DK1611108T3 - Fremgangsmåde til fremstilling af telmisartan - Google Patents

Fremgangsmåde til fremstilling af telmisartan

Info

Publication number: DK1611108T3
Authority: DK; Denmark
Prior art keywords: telmisartan; preparation
Prior art date: 2003-03-31

Application number

DK04739071.1T

Other languages

English (en)

Inventor

Norbert Hauel

Rolf Dach

Helmut Heitger

Oliver Meyer

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-31

Filing date

2004-03-26

Publication date

2011-10-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33016100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1611108(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-03-26 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2011-10-10 Application granted granted Critical

2011-10-10 Publication of DK1611108T3 publication Critical patent/DK1611108T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK04739071.1T 2003-03-31 2004-03-26 Fremgangsmåde til fremstilling af telmisartan DK1611108T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10314702A DE10314702A1 (de)	2003-03-31	2003-03-31	Verfahren zur Herstellung von Telmisartan
PCT/EP2004/003217 WO2004087676A1 (de)	2003-03-31	2004-03-26	Verfahren zur herstellung von telmisartan

Publications (1)

Publication Number	Publication Date
DK1611108T3 true DK1611108T3 (da)	2011-10-10

Family

ID=33016100

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK10192561.8T DK2322511T3 (da)	2003-03-31	2004-03-26	Fremgangsmåde til fremstilling af Telmisartan
DK04739071.1T DK1611108T3 (da)	2003-03-31	2004-03-26	Fremgangsmåde til fremstilling af telmisartan

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK10192561.8T DK2322511T3 (da)	2003-03-31	2004-03-26	Fremgangsmåde til fremstilling af Telmisartan

Country Status (26)

Country	Link
US (2)	US7193089B2 (da)
EP (2)	EP2322511B1 (da)
JP (1)	JP5160740B2 (da)
KR (1)	KR101096499B1 (da)
CN (1)	CN100418953C (da)
AR (2)	AR043794A1 (da)
AT (1)	ATE515500T1 (da)
AU (1)	AU2004226239B2 (da)
BR (1)	BRPI0408861A (da)
CA (1)	CA2520714C (da)
CL (1)	CL2004000687A1 (da)
CY (2)	CY1112020T1 (da)
DE (1)	DE10314702A1 (da)
DK (2)	DK2322511T3 (da)
ES (2)	ES2432647T3 (da)
IL (1)	IL171145A (da)
MX (1)	MXPA05009529A (da)
NZ (1)	NZ543244A (da)
PE (1)	PE20050390A1 (da)
PL (2)	PL2322511T3 (da)
PT (2)	PT2322511E (da)
RU (1)	RU2430092C2 (da)
SI (2)	SI1611108T1 (da)
TW (1)	TWI335916B (da)
UY (1)	UY28246A1 (da)
WO (1)	WO2004087676A1 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10314702A1 (de) *	2003-03-31	2004-10-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung von Telmisartan
GB2414019A (en) *	2004-05-11	2005-11-16	Cipla Ltd	One-step preparation of telmisartan by condensation and hydrolysis
DE102004045796A1 (de) *	2004-09-22	2006-03-23	Merck Patent Gmbh	Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
KR20070061583A (ko) *	2004-10-15	2007-06-13	테바 파마슈티컬 인더스트리즈 리미티드	텔미사르탄의 제조 방법
US7943781B2 (en)	2004-10-18	2011-05-17	Dr. Reddy's Laboratories Limited	Process for preparing telmisartan
EP1871764A1 (en) *	2005-04-01	2008-01-02	LEK Pharmaceuticals D.D.	A synthesis of 4-bromomethyl-2'-formylbiphenyl and 4-bromomethyl-2'- hydroxymethylbiphenyl and its use in preparation of angiotensin ii antagonists
ITMI20050801A1 (it) *	2005-05-03	2006-11-04	Dipharma Spa	Procedimento per la preparazione di telmisartan
WO2006136916A2 (en) *	2005-06-20	2006-12-28	Glenmark Pharmaceuticals Limited	Substantially pure micronized particles of telmisartan and pharmaceutical compositions containing same
US20060264491A1 (en) *	2006-06-08	2006-11-23	Chemagis Ltd.	Telmisartan production process
CN101172968B (zh) *	2006-11-01	2010-05-12	浙江天宇药业有限公司	2-正丙基-4甲基-6-(甲基苯并咪唑-2-基)苯并咪唑盐及其制备方法
CN101743228B (zh) *	2007-07-03	2014-01-29	新梅斯托克尔卡托瓦纳兹德拉韦尔公司	替米沙坦的制备方法
CZ302272B6 (cs)	2007-07-09	2011-01-19	Zentiva, A. S.	Zpusob výroby 4´-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-karboxylové kyseliny (telmisartanu)
WO2009116089A2 (en) *	2008-03-14	2009-09-24	Ipca Laboratories Limited	Novel intermediates and method for synthesis of 4'-[(1,4'-dimethyl-2'-propyl-[2,6'- bi-1hbenzimidazol]-l-yl)methyl]-1,1-biphenyl]-2-carboxylic acid.
EP2103588A1 (en) *	2008-03-20	2009-09-23	Lek Pharmaceuticals D.D.	2'-Halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists
US8410285B2 (en)	2008-03-20	2013-04-02	Lek Pharmaceuticals D.D.	2′-halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists
EP2103609A1 (en) *	2008-03-20	2009-09-23	Lek Pharmaceuticals D.D.	Catalyzed carbonylation in the synthesis of angiotensin ii antagonists
EP2123648A1 (en)	2008-05-20	2009-11-25	Chemo Ibérica, S.A.	A process for the preparation of Telmisartan.
EP2149566A1 (en)	2008-07-15	2010-02-03	Chemo Ibérica, S.A.	A process for the preparation of telmisartan
SI2443094T1 (sl)	2009-06-19	2013-08-30	Krka, Tovarna Zdravil, D.D., Novo Mesto	Postopek za pripravo telmisartana
EP2277866A1 (en) *	2009-06-22	2011-01-26	Inke, S.A.	Process for preparing telmisartan
EP2305650A1 (en)	2009-09-21	2011-04-06	Chemo Ibérica, S.A.	Novel process for the preparation of telmisartan
EA025946B1 (ru)	2010-10-27	2017-02-28	Крка, Товарна Здравил, Д. Д., Ново Место	Многослойная фармацевтическая композиция, содержащая телмисартан и амлодипин
CN102267949A (zh) *	2011-06-14	2011-12-07	张长利	替米沙坦制备新工艺
WO2014027280A1 (en)	2012-08-14	2014-02-20	U Amarnath Amarnath	One pot process for the preparation of telmisartan
CN103787982A (zh) *	2012-10-31	2014-05-14	上海特化医药科技有限公司	制备替米沙坦的方法及其中间体
CN104557724B (zh) *	2014-11-17	2017-01-11	江苏中邦制药有限公司	替米沙坦不定形晶型及其制备方法
CN105130905B (zh) *	2015-09-17	2017-09-08	浙江金立源药业有限公司	一种替米沙坦的合成方法
CN109912512B (zh) *	2017-12-13	2023-05-30	上海科胜药物研发有限公司	一种新的替米沙坦杂质化合物及其制备方法和用途
CN112251770B (zh) *	2020-10-14	2021-07-27	湖南大学	一种抗高血压药替米沙坦中间体电化学制备新方法
CN113307775B (zh) *	2021-04-16	2022-04-22	河北戴桥医药科技有限公司	一种替米沙坦的制备方法
WO2023204729A1 (ru) *	2022-04-19	2023-10-26	Общество с ограниченной ответственностью "Гелеспон"	Фармацевтические композиции на основе новой субстанции 4-[2-(1н-имидазол-4-ил)-этилкарбамоил]-бутановой кислоты и способ получения субстанции

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4023369A1 (de) *	1990-07-23	1992-01-30	Thomae Gmbh Dr K	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
RU1836357C (ru) *	1990-07-23	1993-08-23	Др.Карл Томэ ГмбХ	Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
DE4103492A1 (de) *	1991-02-06	1992-10-08	Thomae Gmbh Dr K	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
SI9210098B (sl) *	1991-02-06	2000-06-30	Dr. Karl Thomae	Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
US5591762A (en)	1991-02-06	1997-01-07	Dr. Karl Thomae Gmbh	Benzimidazoles useful as angiotensin-11 antagonists
DE19901921C2 (de) *	1999-01-19	2001-01-04	Boehringer Ingelheim Pharma	Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels
US6358986B1 (en)	1999-01-19	2002-03-19	Boehringer Ingelheim Pharma Kg	Polymorphs of telmisartan
US6737432B2 (en)	2001-10-31	2004-05-18	Boehringer Ingelheim Pharma Kg	Crystalline form of telmisartan sodium
DE10314702A1 (de) *	2003-03-31	2004-10-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung von Telmisartan

2003
- 2003-03-31 DE DE10314702A patent/DE10314702A1/de not_active Withdrawn
2004
- 2004-03-17 US US10/802,142 patent/US7193089B2/en active Active
- 2004-03-26 NZ NZ543244A patent/NZ543244A/en not_active IP Right Cessation
- 2004-03-26 JP JP2005518684A patent/JP5160740B2/ja not_active Expired - Lifetime
- 2004-03-26 DK DK10192561.8T patent/DK2322511T3/da active
- 2004-03-26 ES ES10192561T patent/ES2432647T3/es not_active Expired - Lifetime
- 2004-03-26 EP EP10192561.8A patent/EP2322511B1/de not_active Expired - Lifetime
- 2004-03-26 KR KR1020057018333A patent/KR101096499B1/ko active IP Right Grant
- 2004-03-26 AU AU2004226239A patent/AU2004226239B2/en not_active Expired
- 2004-03-26 AT AT04739071T patent/ATE515500T1/de active
- 2004-03-26 CA CA2520714A patent/CA2520714C/en not_active Expired - Fee Related
- 2004-03-26 PT PT101925618T patent/PT2322511E/pt unknown
- 2004-03-26 SI SI200431740T patent/SI1611108T1/sl unknown
- 2004-03-26 CN CNB2004800087194A patent/CN100418953C/zh not_active Expired - Lifetime
- 2004-03-26 BR BRPI0408861-1A patent/BRPI0408861A/pt not_active Application Discontinuation
- 2004-03-26 PL PL10192561T patent/PL2322511T3/pl unknown
- 2004-03-26 PL PL04739071T patent/PL1611108T3/pl unknown
- 2004-03-26 SI SI200432083T patent/SI2322511T1/sl unknown
- 2004-03-26 DK DK04739071.1T patent/DK1611108T3/da active
- 2004-03-26 PT PT04739071T patent/PT1611108E/pt unknown
- 2004-03-26 MX MXPA05009529A patent/MXPA05009529A/es active IP Right Grant
- 2004-03-26 EP EP04739071A patent/EP1611108B1/de not_active Expired - Lifetime
- 2004-03-26 WO PCT/EP2004/003217 patent/WO2004087676A1/de active Application Filing
- 2004-03-26 RU RU2005133479/04A patent/RU2430092C2/ru active
- 2004-03-26 ES ES04739071T patent/ES2369081T3/es not_active Expired - Lifetime
- 2004-03-29 UY UY28246A patent/UY28246A1/es not_active Application Discontinuation
- 2004-03-29 TW TW093108537A patent/TWI335916B/zh not_active IP Right Cessation
- 2004-03-29 PE PE2004000331A patent/PE20050390A1/es not_active Application Discontinuation
- 2004-03-30 CL CL200400687A patent/CL2004000687A1/es unknown
- 2004-03-31 AR ARP040101066A patent/AR043794A1/es active IP Right Grant
2005
- 2005-09-28 IL IL171145A patent/IL171145A/en active IP Right Grant
2011
- 2011-09-28 CY CY20111100938T patent/CY1112020T1/el unknown
2012
- 2012-07-17 AR ARP120102582A patent/AR087209A2/es unknown
2013
- 2013-01-25 US US13/750,551 patent/US8993778B2/en active Active
- 2013-10-09 CY CY20131100879T patent/CY1115156T1/el unknown

Also Published As

Publication number	Publication date
DE10314702A1 (de)	2004-10-21
ATE515500T1 (de)	2011-07-15
RU2430092C2 (ru)	2011-09-27
MXPA05009529A (es)	2005-10-19
US20040236113A1 (en)	2004-11-25
PT2322511E (pt)	2013-08-29
JP2006521289A (ja)	2006-09-21
SI1611108T1 (sl)	2011-10-28
CL2004000687A1 (es)	2005-02-04
NZ543244A (en)	2010-02-26
IL171145A (en)	2010-12-30
US8993778B2 (en)	2015-03-31
EP1611108B1 (de)	2011-07-06
PL1611108T3 (pl)	2011-12-30
EP2322511A1 (de)	2011-05-18
CA2520714C (en)	2012-05-15
CY1115156T1 (el)	2016-12-14
WO2004087676A1 (de)	2004-10-14
AR087209A2 (es)	2014-02-26
AU2004226239A1 (en)	2004-10-14
CN1768044A (zh)	2006-05-03
PE20050390A1 (es)	2005-06-23
US20130137878A1 (en)	2013-05-30
SI2322511T1 (sl)	2013-10-30
DK2322511T3 (da)	2013-10-28
KR101096499B1 (ko)	2011-12-20
PL2322511T3 (pl)	2014-01-31
EP1611108A1 (de)	2006-01-04
UY28246A1 (es)	2004-11-08
KR20050118699A (ko)	2005-12-19
TW200504055A (en)	2005-02-01
BRPI0408861A (pt)	2006-04-11
PT1611108E (pt)	2011-09-01
CA2520714A1 (en)	2004-10-14
ES2369081T3 (es)	2011-11-25
TWI335916B (en)	2011-01-11
AU2004226239B2 (en)	2011-04-21
CN100418953C (zh)	2008-09-17
CY1112020T1 (el)	2015-11-04
JP5160740B2 (ja)	2013-03-13
AR043794A1 (es)	2005-08-10
US7193089B2 (en)	2007-03-20
EP2322511B1 (de)	2013-07-31
RU2005133479A (ru)	2006-07-27
ES2432647T3 (es)	2013-12-04

Publication	Publication Date	Title
DK1611108T3 (da)	2011-10-10	Fremgangsmåde til fremstilling af telmisartan
DK1828164T3 (da)	2008-12-08	Fremgangsmåde til fremstilling af N-phenylpyrazol-1-carboxamider
DK1778668T3 (da)	2013-09-30	Fremgangsmåde til fremstilling af dihydropteridion
DK1893586T3 (da)	2009-01-05	Fremgangsmåde til fremstilling af 1-alkyl-3-phenyluraciler
CR8226A (es)	2008-08-21	Proceso para la preparacion de 4-amino-3-quinolincarbonitrilos
DK1546122T3 (da)	2008-03-03	Fremgangsmåde til fremstilling af valsartan
DK1651622T3 (da)	2007-05-07	Fremgangsmåde til fremstilling af 2-(quinoxalin-5-ylsulfonylamino)-benzamidforbindelser
DK1756049T3 (da)	2008-02-25	Fremgangsmåde til fremstilling af 1,4-diphenylazetidinon-derivater
NO20076030L (no)	2007-12-07	Fremgangsmåte for fremstilling av hydroklorsilaner
DK1840125T3 (da)	2009-11-09	Mellemprodukter til fremstilling af dioxan-2-alkylcarbamater
DK1831223T3 (da)	2013-06-10	Fremgangsmåde til fremstilling af L-biopterin
DK1667967T3 (da)	2012-10-08	Fremgangsmåde til fremstilling af 2-oxo-1-pyrrolidin-derivater
DK1856035T3 (da)	2009-03-09	Fremgangsmåde til fremstilling af beskyttelse amidiner
NO20044814L (no)	2004-01-07	Fremgangsmate for fremstilling av combretastaniner
DK1678135T3 (da)	2009-09-07	Fremgangsm de til fremstilling af n-amino-substituerede hetorocykliske forbindelser
IS7958A (is)	2005-07-26	Aðferð til að framleiða metýl 2-dífenýlmetýlsúlfínýlasetat
DK1572613T3 (da)	2006-12-18	Fremgangsmåde til fremstilling af benzophenoner
DK1575941T3 (da)	2012-07-09	Fremgangsmåde til fremstilling af (S)-pantoprazol
DK1912961T3 (da)	2013-02-11	Fremgangsmåde til fremstilling af bepromolin
DK1682541T3 (da)	2010-06-28	Fremgangsmåde til fremstilling af tiotropiumsalte
DK1931618T3 (da)	2009-11-09	Fremgangsmåde til fremstilling af aniliner
DK1727792T3 (da)	2009-03-30	Fremgangsmåde til fremstilling af semicarbazoner
DK1937662T3 (da)	2009-11-30	Fremgangsmåde til fremstilling af duloxetin
DK1660485T3 (da)	2007-03-19	Forbedret fremgangsmåde til fremstilling af alpha-polymorfisk eletriptanhydrobromid
DK1692137T3 (da)	2007-04-30	Fremgangsmåde til fremstilling af tubulinininhibitorer