahren zur Herstellung von 1-(Thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazinen
DE1670907B2 (de) *	1967-08-16	1976-07-22	Bayer Ag, 5090 Leverkusen	N-disubstituierte 3-amino-1,2benzisothiazole und verfahren in ihrer herstellung
US3528989A (en) *	1967-11-14	1970-09-15	Colgate Palmolive Co	3-aminoalkyl derivatives of 2,1-benzisothiazoline
BE759371A (fr) *	1969-11-24	1971-05-24	Bristol Myers Co	Azaspirodecanediones heterocycliques et procedes pour leur preparation
AR207986A1 (es) *	1974-07-01	1976-11-22	Sumitomo Chemical Co	Un procedimiento para producir compuestos del 3-(aminoalquil n-sustituido)-benz-2,1-isoxazol
US3940398A (en) *	1975-01-23	1976-02-24	E. R. Squibb & Sons, Inc.	2-[[4-(Azine or diazine or triazine)-1-piperazinyl]alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
DE2734866A1 (de) *	1977-08-03	1979-02-22	Basf Ag	Neue 1,2-benzisothiazole und verfahren zu ihrer herstellung
US4182763A (en) *	1978-05-22	1980-01-08	Mead Johnson & Company	Buspirone anti-anxiety method
AU521110B2 (en) *	1978-06-20	1982-03-18	Synthelabo	Phenylpiperazine derivatives

1981
- 1981-12-23 US US06/333,830 patent/US4411901A/en not_active Expired - Lifetime
1982
- 1982-10-25 AU AU90872/82A patent/AU550780B2/en not_active Ceased
- 1982-11-19 ZA ZA828544A patent/ZA828544B/xx unknown
- 1982-11-22 CA CA000416097A patent/CA1205806A/en not_active Expired
- 1982-11-24 GB GB08233503A patent/GB2114119B/en not_active Expired
- 1982-11-24 CY CY137682A patent/CY1376A/xx unknown
- 1982-11-25 GR GR69903A patent/GR77108B/el unknown
- 1982-12-14 ES ES518168A patent/ES8401970A1/es not_active Expired
- 1982-12-20 NL NL8204910A patent/NL8204910A/nl not_active Application Discontinuation
- 1982-12-20 FI FI824379A patent/FI78697C/fi not_active IP Right Cessation
- 1982-12-21 FR FR8221440A patent/FR2521561B1/fr not_active Expired
- 1982-12-21 JP JP57223094A patent/JPS58110576A/ja active Pending
- 1982-12-21 IT IT49709/82A patent/IT1158037B/it active
- 1982-12-21 DK DK566282A patent/DK160939C/da not_active IP Right Cessation
- 1982-12-22 CH CH1924/86A patent/CH659070A5/de not_active IP Right Cessation
- 1982-12-22 PT PT76017A patent/PT76017B/pt not_active IP Right Cessation
- 1982-12-22 DE DE19823247530 patent/DE3247530A1/de not_active Ceased
- 1982-12-22 IE IE3053/82A patent/IE54789B1/en not_active IP Right Cessation
- 1982-12-22 SE SE8207350A patent/SE453502B/sv not_active IP Right Cessation
- 1982-12-22 HU HU86744A patent/HU195806B/hu not_active IP Right Cessation
- 1982-12-22 HU HU824132A patent/HU190997B/hu not_active IP Right Cessation
- 1982-12-22 CH CH7498/82A patent/CH656617A5/de not_active IP Right Cessation
- 1982-12-23 KR KR8205773A patent/KR870001022B1/ko not_active IP Right Cessation
- 1982-12-23 BE BE0/209805A patent/BE895469A/fr not_active IP Right Cessation
- 1982-12-23 LU LU84550A patent/LU84550A1/fr unknown
1983
- 1983-08-12 ES ES524946A patent/ES524946A0/es active Granted
- 1983-09-08 ES ES525470A patent/ES8502991A1/es not_active Expired
- 1983-09-08 ES ES525471A patent/ES8503349A1/es not_active Expired
- 1983-10-21 FR FR8316769A patent/FR2531431B1/fr not_active Expired
1987
- 1987-03-27 SG SG300/87A patent/SG30087G/en unknown
- 1987-03-31 KE KE3718A patent/KE3718A/xx unknown
- 1987-06-09 SE SE8702389A patent/SE462162B/sv not_active IP Right Cessation
1988
- 1988-01-21 HK HK50/88A patent/HK5088A/xx not_active IP Right Cessation
1990
- 1990-12-28 DK DK307590A patent/DK162601C/da not_active IP Right Cessation
1991
- 1991-10-09 JP JP3289360A patent/JPH0517457A/ja active Granted

Also Published As

Publication number	Publication date
DK160939B (da)	1991-05-06
CA1205806A (en)	1986-06-10
GB2114119B (en)	1985-11-27
KE3718A (en)	1987-04-16
GR77108B (da)	1984-09-06
ES518168A0 (es)	1984-01-16
ES8503683A1 (es)	1985-04-01
DE3247530A1 (de)	1983-06-30
ES8401970A1 (es)	1984-01-16
KR840002832A (ko)	1984-07-21
SE8702389D0 (sv)	1987-06-09
ES525471A0 (es)	1985-02-01
GB2114119A (en)	1983-08-17
PT76017B (en)	1985-12-20
SE8207350L (sv)	1983-08-10
BE895469A (fr)	1983-06-23
HU195806B (en)	1988-07-28
DK162601B (da)	1991-11-18
ES525470A0 (es)	1985-02-01
CH656617A5 (de)	1986-07-15
CY1376A (en)	1987-08-07
AU9087282A (en)	1983-06-23
CH659070A5 (de)	1986-12-31
AU550780B2 (en)	1986-04-10
ES524946A0 (es)	1985-04-01
DK160939C (da)	1991-10-21
SE462162B (sv)	1990-05-14
IE54789B1 (en)	1990-02-14
ES8502991A1 (es)	1985-02-01
JPH0517457A (ja)	1993-01-26
DK307590A (da)	1990-12-28
FR2531431B1 (da)	1986-10-10
DK307590D0 (da)	1990-12-28
HU190997B (en)	1986-12-28
HK5088A (en)	1988-01-29
FI78697C (fi)	1989-09-11
SE453502B (sv)	1988-02-08
LU84550A1 (fr)	1983-09-08
FI824379A0 (fi)	1982-12-20
IT1158037B (it)	1987-02-18
JPS58110576A (ja)	1983-07-01
ES8503349A1 (es)	1985-02-01
KR870001022B1 (ko)	1987-05-23
FI78697B (fi)	1989-05-31
JPH0577669B2 (da)	1993-10-27
IE823053L (en)	1983-06-23
US4411901A (en)	1983-10-25
SE8207350D0 (sv)	1982-12-22
SE8702389L (sv)	1987-06-09
ZA828544B (en)	1983-09-28
FR2531431A1 (da)	1984-02-10
FR2521561A1 (fr)	1983-08-19
PT76017A (en)	1983-01-01
FR2521561B1 (fr)	1986-10-10
IT8249709A0 (it)	1982-12-21
FI824379L (fi)	1983-06-24
DK566282A (da)	1983-06-24
NL8204910A (nl)	1983-07-18
SG30087G (en)	1987-07-17

Publication	Publication Date	Title
DK162601C (da)	1992-05-11	Analogifremgangsmaade til fremstilling af 8-oe4-oe4-(2,1-benzisothiazol-3-yl)-1-piperazinylaabutylaa-8-azaspirooe4.5aadecan-7,9-dion
DK528982A (da)	1983-05-28	Fremgangsmaade til fremstilling af 13,14-didehydro-prostaglandiner
DK159442C (da)	1991-03-18	Analogifremgangsmaade til fremstilling af 6,7-substitueret-4-ethyl-quinazoliner
NO822722L (no)	1983-02-14	Fremgangsmaate til fremstilling av benzazepin-2-oner.
DK219382A (da)	1982-11-19	Fremgangsmaade til fremstilling af 1,2-diaminocyclobuten-3,4-dioner
DK156001C (da)	1989-11-06	Analogifremgangsmaade til fremstilling af mercaptosubstituerede 2,3,4,5-tetrahydro-1h-3-benzazepiner
DK161147C (da)	1991-11-18	Analogifremgangsmaade til fremstilling af oe3haa-imidazo-oe5,1-daa-1,2,3,5-tetrazin-4-onderivater
NO157861C (no)	1988-06-01	Analogifremgangsmaate til fremstilling av aminopyridaziner.
DK149846C (da)	1987-06-29	Analogifremgangsmaade til fremstilling af n,n'-bis-tetrahydro-isoquinolyldisulfonylimider
DK143491D0 (da)	1991-08-06	Fremgangsmaade til fremstilling af 3-oen-phenylacetylaminopiperidinaa-2,6-dion
DK379985D0 (da)	1985-08-21	Fremgangsmaade til fremstilling af 6-chlor-n-methyl-2,3,4,5-tetrahydro-lh-benzazepin
DK157855C (da)	1990-07-30	Fremgangsmaade til fremstilling af 2,3-dichlor-5-trichlormethylpyridin
DK117779A (da)	1979-09-24	Fremgangsmaade til fremstilling af 2,6-dialkoxybenzamider
DK162581A (da)	1981-10-12	Fr&mgangsmaade til fremstilling af substituerede 1,4-dihydropyridiner
NO823183L (no)	1983-03-22	Fremgangsmaate til fremstilling av 1,2-dikloretan.
DK400381A (da)	1982-03-11	Fremgansmaade til fremstilling af penicillanoyloxymethyl-penicillanoyloxymethyl-penicillanat-1,1,1!,1!-tetraoxid
DK159681A (da)	1981-10-19	Fremgangsmaade til fremstilling af 4,5-diaryl-alfa-(polyfluoralkyl)-1h-pyrrol-2-methanaminer
NO154547C (no)	1986-10-15	Fremgangsmaate til fremstilling av 1,2-dikloretan.
NO155575C (no)	1987-04-22	Fremgangsmaate til fremstilling av 1,2-dikloretan.
DK314682A (da)	1983-01-16	Fremgangsmaade til fremstilling af substituerede thiazolo-(3,2-a)pyrimidiner
DK113483D0 (da)	1983-03-08	Fremgangsmade til fremstilling af 3,4-diphenyl-5-methylpyrazolderivater
DK153488C (da)	1988-12-19	Fremgangsmaade til fremstilling af 5,6,7,7a-tetrahydro-4h-thieno(3,2-c-)-pyridin-2-onderivater
NO158621C (no)	1988-10-12	Fremgangsmaate til fremstilling av 1,2-dikloretan.
NO158299C (no)	1988-08-17	Analogifremgangsmaate for fremstilling av 17, 18-dehydro-apovincaminol-l-3', 4', 5'-trimethoxy-benzoat.
NO821142L (no)	1982-10-29	Fremgangsmaate til avvanning av torvstykker.

Legal Events

Date	Code	Title	Description
2002-08-05	PBP	Patent lapsed